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Plant Chemical Genomics
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Book Synopsis Plant Chemical Genomics by : Glenn R. Hicks
Download or read book Plant Chemical Genomics written by Glenn R. Hicks and published by Humana. This book was released on 2020-12-04 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume is a companion volume to the previous edition and looks at new findings on novel bioactive chemicals and cognate targets, as well as the use of synthetic small molecules and a variety of tools to understand these processes. Chapters in this book cover topics such as screening plants for novel bioactive chemicals including lipid signaling and photo receptors; small molecule screens to include peptide ligands to generate new variations; using new chemicals to affect and dissect hormone signaling; and the application of easier microscale methods to simplify target identification and validation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Plant Chemical Genomics: Methods and Protocols, Second Edition is a valuable resource that provides a foundation of techniques for novice and expert researchers in the plant chemical biology community.
Download or read book Chemical Genomics written by Haian Fu and published by Cambridge University Press. This book was released on 2012-02-13 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular- and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals and graduate students in many fields, including biology, biomedicine and chemistry.
Book Synopsis Chemical Genomics by : Stefan Jaroch
Download or read book Chemical Genomics written by Stefan Jaroch and published by Springer Science & Business Media. This book was released on 2007-05-26 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.
Book Synopsis Chemogenomics and Chemical Genetics by : ERIC MARECHAL
Download or read book Chemogenomics and Chemical Genetics written by ERIC MARECHAL and published by Springer Science & Business Media. This book was released on 2011-06-21 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new small molecules, based on enhanced chemical synthesis strategies. Automated screening of small molecules is one of the technologies that has revolutionized biology, first developed for the pharmaceutical industry and recently introduced in academic laboratories. High-throughput and high-content screening allow the identification of bioactive compounds in collections of molecules (chemical libraries), being effective on biological targets defined at various organisational scales, from proteins to cells to complete organisms. These bioactive molecules can be therapeutic drug candidates, molecules for biotech, diagnostic or agronomic applications, or tools for basic research. Handling a large number of biological (genomic and post-genomic), chemical and experimental information, screening approaches cannot be envisaged without any electronic storage and mathematical treatment of the data. “Chemogenomics and Chemical Genetics” is an introductory manual presenting methods and concepts making up the basis for this recent discipline. This book is dedicated to biologists, chemists and computer scientist beginners. It is organized in brief, illustrated chapters with practical examples. Clear definitions of biological, chemical and IT concepts are given in a glossary section to help readers who are not familiar with one of these disciplines. "Chemogenomics and Chemical Genetics" should therefore be helpful for students (from Bachelor's degree level), technological platform engineers, and researchers in biology, chemistry, bioinformatics, cheminformatics, both in biotech and academic laboratories.
Book Synopsis Applied Plant Genomics and Biotechnology by : Palmiro Poltronieri
Download or read book Applied Plant Genomics and Biotechnology written by Palmiro Poltronieri and published by Woodhead Publishing. This book was released on 2015-01-27 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied plant genomics and biotechnology reviews the recent advancements in the post-genomic era, discussing how different varieties respond to abiotic and biotic stresses, investigating epigenetic modifications and epigenetic memory through analysis of DNA methylation states, applicative uses of RNA silencing and RNA interference in plant physiology and in experimental transgenics, and plants modified to produce high-value pharmaceutical proteins. The book provides an overview of research advances in application of RNA silencing and RNA interference, through Virus-based transient gene expression systems, Virus induced gene complementation (VIGC), Virus induced gene silencing (Sir VIGS, Mr VIGS) Virus-based microRNA silencing (VbMS) and Virus-based RNA mobility assays (VRMA); RNA based vaccines and expression of virus proteins or RNA, and virus-like particles in plants, the potential of virus vaccines and therapeutics, and exploring plants as factories for useful products and pharmaceuticals are topics wholly deepened. The book reviews and discuss Plant Functional Genomic studies discussing the technologies supporting the genetic improvement of plants and the production of plant varieties more resistant to biotic and abiotic stresses. Several important crops are analysed providing a glimpse on the most up-to-date methods and topics of investigation. The book presents a review on current state of GMO, the cisgenesis-derived plants and novel plant products devoid of transgene elements, discuss their regulation and the production of desired traits such as resistance to viruses and disease also in fruit trees and wood trees with long vegetative periods. Several chapters cover aspects of plant physiology related to plant improvement: cytokinin metabolism and hormone signaling pathways are discussed in barley; PARP-domain proteins involved in Stress-Induced Morphogenetic Response, regulation of NAD signaling and ROS dependent synthesis of anthocyanins. Apple allergen isoforms and the various content in different varieties are discussed and approaches to reduce their presence. Euphorbiaceae, castor bean, cassava and Jathropa are discussed at genomic structure, their diseases and viruses, and methods of transformation. Rice genomics and agricultural traits are discussed, and biotechnology for engineering and improve rice varieties. Mango topics are presented with an overview of molecular methods for variety differentiation, and aspects of fruit improvement by traditional and biotechnology methods. Oilseed rape is presented, discussing the genetic diversity, quality traits, genetic maps, genomic selection and comparative genomics for improvement of varieties. Tomato studies are presented, with an overview on the knowledge of the regulatory networks involved in flowering, methods applied to study the tomato genome-wide DNA methylation, its regulation by small RNAs, microRNA-dependent control of transcription factors expression, the development and ripening processes in tomato, genomic studies and fruit modelling to establish fleshy fruit traits of interest; the gene reprogramming during fruit ripening, and the ethylene dependent and independent DNA methylation changes. provides an overview on the ongoing projects and activities in the field of applied biotechnology includes examples of different crops and applications to be exploited reviews and discusses Plant Functional Genomic studies and the future developments in the field explores the new technologies supporting the genetic improvement of plants
Book Synopsis Chemical Genomics by : Edward D. Zanders
Download or read book Chemical Genomics written by Edward D. Zanders and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical genomics is an exciting new field that aims to transform biolo- cal chemistry into a high-throughput industrialized process, much in the same way that molecular biology has been transformed by genomics. The inter- tion of small organic molecules with biological systems (mostly proteins) underpins drug discovery in the pharmaceutical and biotechnology industries, and therefore a volume of laboratory protocols that covers the key aspects of chemical genomics would be of use to biologists and chemists in these orga- zations. Academic scientists have been exploring the functions of proteins using small molecules as probes for many years and therefore would also b- efit from sharing ideas and laboratory procedures. Whatever the organizational backgrounds of the scientists involved, the challenges of extracting the ma- mum human benefit from genome sequencing projects remains considerable, and one where it is increasingly recognized that chemical genomics will play an important part. Chemical Genomics: Reviews and Protocols is divided into two sections, the first being a series of reviews to describe what chemical genomics is about and to set the scene for the protocol chapters. The subject is introduced by Paul Caron, who explains the various flavors of chemical genomics. This is f- lowed by Lutz Weber and Philip Dean who cover the interaction between organic molecules and protein targets from the different perspectives of la- ratory experimentation and in silico design. The protocols begin with the me- ods developed in Christopher Lowes’ laboratory (Roque et al.
