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Book Synopsis Polarization Sensitive Optical Coherence Tomography Detection Method by :
Download or read book Polarization Sensitive Optical Coherence Tomography Detection Method written by and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This study demonstrates the potential of polarization sensitive optical coherence tomography (PS-OCT) for non-invasive in vivo detection and characterization of early, incipient caries lesions. PS-OCT generates cross-sectional images of biological tissue while measuring the effect of the tissue on the polarization state of incident light. Clear discrimination between regions of normal and demineralized enamel is first shown in PS-OCT images of bovine enamel blocks containing well-characterized artificial lesions. High-resolution, cross-sectional images of extracted human teeth are then generated that clearly discriminate between the normal and carious regions on both the smooth and occlusal surfaces. Regions of the teeth that appeared to be demineralized in the PS-OCT images were verified using histological thin sections examined under polarized light microscopy. The PS-OCT system discriminates between normal and carious regions by measuring the polarization state of the back-scattered 1310 nm light, which is affected by the state of demineralization of the enamel. Demineralization of enamel increases the scattereing coefficient, thus depolarizing the incident light. This study shows that PS-OCT has great potential for the detection, characterization, and monitoring of incipient caries lesions.
Book Synopsis Development and Application of Polarization Sensitive Optical Coherence Tomography by : Peijun Tang
Download or read book Development and Application of Polarization Sensitive Optical Coherence Tomography written by Peijun Tang and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT), a three-dimensional optical imaging technique based on low coherence interferometry, can be extended to measure the functional property of the biological sample. As a functional extension of OCT, polarization sensitive optical coherence tomography (PSOCT) enables 3D imaging of the anisotropic biological samples, such as scar, tendon, muscle, collagen, and nerve fiber bundles. This thesis focuses on the development and application of PSOCT. This goal includes four specific aims. The first aim is to develop a single input PSOCT imaging system with an improved image contrast. To achieve this aim, the polarization state is utilized as the imaging parameter and visualized using the Stokes parameters-based color-encoded algorithm. The second aim is to develop an algorithm that can derive depth-resolved polarization parameters with the single input PSOCT system. Towards this aim, a PSOCT-based polarization state transmission model is proposed. Based on this model, a novel method that utilizes discrete differential geometry (DDG) combined with a series of 3D rotations is developed to derive the local axis orientation and phase retardation. The third aim is to use the developed DDG-based PST method to extract the collagen organization embedded within the soft biological tissues. To achieve this aim, the proposed method is utilized to image the local axis orientation of the collagen fibers of the rodent heart and human facial skin. The fourth aim is to use the multiparameter provided by the PSOCT to detect and characterize the white spot lesions in the enamel of the tooth. Towards this aim, multiple parameters in the PSOCT: scattering, attenuation, degree of polarization (DOP), local axis orientation, and local phase retardation of the sample are provided simultaneously for the comprehensive investigation of the location, depth, and severity of the white spot lesions.
Book Synopsis Optical Coherence Tomography by : Wolfgang Drexler
Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
Book Synopsis Application of Polarization Sensitive Optical Coherence Tomography (PS-OCT) and Phase Sensitive Optical Coherence Tomography (PhS-OCT) for Retinal Diagnostics by : Amit Shrikant Paranjape
Download or read book Application of Polarization Sensitive Optical Coherence Tomography (PS-OCT) and Phase Sensitive Optical Coherence Tomography (PhS-OCT) for Retinal Diagnostics written by Amit Shrikant Paranjape and published by . This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Enhanced Polarization-Sensitive Swept Source Optical Coherence Tomography (EPS-SS-OCT) instrument for high sensitivity cross-sectional imaging of Retinal Nerve Fiber Layer (RNFL) has been designed, constructed, and verified. The instrument is capable of measuring the thickness and birefringence of the RNFL. Birefringence change of the RNFL could serve as an early indicator of glaucoma. The associated image processing methods for completely automated, time efficient algorithm to segment the RNFL in images of the human retina recorded by the EPS-SS-OCT. Detected RNFL boundaries are used to compute peripapillary thickness maps. Numerical algorithms to compute the birefringence of the detected RNFL layer are presented along with the associated phase retardation and birefringence peripapillary maps. Glaucoma affects the vitality of retinal ganglion cell axons in the retinal nerve fiber layer (RNFL) and may be clinically detected through a change in RNFL birefringence. Comprehensive peripapillary maps of healthy and glaucoma suspect human RNFL birefringence were constructed using EPS-SS-OCT. Presence of macrophages is a hallmark of several retinal diseases such as drusen and age related macular degeneration. Application of photothermal Optical Coherence Tomography (OCT) to detect macrophages in ex vivo arteries which have engulfed nanoclusters of gold coated iron oxide (nanorose) is reported. Nanorose engulfed by macrophages in arteries absorb incident laser (800nm) energy and cause optical pathlength (OP) variation which is measured using photothermal OCT. OP variation in polydimethyl siloxane tissue phantoms containing varying concentrations of nanorose match values predicted from nanoparticle and material properties. Measurement of OP variation in arteries in response to laser excitation provides an estimate of nanorose concentration in arteries 2.5x109 particles/ml. OP variation in nanoparticle containing artery sections and tissue phantoms taking up nanorose has a different magnitude and profile from that observed in control aorta and phantoms without macrophages and is consistent with macrophage presence as identified with RAM-11 histology staining. Our results suggest that tissue regions with macrophages taking up nanorose can be detected using photothermal OCT.
