Phosphoramide Mustards Advances In Research And Application 2012 Edition

Download Phosphoramide Mustards Advances In Research And Application 2012 Edition full books in PDF, epub, and Kindle. Read online Phosphoramide Mustards Advances In Research And Application 2012 Edition ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Phosphoramide Mustards—Advances in Research and Application: 2012 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 148160452X
Total Pages : 111 pages
Book Rating : 4.4/5 (816 download)

DOWNLOAD NOW!

Book Synopsis Phosphoramide Mustards—Advances in Research and Application: 2012 Edition by :

Download or read book Phosphoramide Mustards—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoramide Mustards—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Phosphoramide Mustards in a concise format. The editors have built Phosphoramide Mustards—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Phosphoramide Mustards in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phosphoramide Mustards—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Phosphoramide Mustards—Advances in Research and Application: 2013 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481679082
Total Pages : 65 pages
Book Rating : 4.4/5 (816 download)

DOWNLOAD NOW!

Book Synopsis Phosphoramide Mustards—Advances in Research and Application: 2013 Edition by :

Download or read book Phosphoramide Mustards—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoramide Mustards—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Phosphoramide Mustards—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phosphoramide Mustards—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Phosphoramide Mustards: Advances in Research and Application: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464940797
Total Pages : 44 pages
Book Rating : 4.4/5 (649 download)

DOWNLOAD NOW!

Book Synopsis Phosphoramide Mustards: Advances in Research and Application: 2011 Edition by :

Download or read book Phosphoramide Mustards: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoramide Mustards: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Phosphoramide Mustards in a concise format. The editors have built Phosphoramide Mustards: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Phosphoramide Mustards in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phosphoramide Mustards: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Nitrogen Mustard Compounds: Advances in Research and Application: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464941181
Total Pages : 45 pages
Book Rating : 4.4/5 (649 download)

DOWNLOAD NOW!

Book Synopsis Nitrogen Mustard Compounds: Advances in Research and Application: 2011 Edition by :

Download or read book Nitrogen Mustard Compounds: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitrogen Mustard Compounds: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Nitrogen Mustard Compounds in a concise format. The editors have built Nitrogen Mustard Compounds: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nitrogen Mustard Compounds in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nitrogen Mustard Compounds: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Mustard Compounds: Advances in Research and Application: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464941165
Total Pages : 48 pages
Book Rating : 4.4/5 (649 download)

DOWNLOAD NOW!

Book Synopsis Mustard Compounds: Advances in Research and Application: 2011 Edition by :

Download or read book Mustard Compounds: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mustard Compounds: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Mustard Compounds in a concise format. The editors have built Mustard Compounds: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Mustard Compounds in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Mustard Compounds: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Brody's Human Pharmacology

Author : Lynn Wecker
Publisher : Elsevier Health Sciences
ISBN 13 : 0323596622
Total Pages : 712 pages
Book Rating : 4.3/5 (235 download)

DOWNLOAD NOW!

Book Synopsis Brody's Human Pharmacology by : Lynn Wecker

Download or read book Brody's Human Pharmacology written by Lynn Wecker and published by Elsevier Health Sciences. This book was released on 2018-05-31 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on the essential aspects of pharmacology you need to know, Brody‘s Human Pharmacology, 6th Edition, keeps you fully up to date with all that’s new in the field. Streamlined content, a new organizational approach, and thoroughly updated information ensure your grasp of key concepts and prepare you for exams. Nearly 500 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names reinforce your mastery of the information. The 6th Edition of this easy-to-use text is now fully up to date with: NEW chapter devoted entirely to pharmacogenomics and personalized medicine. NEW chapter on cannabinoids and their use for pain and other disorders, in light of recent legalization in many states. NEW chapters on recent developments in the treatment of Alzheimer's disease, ADHD and the latest treatments for HIV. NEW section on pain management. NEW section in each chapter covering "Clinical Relevance for Healthcare Professionals" that provides important information specific to physical therapists, dentists and dental hygienists, and many other medical professionals. Plus these student-friendly features: A new organizational approach, focusing on integration and systems-based learning. Contributions from leading faculty who cover the most important aspects of pharmacology necessary for a basic understanding of the subject, including concepts, clinical applications, and side effects. USMLE-style self-assessment questions at the end of every chapter, answers and rationales in the Appendix. Evolve Instructor Resources, including a downloadable image and test bank, are available to instructors through their Elsevier sales rep or via request at: https://evolve.elsevier.com

