Polymeric Nanogels for Therapeutic and Diagnostic Applications

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Author :
Publisher : Elsevier
ISBN 13 : 0443215138
Total Pages : 0 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis Polymeric Nanogels for Therapeutic and Diagnostic Applications by : Emmanuel Rotimi Sadiku

Download or read book Polymeric Nanogels for Therapeutic and Diagnostic Applications written by Emmanuel Rotimi Sadiku and published by Elsevier. This book was released on 2024-12-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric Nanogels for Therapeutic and Diagnostic Applications explores the design and use of polymer-based nanogels as multifunctional nanosystems for various biomedical applications. The book introduces the reader to the unique properties, characterization, synthesis, and functionalization of polymeric nanogels, providing a step-by-step overview of the core development aspects. A broad range of therapeutic and diagnostic applications is covered, from tissue regeneration, antimicrobial therapy, and cancer detection to treatment of neurological and metabolic disorders. This resource presents readers with a research-led and accessible reference to aid in the development of novel nanosystems. Combines materials science, nanotechnology, and chemistry approaches to provide a multidisciplinary and comprehensive overview of polymeric nanogels in therapeutics and diagnostics Details both the formulation and the application of polymeric nanogels, offering a holistic view Covers a wide selection of therapeutic and diagnostic applications, such as targeted gene modification, targeted substrate delivery, biosensing, treatment of degenerative diseases, and more

Nanogels for Biomedical Applications

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Author :
Publisher : Royal Society of Chemistry
ISBN 13 : 1788012526
Total Pages : 322 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Nanogels for Biomedical Applications by : Arti Vashist

Download or read book Nanogels for Biomedical Applications written by Arti Vashist and published by Royal Society of Chemistry. This book was released on 2017-11-20 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanogel-based systems have gained tremendous attention due to their diverse range of applications in tissue engineering, regenerative medicine, biosensors, orthopaedics, wound healing and drug delivery. Nanogels for Biomedical Applications provides a comprehensive overview of nanogels and their use in nanomedicine. The book starts with the synthesis, methods and characterization techniques for nanogel-based smart materials followed by individual chapters demonstrating the different uses of the materials. Applications covered include anticancer therapy, tuberculosis diagnosis and treatment, tissue engineering, gene delivery and targeted drug delivery. The book will appeal to biologists, chemists, and nanotechnologists interested in translation research for personalized nanomedicine for health care.

Design and Synthesis of Stimuli-responsive Polymeric Nanogels Towards Therapeutic Translation

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (14 download)

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Book Synopsis Design and Synthesis of Stimuli-responsive Polymeric Nanogels Towards Therapeutic Translation by : Mallory R. Gordon

Download or read book Design and Synthesis of Stimuli-responsive Polymeric Nanogels Towards Therapeutic Translation written by Mallory R. Gordon and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In the application of delivery of therapeutics, nanostructures of various composition have been employed due to their capacity to act as a host for lipophilic payloads. Advances in the synthetic preparation, size, morphology, and chemical or physical characteristics of polymers have impacted their development and versatility. A detailed understanding of polymeric nanoparticle host-guest properties is crucial to their practical translation to specific delivery applications. Further, these features must be highly tailorable to overcome biological barriers, stably encapsulate their therapeutic contexts, and exhibit payload release selectively in the target environment. In this dissertation, we aim to rationally design polymeric nano-scale assemblies with well-defined compositions and unique stimuli-responsiveness to achieve desirable host properties and interfacial characteristics. While each chapter is specific in focus, we expect that the fundamental findings in this dissertation to broadly impact principles in drug delivery, including nanoparticle biodistribution (chapter 2), hydrophobic delivery (chapter 3), stimuli-responsive "smart" materials (chapter 4), and polymeric composition development (chapter 5).