Book Synopsis From Plant Genomics to Plant Biotechnology by : Palmiro Poltronieri
Download or read book From Plant Genomics to Plant Biotechnology written by Palmiro Poltronieri and published by Elsevier. This book was released on 2013-08-31 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the appearance of methods for the sequencing of genomes and less expensive next generation sequencing methods, we face rapid advancements of the -omics technologies and plant biology studies: reverse and forward genetics, functional genomics, transcriptomics, proteomics, metabolomics, the movement at distance of effectors and structural biology. From plant genomics to plant biotechnology reviews the recent advancements in the post-genomic era, discussing how different varieties respond to abiotic and biotic stresses, understanding the epigenetic control and epigenetic memory, the roles of non-coding RNAs, applicative uses of RNA silencing and RNA interference in plant physiology and in experimental transgenics and plants modified to specific aims. In the forthcoming years these advancements will support the production of plant varieties better suited to resist biotic and abiotic stresses, for food and non-food applications. This book covers these issues, showing how such technologies are influencing the plant field in sectors such as the selection of plant varieties and plant breeding, selection of optimum agronomic traits, stress-resistant varieties, improvement of plant fitness, improving crop yield, and non-food applications in the knowledge based bio-economy. Discusses a broad range of applications: the examples originate from a variety of sectors (including in field studies, breeding, RNA regulation, pharmaceuticals and biotech) and a variety of scientific areas (such as bioinformatics, -omics sciences, epigenetics, and the agro-industry) Provides a unique perspective on work normally performed 'behind closed doors'. As such, it presents an opportunity for those within the field to learn from each other, and for those on the 'outside' to see how different groups have approached key problems Highlights the criteria used to compare and assess different approaches to solving problems. Shows the thinking process, practical limitations and any other considerations, aiding in the understanding of a deeper approach
Book Synopsis Plant Chemical Biology by : Dominique Audenaert
Download or read book Plant Chemical Biology written by Dominique Audenaert and published by John Wiley & Sons. This book was released on 2013-11-05 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demonstrates how advances in plant chemical biology can translate to field applications With contributions from a team of leading researchers and pioneers in the field, this book explains how chemical biology is used as a tool to enhance our understanding of plant biology. Readers are introduced to a variety of chemical biology studies that have provided novel insights into plant physiology and plant cellular processes. Moreover, they will discover that chemical biology not only leads to a better understanding of the underlying mechanisms of plant biology, but also the development of practical applications. For example, the authors discuss small molecules that can be used to identify targets of herbicides and develop new herbicides and plant growth regulators. The book begins with a historical perspective on plant chemical biology. Next, the authors introduce the chemical biology toolbox needed to perform successful studies, with chapters covering: Sources of small molecules Identification of new chemical tools by high-throughput screening (HTS) Use of chemical biology to study plant physiology Use of chemical biology to study plant cellular processes Target identification Translation of plant chemical biology from the lab to the field Based on the latest findings and extensively referenced, the book explores available compound collections, principles of assay design, and the use of new research tools for the development of new applications. Plant Chemical Biology is recommended for students and professionals in all facets of plant biology, including molecular biology, physiology, biochemistry, agriculture, horticulture, and agronomy. All readers will discover new approaches that can lead to the development of a healthier and more plentiful global food supply.
Book Synopsis Plant Genomics: Methods and Functions by : Isabelle Nickel
Download or read book Plant Genomics: Methods and Functions written by Isabelle Nickel and published by . This book was released on 2019-06-24 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant genomics is a vast field of study. It studies the structure, mapping, function, evolution and editing of genomes. It is instrumental in the splicing and deletion of specific genes to produce desired phenotypes as a response to the changed genotype. Such genetic modifications can be generated by the "Gene Gun" method and by transformation via Agrobacterium. Introduction of new traits and control over existing traits in plants is possible due to research in plant genetics and genomics. Most of the topics introduced in this book cover new techniques and applications of plant genomics. While understanding the long-term perspectives of the topics, the book makes an effort in highlighting their impact as a modern tool for the growth of the discipline. Those with an interest in this field would find this book helpful.
Book Synopsis Chemical Genomics by : Stefan Jaroch
Download or read book Chemical Genomics written by Stefan Jaroch and published by Springer. This book was released on 2009-09-02 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.
Book Synopsis Plant Functional Genomics by : Erich Grotewold
Download or read book Plant Functional Genomics written by Erich Grotewold and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional genomics is a young discipline whose origin can be traced back to the late 1980s and early 1990s, when molecular tools became available to determine the cellular functions of genes. Today, functional genomics is p- ceived as the analysis, often large-scale, that bridges the structure and organi- tion of genomes and the assessment of gene function. The completion in 2000 of the genome sequence of Arabidopsis thaliana has created a number of new and exciting challenges in plant functional genomics. The immediate task for the plant biology community is to establish the functions of the approximately 25,000 genes present in this model plant. One major issue that will remain even after this formidable task is c- pleted is establishing to what degree our understanding of the genome of one model organism, such as the dicot Arabidopsis, provides insight into the or- nization and function of genes in other plants. The genome sequence of rice, completed in 2002 as a result of the synergistic interaction of the private and public sectors, promises to significantly enrich our knowledge of the general organization of plant genomes. However, the tools available to investigate gene function in rice are lagging behind those offered by other model plant systems. Approaches available to investigate gene function become even more limited for plants other than the model systems of Arabidopsis, rice, and maize.
Download or read book LATCA written by Freeman Tsz-fung Chow and published by . This book was released on 2007 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical genomics utilizes small molecules to alter the functions of specific target genes/proteins. To promote its use in plant research, I assembled a chemical library enriched with plant bioactive compounds, which is named Library of AcTive Compounds in Arabidopsis (LATCA). The chemicals were selected with an etiolated hypocotyl growth inhibition assay using three chemical libraries which identified & sim;1100 chemicals. The collection is complemented with an additional 900 chemicals. In total LATCA contains 2080 compounds, & sim;300 are known bioactive chemicals. As a new approach to classifying chemical effects, I developed a phenotype based clustering scheme. The chemicals are also clustered according to their structural similarities. In addition, potencies of the chemicals were assessed with dose curve analysis. These three datasets together enable analyses of structure-activity relationships of well defined phenotypic clusters. The LATCA collection provides integrated datasets with which future studies and other chemical genomic screens can systematically build upon.
Book Synopsis Ecological Genomics by : Christian R. Landry
Download or read book Ecological Genomics written by Christian R. Landry and published by Springer Science & Business Media. This book was released on 2013-11-25 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Researchers in the field of ecological genomics aim to determine how a genome or a population of genomes interacts with its environment across ecological and evolutionary timescales. Ecological genomics is trans-disciplinary by nature. Ecologists have turned to genomics to be able to elucidate the mechanistic bases of the biodiversity their research tries to understand. Genomicists have turned to ecology in order to better explain the functional cellular and molecular variation they observed in their model organisms. We provide an advanced-level book that covers this recent research and proposes future development for this field. A synthesis of the field of ecological genomics emerges from this volume. Ecological Genomics covers a wide array of organisms (microbes, plants and animals) in order to be able to identify central concepts that motivate and derive from recent investigations in different branches of the tree of life. Ecological Genomics covers 3 fields of research that have most benefited from the recent technological and conceptual developments in the field of ecological genomics: the study of life-history evolution and its impact of genome architectures; the study of the genomic bases of phenotypic plasticity and the study of the genomic bases of adaptation and speciation.
Book Synopsis Genomics of Plant–Pathogen Interaction and the Stress Response by : Ashutosh Mani
Download or read book Genomics of Plant–Pathogen Interaction and the Stress Response written by Ashutosh Mani and published by CRC Press. This book was released on 2023-09-25 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants are an indispensable part of human and animal lives for nutrition and health. But pests, diseases and abiotic stress adversely affect crop yield, which ultimately places significant pressure on society to provide food to an increasing population. Moreover, it also encourages increased chemical/pesticide usage on crops, which we see in the biomagnification of toxic and hazardous compounds polluting water bodies, soil and the environment. This condition will continue to worsen in the future due to the resistance-acquiring ability of pathogens against plant defense and chemical treatments. In addition, environmental disturbances and consumer health issues are being reported more promptly than before due to intensive use of pesticides in food production. Plant diseases affect our daily lives, as the use of insecticides and pesticides has become part of our food chain. As a result, precise disease diagnosis and management is crucial in order to avoid huge losses in plant production and related commodities. Accurate detection, precise diagnosis and proper management can play a significant role in keeping plants free from pathogens. In this book, scientists, researchers and scholars share their research knowledge, offering a valuable resource for understanding plant diseases, pathogen interaction and responses to stress through an omics perspective, contributing to further advancements in the field Diseases in plants may be caused by various factors, such as viruses, bacteria, fungi and abiotic stress. Disease causes low crop yield, production of poor-quality fruits and grains, and deficiency of nutrients, which have a direct impact on human and animal health. A genomics-based approach can be applied to disease diagnosis; disease outbreak; evolution of plant and pathogen genome for disease outbreak in relation to climate change; and development of long-term strategies for plant health and defense. This book presents an overview of omics technologies and approaches used to understand: 1) the relation between plants and their environment in terms of diseases 2) responses to abiotic stress 3) the genomics of plant–pathogen interaction 4) herbicide-resistance mechanisms 5) the epigenetics of plant–pathogen interaction 6) gene regulation during abiotic stress response 7) the oxidative stress response
