Platelets as Immune Cells in Physiology and Immunopathology

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Publisher : Frontiers Media SA
ISBN 13 : 2889197409
Total Pages : 113 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Platelets as Immune Cells in Physiology and Immunopathology by : Olivier Garraud

Download or read book Platelets as Immune Cells in Physiology and Immunopathology written by Olivier Garraud and published by Frontiers Media SA. This book was released on 2016-01-05 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Are platelets cells? (Not everyone agrees, since they are non-nucleate). And if platelets are cells - which all specialists consider at the time being - are they immune cells? The issue that platelets participate in immunity is no longer debated; however, the issue that they are key cells in immunity is challenged. It has even been proposed a couple of years ago that platelets can present antigen to T-lymphocytes by using their HLA class I molecules. No one has the same functional definition of platelets. The ‘Frontiers Research Topic’- coordinators’ own view is that platelets are primarily repairing cells, what they do in deploying tools of physiological inflammation. This function is better acknowledged as primary hemostasis, i.e. platelet adherence to injured or wounded vessels, followed by activation, aggregation, and constitution of the initial clot. Platelets would thus repair damaged vascular endothelium; so doing, as they patrol to detect damages, they sense danger along the vascular arborescence. As the latter is immense, platelets get close to tissues, which are not allowed to them under ‘physiological’ conditions but are readily accessible in pathology. Platelets are equipped with a variety of Pathogen Recognition Receptors such as TLRs; they have a complete signalosome, which is functional until the phosphorylation of NFkB; they have been proved to retro-transcribe RNA and synthesize de novo proteins; etc. Platelets participate to inflammation along the whole spectrum: from physiological (tissue repair, healing) to acute/severe inflammation (as can be seen in e.g. sepsis). In general, platelets engage complex interactions with most infectious pathogens. We propose there to cover those topics - from physiology to pathology, that put platelets within cells that not only take place in-, but also are key players of-, innate immunity. The relation of platelets with adaptive immunity is even more complex. Not everyone is convinced that platelets present antigens; however, platelets influence adaptive immunity since they have mutual interactions with Dendritic cells, Monocytes/Macrophages, and B-lymphocytes (the key players of antigen presentation); they also have mutual interactions with T-lymphocytes, though is issue is less clearly deciphered. We propose to also cover these topics - or to present the forum. There is another issue which is medically relevant - speaking of physiology/physiopathology-: this is fetal maternal incompatibility of platelet specific antigens (the HPA system) and the likely formation of maternal antibodies that often injure the newborn with risks of severe thrombocytopenia and intracranial hemorrhage. We propose an update on this issue as well. Last, platelets are very special because they can be directly therapeutic (by transfusion), even when being offered by a generous blood donor displaying given genetic and phenotypic parameters to a patient/recipient in need, who also display his/her own genetic and phenotypic parameters, which - for a large part - differ from the donor's ones. Besides immunization - via mechanisms probably close to the fetal maternal platelet incompatibility, but likely not similar -, transfusion has allowed the identification of the tremendous capacity of platelets to mediate inflammation: we propose to conclude the Topics with this item/forum.

Cooperation of Liver Cells in Health and Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Cooperation of Liver Cells in Health and Disease by : Z. Kmiec

Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Platelets in Thrombotic and Non-Thrombotic Disorders

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Publisher : Springer
ISBN 13 : 3319474626
Total Pages : 1402 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Platelets in Thrombotic and Non-Thrombotic Disorders by : Paolo Gresele

Download or read book Platelets in Thrombotic and Non-Thrombotic Disorders written by Paolo Gresele and published by Springer. This book was released on 2017-03-08 with total page 1402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.

The Physiology of Immunity

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Publisher : CRC Press
ISBN 13 : 9780849380334
Total Pages : 464 pages
Book Rating : 4.3/5 (83 download)

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Book Synopsis The Physiology of Immunity by : James A. Marsh

Download or read book The Physiology of Immunity written by James A. Marsh and published by CRC Press. This book was released on 1996-07-24 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of neuroendocrine-immune interactions has become a highly visible and fast-growing segment of mainstream immunology. This book provides an overview of the immune system and in-depth coverage of the many different areas that make up neuroendocrine-immune research. The main emphasis is on the physiology of the processes involved, stressing an integrated approach to immunology. The text is organized in seven sections, beginning with an introduction to the immune system. Section II outlines how the central nervous system (CNS) communicates with central and peripheral lymphoid organs. Section III provides information on factors from the immune system that act as messengers to the CNS. The metabolic regulation of growth and development is discussed in Section IV. Section V examines the interactions occurring between the reproductive and immune systems. The effects of other physiologic stressors on immunity are reviewed in Section VI. Section VII considers cyclic and periodic influences on the immune system. Finally, there is a consideration of a new unifying theory for immunology. Students, researchers, clinicians, and veterinary scientists can discover new areas of interest in specific diseases and immune interactions in this novel presentation.

Essential Immunology

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Publisher :
ISBN 13 :
Total Pages : 244 pages
Book Rating : 4.:/5 (42 download)

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Book Synopsis Essential Immunology by : Ivan Maurice Roitt

Download or read book Essential Immunology written by Ivan Maurice Roitt and published by . This book was released on 1971 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:

B Cell Receptor Signaling

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Publisher : Springer
ISBN 13 : 3319261339
Total Pages : 233 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis B Cell Receptor Signaling by : Tomohiro Kurosaki

Download or read book B Cell Receptor Signaling written by Tomohiro Kurosaki and published by Springer. This book was released on 2015-12-26 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.

Integument, Respiration and Circulation

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Publisher : Elsevier
ISBN 13 : 1483286193
Total Pages : 644 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Integument, Respiration and Circulation by : G. A. Kerkut

Download or read book Integument, Respiration and Circulation written by G. A. Kerkut and published by Elsevier. This book was released on 2013-10-22 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is primarily devoted to the analysis of the integument (epidermis, cuticle), the fat body, the connective tissues, the circulatory and respiratory systems. It discusses the organization and functioning of the insect systems implicated in growth, intermediary metabolism, homeostasis and defence mechanisms. Much of the volume is devoted to anatomical and structural developments, which appear as introductions to corresponding biochemical and physiological aspects. Many diagrams, drawings and photographs accompany the text throughout. Altogether, this volume presents a clear and up-to-date account of the most recent and important discoveries in the fields and shows the extent of progress which is expected in the near future.

Immune Regulation

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Publisher : Springer Science & Business Media
ISBN 13 : 1461249961
Total Pages : 384 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Immune Regulation by : Marc Feldmann

Download or read book Immune Regulation written by Marc Feldmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leukocyte culture conferences have a long pedigree. This volume records some of the scientific highlights of the 16th such annual con ference, and is a witness to the continuing evolution and popularity of leukocyte culture and of immunology. There is strong evidence of the widening horizons of immunology, both technically, with the obviously major impact of molecular biology into our understanding of cellular processes, and also conceptually. Traditionally, the 'proceedings' of these conferences have been published. But have the books produced really recorded the major part of the conference, the informal, friendly, but intense and some times heated exchanges that take place between workers in tackling very similar problems and systems and which are at the heart of every successful conference? Unfortunately this essence cannot be incorpo rated by soliciting manuscripts. For this reason, we have changed the format of publication, retaining published versions of the symposium papers, but requesting the workshop chairmen to produce a summary of the major new observations and areas of controversy highlighted in their sessions, as a vehicle for defining current areas of interest and debate. Not an easy task, as the workshop topics were culled from the abstracts submitted by the participants, rather than being on predefined topics. The unseasonal warmth in Cambridge was reflected in the atmos phere of the conference, the organization of which benefited from the administrative skills of Jean Bacon, Philippa Wells, Mr. Peter Irving, and Mrs.

Essential Immunology for Surgeons

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Publisher : Oxford University Press, USA
ISBN 13 : 019958687X
Total Pages : 547 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Essential Immunology for Surgeons by : Oleg Eremin

Download or read book Essential Immunology for Surgeons written by Oleg Eremin and published by Oxford University Press, USA. This book was released on 2011-04-28 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing the necessary foundation for a critical understanding of this rapidly expanding area of biological science that underpins and explains the modern concepts of a wide range of diseases and conditions, this book gives a concise, readable, and up-to-date account of immunology in general and its translation into key areas of clinical practice.

Philosophy of Immunology

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Publisher : Cambridge University Press
ISBN 13 : 1108575021
Total Pages : pages
Book Rating : 4.1/5 (85 download)

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Book Synopsis Philosophy of Immunology by : Thomas Pradeu

Download or read book Philosophy of Immunology written by Thomas Pradeu and published by Cambridge University Press. This book was released on 2020-02-13 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology is central to contemporary biology and medicine, but it also provides novel philosophical insights. Its most significant contribution to philosophy concerns the understanding of biological individuality: what a biological individual is, what makes it unique, how its boundaries are established and what ensures its identity through time. Immunology also offers answers to some of the most interesting philosophical questions. What is the definition of life? How are bodily systems delineated? How do the mind and the body interact? In this Element, Thomas Pradeu considers the ways in which immunology can shed light on these and other important philosophical issues. This title is also available as Open Access on Cambridge Core.

Biomedical Index to PHS-supported Research: pt. A. Subject access A-H

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Publisher :
ISBN 13 :
Total Pages : 1064 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Biomedical Index to PHS-supported Research: pt. A. Subject access A-H by :

Download or read book Biomedical Index to PHS-supported Research: pt. A. Subject access A-H written by and published by . This book was released on 1992 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biomedical Index to PHS-supported Research

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Publisher :
ISBN 13 :
Total Pages : 1104 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Biomedical Index to PHS-supported Research by :

Download or read book Biomedical Index to PHS-supported Research written by and published by . This book was released on 1991 with total page 1104 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Research Awards Index

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Publisher :
ISBN 13 :
Total Pages : 742 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on 1989 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immunology of Pregnancy

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805579705
Total Pages : 201 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Immunology of Pregnancy by : Udo R. Markert

Download or read book Immunology of Pregnancy written by Udo R. Markert and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the discipline of immunology which studies a unique physiological phenomenon contradicting many of the generally established rules in the field: immunology of pregnancy. It provides a wide overview of the current research of this topic. Prominent and leading international groups contributed by reviewing the most significant findings in the field.

Research Grants Index

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Publisher :
ISBN 13 :
Total Pages : 1224 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Research Grants Index by : National Institutes of Health (U.S.). Division of Research Grants

Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1975 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Neutrophil

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Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 348 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Neutrophil by : Jon S. Abramson

Download or read book The Neutrophil written by Jon S. Abramson and published by Oxford University Press, USA. This book was released on 1993 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third book in the group devoted to the "natural" immune system, this volume provides the ideal detailed, up-to-date overview of neutrophil function. Distilling new information alongside observations of the past, the book focuses on some of the most critical developments in currentneutrophil research. Specific examples of diseases resulting from neutrophil dysfunction and deficiency are brought to life by clinical case studies. An essential source of current research into this exciting field, this volume will be invaluable for advanced students and researchers in immunology,cell biology, and medicine.

Encyclopedia of Malaria

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Publisher : Springer
ISBN 13 : 9781461483250
Total Pages : 0 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Encyclopedia of Malaria by :

Download or read book Encyclopedia of Malaria written by and published by Springer. This book was released on 2018-07-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Malaria represents a vast databank of information about the study of malaria. It provides an overview of the historical, rapid and significant developments that have occurred in malaria research, including the 2002 genome sequencing of Plasmodium falciparum and its mosquito vector, Anopheles gambiae. This work provides a concise source of up-to-date research findings in the form of definitions and essays and present comprehensive coverage of topics from history to findings to diagnosis and treatment, written by recognized malaria researchers with practical experience. It appeals to a diverse audience, including malaria researchers, teachers, investigators and public health professionals.