Mustard Lung

Author : Mostafa Ghanei
Publisher : Academic Press
ISBN 13 : 0128039795
Total Pages : 162 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Mustard Lung by : Mostafa Ghanei

Download or read book Mustard Lung written by Mostafa Ghanei and published by Academic Press. This book was released on 2016-05-03 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mustard Lung: Diagnosis and Treatment of Respiratory Disorders in Sulfur-Mustard Injured Patients brings together the details regarding pathophysiology, medication, and protective issues to provide a comprehensive look at health problems associated with sulfur mustard injury. It provides a bench-to-bedside look at the long term complications of vesicant exposure in humans as well as how mustard gas exposure affects lung function. By providing guidelines and approaches for the diagnosis, pathogenesis, and treatment of SM injury cases, this book is helpful for a wide range of medical researchers and clinicians. For decades, chemical respiratory disorders were diagnosed and managed traditionally similar to other chronic respiratory diseases. However, the exact nature of chemical respiratory disorders is different and needs to be treated as such. Includes the most up-to-date basic and clinical research findings on sulfur mustard from top researchers Provides information on chemical agents, complications that arise due to sulfur mustard exposure, and drugs available to treat injuries Contains an appendix with practical prescription recommendations for patients affected by mustard lung Provides a bench-to-bedside look at the long term complications of vesicant exposure in humans as well as how mustard gas exposure affects lung function

The Pathobiology of Neoplasia

Author : A.E. Sirica
Publisher : Springer Science & Business Media
ISBN 13 : 1468455230
Total Pages : 591 pages
Book Rating : 4.4/5 (684 download)

DOWNLOAD NOW!

Book Synopsis The Pathobiology of Neoplasia by : A.E. Sirica

Download or read book The Pathobiology of Neoplasia written by A.E. Sirica and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is directed primarily to advanced graduate and medical students, postdoctoral trainees, and established investigators having basic research interests in neoplasia. Its content is based in part on the lecture outlines and selected histopathology laboratory components of an advanced course entitled The Pathobiology of Experimental Animal and Human Neoplasia, developed by me for the Experimental Pathology Curriculum of the Department of Pathology at the Medical College of Virginia. In this regard, an effort has been made to integrate pathology with carcinogenesis, genetics, biochemistry, and cellular and molecular biology in order to present a comprehensive and current view of the neoplastic process. For focus, emphasis is mainly being placed on the neoplastic cells themselves, and not on associated host-mediated responses. It ishoped that this book will accomplish its purpose of providing students and researchers who already possess strong but diverse basic science backgrounds with unifying concepts in tumor pathobiology, so as to stimulate new research aimed at furthering our understanding of neoplastic disease. I wish to express my appreciation and heartfelt thanks to the authors, whose individual ranges of expertise and research experience clearly bring to their respective chapters unique perspectives that easily transcend any redundancy that may be present. In addition, I am grateful to Drs. George Vennart, Saul Kay, and Fred Meier, and to Ms. Connie Wilkerson of the Department of Pathology at MCV, for their helpful comments and their review of some of the material.

Recent Advancement in Prodrugs

Author : Kamal Shah
Publisher : CRC Press
ISBN 13 : 1000057976
Total Pages : 350 pages
Book Rating : 4.0/5 ( download)

DOWNLOAD NOW!

Book Synopsis Recent Advancement in Prodrugs by : Kamal Shah

Download or read book Recent Advancement in Prodrugs written by Kamal Shah and published by CRC Press. This book was released on 2020-05-13 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Advancement in Prodrugs Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations. Key features Covers recent advancements in development of prodrugs Presents balanced synthesis and applications of prodrug chemistry Discusses broad spectrum of prodrug categories and outlines industrial applications Reviews prodrugs in cancer nanomedicine, its therapy and treatment Elucidates mathematical models to study the kinetics of prodrugs This book covers recent advances in the design of prodrugs. It contains all the significant recent examples of prodrug chemistry developments and will aid academics and researchers seeking to generate new projects in the field.

Mechanisms of Carcinogenesis

Author : Elizabeth K. Weisburger
Publisher : Springer Science & Business Media
ISBN 13 : 9400925263
Total Pages : 210 pages
Book Rating : 4.4/5 (9 download)

DOWNLOAD NOW!

Book Synopsis Mechanisms of Carcinogenesis by : Elizabeth K. Weisburger

Download or read book Mechanisms of Carcinogenesis written by Elizabeth K. Weisburger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.

Research Grants Index

Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher :
ISBN 13 :
Total Pages : 768 pages
Book Rating : 4.3/5 ( download)

DOWNLOAD NOW!

Book Synopsis Research Grants Index by : National Institutes of Health (U.S.). Division of Research Grants

Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1968 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Experimental and Clinical Progress in Cancer Chemotherapy

Author : Franco M. Muggia
Publisher : Springer Science & Business Media
ISBN 13 : 1461325633
Total Pages : 280 pages
Book Rating : 4.4/5 (613 download)

DOWNLOAD NOW!

Book Synopsis Experimental and Clinical Progress in Cancer Chemotherapy by : Franco M. Muggia

Download or read book Experimental and Clinical Progress in Cancer Chemotherapy written by Franco M. Muggia and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: As in CANCER CHEMOTHERAPY 1, this volume brings to the reader highlights in three different areas of cancer therapeutics: new concepts and models; drug classes; and clinical settings. Topics were chosen because of their timeliness or probable current impact in cancer treatment. Authors were selected on the basis of their ability to provide a critical overview of specific subjects and their involvement in original work. I shall review the aims of this second volume, and then elaborate on the scope of its con tents. The principal aim of the volumes on cancer chemotherapy in the' Cancer Treatment and Research' series, as stated in the preface to the first volume, is to assemble in a concentrated form selected ingredients of chemothera peutic progress. These ingredients are to include concepts in therapeutic strategy, pre-clinical studies, development of major classes of compounds, identificatlon of new directions and of landmarks of clinical progress. Thus we do not foresee overlap with series which provide an yearly update of chemotherapy in an encyclopedic manner, or reviews of cancer chemother apy. Unlike those publications, our volumes are not intended to seek a place in shelves as a reference manual. It is this Editor's hope that persons repre senting various biomedical disciplines will seek the' Cancer Treatment and Research' chemotherapy volumes to survey advances in the field at regular intervals.

Predictive Drug Testing on Human Tumor Cells

Author : V. Hofmann
Publisher : Springer Science & Business Media
ISBN 13 : 3642822959
Total Pages : 334 pages
Book Rating : 4.6/5 (428 download)

DOWNLOAD NOW!

Book Synopsis Predictive Drug Testing on Human Tumor Cells by : V. Hofmann

Download or read book Predictive Drug Testing on Human Tumor Cells written by V. Hofmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Predictive drug testing on human tumor cells in order to define the appropriate chemotherapy will remain imperative as long as the anticancer agents available are few in number and show only limited activity. The advantages of an effective test would lie in obviating the need for testing antineoplastic agents on large cohorts of patients for assessment of drug activity (phase II studies) and in allowing determination of optimal use of anticancer agents (phase III trials). Such an in vitro test could help to better define dose and schedule of drugs preclinically. The additive value of individual drugs could be determined on tumor cells in vitro in order to define the best combination chemotherapy in vivo. Test-directed therapy would avoid unnecessary drug-related morbidity in patients with refractory tumors. Chemotherapy treatment would be more than justified even with side effects if palliation or even prolonged survival could be anticipated as a result. The benefits of predictive drug testing on human tumor cells would extend beyond improvement of individual patient treatment if the testing helped to identify new active agents. This spectrum of benefits to the entire field of oncology pro vides tremendous motivation for the development of such testing. Although a number of chemosensitivity tests have been proposed since the advent of modern anticancer chemotherapy, interest has been renewed by the possibility of cloning human tumor cells on agar plates, with a view to testing drug activity on cells with high pro liferation capacity.

Anticancer Drug Resistance

Author : Lori J. Goldstein
Publisher : Springer Science & Business Media
ISBN 13 : 1461526329
Total Pages : 302 pages
Book Rating : 4.4/5 (615 download)

DOWNLOAD NOW!

Book Synopsis Anticancer Drug Resistance by : Lori J. Goldstein

Download or read book Anticancer Drug Resistance written by Lori J. Goldstein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last 50 years, drug development and clinical trials have resulted in successful complete responses in diseases such as childhood leukemia, testicular cancer and Hodgkin's disease. We are still, however, confronted with over 500,000 cancer-related deaths per year. Clearly, the phenomenon of drug resistance is largely responsible for these failures and continues to be an area of active investigation. Since the last volume in this series, we have learned that the energy-dependent drug efflux protein, p-glycoprotein, encoded by the MDR 1 gene, is a member of a family of structurally related transport polypeptides, thus allowing us to explore the relationship between structure and function. In addition to ongoing well designed clinical trials aimed at reversing MDR mediated drug resistance, the first gene therapy studies with the MDR 1 gene retrovirally transduced into human bone marrow cells are about to be initiated. Although MDR is currently the most understood mechanism of drug resistance, we are uncovering increasing knowledge of alternative molecular and biochemical mechanisms of drug resistance to antimetabolites, cisplatin and alkylating agents and developing new strategies for circumventing such resistance. It is clear that drug resistance is complex, and many mechanisms exist by which cancer cells may overcome the cytotoxicity of our known chemotherapeutic agents. As our understanding of each of these mechanisms expands, well designed models will be necessary to test laboratory hypotheses and determine their relationship to drug resistance in humans. It is this integration of basic science and clinical investigation that will both advance our scientific knowledge and result in the improvement of cancer therapy.

Drug Toxicity in Embryonic Development I

Author : Robert J. Kavlock
Publisher : Springer Science & Business Media
ISBN 13 : 3642604455
Total Pages : 631 pages
Book Rating : 4.6/5 (426 download)

DOWNLOAD NOW!

Book Synopsis Drug Toxicity in Embryonic Development I by : Robert J. Kavlock

Download or read book Drug Toxicity in Embryonic Development I written by Robert J. Kavlock and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that the experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.

Fate and Effects of Anticancer Drugs in the Environment

Author : Ester Heath
Publisher : Springer Nature
ISBN 13 : 3030210480
Total Pages : 472 pages
Book Rating : 4.0/5 (32 download)

DOWNLOAD NOW!

Book Synopsis Fate and Effects of Anticancer Drugs in the Environment by : Ester Heath

Download or read book Fate and Effects of Anticancer Drugs in the Environment written by Ester Heath and published by Springer Nature. This book was released on 2020-01-01 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides current knowledge and research on the presence and effects of anticancer drug residues in the aqueous environment and covers all relevant aspects of the presence of these residues in wastewaters and natural aquatic systems, where numerous analogies between their pharmacokinetics and pharmacodynamics in humans and their effects in the environment can be drawn. This book comprises of 18 chapters and represents the combined work of leading scientists from different research institutions from across the globe. We present the state of the art in the field of anticancer drug residues in the aquatic environment while being cognizant of the many challenges that remain.

Clinically Relevant Resistance in Cancer Chemotherapy

Author : Borje Andersson
Publisher : Springer Science & Business Media
ISBN 13 : 1461511739
Total Pages : 391 pages
Book Rating : 4.4/5 (615 download)

DOWNLOAD NOW!

Book Synopsis Clinically Relevant Resistance in Cancer Chemotherapy by : Borje Andersson

Download or read book Clinically Relevant Resistance in Cancer Chemotherapy written by Borje Andersson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last several decades, the introduction of new chemotherapeutic drugs and drug combinations has resulted in increased long term remission rates in several important tumor types. These include childhood leukemia, adult leukemias and lymphomas, as well as testicular and trophoblastic tumors. The addition of high-dose chemotherapy with growth factor and hemopoietic stem cell support has increased clinical remission rates even further. For the majority of patients with some of the more common malignancies, however, palliation (rather than cure) is still the most realistic goal of chemotherapy for metastatic disease. The failure of chemotherapy to cure metastatic cancer is commonly referred to among clinicians as "drug resistance". This phenomenon can, however, often be viewed as the survival of malignant cells that resulted from a failure to deliver an effective drug dose to the (cellular) target because of anyone of or combination of a multitude of individual factors. Clinically, this treatment failure is often viewed as the rapid occurrence of resistance at the single cell level. However, in experimental systems, stable drug resistance is usually relatively slow to emerge.