Book Synopsis Genomics of Plant–Pathogen Interaction and the Stress Response by : Ashutosh Mani
Download or read book Genomics of Plant–Pathogen Interaction and the Stress Response written by Ashutosh Mani and published by CRC Press. This book was released on 2023-09-25 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants are an indispensable part of human and animal lives for nutrition and health. But pests, diseases and abiotic stress adversely affect crop yield, which ultimately places significant pressure on society to provide food to an increasing population. Moreover, it also encourages increased chemical/pesticide usage on crops, which we see in the biomagnification of toxic and hazardous compounds polluting water bodies, soil and the environment. This condition will continue to worsen in the future due to the resistance-acquiring ability of pathogens against plant defense and chemical treatments. In addition, environmental disturbances and consumer health issues are being reported more promptly than before due to intensive use of pesticides in food production. Plant diseases affect our daily lives, as the use of insecticides and pesticides has become part of our food chain. As a result, precise disease diagnosis and management is crucial in order to avoid huge losses in plant production and related commodities. Accurate detection, precise diagnosis and proper management can play a significant role in keeping plants free from pathogens. In this book, scientists, researchers and scholars share their research knowledge, offering a valuable resource for understanding plant diseases, pathogen interaction and responses to stress through an omics perspective, contributing to further advancements in the field Diseases in plants may be caused by various factors, such as viruses, bacteria, fungi and abiotic stress. Disease causes low crop yield, production of poor-quality fruits and grains, and deficiency of nutrients, which have a direct impact on human and animal health. A genomics-based approach can be applied to disease diagnosis; disease outbreak; evolution of plant and pathogen genome for disease outbreak in relation to climate change; and development of long-term strategies for plant health and defense. This book presents an overview of omics technologies and approaches used to understand: the relation between plants and their environment in terms of diseases responses to abiotic stress the genomics of plant–pathogen interaction herbicide-resistance mechanisms the epigenetics of plant–pathogen interaction gene regulation during abiotic stress response the oxidative stress response
Book Synopsis Phytochemical Genomics by : Mallappa Kumara Swamy
Download or read book Phytochemical Genomics written by Mallappa Kumara Swamy and published by Springer Nature. This book was released on 2023-01-01 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive reference for various plant bioactive compounds for research and pharmacological significance across the entire spectrum of phytochemical genomics. The book opens with general information on diversity, analysis and genomic basis of phytochemicals, computational approaches, databases for responsible genes, and biosynthetic pathways, and it delves very much into the details behind phytochemical diversity and diverse roles of plant metabolites. The later parts of the book also explore the direct drug discovery and omics approaches including metabolomics, transcriptomics, as well as gene editing technology experiments to further inspire readers into its unlimited potentials. Each chapter includes detailed analysis and relevant experiments for better and deeper understanding of the concepts. The book will be an invaluable aid for medicinal plant researchers and a rich source of information and advice for advanced undergraduates and graduates in the fields of medicine, nutraceuticals, cosmetics, flavor, and fragrance studies.
Book Synopsis Phytochemistry in the Genomics and Post-Genomics Eras by : John Romeo
Download or read book Phytochemistry in the Genomics and Post-Genomics Eras written by John Romeo and published by Elsevier. This book was released on 2002-06-20 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph series is commissioned by the Phytochemical Society of North America (PSNA). The volumes in this series contain articles on developing topics of interest to scientists, students and individuals interested in recent developments in the biochemistry, chemistry and molecular biology of plants. Volume 36 centers on the role of phytochemistry in the rapid developments in biology brought about by the application of large-scale genomics approaches. Several functional genomic approaches discussed in this volume address plant gene function on a large scale. Plants are combinatorial chemists par excellence, and understanding the principles that relate enzyme structure to function will open up unlimited possibilities for the rational design of new enzymes to generate novel biologically active natural products. Knowledge of the molecular genetics of plant natural product pathways will also facilitate the engineering of these pathways for plant improvement and human benefit. Phytochemistry truly has a great future in the genomics and post-genomics eras.