Polymeric Nanomaterials in Nanotherapeutics

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Author :
Publisher : Elsevier
ISBN 13 : 0128139331
Total Pages : 561 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Polymeric Nanomaterials in Nanotherapeutics by :

Download or read book Polymeric Nanomaterials in Nanotherapeutics written by and published by Elsevier. This book was released on 2018-10-26 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric Nanomaterials in Nanotherapeutics describes how polymeric nanosensors and nanorobotics are used for biomedical instrumentation, surgery, diagnosis and targeted drug delivery for cancer, pharmacokinetics, monitoring of diabetes and healthcare. Key areas of coverage include drug administration and formulations for targeted delivery and release of active agents (drug molecules) to non-healthy tissues and cells. The book demonstrates how these are applied to dental work, wound healing, cancer, cardiovascular diseases, neurodegenerative disorders, infectious diseases, chronic inflammatory diseases, metabolic diseases, and more. Methods of administration discussed include oral, dental, topical and transdermal, pulmonary and nasal, ocular, vaginal, and brain drug delivery and targeting. Drug delivery topics treated in several subchapters includes materials for active targeting and cases study of polymeric nanomaterials in clinical trials. The toxicity and regulatory status of therapeutic polymeric nanomaterials are also examined. The book gives a broad perspective on the topic for researchers, postgraduate students and professionals in the biomaterials, biotechnology, and biomedical fields. Shows how the properties of polymeric nanomaterials can be used to create more efficient medical treatments/therapies Demonstrates the potential and range of applications of polymeric nanomaterials in disease prevention, diagnosis, drug development, and for improving treatment outcomes Accurately explains how nanotherapeutics can help in solving problems in the field through the latest technologies and formulations

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications by : Nedal Abu-Thabit

Download or read book Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications written by Nedal Abu-Thabit and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encapsulation remains a fundamental and consistent approach of fabrication of drug and diagnostic delivery systems in the health space and natural polymers such as polysaccharides and proteins continue to play significant roles. Micro- or nanoencapsulation is employed for the conventional pharmaceuticals, biopharmaceuticals, or biologics, bioactives from natural sources and diagnostics such as biomarkers. The outcome of any encapsulation depends on the technique employed and the encapsulating material. The encapsulating materials employed influence the physical and chemical attributes of the fabricated micro- and nanocapsules. The encapsulating materials could be natural or synthetic, however, natural polymers are preferred because they are human and environmentally friendly. Polysaccharides and proteins are abundant in nature, biogenic, biocompatible, biodegradable and possess biological functions making them materials of choice for encapsulation of drugs and diagnostics. This chapter reviews the recent and advanced applications of polysaccharides and proteins as nanocarrier materials for micro- and nanoencapsulation of therapeutics and diagnostics.

Nanobiotechnology in Diagnosis, Drug Delivery and Treatment

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1119671868
Total Pages : 416 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Nanobiotechnology in Diagnosis, Drug Delivery and Treatment by : Mahendra Rai

Download or read book Nanobiotechnology in Diagnosis, Drug Delivery and Treatment written by Mahendra Rai and published by John Wiley & Sons. This book was released on 2020-11-17 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents nanobiotechnology in drug delivery and disease management Featuring contributions from noted experts in the field, this book highlights recent advances in the nano-based drug delivery systems. It also covers the diagnosis and role of various nanomaterials in the management of infectious diseases and non-infectious disorders, such as cancers and other malignancies and their role in future medicine. Nanobiotechnology in Diagnosis, Drug Delivery and Treatment starts by introducing how nanotechnology has revolutionized drug delivery, diagnosis, and treatments of diseases. It then focuses on the role of various nanocomposites in diagnosis, drug delivery, and treatment of diseases like cancer, Alzheimer's disease, diabetes, and many others. Next, it discusses the application of a variety of nanomaterials in the diagnosis and management of gastrointestinal tract disorders. The book explains the concept of nanotheranostics in detail and its role in effective monitoring of drug response, targeted drug delivery, enhanced drug accumulation in the target tissues, sustained as well as triggered release of drugs, and reduction in adverse effects. Other chapters cover aptamer-incorporated nanoparticle systems; magnetic nanoparticles; theranostics and vaccines; toxicological concerns of nanomaterials used in nanomedicine; and more. Provides a concise overview of state-of-the-art nanomaterials and their application like drug delivery in infectious diseases and non-infectious disorders Highlights recent advances in the nano-based drug delivery systems and role of various nanomaterials Introduces nano-based sensors which detect various pathogens Covers the use of nanodevices in diagnostics and theranostics Nanobiotechnology in Diagnosis, Drug Delivery and Treatment is an ideal book for researchers and scientists working in various disciplines such as microbiology, biotechnology, nanotechnology, pharmaceutical biotechnology, pharmacology, pharmaceutics, and nanomedicine.

