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Piperidine
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Book Synopsis Piperidine-Based Drug Discovery by : Ruben Vardanyan
Download or read book Piperidine-Based Drug Discovery written by Ruben Vardanyan and published by Elsevier. This book was released on 2017-06-12 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. - Explores this extremely important heterocycle to a high level of detail - Describes synthesis methods for 70 current drugs based on Piperidine scaffolds - Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine - Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs
Download or read book Piperidine written by M. Rubiralta and published by Elsevier. This book was released on 2013-10-22 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Piperidine, one of the simplest heterocyclic systems, is found in nature as part of several alkaloid compounds. Both natural and especially unnatural piperidine derivatives present interesting pharmacological properties. From a structural viewpoint, the conformation of piperidine has been the subject of one of the fiercest controversies in structural organic chemistry in the last few years. As a result of the combined use of several spectroscopic techniques, the conformational behavior of most types of piperidine-related compounds has been clarified. Some piperidine derivatives, namely, N-acylpiperidine, &agr;-cyanopiperidines and piperidones are extremely useful and versatile intermediates in organic synthesis. The present book offers an updated and integrated view of all these topics. The aim of the book is twofold. Firstly, to reveal to the reader the combined use of different spectroscopic data, to facilitate an insight into the structure and conformational properties of any new piperidine derivative. Secondly, to establish a consistent link between conformation and reactivity for a variety of piperidine derivatives. Such a bridge is a key step for stereocontrol when dealing with the application of piperidine derivatives as synthetic intermediates. The book is conceived so that most of the information comes from visual inspection of the very abundant graphic material. An exhaustive subject index of more than 450 entries is also included.
Book Synopsis Some Compounds of Piperidine with Halides by : Clifford Shattuck Leonard
Download or read book Some Compounds of Piperidine with Halides written by Clifford Shattuck Leonard and published by . This book was released on 1920 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Copper in N-Heterocyclic Chemistry by : Ananya Srivastava
Download or read book Copper in N-Heterocyclic Chemistry written by Ananya Srivastava and published by Elsevier. This book was released on 2020-11-13 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Copper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds, covering all recent developments in a way that is ideal for researchers and students working in the area of synthetic organic chemistry and medicinal chemistry. The book explores N-heterocyclic compounds as unique structural units in the development of natural products and pharmaceuticals, along with the remarkable progress made in the area of high atom economic strategies, and more recently, copper-catalyzed C-H activation and its applications in organic synthesis. Readers will find troubleshooting protocols, as well as the advantages and limitations of each method discussed. As copper catalysts show versatile chemical reactivity in many aspects, including their oxidation states 0–3 are accessible and their ability to facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and catalysts, this book is an ideal resource on the topics explored. - Discusses novel synthetic methods developed over the past decade for copper-catalyzed synthesis of N-heterocyclic compounds - Covers the most recent methodologies adapted in synthetic chemistry for applications in natural products and pharmaceuticals - Includes troubleshooting protocols, as well as the advantages and limitations of each method discussed in detail
Book Synopsis Journal of the American Chemical Society by : American Chemical Society
Download or read book Journal of the American Chemical Society written by American Chemical Society and published by . This book was released on 1921 with total page 1348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Society are included in v. 1-59, 1879-1937.
Book Synopsis Comprehensive Heterocyclic Chemistry IV by : David St. Clair Black
Download or read book Comprehensive Heterocyclic Chemistry IV written by David St. Clair Black and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Journal of the Chemical Society by : Chemical Society (Great Britain)
Download or read book Journal of the Chemical Society written by Chemical Society (Great Britain) and published by . This book was released on 1883 with total page 1320 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Titles of chemical papers in British and foreign journals" included in Quarterly journal, v. 1-12.
Book Synopsis Green Approaches in Medicinal Chemistry for Sustainable Drug Design by : Bimal Banik
Download or read book Green Approaches in Medicinal Chemistry for Sustainable Drug Design written by Bimal Banik and published by Elsevier. This book was released on 2024-05-31 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry, Second Edition encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This second volume of the second edition includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods. - Highlights the need for adoption of sustainable and green chemistry pathways in drug development - Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these - Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability
Book Synopsis Acute Exposure Guideline Levels for Selected Airborne Chemicals by : National Research Council
Download or read book Acute Exposure Guideline Levels for Selected Airborne Chemicals written by National Research Council and published by National Academies Press. This book was released on 2013-01-28 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the request of the Department of Defense and the Environmental Protection Agency, the National Research Council has reviewed the relevant scientific literature compiled by an expert panel and established Acute Exposure Guideline Levels (AEGLs) for several chemicals. AEGLs represent exposure levels below which adverse health effects are not likely to occur and are useful in responding to emergencies, such as accidental or intentional chemical releases in community, workplace, transportation, and military settings, and for the remediation of contaminated sites. Three AEGLs are approved for each chemical, representing exposure levels that result in: 1) notable but reversible discomfort; 2) long-lasting health effects; and 3) life-threatening health impacts. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 13 includes AEGLs for boron trifluoride, bromoacetone, chloroacetone, hexafluoroacetone, perchloryl fluoride, piperidine, propargyl alcohol, trimethoxysilane and tetramethoxysilane, and trimethylbenzenes.
Book Synopsis Chemistry of the Carbon Compounds; Or, Organic Chemistry by : Victor von Richter
Download or read book Chemistry of the Carbon Compounds; Or, Organic Chemistry written by Victor von Richter and published by . This book was released on 1885 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Registry of Toxic Effects of Chemical Substances by : National Institute for Occupational Safety and Health
Download or read book Registry of Toxic Effects of Chemical Substances written by National Institute for Occupational Safety and Health and published by . This book was released on 1980 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This compilation will provide ready reference for potential toxicity of chemicals found in the workplace, and should be useful to occupational health physicians, industrial hygienists, toxicologists, and researchers." Alphabetical arrangement by substances. Entries include such details as molecular weight, Wiswesser Line Notation, synonyms, and reference from which data about toxicity derived. Miscellaneous appendixes, including one titled Aquatic toxicity. Bibliographic references.
Book Synopsis Some Compounds of Piperidine with Halides by : Clifford Shattuck Leonard
Download or read book Some Compounds of Piperidine with Halides written by Clifford Shattuck Leonard and published by Palala Press. This book was released on 2016-04-26 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Book Synopsis Registry of Toxic Effects of Chemical Substances by : Richard J. Lewis (Sr.)
Download or read book Registry of Toxic Effects of Chemical Substances written by Richard J. Lewis (Sr.) and published by . This book was released on 1983 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hand-book of Chemistry by : Leopold Gmelin
Download or read book Hand-book of Chemistry written by Leopold Gmelin and published by . This book was released on 1862 with total page 1978 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several volumes contain reports of the meetings of the Cavedish Society.
Book Synopsis Systematic Survey of Rubber Chemistry by : Clayton W. Bedford
Download or read book Systematic Survey of Rubber Chemistry written by Clayton W. Bedford and published by . This book was released on 1923 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic accelerators of vulcanization. Theories of vulcanization.
Download or read book American Journal of Science written by and published by . This book was released on 1852 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Journal of the Chemical Society by :
Download or read book Journal of the Chemical Society written by and published by . This book was released on 1927 with total page 1158 pages. Available in PDF, EPUB and Kindle. Book excerpt:
