Oral Bioavailability Assessment

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 111891693X
Total Pages : 448 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Oral Bioavailability Assessment by : Ayman F. El-Kattan

Download or read book Oral Bioavailability Assessment written by Ayman F. El-Kattan and published by John Wiley & Sons. This book was released on 2017-05-15 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development. • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

Play 1.b3!

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Author :
Publisher : New In Chess,Csi
ISBN 13 : 9789056912567
Total Pages : 0 pages
Book Rating : 4.9/5 (125 download)

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Book Synopsis Play 1.b3! by : Ilya Odessky

Download or read book Play 1.b3! written by Ilya Odessky and published by New In Chess,Csi. This book was released on 2008-09-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The popularity of the Nimzo-Larsen Attack is largely based on its surprise value, but in fact 1.b3 is one of White's more logical first moves, since by immediately developing his queen's bishop, White aims at undermining the black centre. Odessky, an International Master from Russia, a well-known chess coach and an outstanding chess writer, will amuse and surprise you, but also teach you all the ins and outs of this offbeat system, which has been used by top players like Bobby Fischer and Bent Larsen. A good choice for players who want to avoid the many theoretical landmines of mainline openings and prefer to steer towards an open battle, right from the start.

Winning Quickly with 1.b3 and 1...b6

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Author :
Publisher : New In Chess
ISBN 13 : 9056918915
Total Pages : 735 pages
Book Rating : 4.0/5 (569 download)

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Book Synopsis Winning Quickly with 1.b3 and 1...b6 by : Ilya Odessky

Download or read book Winning Quickly with 1.b3 and 1...b6 written by Ilya Odessky and published by New In Chess. This book was released on 2020-07-03 with total page 735 pages. Available in PDF, EPUB and Kindle. Book excerpt: “I left chess in 2012. I did not touch it for several years. Then I decided to test my strength in Internet blitz. I started from scratch. The board floated before my eyes, and my knee twitched. Less than two months later, I crossed the grandmaster rating mark. My opponents, among them lots of players with a big name, played chess better than me. Surprisingly though, I knew more. On a small island of chess theory, onto which I lured them, I was better equipped. Much better! About 30% of the games ended in wins around the 20th move. A quarter of the games simply ended in mate. In all games, I opened with the moves 1.b3 and 1…b6.” International Master Ilya Odessky is the world’s leading expert on the 1.b3 and 1…b6 chess opening systems. Despite their apparent calm, these openings can get extremely sharp. Now Odessky presents his findings and achievements of recent years. His baffling traps will help you crush your opponents in the opening, with both White and Black. Odessky admits that some of his lines may objectively be somewhat dubious. But in blitz and rapid games they will lead to spectacular play and many surprising wins. Ilya Odessky will entertain, amuse and surprise you in this highly unusual chess opening book full of ultra-romantic chess.

Circadian Pharmacokinetics

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Publisher : Springer Nature
ISBN 13 : 9811588074
Total Pages : 254 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Circadian Pharmacokinetics by : Baojian Wu

Download or read book Circadian Pharmacokinetics written by Baojian Wu and published by Springer Nature. This book was released on 2020-10-28 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.

Jon Speelman's Best Games

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Publisher : Batsford Books
ISBN 13 : 1849942331
Total Pages : 279 pages
Book Rating : 4.8/5 (499 download)

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Book Synopsis Jon Speelman's Best Games by : Jon Speelman

Download or read book Jon Speelman's Best Games written by Jon Speelman and published by Batsford Books. This book was released on 2014-11-12 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mind-bending analysis and instructive comment from a man who has participated in world chess at the very highest levels. World championship candidate and three-times British Champion Jon Speelman annotates the best of his games. He is renowned as a great fighter and analyst, and a highly original player. This book provides entertainment and instruction in abudance.

Progressive Complete Learn To Play Jazz Guitar Manual

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Publisher : LearnToPlayMusic.com
ISBN 13 : 9825325364
Total Pages : 226 pages
Book Rating : 4.8/5 (253 download)

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Book Synopsis Progressive Complete Learn To Play Jazz Guitar Manual by : Muzician.com

Download or read book Progressive Complete Learn To Play Jazz Guitar Manual written by Muzician.com and published by LearnToPlayMusic.com. This book was released on 2023-03-24 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: For beginner jazz guitarists. Covers all the chords, scales, rhythms and techniques used by great jazz musicians along with an in-depth analysis of improvisation. Also covers comping, chord substitution, harmony and ear training. Contains lots of great licks and solos in a variety of Jazz styles.

Progressive Complete Learn To Play Guitar Chords Manual

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Publisher : LearnToPlayMusic.com
ISBN 13 : 9825325240
Total Pages : 210 pages
Book Rating : 4.8/5 (253 download)

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Book Synopsis Progressive Complete Learn To Play Guitar Chords Manual by : Muzician.com

Download or read book Progressive Complete Learn To Play Guitar Chords Manual written by Muzician.com and published by LearnToPlayMusic.com. This book was released on 2023-03-24 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: For beginner guitarists. Everything you wanted to know about Guitar chords, contained within one book. Contains multiple fingering for all types of chords along with a complete system for playing chords and arpeggios along the whole fretboard. An essential guide for guitarists at any level.

The British Chess Magazine

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Author :
Publisher :
ISBN 13 :
Total Pages : 522 pages
Book Rating : 4.:/5 (321 download)

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Book Synopsis The British Chess Magazine by :

Download or read book The British Chess Magazine written by and published by . This book was released on 1897 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Timman's Triumphs

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Publisher : New In Chess
ISBN 13 : 9056919180
Total Pages : 650 pages
Book Rating : 4.0/5 (569 download)

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Book Synopsis Timman's Triumphs by : Jan Timman

Download or read book Timman's Triumphs written by Jan Timman and published by New In Chess. This book was released on 2020-09-05 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jan Timman is one of the greatest chess players never to win the world title. For many years ‘the Best of the West’ belonged to the chess elite, collecting quite a few super tournament victories. Three times Timman was a Candidate for the World Championship and his peak in the world rankings was second place, in 1982. For this definitive collection, Timman has revisited his career and subjected his finest efforts to fresh analysis supported by modern technology. The result is startling and fascinating. From the games that he chose for his Timman’s Selected Games (1994, also published as Chess the Adventurous Way), only 10(!) made the cut. Some games that he had been proud of turned out to be flawed, others that he remembered as messy were actually well played. Timman’s Triumphs includes wins against great players such as Karpov, Kasparov, Kortchnoi, Smyslov, Tal, Spassky, Bronstein, Larsen and Topalov. The annotations are in the author’s trademark lucid style, a happy mix of colourful background information and sharp, crystal-clear explanations. Once again Jan Timman shows that he is not only one of the best players the game has seen, but also as one of the best chess analysts and writers.

Winning the Won Game

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Publisher : Batsford Books
ISBN 13 : 1849943389
Total Pages : 318 pages
Book Rating : 4.8/5 (499 download)

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Book Synopsis Winning the Won Game by : Dr. Danny Kopec

Download or read book Winning the Won Game written by Dr. Danny Kopec and published by Batsford Books. This book was released on 2015-07-30 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every chessplayer who aspires to achieve chess mastery must learn the techniques for winning a won game. It is the perennial problem which confronts players at all levels of play. This book will enable chessplayers to better recognize their positional advantages and the ways in which these can be used in order to bring them closer to victory. It also provides many instructive examples of using this knowledge to reach a faster and more spectacular victory. Mr. Paul M. Albert, Jr. has been donating over $2000 per year to the most brilliantly played at both the Women's and Men's United States Championships for over 20 years. This book presents, describes and illustrates the most significant examples, with emphasis on what can be learned from them in terms of winning a won game.

Chess

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Publisher :
ISBN 13 :
Total Pages : 856 pages
Book Rating : 4.X/5 (2 download)

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Book Synopsis Chess by :

Download or read book Chess written by and published by . This book was released on 1991 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Jaenisch's Chefs Preceptor, a New Analysis of the Openings of Games

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Publisher :
ISBN 13 :
Total Pages : 352 pages
Book Rating : 4.V/5 ( download)

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Book Synopsis Jaenisch's Chefs Preceptor, a New Analysis of the Openings of Games by : C. F. de Jaenisch

Download or read book Jaenisch's Chefs Preceptor, a New Analysis of the Openings of Games written by C. F. de Jaenisch and published by . This book was released on 1847 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:

David, Doeg, and King Saul as Comedy

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Publisher : Lulu.com
ISBN 13 : 0359716601
Total Pages : 148 pages
Book Rating : 4.3/5 (597 download)

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Book Synopsis David, Doeg, and King Saul as Comedy by : Antony Michael Hylton

Download or read book David, Doeg, and King Saul as Comedy written by Antony Michael Hylton and published by Lulu.com. This book was released on with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mean-Field-Type Games for Engineers

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Publisher : CRC Press
ISBN 13 : 1000473538
Total Pages : 526 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Mean-Field-Type Games for Engineers by : Julian Barreiro-Gomez

