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Phagocytosis
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Book Synopsis Molecular and Cellular Biology of Phagocytosis by : Maurice B. Hallett
Download or read book Molecular and Cellular Biology of Phagocytosis written by Maurice B. Hallett and published by Springer Nature. This book was released on 2020-05-12 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phagocytosis is the engulfment of particulate matter by cells. It is a fundamental (and probably “primitive”) cell biological process which is important in single celled organisms such as amoeba; multicellular animals including coelenterates; and in higher animals. In humans and other mammals, specialised immune cells (phagocytes) utilise phagocytosis in their crucial role of engulfing and destroying infecting microbes. Yet, surprisingly, the biophysics and biochemistry underlying the process has only become clear recently with the advent of genetic manipulation and advances in single cell imaging. In this volume, the aim is to bring together recent fundamental advances that give a clear picture of the underlying mechanism involved in phagocytosis. Not only is this an important topic in its own right, but a full understanding of the process will have a potential impact on human medicine, since as antibiotics become less effective in fight infection, researchers are looking at alternative approaches, including enhancing the “natural” immunity brought about by immune phagocytes. The aim is to provide a comprehensive volume on the topic, with separate chapters on identified recent advances, each written by the major contributors in each area. In addition, the volume will attempt to give a wider overview than is often the case in single author reviews, with an emphasis here on the cell biological understanding of phagocytosis using biophysical approaches alongside the biochemical and imaging approaches.
Book Synopsis Phagocytosis and Phagosomes by : Roberto Botelho
Download or read book Phagocytosis and Phagosomes written by Roberto Botelho and published by Humana. This book was released on 2016-11-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details experimental approaches used to investigate phagocytosis and phagosome maturation. Chapters present methods and protocols on quantifying uptake and phagosome maturation using biophysical and biochemical approaches, proteomics, microscopy, and flow cytometry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Phagocytosis and Phagosomes: Methods and Protocols aims to be an important resource for both experts in the field and for those investigators delving into phagocytosis and phagosome maturation for the first time.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mononuclear Phagocytes by : R. van Furth
Download or read book Mononuclear Phagocytes written by R. van Furth and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 1949 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Book Synopsis Phagocytosis: Molecular Mechanisms and Physiological Implications by : Esther M. Lafuente
Download or read book Phagocytosis: Molecular Mechanisms and Physiological Implications written by Esther M. Lafuente and published by Frontiers Media SA. This book was released on 2020-12-03 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis Bacterial Virulence Factors and Rho GTPases by : Patrice Boquet
Download or read book Bacterial Virulence Factors and Rho GTPases written by Patrice Boquet and published by Springer Science & Business Media. This book was released on 2006-03-30 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathogenic bacteria for human and animals have developed sophisticated weapons, termed virulence factors, to ensure their replication and persistence into their hosts. The authors in this volume show a synthesis on how the various host cellular Rho GTPases activities are manipulated by bacteria to fulfil their virulence.
Book Synopsis Allergy and Clinical Immunology by : Hugh A. Sampson
Download or read book Allergy and Clinical Immunology written by Hugh A. Sampson and published by John Wiley & Sons. This book was released on 2015-02-26 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mount Sinai Expert Guides: Allergy and Clinical Immunology will provide trainees in allergy and immunology with an extremely clinical and accessible handbook covering the major disorders and symptoms, their diagnosis and clinical management. Perfect as a point-of-care resource on the hospital wards and also as a refresher for board exam preparation, the focus throughout is on providing rapid reference, essential information on each disorder to allow for quick, easy browsing and assimilation of the must-know information. All chapters follow a consistent template including the following features: An opening bottom-line/key points section Classification, pathogenesis and prevention of disorder Evidence-based diagnosis, including relevant algorithms, laboratory and imaging tests, and potential pitfalls when diagnosing a patient Disease management including commonly used medications with dosages, management algorithms and how to prevent complications How to manage special populations, ie, in pregnancy, children and the elderly The very latest evidence-based results, major society guidelines and key external sources to consult In addition, the book comes with a companion website housing extra features such as case studies with related questions for self-assessment, key patient advice and ICD codes. Each guide also has its own mobile app available for purchase, allowing you rapid access to the key features wherever you may be. If you're specialising in allergy and immunology and require concise, practical and clinical guidance from one of the world's leading institutions in this field, then this is the perfect book for you. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.
