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Post Transcriptional Regulation By Unr
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Book Synopsis Post-transcriptional Regulation by UNR by : Marta Inglés Ferrándiz
Download or read book Post-transcriptional Regulation by UNR written by Marta Inglés Ferrándiz and published by . This book was released on 2018 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, we have been studying the role of UNR, and RNA-binding protein that regulates translation and/or stability of its targets. The functional relevance of UNR was studied in two different molecular contexts: histone mRNA metabolism and cellular senescence. UNR strongly binds to the 3' untranslated region very close to the stem-loop. Previous data from the laboratory suggested that UNR stabilizes these mRNAs. As UNR is localized mainly in the cytoplasm, we hypothesized that it might be controlling post-transcriptional events. However, after several experimental trials in vitro and in cellulo we did not reach into any conclusion of how UNR might be influencing histone mRNAs metabolism. For this reason, we undertook an additional project. We found a novel role of UNR in oncogene-induced senescence (OIS) and determined cell-autonomous tumour suppressive properties in this context. In addition, we suspect that UNR influences the secretion of senescence associated secretory phenotype (SASP) of senescent cells, exerting tumour suppressive properties also in non-autonomous manner. Further experiments are needed to fully understand the contribution of UNR in OIS.
Book Synopsis Post-Transcriptional Gene Regulation by : Jane Wu
Download or read book Post-Transcriptional Gene Regulation written by Jane Wu and published by John Wiley & Sons. This book was released on 2013-04-24 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the rapid progress in the field, the book presents the current understanding of molecular mechanisms of post-transcriptional gene regulation thereby focusing on RNA processing mechanisms in eucaryotic cells. With chapters on mechanisms as RNA splicing, RNA interference, MicroRNAs, RNA editing and others, the book also discusses the critical role of RNA processing for the pathogenesis of a wide range of human diseases. The interdisciplinary importance of the topic makes the title a useful resource for a wide reader group in science, clinics as well as pharmaceutical industry.
Book Synopsis Transcriptional and Post-transcriptional Regulation by : Ghedira Kais
Download or read book Transcriptional and Post-transcriptional Regulation written by Ghedira Kais and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes are regulated at the cellular level. The editor embarked upon this writing project entitled "Transcriptional and Post-transcriptional Regulation" to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will enjoy reading and benefit from the chapters of this book.
Book Synopsis Post-transcriptional Control of Gene Expression by : Orna Resnekov
Download or read book Post-transcriptional Control of Gene Expression written by Orna Resnekov and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many important cellular processes rely on posttranscriptional control of gene expression. This book describes the mechanisms of gene expression at this level that occur in the cytoplasm of prokaryotes and eukaryotes. Several introductory chapters discuss the general principles of translation and mRNA stability. The interactions of mature mRNA with the translational machinery, the components of mRNA degradation and antisense RNA are surveyed. Subsequent chapters discuss protein folding, transport, modification and degradation. The book is an invaluable source of information for both newcomers and those wishing an overview of the field.
Book Synopsis Posttranscriptional Gene Regulation by : Jane Wu
Download or read book Posttranscriptional Gene Regulation written by Jane Wu and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: 2.4 Regulation of Transcription by Termination2.4.1 Transcription Attenuation, Promoter Upstream/Associated Transcription, and Pausing of RNApII; 2.4.2 Alternative Polyadenylation and Termination; 2.5 Mechanisms of Termination by Other RNA Polymerases; 2.6 Future Perspectives; Acknowledgments; References; 3: Posttranscriptional Gene Regulation by an Editor: ADAR and its Role in RNA Editing; 3.1 Introduction; 3.2 The RNA Editing Kinship; 3.3 The ADAR Gene Family; 3.4 The Role of RNA in the A-to-I Editing Mechanism; 3.5 Splice Site Alterations.
Book Synopsis Post-transcriptional Regulation of the Eukaryotic Transcriptome by the Covalent RNA Modification N6-methyladenosine by : Stephen James Anderson
Download or read book Post-transcriptional Regulation of the Eukaryotic Transcriptome by the Covalent RNA Modification N6-methyladenosine written by Stephen James Anderson and published by . This book was released on 2019 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Once a messenger RNA molecule is transcribed, a myriad of RNA fate decisions must be made. How these fate decisions are made is often unclear, and elucidating factors determining these fate outcomes is an essential task in order to fully understand gene regulation. One poorly- understood but undoubtedly important factor in post-transcriptional gene regulation is the covalent modification of ribonucleotides. Much like DNA can have chemical groups added to a nucleotide within its primary sequence, RNA can be modified in a similar manner. These covalent modifications of RNA are a ubiquitous feature found within the RNA of all organisms. Dozens of these modifications have been described to date, yet the function or importance of most of these modifications remains unclear. One crucial RNA modification is N6-methyladenosine (m6A), as it is the most abundant known non-cap modification within the eukaryotic transcriptome. In this work, we characterize the role of m6A in the Arabidopsis transcriptome using various sequencing methods that demonstrate that m6A is an abundant mark that is largely maintained across differing Arabidopsis tissues and developmental stages. This prevalent mark promotes transcript stability in mNRAs involved in many important and diverse biological processes, such as salt stress. The absence of this mark results in endonucleolytic cleavage and degradation of the transcript in a highly specific and local manner. We further demonstrate that this modification modulates secondary structure throughout the transcriptome, and that m6A is associated with changes in RNA-binding protein association. Lastly, we turn our view to how an association between m6A and the m6A-specific binding protein YTHDC1 influences the development and transcriptome-wide splicing and polyadenylation pattern in the mouse germline. We demonstrate that in the absence of YTHDC1, widespread developmental, splicing, and polyadenylation defects occur, resulting in non-functional gametes. In total, this work greatly expands our knowledge and understanding of the biological importance and mechanisms of m6A-mediated post-transcriptional regulation.
