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Positive Negative Ion Analysis Of Oligopeptides Utilizing Fast Atom Bombardment And Triple Stage Quadrupole Mass Spectrometry
Download Positive Negative Ion Analysis Of Oligopeptides Utilizing Fast Atom Bombardment And Triple Stage Quadrupole Mass Spectrometry full books in PDF, epub, and Kindle. Read online Positive Negative Ion Analysis Of Oligopeptides Utilizing Fast Atom Bombardment And Triple Stage Quadrupole Mass Spectrometry ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Positive Negative Ion Analysis of Oligopeptides Utilizing Fast Atom Bombardment and Triple Stage Quadrupole Mass Spectrometry by : George Alexander Parker
Download or read book Positive Negative Ion Analysis of Oligopeptides Utilizing Fast Atom Bombardment and Triple Stage Quadrupole Mass Spectrometry written by George Alexander Parker and published by . This book was released on 1984 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Signal Enhancement of Polyanionic Analytes in Negative Ion Fast Atom Bombardment Mass Spectrometry Using Matrix Additives by : Kathleen Rose Noon
Download or read book Signal Enhancement of Polyanionic Analytes in Negative Ion Fast Atom Bombardment Mass Spectrometry Using Matrix Additives written by Kathleen Rose Noon and published by . This book was released on 1995 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Analysis of Organic and Biochemical Compounds by Desorption Ionization Mass Spectrometry by : Kevin L. Duffin
Download or read book Analysis of Organic and Biochemical Compounds by Desorption Ionization Mass Spectrometry written by Kevin L. Duffin and published by . This book was released on 1989 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ionization Methods in Organic Mass Spectrometry by : Alison E Ashcroft
Download or read book Ionization Methods in Organic Mass Spectrometry written by Alison E Ashcroft and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ionization Methods in Organic Mass Spectrometry is a basic practical guide for scientists of all disciplines who wish to analyse samples by organic mass spectrometry. Concentrating on instrumental operation, this book gives step-by-step instructions on how to set up, and how to achieve the best results, using a range of ionization methods, including atmospheric pressure chemical ionization, electrospray ionization and matrix assisted laser desorption ionization. Ionization Methods in Organic Mass Spectrometry will enable a beginner, or practitioner with limited experience, to choose the most appropriate ionization technique in application areas such as biomolecules, drugs and metabolites, pesticides, polymers and many other organic compounds. It will be a valuable practical guide for technicians, graduates, students or researchers - or indeed anyone new to practical organic mass spectrometry.
Book Synopsis The Chemical Modification of Oligopeptides for Fast Atom Bombardment Mass Spectrometry by : John Charles Karris
Download or read book The Chemical Modification of Oligopeptides for Fast Atom Bombardment Mass Spectrometry written by John Charles Karris and published by . This book was released on 1984 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Laser Desorption Fourier Transform Mass Spectrometric Studies of Oligopeptides by : Liub-Chii Yang
Download or read book Laser Desorption Fourier Transform Mass Spectrometric Studies of Oligopeptides written by Liub-Chii Yang and published by . This book was released on 1988 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Study of Ion/molecule Reactions by Triple Quadrupole Mass Spectrometry by : Gregory G. Dolnikowski
Download or read book The Study of Ion/molecule Reactions by Triple Quadrupole Mass Spectrometry written by Gregory G. Dolnikowski and published by . This book was released on 1987 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enhancement of Ion Emission in Fast Atom Bombardment Mass Spectrometry by : Brian D. Bennett
Download or read book Enhancement of Ion Emission in Fast Atom Bombardment Mass Spectrometry written by Brian D. Bennett and published by . This book was released on 1990 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of the Triphenylphosphonium Derivative of Peptides by Fast Atom Bombardment-tandem Mass Spectrometry, and Investigations of the Mechanisms of Fragmentation of Peptides by : David Scott Wagner
Download or read book Characterization of the Triphenylphosphonium Derivative of Peptides by Fast Atom Bombardment-tandem Mass Spectrometry, and Investigations of the Mechanisms of Fragmentation of Peptides written by David Scott Wagner and published by . This book was released on 1992 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ion Formation from Organic Solids (IFOS III) by : A. Benninghoven
Download or read book Ion Formation from Organic Solids (IFOS III) written by A. Benninghoven and published by Springer. This book was released on 1986 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Application of Positive and Negative Ion Chemical Ionization Mass Spectrometry to the Sequence Analysis of Polypeptides by : Alexander Michael Buko
Download or read book The Application of Positive and Negative Ion Chemical Ionization Mass Spectrometry to the Sequence Analysis of Polypeptides written by Alexander Michael Buko and published by . This book was released on 1981 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Systematic Studies of Charged Derivatives of Peptides Analyzed by Mass Spectrometry by : Kenneth David William Roth
Download or read book Systematic Studies of Charged Derivatives of Peptides Analyzed by Mass Spectrometry written by Kenneth David William Roth and published by . This book was released on 1999 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of a Novel Mass-selected Internal Positive Chemical Ionization Quadrupole Ion Trap Mass Spectrometry Technique for the Quantitative Analysis of Isotopic Polyunsaturated Fatty Acids by : Hamid Izadi