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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Publisher : John Wiley & Sons
ISBN 13 : 1118644743
Total Pages : 633 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering by : Ashutosh Tiwari

Download or read book Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2013-02-19 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume provides the reader valuable insight into the major areas of biomedical nanomaterials, advanced nanomedicine, nanotheragnostics, and cutting-edge nanoscaffolds. The ability to control the structure of materials allows scientists to accomplish what once appeared impossible before the advent of nanotechnology. It is now possible to generate nanoscopic self-assembled and self-destructive robots for effective utilization in therapeutics, diagnostics, and biomedical implants. Nanoscopic therapeutic systems incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities and they have emerged as the next generation of multifarious nanomedicine to improve the therapeutic outcome including chemo and translational therapy. Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering comprises fifteen chapters authored by senior scientists, and is one of the first books to cover nanotheragnostics, which is the new developmental edge of nanomedicine combining both diagnostic and therapeutic elements at the nano level. This large multidisciplinary reference work has four main parts: biomedical nanomaterials; advanced nanomedicine; nanotheragnostics; and nanoscaffolds technology. This groundbreaking volume also covers: Multifunctional polymeric nanostructures for therapy and diagnosis Metalla-assemblies acting as drug carriers Nanomaterials for management of lung disorders and drug delivery Responsive polymer-inorganic hybrid nanogels for optical sensing, imaging, and drug delivery Core/shell nanoparticles for drug delivery and diagnosis Theranostic nanoparticles for cancer imaging and therapy Magnetic nanoparticles in tissue regeneration Core-sheath fibers for regenerative medicine

Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications

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Author :
Publisher : Elsevier
ISBN 13 : 0128210133
Total Pages : 610 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications by : Krishnan Anand

Download or read book Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications written by Krishnan Anand and published by Elsevier. This book was released on 2021-03-19 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Nano-biomaterials for Therapeutics and Diagnostic Applications covers in-depth topics on nano-biomaterials and nano drug delivery systems (biosensors and bioimaging) involving polymer nanocomposites, metal nanocomposites, and other carbon family fibers and proteins. The book covers the current application of tiny machines or nanodevices and their use as early detection systems for life threatening diseases, giving detailed literature on the development of nanodevices, their use as diagnostic tools, and their present trend in the industry and market. In addition, their synthesis, potential applications and future of smart nanodevices in diagnosis of diseases and their use as smart clinical devices is covered. Users will find sections on recent advances in interdisciplinary research on the processing, morphology, structure and properties of nanostructured materials and their applications in drug delivery for various diseases such as cancer, tuberculosis, Alzheimer disease, ophthalmic diseases, and more. Offers a comprehensive coverage of the therapeutics and smart nanodevices as diagnostic tools and their potential clinical applications in biosensing and bioimaging Includes a glimpse into the nano-biomaterials that are essential components in nanomedicines Describes nanodevices in the early diagnosis of the diseases Explains the nano-drug delivery system for the treatment of various diseases, including cancer, tuberculosis, Alzheimer disease, and ophthalmic diseases Encompasses all information, starting from the design of nano-biomaterials to their applications in theranostics

Design of Nanostructures for Theranostics Applications

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Author :
Publisher : William Andrew
ISBN 13 : 0128136707
Total Pages : 695 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Design of Nanostructures for Theranostics Applications by : Alexandru Mihai Grumezescu

Download or read book Design of Nanostructures for Theranostics Applications written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2017-11-30 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design of Nanostructures for Theranostics Applications focuses on the theranostics applications of nanostructures. In particular, multifunctional nanoparticles for diagnostics and treatment of different diseases, including those relating to the blood-brain barrier, are discussed in detail. Chapters explore different type of nanostructures, covering design, fabrication, functionalization and optimization, helping readers obtain the desired properties. Written by a diverse range of international academics, this book is a valuable reference resource for those working in both nanoscience and the pharmaceutical industry. Explores how the design of a range of nanomaterials make them effective theranostic agents, including multifunctional core-shell nanostructures, mesoporous silica nanoparticles, and quantum dots Shows how nanomaterials are used effectively for a range of diseases, including breast cancer, prostate cancer and neurological disorders Assesses the pros and cons of using different nanomaterials for different types of treatment

Polymer Nanoparticles for Nanomedicines

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Publisher : Springer
ISBN 13 : 3319414216
Total Pages : 649 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Polymer Nanoparticles for Nanomedicines by : Christine Vauthier

Download or read book Polymer Nanoparticles for Nanomedicines written by Christine Vauthier and published by Springer. This book was released on 2017-01-07 with total page 649 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume serves as a valuable handbook for the development of nanomedicines made of polymer nanoparticles because it provides researchers, students, and entrepreneurs with all the material necessary to begin their own projects in this field. Readers will find protocols to prepare polymer nanoparticles using different methods, since these are based on the variety of experiences that experts encounter in the field. In addition, complex topics such as, the optimal characterization of polymer nanoparticles is discussed, as well as practical guidelines on how to formulate polymer nanoparticles into nanomedicines, and how to modify the properties of nanoparticles to give them the different functionalities required to become an efficient nanomedicine for different clinical applications. The book also discusses the translation of technology from research to practice, considering aspects related to industrialization of preparation and aspects of regulatory and clinical development.

Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics

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Author :
Publisher : Academic Press
ISBN 13 : 0128173319
Total Pages : 434 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics by : Prashant Kesharwani

Download or read book Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics written by Prashant Kesharwani and published by Academic Press. This book was released on 2019-06-25 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric Nanoparticles as Promising Tool for Anti-cancer Therapeutics provides an understanding of polymeric compounds and their use in cancer therapies. The book begins by giving an overview of the current status, future challenges and potential utilization of polymeric nanoparticles. It then covers specific polymeric nanoparticles through contributions from world-renowned experts and researchers. Chapters examine specific polymeric nanoparticles, their development as potential targeted delivery systems, and cancer characteristics that can be targeted for therapy development. The book synthesizes current research trends in the field, thus enhancing existing knowledge of nanomedicine, drug delivery and therapeutic intervention strategies in human cancers. Users will find this to be an ideal reference for research scientists and those in the pharmaceutical and medical fields who are working to develop novel cancer therapies using nanoparticle-based delivery systems. Explores the development of polymeric nanoparticle systems for the purpose of cancer therapy Presents thoroughly analyzed data and results regarding the usage of polymeric nanoparticles-based platforms for the diagnosis and treatment of cancer Highlights various cancer characteristics that can be targeted for therapeutic development using polymeric nanoparticles

Polymer-based Nanostructures

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Publisher : Rsc Nanoscience and Nanotechno
ISBN 13 : 9780854049561
Total Pages : 372 pages
Book Rating : 4.0/5 (495 download)

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Book Synopsis Polymer-based Nanostructures by : Pavel Broz

Download or read book Polymer-based Nanostructures written by Pavel Broz and published by Rsc Nanoscience and Nanotechno. This book was released on 2010 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a truly interdisciplinary perspective on polymer-based nanometre-sized macrostructures and their use in biology and medicine, with a special concentration on diagnostic and therapeutic applications. A summary of the necessary steps leading to the development and application of a complex-based nanostructure is provided as well as reviews of the main literature in areas covered. The content of the book has high clinical and practical significance and offers a broad overview of this rapidly growing field. The interdisciplinary nature of this title will make it of interest to polymer chemists, pharmacologists, biologists and clinicians alike.

Intelligent Hydrogels in Diagnostics and Therapeutics

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Publisher : CRC Press
ISBN 13 : 1000056147
Total Pages : 164 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Intelligent Hydrogels in Diagnostics and Therapeutics by : Anujit Ghosal

Download or read book Intelligent Hydrogels in Diagnostics and Therapeutics written by Anujit Ghosal and published by CRC Press. This book was released on 2020-05-27 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the potential of hydrogels as a multiutility system and their benefits (biocompatibility, degradability, and supporting scaffolds) for a wide range of applications in diagnostics and therapeutics. It also discusses the future prospects and challenges facing hydrogels. A wide variety of smart hydrogels (conducting, stimuli responsive, and others) with possible biomedical applications are elaborated. The book demonstrates the effectiveness of hydrogels in diagnostics of diseases in various in vivo and in vitro environments and highlights the engineering/functionalization of hydrogels for everyday drug dosage as an efficient drug carrier, scaffold, and sensing application. Explores the potential of hydrogels as a multifunctional system and their benefits, particularly for biomedical applications in diagnostics as well as therapeutics. Highlights the designing and engineering of hydrogels for everyday drug dosage and possible functionalization to fabricate an efficient drug carrier. Examines the significance of biopolymer-based hydrogels and their responsiveness in different physiological fluids. Demonstrates the effectiveness of hydrogels in diagnostics of diseases in various in,vivo and in,vitro environments. Presents challenges associated with the hydrogels and discusses possible in-hand modifications at length. Dr. Anujit Ghosal worked in the School of Biotechnology, Jawaharlal Nehru University, India. Currently, he is affiliated with the School of Life Sciences, Beijing Institute of Technology, Beijing, PRC. Dr. Ghosal researches in biochemistry, polymer chemistry, and nanotechnology. He has been the recipient of prestigious fellowships throughout his research career. His research ability is proven by his published peer-reviewed research and review articles and contributed book chapters. Dr. Ajeet Kaushik works as an assistant professor of chemistry and is exploring advanced electrochemical sensing systems and nanomedicine for personalized health wellness at the Department of Natural Sciences of the Division of Science, Arts, and Mathematics at Florida Polytechnic University, Lakeland, US. He is the recipient of various reputed awards for his service in the area of nanobiotechnology for health care. His excellent research credentials are reflected by his four edited books, 100 international research peer-reviewed publications, and three patents in the area of nanomedicine and smart biosensors for personalized health care.

