Phenotypic Switching

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Phenotypic Switching

Author : Herbert Levine
Publisher : Academic Press
ISBN 13 : 012817997X
Total Pages : 773 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Phenotypic Switching by : Herbert Levine

Download or read book Phenotypic Switching written by Herbert Levine and published by Academic Press. This book was released on 2020-06-10 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast. Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies Features a diverse range of chapter contributions from international leaders in the field

Phenotypic Switching in Bacteria

Author : Jack Merrin
Publisher :
ISBN 13 :
Total Pages : 266 pages
Book Rating : 4.:/5 (665 download)

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Book Synopsis Phenotypic Switching in Bacteria by : Jack Merrin

Download or read book Phenotypic Switching in Bacteria written by Jack Merrin and published by . This book was released on 2006 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cellular and Phenotypic Plasticity in Cancer

Author : Petranel Theresa Ferrao
Publisher : Frontiers Media SA
ISBN 13 : 2889196623
Total Pages : 79 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Cellular and Phenotypic Plasticity in Cancer by : Petranel Theresa Ferrao

Download or read book Cellular and Phenotypic Plasticity in Cancer written by Petranel Theresa Ferrao and published by Frontiers Media SA. This book was released on 2015-09-17 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt: The process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various cancers and has also been associated with drug resistance to cytotoxics and targeted therapeutics. Recently phenotype switching akin to EMT has been reported in non-epithelial cancers such as metastatic melanoma. This process involves changes in EMT-Transcription Factors (EMT-TFs), suggesting that phenotype-switching may be common to several tumour types. It remains unclear as to whether the presence of both Epilthelial-like and Mesenchymal-like cells are a pre-requisite for phenotype switching within a tumour, how this heterogeneity is regulated, and if alteration of cell phenotype is sufficient to mediate migratory changes, or whether drivers of cell migration result in an associated phenotype switch in cancer cells. Similarly it has yet to be clarified if cells in an altered phenotype can be refractory to drug therapy or whether mediators of drug resistance induce a concurrent phenotypic change. Little is known today about the underlying genetic, epigenetic and transient changes that accompany this phenotypic switch and about the role for the tumor micro-environment in influencing it. Hence this is currently an area of speculation and keen interest in the Oncology field with wide-ranging translational implications. In this Frontiers Research Topic, we discuss our current understanding of these concepts in various cancer types including breast cancer, colorectal cancer and metastatic melanoma. This topic covers how these processes of cellular and phenotypic plasticity are regulated and how they relate to cancer initiation, progression, dormancy, metastases and response to cytotoxics or targeted therapies.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology of Fungal Development

Author : Heinz D. Osiewacz
Publisher : CRC Press
ISBN 13 : 0824744527
Total Pages : 592 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Molecular Biology of Fungal Development by : Heinz D. Osiewacz

Download or read book Molecular Biology of Fungal Development written by Heinz D. Osiewacz and published by CRC Press. This book was released on 2002-05-07 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text gives an overview of the fundamental aspects of molecular fungal development in one comprehensive volume, highlighting different elements in the maturational and reproductive cycles of selected fungal taxa.

Developmental Programing of Vertebrate Health and Disease

Author : Gina Galli
Publisher : Frontiers Media SA
ISBN 13 : 2889668029
Total Pages : 141 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Developmental Programing of Vertebrate Health and Disease by : Gina Galli

Download or read book Developmental Programing of Vertebrate Health and Disease written by Gina Galli and published by Frontiers Media SA. This book was released on 2021-05-25 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Growing Fungus

Author : N.A. Gow
Publisher : Springer Science & Business Media
ISBN 13 : 0585275769
Total Pages : 479 pages
Book Rating : 4.5/5 (852 download)

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Book Synopsis Growing Fungus by : N.A. Gow

Download or read book Growing Fungus written by N.A. Gow and published by Springer Science & Business Media. This book was released on 2007-08-28 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the growth and differentiation processes underlying the growth and differentia of filamentous fungi. The impetus for this work tion of fungi and that it provides the reader with stems from our perception that the coverage of adequate source references for further information. this highly diverse and important group of organ It is estimated conservatively that there are more isms has been neglected in recent years, despite than 1. 5 million species of fungi - more than five many significant advances in our understanding of times the number of vascular plants and second the underlying mechanisms of growth. This situ only in diversity to the insects. The extreme ation contrasts with the treatment of Saccharomyces diversity of form in the fungi has always been a cerevisiae, for example, which because of its ideal source of inspiration for mycologists. This book is properties for genetic analyses, has established concerned mainly with those systems that have itself as the model eukaryote for the analysis of the been well characterized from the biochemical, cell cycle, and basic studies of biochemical and physiological or genetic points of view. Although genetic regulation. This book does not deal with it has not been possible to illustrate the breadth of the detailed growth phYSiology of S.

Handbook of Epigenetics

Author : Trygve O Tollefsbol
Publisher : Academic Press
ISBN 13 : 0323919502
Total Pages : 920 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Handbook of Epigenetics by : Trygve O Tollefsbol

Download or read book Handbook of Epigenetics written by Trygve O Tollefsbol and published by Academic Press. This book was released on 2022-09-08 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses. In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources. Provides a timely and comprehensive collection of fully up-to-date coverage of epigenetics Covers basic epigenetic biology, research methods and technology, disease relationships and clinical medicine Written at a verbal and technical level that can be understood by scientists and students alike, with chapter summaries and conclusions included throughout Discusses exciting new topics in epigenetics, such as DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction Includes step-by-step instructions in research protocols to aid reproducibility, as well as easy-to-digest disease case studies and clinical trials, providing context and applied examples of recent clinical translation

Stochastic Processes in Cell Biology

Author : Paul C. Bressloff
Publisher : Springer Nature
ISBN 13 : 3030725197
Total Pages : 724 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Stochastic Processes in Cell Biology by : Paul C. Bressloff

Download or read book Stochastic Processes in Cell Biology written by Paul C. Bressloff and published by Springer Nature. This book was released on 2022-01-10 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book develops the theory of continuous and discrete stochastic processes within the context of cell biology. In the second edition the material has been significantly expanded, particularly within the context of nonequilibrium and self-organizing systems. Given the amount of additional material, the book has been divided into two volumes, with volume I mainly covering molecular processes and volume II focusing on cellular processes. A wide range of biological topics are covered in the new edition, including stochastic ion channels and excitable systems, molecular motors, stochastic gene networks, genetic switches and oscillators, epigenetics, normal and anomalous diffusion in complex cellular environments, stochastically-gated diffusion, active intracellular transport, signal transduction, cell sensing, bacterial chemotaxis, intracellular pattern formation, cell polarization, cell mechanics, biological polymers and membranes, nuclear structure and dynamics, biological condensates, molecular aggregation and nucleation, cellular length control, cell mitosis, cell motility, cell adhesion, cytoneme-based morphogenesis, bacterial growth, and quorum sensing. The book also provides a pedagogical introduction to the theory of stochastic and nonequilibrium processes – Fokker Planck equations, stochastic differential equations, stochastic calculus, master equations and jump Markov processes, birth-death processes, Poisson processes, first passage time problems, stochastic hybrid systems, queuing and renewal theory, narrow capture and escape, extreme statistics, search processes and stochastic resetting, exclusion processes, WKB methods, large deviation theory, path integrals, martingales and branching processes, numerical methods, linear response theory, phase separation, fluctuation-dissipation theorems, age-structured models, and statistical field theory. This text is primarily aimed at graduate students and researchers working in mathematical biology, statistical and biological physicists, and applied mathematicians interested in stochastic modeling. Applied probabilists should also find it of interest. It provides significant background material in applied mathematics and statistical physics, and introduces concepts in stochastic and nonequilibrium processes via motivating biological applications. The book is highly illustrated and contains a large number of examples and exercises that further develop the models and ideas in the body of the text. It is based on a course that the author has taught at the University of Utah for many years.

Research on Melanoma

Author : Mandi Murph
Publisher : BoD – Books on Demand
ISBN 13 : 9533072938
Total Pages : 430 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Research on Melanoma by : Mandi Murph

Download or read book Research on Melanoma written by Mandi Murph and published by BoD – Books on Demand. This book was released on 2011-09-12 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Research on Melanoma: A Glimpse into Current Directions and Future Trends, is divided into sections to represent the most cutting-edge topics in melanoma from around the world. The emerging epigenetics of disease, novel therapeutics under development and the molecular signaling aberrations are explained in detail. Since there are a number of areas in which unknowns exist surrounding the complex development of melanoma and its response to therapy, this book illuminates and comprehensively discusses such aspects. It is relevant for teaching the novice researcher who wants to initiate projects in melanoma and the more senior researcher seeking to polish their existing knowledge in this area. Many chapters include visuals and illustrations designed to easily guide the reader through the ideas presented.

Mechanisms of Vascular Disease

Author : Robert Fitridge
Publisher : Springer Nature
ISBN 13 : 3030436837
Total Pages : 739 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge

Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by Springer Nature. This book was released on 2020-07-30 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensively revised third edition provides a practically applicable guide to the pathophysiology, assessment and management of vascular disorders encountered in vascular surgical practice. It features detailed information on the latest developments in the pathophysiology of conditions including atherosclerosis, multi-organ failure, limb compartment syndromes and Raynaud’s phenomenon in a clear easy to digest format. Disorders such as reperfusion injuries, vasculitides, and aortic dissection are covered. Furthermore, key topics in vascular and endovascular practice such as radiation biology and radiation safety are also detailed. Each chapter contains a set of learning objectives and key references, enabling the reader to quickly identify key points. Mechanisms of Vascular Disease: A Textbook for Vascular Specialists comprehensively covers a variety of common and unusual pathophysiologies encountered in vascular surgery, and is an ideal resource for both the trainee, and practicing clinical vascular surgeon seeking an up-to-date resource on the topic.

Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases

Author : Jun Sun
Publisher : Springer
ISBN 13 : 149397534X
Total Pages : 381 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases by : Jun Sun

Download or read book Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases written by Jun Sun and published by Springer. This book was released on 2018-01-26 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Only recently have we begun to appreciate the role of microbiome in health and disease. Environmental factors and change of life style including diet significantly shape human microbiome that in turn appears to modify gut barrier function affecting nutrient & electrolyte absorption and inflammation. Approaches that can reverse the gut dysbiosis represent as reasonable and novel strategies for restoring the balance between host and microbes. In the book, we offer summary and discussion on the advances in understanding of pathophysiological mechanisms of microbial host interactions in human diseases. We will not only discuss intestinal bacterial community, but also viruses, fungi and oral microbiome. Microbiome studies will facilitate diagnosis, functional studies, drug development and personalized medicine. Thus, this book will further highlight the microbiome in the context of health and disease, focusing on mechanistic concepts that underlie the complex relationships between host and microbes.

Pseudomonas

Author : Juan-Luis Ramos
Publisher : Springer Science & Business Media
ISBN 13 : 1441990860
Total Pages : 837 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Pseudomonas by : Juan-Luis Ramos

Download or read book Pseudomonas written by Juan-Luis Ramos and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 837 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pseudomonas comprises three volumes covering the biology of pseudomonads in a wide context, including the niches they inhabit, the taxonomic relations among members of this group, the molecular biology of gene expression in different niches and under different environmental conditions, the analysis of virulence traits in plants, animals and human pathogens as well as the determinants that make some strains useful for biotechnological applications and promotion of plant growth. There has been growing interest in pseudomonads and a particular urge to understand the biology underlying the complex metabolism of these ubiquitous microbes. These bacteria are capable of colonizing a wide range of niches, including the soil, the plant rhizosphere and phylosphere, and animal tissues; more recently they have attracted attention because of their capacity to form biofilms, a characteristic with potentially important medical and environmental implications. The three volumes cover the following topics: - Taxonomy, - Genomics, - Life styles, - Cell Architecture, - Virulence, - Regulation, - Macromolecules, - Alternative Respiratory Substrates, - Catabolism and Biotransformations. Pseudomonas will be of use to all researchers working on these bacteria, particularly those studying microbiology, plant crops, pathogenesis, and chemical engineering. Advanced students in biology, medicine and agronomy will also find these three volumes a valuable reference during their studies.

Endodontic Microbiology

Author : Ashraf F. Fouad
Publisher : John Wiley & Sons
ISBN 13 : 1118975499
Total Pages : 472 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Endodontic Microbiology by : Ashraf F. Fouad

Download or read book Endodontic Microbiology written by Ashraf F. Fouad and published by John Wiley & Sons. This book was released on 2017-01-24 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endodontic Microbiology, Second Edition presents a comprehensive reference to the microbiology, pathogenesis, management, and healing of endodontic pathosis, emphasizing the importance of biological sciences in understanding and managing endodontic disease and its interaction with systemic health. Provides a major revision to the first book to focus on the problems related to microbes in the root canal and periapical tissues Updates current knowledge in endodontic pathosis, especially regarding next generation sequencing and microbial virulence Presents useful diagrams, images, radiographs, and annotated histological images to illustrate the concepts Emphasizes the importance of biological science in understanding and managing endodontic disease Includes contributions from the leading researchers and educators in the field

Vascular Smooth Muscle Cell fate and Vascular Remodeling: Mechanisms, Therapeutic Targets, and Drugs, Volume I

Author : Ping Song
Publisher : Frontiers Media SA
ISBN 13 : 2832500706
Total Pages : 172 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Vascular Smooth Muscle Cell fate and Vascular Remodeling: Mechanisms, Therapeutic Targets, and Drugs, Volume I by : Ping Song

Download or read book Vascular Smooth Muscle Cell fate and Vascular Remodeling: Mechanisms, Therapeutic Targets, and Drugs, Volume I written by Ping Song and published by Frontiers Media SA. This book was released on 2022-09-26 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Extracellular Space Research and Application: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464923434
Total Pages : 262 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Advances in Extracellular Space Research and Application: 2011 Edition by :

Download or read book Advances in Extracellular Space Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Extracellular Space Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Extracellular Space. The editors have built Advances in Extracellular Space Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Extracellular Space in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Extracellular Space Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A

Author :
Publisher : Academic Press
ISBN 13 : 0128168528
Total Pages : 424 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A by :

Download or read book Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A written by and published by Academic Press. This book was released on 2019-09-11 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field