Download or read book Mean-Field-Type Games for Engineers written by Julian Barreiro-Gomez and published by CRC Press. This book was released on 2021-11-18 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contents of this book comprise an appropriate background to start working and doing research on mean-field-type control and game theory. To make the exposition and explanation even easier, we first study the deterministic optimal control and differential linear-quadratic games. Then, we progressively add complexity step-by-step and little-by-little to the problem settings until we finally study and analyze mean-field-type control and game problems incorporating several stochastic processes, e.g., Brownian motions, Poisson jumps, and random coefficients. We go beyond the Nash equilibrium, which provides a solution for non- cooperative games, by analyzing other game-theoretical concepts such as the Berge, Stackelberg, adversarial/robust, and co-opetitive equilibria. For the mean-field-type game analysis, we provide several numerical examples using a Matlab-based user-friendly toolbox that is available for the free use to the readers of this book. We present several engineering applications in both continuous and discrete time. Among these applications we find the following: water distribution systems, micro-grid energy storage, stirred tank reactor, mechanism design for evolutionary dynamics, multi-level building evacuation problem, and the COVID-19 propagation control. Julian Barreiro-Gomez Hamidou Tembine With such a demand from engineering audiences, this book is very timely and provides a thorough study of mean-field-type game theory. The strenuous protagonist of this book is to bridge between the theoretical findings and engineering solutions. The book introduces the basics first, and then mathematical frameworks are elaborately explained. The engineering application examples are shown in detail, and the popular learning approaches are also investigated. Those advantageous characteristics will make this book a comprehensive handbook of many engineering fields for many years, and I will buy one when it gets published. Zhu Han

Handbook of Dialysis Therapy, E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323791360
Total Pages : 899 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Handbook of Dialysis Therapy, E-Book by : Allen R. Nissenson

Download or read book Handbook of Dialysis Therapy, E-Book written by Allen R. Nissenson and published by Elsevier Health Sciences. This book was released on 2022-05-15 with total page 899 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited and written by top experts and pioneers in dialysis, Handbook of Dialysis Therapy, 6th Edition, provides the entire dialysis team with a comprehensive overview of this growing field. It covers traditional and advanced procedures, what pitfalls to expect and how to overcome them, and how best to treat various patient populations—all with a practical approach that can be directly applied to patient care. This must-have resource has been updated with the latest cutting-edge technology, dialysis techniques, and complications related to various diseases for both pediatric and adult patients. Explains complex dialysis concepts through abundant diagrams, photos, line drawings, and tables, while its readable, hands-on approach allows for quick review of key information. Covers both adult and pediatric patients in detail, and offers guidance on special populations such as the geriatric patients and the chronically ill. Features increased content on home-based dialysis modalities, new alternatives for establishing vascular access for hemodialysis, new protocols for reducing the risk of infection and complications, and advancements in establishing and managing peritoneal dialysis. Includes extensive pediatric content such as prevention and treatment of bone disease, management of anemia, assessing quality of life in pediatric patients undergoing dialysis, and immunizations in children undergoing dialysis. Defines the quality imperatives, roles, and responsibilities of dialysis facility medical directors and attending nephrologists. Updates nephrologists on the latest alternative dialysis modalities.

Hex

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Publisher : American Mathematical Society
ISBN 13 : 1470464926
Total Pages : 124 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Hex by : Ryan B. Hayward

Download or read book Hex written by Ryan B. Hayward and published by American Mathematical Society. This book was released on 2022-02-03 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a gentle introduction to Hex, the classic board game created by Piet Hein and popularized by John Nash and Martin Gardner. The first three chapters cover rules, basic strategy, and history. The remaining eight chapters cover a variety of topics: mathematical properties (there are no draws, the first player can win, the acute corner is a losing first move), the related game of Y, winning strategies for small boards, how computers play Hex, and analysis of Random-Move Hex (where one or both players move randomly) and Dark Hex (the imperfect information version of the game, where you can't see your opponent's moves). Did we mention puzzles? There are puzzles in every chapter, with solutions. This book is intended for anyone interested in playing board games or learning some recreational mathematics. It is written for a wide audience and will be enjoyed equally by general readers and professional mathematicians. The book could be used as a textbook or companion resource for a topics course on recreational mathematics or game theory or as a source for undergraduate research questions.

Official Gazette of the United States Patent and Trademark Office

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Publisher :
ISBN 13 :
Total Pages : 1790 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Official Gazette of the United States Patent and Trademark Office by : United States. Patent and Trademark Office

Download or read book Official Gazette of the United States Patent and Trademark Office written by United States. Patent and Trademark Office and published by . This book was released on 1979 with total page 1790 pages. Available in PDF, EPUB and Kindle. Book excerpt: