Pharmacoinformatics and Drug Discovery Technologies: Theories and Applications

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Publisher : IGI Global
ISBN 13 : 1466603100
Total Pages : 442 pages
Book Rating : 4.4/5 (666 download)

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Book Synopsis Pharmacoinformatics and Drug Discovery Technologies: Theories and Applications by : Gasmelseid, Tagelsir Mohamed

Download or read book Pharmacoinformatics and Drug Discovery Technologies: Theories and Applications written by Gasmelseid, Tagelsir Mohamed and published by IGI Global. This book was released on 2012-03-31 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the context of integrated health management domains, pharmacoinformatics aims at maximizing the benefits from the use of information systems and technologies for the provision of decision support tools necessary for improved drug management, use, and administration practices. Pharmacoinformatics and Drug Discovery Technologies: Theories and Applications offers the latest the field has to offer to practitioners and academics alike, presented through theoretical frameworks, case studies, and future directions. This vital resource gathers an integrated pattern of high quality publications from around the world providing current, cutting-edge, and provocative scientific work in the three domains of pharmacoinformatics: decision making domains, knowledge utilization and representation environment, and the technological and infrastructural context.

Drug Discovery and Development, Third Edition

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Publisher : CRC Press
ISBN 13 : 1351625144
Total Pages : 697 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Drug Discovery and Development, Third Edition by : James J. O'Donnell

Download or read book Drug Discovery and Development, Third Edition written by James J. O'Donnell and published by CRC Press. This book was released on 2019-11-21 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

Computer Applications in Drug Discovery and Development

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Publisher : IGI Global
ISBN 13 : 1522573275
Total Pages : 348 pages
Book Rating : 4.5/5 (225 download)

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Book Synopsis Computer Applications in Drug Discovery and Development by : Puratchikody, A.

Download or read book Computer Applications in Drug Discovery and Development written by Puratchikody, A. and published by IGI Global. This book was released on 2018-11-23 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: With more restrictions upon animal experimentations, pharmaceutical industries are currently focusing on a new generation of experiments and technologies that are considerably more efficient and less controversial. The integration of computational and experimental strategies has led to the identification and development of promising compounds. Computer Applications in Drug Discovery and Development is a pivotal reference source that provides innovative research on the application of computers for discovering and designing new drugs in modern molecular biology and medicinal chemistry. While highlighting topics such as chemical structure databases and dataset utilization, this publication delves into the current panorama of drug discovery, where high drug failure rates are a major concern and properly designed virtual screening strategies can be a time-saving, cost-effective, and productive alternative. This book is ideally designed for chemical engineers, pharmacists, molecular biologists, students, researchers, and academicians seeking current research on the unexplored avenues and future perspectives of drug design.

Modern Methods of Drug Discovery

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Publisher : Springer Science & Business Media
ISBN 13 : 9783764360818
Total Pages : 312 pages
Book Rating : 4.3/5 (68 download)

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Book Synopsis Modern Methods of Drug Discovery by : Alexander Hillisch

Download or read book Modern Methods of Drug Discovery written by Alexander Hillisch and published by Springer Science & Business Media. This book was released on 2002-12-11 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.

Pharmacogenomics in Drug Discovery and Development

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Publisher : Humana Press
ISBN 13 : 9781588298874
Total Pages : 0 pages
Book Rating : 4.2/5 (988 download)

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Book Synopsis Pharmacogenomics in Drug Discovery and Development by : Qing Yan

Download or read book Pharmacogenomics in Drug Discovery and Development written by Qing Yan and published by Humana Press. This book was released on 2008-03-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In this book, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. The volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases. This book is ideal for scientists striving to transform disease treatment into disease prevention.

Chemoinformatics

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Publisher : Springer Science & Business Media
ISBN 13 : 1592598021
Total Pages : 530 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Chemoinformatics by : Jürgen Bajorath

Download or read book Chemoinformatics written by Jürgen Bajorath and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the literature, several terms are used synonymously to name the topic of this book: chem-, chemi-, or chemo-informatics. A widely recognized de- nition of this discipline is the one by Frank Brown from 1998 (1) who defined chemoinformatics as the combination of “all the information resources that a scientist needs to optimize the properties of a ligand to become a drug. ” In Brown’s definition, two aspects play a fundamentally important role: de- sion support by computational means and drug discovery, which distinguishes it from the term “chemical informatics” that was introduced at least ten years earlier and described as the application of information technology to ch- istry (not with a specific focus on drug discovery). In addition, there is of course “chemometrics,” which is generally understood as the application of statistical methods to chemical data and the derivation of relevant statistical models and descriptors (2). The pharmaceutical focus of many developments and efforts in this area—and the current popularity of gene-to-drug or si- lar paradigms—is further reflected by the recent introduction of such terms as “discovery informatics” (3), which takes into account that gaining kno- edge from chemical data alone is not sufficient to be ultimately successful in drug discovery. Such insights are well in accord with other views that the boundaries between bio- and chemoinformatics are fluid and that these d- ciplines should be closely combined or merged to significantly impact b- technology or pharmaceutical research (4).

The Science and Business of Drug Discovery

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Publisher : Springer Nature
ISBN 13 : 3030578143
Total Pages : 401 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis The Science and Business of Drug Discovery by : Edward D. Zanders

Download or read book The Science and Business of Drug Discovery written by Edward D. Zanders and published by Springer Nature. This book was released on 2020-11-09 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators

In Silico Drug Discovery and Design

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Publisher : CRC Press
ISBN 13 : 1482217856
Total Pages : 558 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis In Silico Drug Discovery and Design by : Claudio N. Cavasotto

Download or read book In Silico Drug Discovery and Design written by Claudio N. Cavasotto and published by CRC Press. This book was released on 2015-08-06 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design. Its main aims are to introduce the theoretical framework and algorithms, discuss the range of validity, strengths and limita

Case Studies in Modern Drug Discovery and Development

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Publisher : John Wiley & Sons
ISBN 13 : 0470601817
Total Pages : 488 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Case Studies in Modern Drug Discovery and Development by : Xianhai Huang

Download or read book Case Studies in Modern Drug Discovery and Development written by Xianhai Huang and published by John Wiley & Sons. This book was released on 2012-05-29 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn why some drug discovery and development efforts succeed . . . and others fail Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples. Each case study focuses on a particular drug and therapeutic target, guiding readers through the drug discovery and development process, including drug design rationale, structure-activity relationships, pharmacology, drug metabolism, biology, and clinical studies. Case Studies in Modern Drug Discovery and Development begins with an introductory chapter that puts into perspective the underlying issues facing the pharmaceutical industry and provides insight into future research opportunities. Next, there are fourteen detailed case studies, examining: All phases of drug discovery and development from initial idea to commercialization Some of today's most important and life-saving medications Drugs designed for different therapeutic areas such as cardiovascular disease, infection, inflammation, cancer, metabolic syndrome, and allergies Examples of prodrugs and inhaled drugs Reasons why certain drugs failed to advance to market despite major research investments Each chapter ends with a list of references leading to the primary literature. There are also plenty of tables and illustrations to help readers fully understand key concepts, processes, and technologies. Improving the success rate of the drug discovery and development process is paramount to the pharmaceutical industry. With this book as their guide, readers can learn from both successful and unsuccessful efforts in order to apply tested and proven science and technologies that increase the probability of success for new drug discovery and development projects.