Book Synopsis Development and Application of Optical Coherence Tomography (OCT) by : Michael Pircher
Download or read book Development and Application of Optical Coherence Tomography (OCT) written by Michael Pircher and published by MDPI. This book was released on 2018-03-23 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Development and Application of Optical Coherence Tomography (OCT)" that was published in Applied Sciences
Book Synopsis Polarization-sensitive Optical Coherence Tomography by : James J Pasquesi (Jr.)
Download or read book Polarization-sensitive Optical Coherence Tomography written by James J Pasquesi (Jr.) and published by . This book was released on 2005 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Polarization-sensitive Optical Coherence Tomography by : Simon Christopher Schlachter
Download or read book Polarization-sensitive Optical Coherence Tomography written by Simon Christopher Schlachter and published by . This book was released on 2006 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Swept Source Polarization Sensitive Optical Coherence Tomography for Retinal Imaging at 1 Micron by : Badr Elmaanaoui
Download or read book Swept Source Polarization Sensitive Optical Coherence Tomography for Retinal Imaging at 1 Micron written by Badr Elmaanaoui and published by . This book was released on 2010 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glaucoma is the second leading cause of blindness in the world. The disease is characterized by irreversible damage to retinal ganglion cells. Once glaucoma is detected, further vision loss can be prevented by pharmacological or surgical treatment. However, current diagnostic methods lack the necessary sensitivity and up to 40% of vision maybe irreversibly lost before detection occurs. A Swept Source Polarization-Sensitive Optical Coherence Tomography (SS-PSOCT) instrument for high sensitivity cross-sectional imaging of optical anisotropy in turbid media has been designed, constructed, and verified. A multiple-state nonlinear fitting algorithm was used to measure birefringence of the retinal nerve fiber layer with less than 1%" average uncertainty. To perform eye imaging efficiently a slit-lamp based interface for the SS-PSOCT instrument with a Line Scanning Laser Ophthalmoscope (LSLO) was used. This interface allowed for repeatable, stable, and registered measurements of the retina. A fixation target was used to stabilize the volunteer's eye and image desired areas of the retina. The LSLO allowed for an optimization of the location of OCT scans on the retina and provided a fundus blood vessel signature for registration between different imaging sessions. The SS-PSOCT system was used to measure depth-resolved thickness, birefringence, phase retardation and optic axis orientation of the retinal nerve fiber layer in normal volunteers. The peripapillary area around the optic nerve head (ONH) is most sensitive to glaucoma changes and hence data was acquired as concentric ring scans about the ONH with increasing diameters from 2mm to 5mm. Imaging of normal patients showed that higher values of phase retardation occurred superior and inferior to the optic nerve head especially next to blood vessels and thicker parts of the retinal nerve fiber layer.
Book Synopsis Polarization sensitive optical coherence tomography of the eye by : Jason David Marsack
Download or read book Polarization sensitive optical coherence tomography of the eye written by Jason David Marsack and published by . This book was released on 2001 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Polarization-sensitive Optical Coherence Tomography Using Polarization-maintaining Fibers by : Muhammad K. Al-Qaisi
Download or read book Polarization-sensitive Optical Coherence Tomography Using Polarization-maintaining Fibers written by Muhammad K. Al-Qaisi and published by . This book was released on 2010 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Time-domain Polarization-sensitive Optical Coherence Tomography in Soft Biological Tissue by : Milos Todorovic
Download or read book Time-domain Polarization-sensitive Optical Coherence Tomography in Soft Biological Tissue written by Milos Todorovic and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A new, high-speed, fiber-based Mueller-matrix optical coherence tomography system with continuous source-polarization modulation is presented. For in vivo experimentation, the sample arm optics are integrated into a hand-held probe. The system0́9s parameters were verified through imaging standard optical elements. A unique feature of polarization-sensitive Mueller optical coherence tomography is that by measuring Jones or Mueller matrices, it can reveal the complete polarization properties of biological samples, even in the presence of diattenuation. Presented here for the first time are mapped local polarization properties of biological samples obtained by using polar decomposition in combination with least-squares fitting to differentiate measured integrated Jones matrices with respect to depth. In addition, a new concept of dual attenuation coefficients to characterize diattenuation per unit infinitesimal length in tissues is introduced. The algorithm was experimentally verified using measurements of a section of porcine tendon and the septum of a rat heart. The application of the system for burn imaging and healing monitoring was demonstrated on porcine skin because of its similarity to the human skin. The results showed a clear localization of the thermally damaged region. The local birefringence of the intravital porcine skin was mapped by using a differentiation algorithm. The burn areas in the OCT images agree well with the histology, thus demonstrating the system0́9s potential for burn-depth determination and post-injury healing monitoring. Another major application of the fiber-based Mueller-matrix optical coherence tomography system with continuous source-polarization modulation covered here is in vivo imaging of early stages of skin cancer. The OCT images of SENCAR mice skin affected by the tumorigenesis show the structural changes in skin resulting from precancerous papilloma formations that are consistent with histology, which proves the system0́9s potential for early skin cancer detection.