Theory and Applications of Nonparenteral Nanomedicines

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Publisher : Academic Press
ISBN 13 : 0128204672
Total Pages : 542 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Theory and Applications of Nonparenteral Nanomedicines by : Prashant Kesharwani

Download or read book Theory and Applications of Nonparenteral Nanomedicines written by Prashant Kesharwani and published by Academic Press. This book was released on 2020-09-12 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theory and Applications of Nonparenteral Nanomedicines presents thoroughly analysed data and results regarding the potential of nanomedicines conceived by diverse non-parenteral routes. In the context of nanotechnology-based approaches, various routes such as oral, pulmonary, transdermal, delivery and local administration of nanomedicine have been utilized for the delivery of nanomedicine. This book discusses the non-parenteral application of nanomedicine, its regulatory implications, application of mucus penetrating nanocarrier, and detailed chapters on development of nanomedicines developed for drug delivery by various route. Beginning with a brief introduction to the non-parenteral delivery of nanomedicine and the safety and regulatory implications of the nanoformulations, further chapters discuss the physiology of the biological barriers, the specificity of the nanocarriers as well as their multiple applications. Theory and Applications of Nonparenteral Nanomedicines helps clinical researchers, researchers working in pharmaceutical industries, graduate students, and anyone working in the development of non-parenteral nanomedicines to understand the recent progress in the design and development of nanoformulations compatible with non-parenteral applications. Contains a comprehensive review of non-parenteral nanomedicines Provides analysis of non-parenteral methods of nanomedicines including regulatory implications and future applications Explores a wide range of promising approaches for non-parenteral drug delivery using the latest advancement in nanomedicine written by experts in industry and academia

Engineering Polymeric Matrices for Controlled Drug Delivery Applications

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Author :
Publisher :
ISBN 13 : 9781369351644
Total Pages : 171 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Engineering Polymeric Matrices for Controlled Drug Delivery Applications by : Yingkai Liang

Download or read book Engineering Polymeric Matrices for Controlled Drug Delivery Applications written by Yingkai Liang and published by . This book was released on 2016 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few decades, drug delivery systems have been designed using a wide array of materials and chemical strategies to improve the specificity of therapeutics by increasing drug stabilities, controlling release profiles and localizing therapeutic effects. Among various types of drug delivery systems, hydrogels have emerged as a promising class of materials for the controlled release of bioactive molecules. Composed of hydrophilic three-dimensional polymer networks, hydrogels have several advantageous properties including high water content, tunable viscoelasticity, and biocompatibility, which allow bioactive molecules to be protected against degradation and released from the hydrogel matrix in a controlled manner over an extended period of time. Particularly, polyethylene glycol (PEG) hydrogels have been extensively used for controlled drug delivery applications with encouraging preclinical and clinical results, owing to the non-immunogenic nature, hydrophilicity and chemical versatility of PEG polymers. PEG hydrogel-based materials have received approval for use in a number of medical products including wound healing matrices, medical implants, and drug delivery depots. In this work, we have specifically engineered PEG hydrogel matrices from bulk to nanoscale, including bulk hydrogels, nanoparticle-crosslinked hybrid hydrogels and nanogels for different delivery applications. Firstly, a library of hydrophilic and hydrolytically degradable PEG hydrogels has been developed for the sustained delivery of an anthrax toxin-neutralizing monoclonal antibody from 14-56 days. The hydrogels were formed via a Michael-type addition between multi-arm PEG-SH and hydrolytically degradable crosslinkers of linear PEG-diacrylate. By varying the polymer architectures and molecular weights of the precursors, the degradation rate of the matrix can be systematically tuned, which in turn tailors the rate of antibody release from the hydrogels. In-gel and post-release analysis of the antibody samples indicate that the conformational properties and biological activity of the protein were well maintained. In addition to bulk hydrogels for the long-term delivery of therapeutics, stimuliresponsive, nanoparticle-crosslinked hybrid hydrogels have also been introduced for the triggered and targeted release of therapeutic molecules. These hybrid hydrogels were constructed using maleimide-functionalized liposomes (~100nm) as structural elements to crosslink with thiolated 4-arm PEG polymers via Michael-type addition. Degradation of these hydrogels was selectively triggered upon exposure to thiol-containing molecules such as glutathione (GSH), offering great advantages for controlled and triggered release of therapeutic cargos under reducing environments that are analogous to the GSH-overproduced tumor microenvironment. The hierarchical structure of these hybrid hydrogels allows dual encapsulation and prolonged, sequential delivery of multiple therapeutic molecules with different release mechanism. Motivated by the significant impact of nanotechnology on the development of nanoscale drug delivery vehicles, PEG nanogels that combine the advantages of both nanoparticulate and polymeric hydrogel systems were prepared via the use of liposome templates. The nanogels were formed by photo-triggered Michael-type addition of PEG polymer precursors encapsulated within the aqeuous lumen of liposomes under UV irradiation. The production of nanogels was confirmed via dynamic light scattering (DLS) and transmission electron microscopy (TEM). The surface functionality of the lipid-coated nanogels was demonstrated by surface modification with a reactive fluorescent dye as a proof of concept. These PEG-based polymeric matrices provide a powerful platform for different specific delivery applications. The bulk, hydrolytically degradable PEG hydrogels present a simple yet efficient strategy to provide protein stabilization and long-term delivery of therapeutic proteins. The liposome-crosslinked hybrid hydrogels, on the other hand, suggest significant potential in the triggered and temporal release of multiple therapeutic molecules. Lastly, the PEG nanogels offer a unique strategy for the development of multifunctional nanoparticle therapeutics.

Polymeric Nanoparticles for Biomedical Applications

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Author :
Publisher : Mdpi AG
ISBN 13 : 9783725801527
Total Pages : 0 pages
Book Rating : 4.8/5 (15 download)

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Book Synopsis Polymeric Nanoparticles for Biomedical Applications by : Stephanie Andrade

Download or read book Polymeric Nanoparticles for Biomedical Applications written by Stephanie Andrade and published by Mdpi AG. This book was released on 2024-01-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, polymeric nanoparticles (NPs) have attracted significant attention in biomedical applications. Due to their advantageous properties, including biodegradability, biocompatibility, and non-toxicity, natural and synthetic polymers are versatile materials that offer several advantages for the therapy and diagnosis of a vast range of diseases and health conditions. Encapsulating therapeutic agents in polymeric NPs allows for sustained drug release, which improves drug efficacy and safety, reduces unwanted side effects, and enhances patient acceptance and compliance. This Special Issue presents the most recent insights on advanced polymeric NPs and their current applications in healthcare, including the prevention, diagnosis, and treatment of diseases.

Polymeric Nanomaterials

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Author :
Publisher : Wiley-VCH
ISBN 13 : 9783527321704
Total Pages : 0 pages
Book Rating : 4.3/5 (217 download)

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Book Synopsis Polymeric Nanomaterials by : Challa S. S. R. Kumar

Download or read book Polymeric Nanomaterials written by Challa S. S. R. Kumar and published by Wiley-VCH. This book was released on 2011-04-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book series Nanomaterials for the Life Sciences, provides an in-depth overview of all nanomaterial types and their uses in the life sciences. Each volume is dedicated to a specific material class and covers fundamentals, synthesis and characterization strategies, structure-property relationships and biomedical applications. The series brings nanomaterials to the Life Scientists and life science to the Materials Scientists so that synergies are seen and developed to the fullest. Written by international experts of various facets of this exciting field of research, the series is aimed at scientists of the following disciplines: biology, chemistry, materials science, physics, bioengineering, and medicine, together with cell biology, biomedical engineering, pharmaceutical chemistry, and toxicology, both in academia and fundamental research as well as in pharmaceutical companies. VOLUME 10 - Polymeric Nanomaterials