Drug Discovery and Development

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Publisher : Elsevier Health Sciences
ISBN 13 : 0702078050
Total Pages : 387 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Drug Discovery and Development by : Raymond G Hill

Download or read book Drug Discovery and Development written by Raymond G Hill and published by Elsevier Health Sciences. This book was released on 2021-05-16 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: With unprecedented interest in the power that the modern therapeutic armamentarium has to combat disease, the new edition of Drug Discovery and Development is an essential resource for anyone interested in understanding how drugs and other therapeutic interventions are discovered and developed, through to clinical research, registration, and market access. The text has been thoroughly updated, with new information on biopharmaceuticals and vaccines as well as clinical development and target identification. Drug discovery and development continues to evolve rapidly and this new edition reflects important changes in the landscape. Edited by industry experts Raymond Hill and Duncan Richards, this market-leading text is suitable for undergraduates and graduates undertaking degrees in pharmacy, pharmacology, toxicology, and clinical development through to those embarking on a career in the pharmaceutical industry. Key stages of drug discovery and development Chapters outline the contribution of individual disciplines to the overall process Supplemented by specific chapters on different modalities Includes coverage of Oligonucleotide therapies; cell and gene therapy Now comes with online access on StudentConsult

The Process of New Drug Discovery and Development

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Publisher : CRC Press
ISBN 13 : 9780849342110
Total Pages : 166 pages
Book Rating : 4.3/5 (421 download)

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Book Synopsis The Process of New Drug Discovery and Development by : G. Smith Charles

Download or read book The Process of New Drug Discovery and Development written by G. Smith Charles and published by CRC Press. This book was released on 1992-08-24 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Process of New Drug Discovery and Development presents a practical methodology for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It includes detailed discussions regarding the research process and presents critiques of the governmental regulatory aspects of pharmaceutical research. The author also addresses the controversy surrounding the use of animals in biomedical research and provides current information regarding the field of biotechnology, international drug research, and registration activities. The Process of New Drug Discovery and Development is an excellent "how to" text for pharmaceutical researchers, oncologists, biochemists, experimental biologists, and others involved in new drug research and development.

Special Topics in Drug Discovery

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Publisher : BoD – Books on Demand
ISBN 13 : 9535127993
Total Pages : 192 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Special Topics in Drug Discovery by : Taosheng Chen

Download or read book Special Topics in Drug Discovery written by Taosheng Chen and published by BoD – Books on Demand. This book was released on 2016-11-30 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery involves multiple disciplines, technologies, and approaches. This book selects important topics related to drug discovery, including emerging tool (Chapter 1), cutting-edge approaches (Chapters 2, 3, and 4), examples of specific therapeutic area (Chapter 5), quality control in drug development (Chapter 6), and job and career opportunities in the pharmaceutical sector, a topic rarely covered by other books (Chapter 7). This book draws knowledge from experts actively involved in different areas of drug discovery from both industrial and academic settings. We hope that this book will facilitate your efforts in drug discovery.

Integrated Drug Discovery Technologies

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Publisher : CRC Press
ISBN 13 : 0203910699
Total Pages : 561 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis Integrated Drug Discovery Technologies by : Houng-Yau Mei

Download or read book Integrated Drug Discovery Technologies written by Houng-Yau Mei and published by CRC Press. This book was released on 2002-03-19 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrated Drug Discovery Technologies provides a global overview of emerging drug development technologies by presenting and integrating new techniques from the disciplines of chemistry, biology, and computational sciences. It combines integration of contemporary mechanization with strategies in drug delivery. Topics include: target identification and validation, functional genomics, microfabrication techniques, integrated proteomics technologies, high throughput screening, fluorescence correlation spectroscopy methods, and screening lead compounds in the post-genomic era.