Book Synopsis High Resolution Imaging in Microscopy and Ophthalmology by : Josef F. Bille
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Book Synopsis Optical Coherence Tomography for Retinal Diagnostics by : Biwei Yin
Download or read book Optical Coherence Tomography for Retinal Diagnostics written by Biwei Yin and published by . This book was released on 2013 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT) is a non-invasive three-dimensional imaging technique. OCT synthesizes a cross-sectional image from a series of lateral adjacent depth scans, and with a two-dimensional scanning scheme, three-dimensional intensity image of sample can be constructed. Due to its non-invasive capability, OCT has been widely applied in ophthalmology, cardiology and dermatology; and in addition to three-dimensional intensity image construction, various functional OCT imaging techniques have been developed for clinical application. My research is focused on developing functional OCT systems for application in ophthalmology, including polarization-sensitive optical coherence tomography (PS-OCT) for retinal nerve fiber layer (RNFL) birefringence measurement and dual-wavelength photothermal optical coherence tomography (DWP-OCT) for microvasculature blood oxygen saturation (SO2) measurement. In the study, a single-mode-fiber based polarization-sensitive swept-source OCT (PS-SS-OCT) with polarization modulator, polarization-sensitive bulk-optics balanced detection module is constructed and polarization processing methods based on Stokes vectors are applied to determine birefringence. PS-OCT is able to provide human subject's RNFL thickness, phase retardation, and birefringence information. Degradation in the degree of polarization (DOP) along depth is investigated and its difference between four quadrants of RNFL (superior, temporal, inferior and nasal) indicates the structural property difference. DWP-OCT is a novel functional OCT system consisting of a phase-sensitive optical coherence tomography system (PhS-OCT) and two photothermal excitation lasers. PhS-OCT is based on a swept-source laser operating in the 1060 nm wavelength range; the two photothermal excitation lasers with wavelength 770 nm and 800 nm are intensity modulated at different frequencies. PhS-OCT probe beam and two photothermal excitation beams are combined and incident on the sample, optical pathlength (op) change on the sample introduced by two photothermal excitation beams are measured and used for blood SO2 estimation. A polarization microscope is proposed for future study. The polarization microscope is an imaging technique providing molecular structure and orientation based on probe light's polarization state information. The polarization microscope uses a wavelength tunable light source, and can achieve any incident polarization state by a retarder-rotator combination. Specimen's birefringence can be determined based on the changing of detected light amplitude.
Book Synopsis Optical Polarization in Biomedical Applications by : Valery V. Tuchin
Download or read book Optical Polarization in Biomedical Applications written by Valery V. Tuchin and published by Springer Science & Business Media. This book was released on 2006-10-12 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues. This theory uses the modified transfer equation for Stokes parameters and predicts the polarization structure of multiple scattered optical fields. The backscattering polarization matrices (Jones matrix and Mueller matrix) important for noninvasive medical diagnostic are introduced. The text also describes a number of diagnostic techniques such as CW polarization imaging and spectroscopy, polarization microscopy and cytometry. As a new tool for medical diagnosis, optical coherent polarization tomography is analyzed. The monograph also covers a range of biomedical applications, among them cataract and glaucoma diagnostics, glucose sensing, and the detection of bacteria.
Book Synopsis High-speed Polarization-sensitive Optical Coherence Tomography: Toward Intraoperative Cancer Imaging by :
Download or read book High-speed Polarization-sensitive Optical Coherence Tomography: Toward Intraoperative Cancer Imaging written by and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Polarimetric Analysis of Anisotropic Tissue Using Polarization-sensitive Optical Coherence Tomography (PS-OCT). by : Jesung Park
Download or read book Polarimetric Analysis of Anisotropic Tissue Using Polarization-sensitive Optical Coherence Tomography (PS-OCT). written by Jesung Park and published by . This book was released on 2006 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: A novel nonlinear fitting algorithm utilizing multiple incident polarization states was developed for high-sensitive determination of polarimetric properties in weak form-birefringent tissue recorded by PS-OCT. After verification of robustness by simulated PS-OCT data, polarimetric properties of form-birefringent tissues were determined by the algorithm.
Book Synopsis Polarization Sensitive Optical Coherence Tomography by :
Download or read book Polarization Sensitive Optical Coherence Tomography written by and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