Download or read book Amphioxus Immunity written by An-Long Xu and published by Elsevier. This book was released on 2015-12-31 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system, includes 13 topics, such as: Amphioxus as a model for understanding the evolution of vertebrates basic knowledge of immunology immune organs and cells of amphioxus a genomic and transcriptomic view of the Amphioxus immunity pattern recognition system in Amphioxus transcription factors in Amphioxus the complement system of Amphioxus the oxidative burst system in Amphioxus immune effectors in Amphioxus lipid signaling of immune response in Amphioxus apoptosis in amphioxus; primitive adaptive immune system of Amphioxus and future research directions This valuable reference book is loaded with information that will be useful for anyone who wishes to learn more about the origin of vertebrates and adaptive immunity. Provides new evidence on the origin of the adaptive immune system, the evolution of innate immunity, and evolution-stage specific immune defense mechanisms Not only presents the cells and molecules involved in the adaptive immune response in Amphioxus, but also characterizes the origination and evolution of the gene families and pathways involved in innate immunity Includes much pioneering work, from the molecular, genomic, and cellular to the individual level
Book Synopsis The Respiratory Burst and Its Physiological Significance by : A.J. Sbarra
Download or read book The Respiratory Burst and Its Physiological Significance written by A.J. Sbarra and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: When phagocytes are exposed to a number of different stimuli, they undergo dra matic changes in the way they process oxygen. Oxygen uptake increases markedly, frequently more than 50-fold; the phagocytes begin to produce large quantities of superoxide and hydrogen peroxide; and they immediately begin to metabolize large amounts of glucose by way of the hexose monophosphate shunt. This series of changes has become known as the respiratory burst. It was first believed that the major function of this respiratory burst was to generate powerful antibacterial agents by the partial reduction of oxygen. It is becoming apparent that the respiratory burst has much wider application, and its physiological function in many different biolog ical areas is clear. In this volume, we have attempted to bring together the work of experts who have published extensively on the involvement of the respiratory burst in different physiological functions. In the first three chapters, Dr. Borregaard and Dr. Berton and co-workers and Dr. Roos and co-workers bring together what is known about the respiratory burst. They present up-to-date versions of the biochemical and metabolic activities associ ated with the burst. In Chapter 4, Dr. Styrt and Dr. Klempner discuss the respiratory burst as it affects cellular ion homeostasis. Dr. Cohen and Dr. Britigan (Chapter 5) present some interesting data on the competition between the respiratory burst and bacteria for oxygen. Dr. Dobrina and Dr.
Book Synopsis Phagocytosis of Bacteria and Bacterial Pathogenicity by : Joel D. Ernst
Download or read book Phagocytosis of Bacteria and Bacterial Pathogenicity written by Joel D. Ernst and published by Cambridge University Press. This book was released on 2006-09-07 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on the crucial interaction of pathogenic bacteria and professional phagocytes, the host cells whose purpose is to ingest, kill, and digest bacteria in defense against infection. The introductory chapters focus on the receptors used by professional phagocytes to recognize and phagocytose bacteria, and the signal transduction events that are essential for phagocytosis of bacteria. Subsequent chapters discuss specific bacterial pathogens and the strategies they use in confronting professional phagocytes. Examples include Helicobacter pylori, Streptococcus pneumoniae, and Yersinae, each of which uses distinct mechanisms to avoid being phagocytosed and killed. Contrasting examples include Listeria monocytogenes and Mycobacterium tuberculosis, which survive and replicate intracellularly, and actually cooperate with phagocytes to promote their entry into these cells. Together, the contributions in this book provide an outstanding review of current knowledge regarding the mechanisms of phagocytosis and how specific pathogenic bacteria avoid or exploit these mechanisms.
Book Synopsis Mononuclear Phagocytes by : R. van Furth
Download or read book Mononuclear Phagocytes written by R. van Furth and published by Springer. This book was released on 2010-12-01 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mononuclear phagocytes, which include macrophages, monocytes and their precursor cells, are the most important cells in the host defence against micro-organisms and tumor cells. During the last twenty-five years research on the biology of mononuclear phagocytes has increased tremendously. This motivated Professor R. van Furth to organize five international conferences on this subject in Leiden, the Netherlands. The edited proceedings of these meethings were published: in 1970 Mononuclear Phagocytes; in 1975 Mononuclear Phagocytes in Immunity, Infections and Pathology; in 1980 Mononuclear Phagocytes -- Functional Aspects; and in 1985 Mononuclear Phagocytes -- Characteristics, Physiology and Function. Reviews of these volumes, published in international journals, praised them as the most up-to-date state of the art publications. The publication of 1991 includes 88 chapters written by more than 200 authors.