Book Synopsis Post-transcriptional Mechanisms in Endocrine Regulation by : K.M.J. Menon, PhD
Download or read book Post-transcriptional Mechanisms in Endocrine Regulation written by K.M.J. Menon, PhD and published by Springer. This book was released on 2015-12-30 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.
Book Synopsis Transcriptional and Post-transcriptional Regulation of Gene Expression by : Jun Ding
Download or read book Transcriptional and Post-transcriptional Regulation of Gene Expression written by Jun Ding and published by . This book was released on 2016 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulation of gene expression includes a variety of mechanisms to increase or decrease specific gene products. Gene expression can be regulated at any stage from transcription to post-transcription and it's essential to almost all living organisms, as it increases the versatility and adaptability by allowing the cell to express the needed proteins. In this dissertation, we comprehensively studied the gene regulation from both transcriptional and post-transcriptional points of view. Transcriptional regulation is by which cells regulate the transcription from DNA to RNA, thereby directing gene activity. Transcriptional factors (TFs) play a very important role in transcriptional regulation and they are proteins that bind to specific DNA sequences (regulatory elements) to regulate the gene expression. Current studies on TF binding are still very limited and thus, it leaves much to be improved on understanding the TF binding mechanism. To fill this gap, we proposed a variety of computational methods for predicting TF binding elements, which have been proved to be more efficient and accurate compared with other existing tools such as DREME and RSAT peaks-motif. On the other hand, studying only the transcriptional gene regulation is not enough for a comprehensive understanding. Therefore, we also studied the gene regulation at the post-transcriptional level. MicroRNAs (miRNAs) are believed to post-transcriptionally regulate the expression of thousands of target mRNAs, yet the miRNA binding mechanism is still not well understood. In this dissertation, we explored both the traditional and novel features of miRNA-binding and proposed several computational models for miRNA target prediction. The developed tools outperformed the traditional microRNA target prediction methods (.e.g miRanda and TargetScan) in terms of prediction accuracy (precision, recall) and time efficiency.
Book Synopsis Post-Transcriptional Gene Regulation by : Jeffrey Wilusz
Download or read book Post-Transcriptional Gene Regulation written by Jeffrey Wilusz and published by Springer Science & Business Media. This book was released on 2008 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Step-by-step instructions that ensure successful results.
Book Synopsis Post-transcriptional Regulation Mechanisms of SRNA RnTrpL in S. Meliloti and E. Coli by : Siqi Li
Download or read book Post-transcriptional Regulation Mechanisms of SRNA RnTrpL in S. Meliloti and E. Coli written by Siqi Li and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transcriptional/posttranscriptional regulations in agricultural species after stresses by : Suxu Tan
Download or read book Transcriptional/posttranscriptional regulations in agricultural species after stresses written by Suxu Tan and published by Frontiers Media SA. This book was released on 2023-02-03 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Computational Investigations of Post-transcriptional Regulation by : Simon Horskjær Rasmussen
Download or read book Computational Investigations of Post-transcriptional Regulation written by Simon Horskjær Rasmussen and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Post-transcriptional Gene Regulation by : Erin Margaret Wissink
Download or read book Post-transcriptional Gene Regulation written by Erin Margaret Wissink and published by . This book was released on 2016 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis mRNA Translational Control as a Mechanism of Post-transcriptional Gene Regulation by : Daniel L. Kiss
Download or read book mRNA Translational Control as a Mechanism of Post-transcriptional Gene Regulation written by Daniel L. Kiss and published by Frontiers Media SA. This book was released on 2022-07-25 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Post-transcriptional Control by : Robert Leonard Tanguay
Download or read book Post-transcriptional Control written by Robert Leonard Tanguay and published by . This book was released on 1995 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transcriptional and Post-transcriptional Regulation of ATP-binding Cassette Transporters by : Pui Lai Rachel Ee
Download or read book Transcriptional and Post-transcriptional Regulation of ATP-binding Cassette Transporters written by Pui Lai Rachel Ee and published by . This book was released on 2004 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Post Transcriptional Regulation by Star Proteins by : Talila Volk
Download or read book Post Transcriptional Regulation by Star Proteins written by Talila Volk and published by . This book was released on 2011-01-04 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