CADD and Informatics in Drug Discovery

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Publisher : Springer Nature
ISBN 13 : 9819913160
Total Pages : 370 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis CADD and Informatics in Drug Discovery by : Mithun Rudrapal

Download or read book CADD and Informatics in Drug Discovery written by Mithun Rudrapal and published by Springer Nature. This book was released on 2023-05-12 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book updates knowledge on recent advances in computational, biophysical and bioinformatics tools/techniques and their practical applications in modern drug design and discovery paradigm. It also encompasses fundamental principles, advanced methodologies and applications of various CADD approaches including several cutting-edge areas; presenting recent developments covering ongoing trends in the field of computer-aided drug discovery. Having contributions by a global team of experts, the book is expected to be an ideal resource for drug discovery scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, biologists, R&D personnel, researchers, students, teachers and those working in the field of drug discovery. It will fill the knowledge gaps that exist in the current CADD approaches and methodologies/ protocols being widely used in both academic and research practices. Further, a special focus on current status of various computational drug design approaches (SBDD, LBDD, de novo drug design, pharmacophore-based search), bioinformatics tools and databases, computational screening and modeling of phytochemicals/natural products, artificial intelligence and machine learning, and network pharmacology and systems biology would certainly guide researchers, students or readers to conduct their research in the emerging area(s) of interest. It is also expected to be highly beneficial to various stakeholders working in the pharmaceutical and biotechnology industries (R&D), the academic as well as research sectors.

Integrated Pharmaceutics

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Publisher : John Wiley & Sons
ISBN 13 : 1118356721
Total Pages : 1024 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Integrated Pharmaceutics by : Antoine Al-Achi

Download or read book Integrated Pharmaceutics written by Antoine Al-Achi and published by John Wiley & Sons. This book was released on 2013-01-22 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on the application of physical pharmacy, drug design, and drug regulations as they relate to produce effective dosage forms for drug delivery, Integrated Pharmaceutics provides a comprehensive picture of pharmaceutical product design, describing the science and art behind the concepts of dosage form development. Combining physical pharmacy, product design, and regulatory affairs issues in a single book, the authors address topics governing drug regulations of United States, European, and Japanese agencies and detail new regulatory guidelines, including quality by design, design space analysis, and blend sample uniformity.

Real World Drug Discovery

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Publisher : Elsevier
ISBN 13 : 0080914888
Total Pages : 535 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Real World Drug Discovery by : Robert M. Rydzewski

Download or read book Real World Drug Discovery written by Robert M. Rydzewski and published by Elsevier. This book was released on 2010-07-07 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery increasingly requires a common understanding by researchers of the many and diverse factors that go into the making of new medicines. The scientist entering the field will immediately face important issues for which his education may not have prepared him: project teams, patent law, consultants, target product profiles, industry trends, Gantt charts, target validation, pharmacokinetics, proteomics, phenotype assays, biomarkers, and many other unfamiliar topics for which a basic understanding must somehow be obtained. Even the more experienced scientist can find it frustratingly difficult to get an overview of the many factors involved in modern drug discovery and often only after years of exploring does a whole and integrated picture emerge in the mind of the researcher.Real World Drug Discovery: A Chemist’s Guide to Biotech and Pharmaceutical Research presents this kind of map of the landscape of drug discovery. In a single, readable volume it outlines processes and explains essential concepts and terms for the recent science graduate wondering what to expect in pharma or biotech, the medicinal chemist seeking a broader and more timely understanding of the industry, or the contractor or collaborator whose understanding of the commercial drug discovery process could increase the value of his contribution to it. Interviews with well-known experts in many of the fields involved, giving insightful comments from authorities on many of the sub-disciplines important to cutting edge drug discovery. Helpful suggestions gleaned from years of experience in biotech and pharma, which represents a repository drug discovery "lore" not previously available in any book. "Periodic Table of Drugs" listing current top-selling drugs arranged by target and laid out so that structural similarities and differences are plain and clear. Extensive use of diagrams to illustrate concepts like biotech startup models, preteomic profiling for target identification, Gantt charts for project planning, etc.

Drug Design Strategies

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Author :
Publisher : Royal Society of Chemistry
ISBN 13 : 1849731675
Total Pages : 251 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Drug Design Strategies by : Lee Banting

Download or read book Drug Design Strategies written by Lee Banting and published by Royal Society of Chemistry. This book was released on 2012 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, aimed at academics, industrialists and post-graduates, documents the latest research into computer aided drug design.