Download or read book Antibody Fc written by Margaret Ackerman and published by Academic Press. This book was released on 2013-08-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system
Book Synopsis Phagocytosis and Phagosomes by : Roberto J. Botelho
Download or read book Phagocytosis and Phagosomes written by Roberto J. Botelho and published by Springer Nature. This book was released on 2023-06-26 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores updated and entirely new experimental approaches used to investigate phagocytosis and phagosome maturation. In order to aid in the study of engulfment, maturation, resolution, and pathogen manipulation of phagocytes, the book features methodology to quantify uptake and maturation specific to certain phagocytes, particles, or pathogens, while other chapters offer methods that can be applied generically across the field. Methods are presented to study phagocytosis and phagosome maturation in vivo, in cellulo, and through in vitro analyses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Phagocytosis and Phagosomes: Methods and Protocols, Second Edition serves as a vital resource for both experts in the field as well as for investigators delving into phagocytosis and phagosome maturation for the first time.
Book Synopsis Molecular Mechanisms of Phagocytosis by : Carlos Rosales
Download or read book Molecular Mechanisms of Phagocytosis written by Carlos Rosales and published by Springer Science & Business Media. This book was released on 2008-05-07 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although, Phagocytosis was first described nearly 120 year ago, we are just recently beginning to understand the molecules that phagocytic cells use to bring about this complex cell function. Molecular Mechanisms of Phagocytosis was prepared as a series of up-to-date essays (chapters) that describe the present knowledge on the various steps of the phagocytic process from initial cell contact, through internalization of the foreign particle, to the final phagosome formation where the phagocytosed particle is destroyed.
Download or read book Phagocytosis written by Urja Naik and published by Biota Publishing. This book was released on 2013-04-01 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phagocytosis is an evolutionarily conserved mechanism that serves as the first line of host defense in multicellular organisms. The traditional definition of phagocytosis involves the engulfment and degradation of large solid particles (>0.5 μm), initiated by receptor activation on phagocytes. It forms an essential aspect of innate immunity through the uptake and destruction of infectious pathogens, while also participating in the removal of apoptotic cells during tissue remodeling and development. Professional phagocytes, such as macrophages, neutrophils, and dendritic cells, are well equipped with a wide range of phagocytic receptors. In addition, these specialized leukocytes can signal to lymphocytes within the adaptive arm of host immunity. This review emphasizes the role of two well-characterized opsonic receptors, the Fcγ receptor and the complement receptor, CR3 in macrophages. In particular, it focuses on the different mechanisms employed by these receptors during particle recognition and phagocytic uptake. Bacterial species often manipulate phagocyte signaling in order to evade their engulfment and degradation and consequently provide further insight into key regulators of the phagocytic process. Finally, we draw attention to the physiological relevance of studying the simultaneous engagement of multiple phagocytic receptors, in order to better understand receptor crosstalk and the underlying coordination of downstream signaling for efficient phagocytosis.
Book Synopsis Phagocytosis of Dying Cells by : Dmitri V. Krysko
Download or read book Phagocytosis of Dying Cells written by Dmitri V. Krysko and published by Springer Science & Business Media. This book was released on 2009-03-10 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phagocytosis has been at the forefront of cell biology for more than a century. Initially, phagocytosis, which comes from Greek words meaning “devouring cells,” was discovered in the late 19th century by Ilya Metchnikoff, who was awarded, together with Paul Ehrlich, the Nobel Prize in Physiology and Medicine in 1908 “in recognition of their work on immunity.” At that time Metchnikoff had already identified a function for phagocytes not only in host defense but also as scavengers of degenerating host cells during metamorphosis of tadpoles, thus providing one of the first descriptions of apoptotic cell clearance by macrophages (Kaufmann 2008). Since then, much has been learned about phagocytosis, and the previous several decades have witnessed outstanding progress in understanding the functions and the molecular mechanisms of phagocytosis. Two main types of targets are cleared by phagocytosis: microbial pathogens and dying cells. Rapid recognition and clearance of dying cells by phagocytes plays a pivotal role in development, maintenance of tissue homeostasis, control of immune responses, and resolution of inflammation. