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Phase Iii Report
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Book Synopsis The Prevention and Treatment of Missing Data in Clinical Trials by : National Research Council
Download or read book The Prevention and Treatment of Missing Data in Clinical Trials written by National Research Council and published by National Academies Press. This book was released on 2010-12-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Book Synopsis Phase III. by : United States. Cost of Living Council
Download or read book Phase III. written by United States. Cost of Living Council and published by . This book was released on 1973 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Final Report for Phase III by : Friedhelm Krupp
Download or read book Final Report for Phase III written by Friedhelm Krupp and published by . This book was released on 1995 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Sharing Clinical Trial Data by : Institute of Medicine
Download or read book Sharing Clinical Trial Data written by Institute of Medicine and published by National Academies Press. This book was released on 2015-04-20 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.
Book Synopsis Vehicle detection phase III by : Lubke, Roger A.
Download or read book Vehicle detection phase III written by Lubke, Roger A. and published by . This book was released on 1977 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Low Altitude Atmospheric Turbulence LO-LOCAT Phase III Interim Report by : K. R. Monson
Download or read book Low Altitude Atmospheric Turbulence LO-LOCAT Phase III Interim Report written by K. R. Monson and published by . This book was released on 1969 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contents of this report describe accomplishments during the first half of the Low-Level Critical Air Turbulence (LO-LOCAT) Phase III program. Data that were obtained during flight over routes near McConnell Air Force Base, Kansas, and Edwards Air Force Base, California, are presented. Also included are time histories of some of the larger magnitude gust velocities recorded over the Peterson Field, Colorado route. Approximately 72 hours of low-level (0-1000 feet) turbulence and associated meteorological data recorded from August 16, 1968, through January 8, 1969, are presented. The turbulence environment is analyzed in terms of gust velocity primary peaks, amplitude samples, rms values, maximum values and derived equivalent gusts. Mathematical expressions for turbulence spectra and scale length statistics, and correlations between atmospheric gust velocities and meteorological and geophysical phenomena are shown. The most predominant characteristics of these data are the increases in rms values, scale lengths, Taylor micro scales and maximum gust values as compared to the LO-LOCAT Phases I and II data. These differences are attributed to the increased speed of the Phase III airplane which is providing a better definition of the longer wavelengths of atmospheric turbulence. This report consists of two volumes. Volume I contains a discussion of data acquisition and quality, along with a preliminary analysis of turbulence and meteorological data.
Book Synopsis CARE III Phase III Report by : J. J. Stiffler
Download or read book CARE III Phase III Report written by J. J. Stiffler and published by . This book was released on 1982 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis SBIR and the Phase III Challenge of Commercialization by : National Research Council
Download or read book SBIR and the Phase III Challenge of Commercialization written by National Research Council and published by National Academies Press. This book was released on 2007-04-15 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to a Congressional mandate, the National Research Council conducted a review of the Small Business Innovation Research Program (SBIR) at the five federal agencies with SBIR programs with budgets in excess of $100 million (DOD, NIH, NASA, DOE, and NSF). The project was designed to answer questions of program operation and effectiveness, including the quality of the research projects being conducted under the SBIR program, the commercialization of the research, and the program's contribution to accomplishing agency missions. This report summarizes the presentations at a symposium exploring the effectiveness of Phase III of the SBIR program (the commercialization phase), during which innovations funded by Phase II awards move from the laboratory into the marketplace. No SBIR funds support Phase III; instead, to commercialize their products, small businesses are expected to garner additional funds from private investors, the capital markets, or from the agency that made the initial award.
Book Synopsis SBIR and the Phase III Challenge of Commercialization by : National Research Council
Download or read book SBIR and the Phase III Challenge of Commercialization written by National Research Council and published by National Academies Press. This book was released on 2007-03-15 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to a Congressional mandate, the National Research Council conducted a review of the Small Business Innovation Research Program (SBIR) at the five federal agencies with SBIR programs with budgets in excess of $100 million (DOD, NIH, NASA, DOE, and NSF). The project was designed to answer questions of program operation and effectiveness, including the quality of the research projects being conducted under the SBIR program, the commercialization of the research, and the program's contribution to accomplishing agency missions. This report summarizes the presentations at a symposium exploring the effectiveness of Phase III of the SBIR program (the commercialization phase), during which innovations funded by Phase II awards move from the laboratory into the marketplace. No SBIR funds support Phase III; instead, to commercialize their products, small businesses are expected to garner additional funds from private investors, the capital markets, or from the agency that made the initial award.
Book Synopsis Silver Line Phase III, City of Boston by :
Download or read book Silver Line Phase III, City of Boston written by and published by . This book was released on 2005 with total page 1362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Documentation of the Phase III 0.192-scale Northrop/McDonnell-Douglas F-18 Inlet Performance Test at Mach Numbers 0 to 1.55 by : Jimmy Walker
Download or read book Documentation of the Phase III 0.192-scale Northrop/McDonnell-Douglas F-18 Inlet Performance Test at Mach Numbers 0 to 1.55 written by Jimmy Walker and published by . This book was released on 1978 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book CARE III. written by J. J. Stiffler and published by . This book was released on 1982 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Environmental Assessment Tool for Multifamily Buildings : Phase III, Final Report : Environmental Assessment of Four Buildings by : Canada Mortgage and Housing Corporation
Download or read book Environmental Assessment Tool for Multifamily Buildings : Phase III, Final Report : Environmental Assessment of Four Buildings written by Canada Mortgage and Housing Corporation and published by . This book was released on 1998 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis San Francisco Bay to Stockton Phase III Navigation Channel Project, Contra Costa County by :
Download or read book San Francisco Bay to Stockton Phase III Navigation Channel Project, Contra Costa County written by and published by . This book was released on 1997 with total page 780 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Minicars Research Safety Vehicle Program, Phase III. Volume I: Technical Final Report by : V. K. Ausherman
Download or read book The Minicars Research Safety Vehicle Program, Phase III. Volume I: Technical Final Report written by V. K. Ausherman and published by . This book was released on 1981 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Phase III Report by : Water Quality 2000 (Organization)
Download or read book Phase III Report written by Water Quality 2000 (Organization) and published by . This book was released on 1992 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Phase III/Hubline Project, Maritimes & Northeast Pipeline L.L.C., Algonquin Gas Transmission Company and Texas Eastern Transmission Corporation by :
Download or read book Phase III/Hubline Project, Maritimes & Northeast Pipeline L.L.C., Algonquin Gas Transmission Company and Texas Eastern Transmission Corporation written by and published by . This book was released on 2001 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