Download or read book Development of a Novel Mass-selected Internal Positive Chemical Ionization Quadrupole Ion Trap Mass Spectrometry Technique for the Quantitative Analysis of Isotopic Polyunsaturated Fatty Acids written by Hamid Izadi and published by . This book was released on 2009 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical instrumentation for quantitative in vivo stable isotope metabolic studies has included gas chromatography-mass spectrometry (GC-MS) and gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS). Limitations of existing MS techniques include excessive parent ion fragmentation, time-consuming sample preparation, and complex instrument operating parameters. In this thesis, procedures for set up and implementation of four GC-MS techniques are described. The first three replicate existing GC-MS single quadrupole methods on an ion trap, and are electron ionization (EI), external methane positive chemical ionization (PCI), and methane negative chemical ionization (NCI). The fourth method is a novel GC-MS mass-selected ion trap internal isobutane positive chemical ionization technique. Four groups of rats were administered isotopic linoleic acid, and liver tissue was collected for labelled linoleic and n-6 polyunsaturated fatty acids (PUFA) metabolites analyses. Qualitative utility of EI was confirmed, and its quantitative limitations exposed. Labelled 18:2n-6 and n-6 PUFA metabolites were detected using external methane PCI, though limited due to significant fragmentation. Methane NCI also detected labelled 18:2n-6, as well as minimizing fragmentation. However, time-consuming sample preparation and non-linear responses were major limitations. Internal isobutane PCI was useful in detecting isotopic 18:2n-6 and n-6 PUFA metabolites. Fragmentation was reduced compared to EI and external methane PCI. Limitations include fragmentation of HUFAs such as EPA and DHA. The novel internal isobutane PCI is more sensitive than external methane PCI and NCI, produces highly linear responses, is simpler and less expensive to operate than C-IRMS, offers reliable instrument operation, and sample preparation time is minimal. Regular quantitative analyses of HUFAs such as EPA and DHA may require further refinements such as using lower energy reagents than isobutane, including acetonitrile and ammonia.
Book Synopsis Anion Detection in the Positive Ion Mode Electrospray Ionization Mass Spectrometry by Use of Cationic Ion Pairing Agents by : Edra Dodbiba
Download or read book Anion Detection in the Positive Ion Mode Electrospray Ionization Mass Spectrometry by Use of Cationic Ion Pairing Agents written by Edra Dodbiba and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Anion detection and quantitation has long been of great interest to many scientific areas of research in academic and industrial settings. Their importance extends to areas such as water and environmental analysis, biological system analysis, and also the pharmaceutical and food industries. A variety of sensitive detection methods have been developed for anions. Many of these methods have significant advantages, but also drawbacks. In my dissertation I have described a new method for the detection of anions using electrospray ionization mass spectrometry (ESI-MS) positive ion mode, and cationic ion pairing reagents. Using this method, anions are paired with a plethora of different, di-, tri-, and tetra-cationic ion pairing reagents, thus forming positively charged complexes, which can then be detected in the positive ion mode ESI-MS. The behavior and selectivity of the ion pairing reagents is investigated for the different classes of analytes. During this study, large classes of small organic and inorganic anions were analyzed. In addition, three unique classes of moderate size molecules were investigated. Two of which were biological ones: nucleotides and phospholipids. These are very important molecules, which are responsible for the proper functioning of all biological entities. Nucleotides can exist as monomers or constituents of oligomers, thus they can have more than one negative charge. A total of 28 nucleotide and nucleotide based compounds were paired and analyzed with many different cationic ion pairing reagents. Phospholipids are unique molecules due to their amphipathic character. Phospholipids of different polar groups and different sizes were analyzed in the positive ion mode ESI-MS by using newly synthesized ion pairing reagents. Also, analytical separations of phospholipids were developed using both reverse phase high performance liquid chromatography (HPLC) and hydrophilic interaction liquid chromatography (HILIC) The last class of analytes studied were metal ions. They are already positively charged and therefore they can be detected directly in the positive ion mode ESI-MS, however most of them have a small mass and several oxidation states which usually makes them fall in the low mass to charge region of the mass spectra where the background noise is significant. In this study metals of different oxidation states were complexed with commercially available chelating agents forming negatively charged complexes. Ion pairing agents were added to these compounds forming overall ternary positively charged complexes. Analyses for all types of analytes were performed in both single ion monitoring (SIM) and single reaction monitoring (SRM) modes. Limits of detection (LODs) were easily achieved at the parts per billion (ppb) to parts per trillion (ppt) levels, and significant improvements were noticed in the positive versus negative ion mode ESI-MS. This novel method developed herein shows immense potential for sensitive trace studies of many molecules, high throughput and great simplicity. Lastly a mechanism study by ESI-MS was explored to further understand the low limits of detection achieved by this method.
Book Synopsis Studies on the Desorption Ionization Mechanism in Fast Atom Bombardment Mass Spectrometry by : Angelina Morales
Download or read book Studies on the Desorption Ionization Mechanism in Fast Atom Bombardment Mass Spectrometry written by Angelina Morales and published by . This book was released on 1990 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of Peptides Using Thermospray Liquid Chromatography/mass Spectrometry and Fast Atom Bombardment Mass Spectrometry by : Saul W. Fink
Download or read book Characterization of Peptides Using Thermospray Liquid Chromatography/mass Spectrometry and Fast Atom Bombardment Mass Spectrometry written by Saul W. Fink and published by . This book was released on 1990 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Continuous Flow Fast Atom Bombardment and Electrospray Ionization Mass Spectrometry in Natural Products Research by : Katarzyna Janota
Download or read book Continuous Flow Fast Atom Bombardment and Electrospray Ionization Mass Spectrometry in Natural Products Research written by Katarzyna Janota and published by . This book was released on 1995 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous flow fast atom bombardment (CF-FAB) has been applied as a liquid chromatography/mass spectrometry (LC/MS) and liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS) interface in natural products research. Initial studies concentrated on characterization of the interface, optimization of operational parameters and sensitivity assessment. Using a CF-FAB interface, femtomole quantities of different classes of compounds were detected, which is two orders of magnitude more sensitive than by standard FAB. Later, CF-FAB was applied to the analysis of didemnin, streptovaricin, and ecteinascidin mixtures in isocratic and/or gradient modes. The first application led to the discovery of acyclo-desHIP-didemnin A in a mixture of didemnins, cyclic peptides of potent antitumor and antiviral activity. Although related to didemnins, the linear peptide was biologically inactive. The second application project involved streptovaricins, secondary metabolites of Streptomyces spectabilis. In the streptovaricin mixture, besides streptovaricins, protostreptovaricins III and IV were detected by LC/CF-FABMS. The presence of protostreptovaricins in the streptovaricin complex confirmed the biosynthetic pathway proposed for streptovaricin C. Even though these precursors were known previously, they were not observed as components of the mixture by standard FABMS. When ecteinascidins were analyzed by LC/CF-FABMS, the most significant difference was the amount of structural information generated in the low mass range in comparison to the standard FAB spectra. The hydrates of structurally significant fragment ions were observed when the background was subtracted. The use of a CF-FAB interface was extended to on-line high resolution mass measurements of different components in the mixture. Mass measurements were within the range of acceptable error. On-line LC/CF-FABMS/MS was performed on the ecteinascidin mixture using B/E linked scans. Observed ions were then classified as group-characteristic or compound-specific. Finally, CF-FAB was compared to electrospray ionization (ESI) as an LC/MS and LC/MS/MS interface with respect to sensitivity and structural information. In the selected ion chromatogram mode, the sensitivity of CF-FAB is comparable to that of LC/ESIMS. However, identification of unknowns is more feasible by LC/ESIMS than by LC/CF-FABMS. Also, the daughter ion mass spectra can be produced even on trace amounts by LC/ESIMS/MS and are of better quality than by LC/CF-FABMS/MS. In LC/ESIMS/MS, similar structural information is obtained; however, the main difference is the relative intensities of the fragment ions. Several new ecteinascidins were observed by LC/ESIMS. Their structures are proposed on the basis of LC/ESIMS/MS data.
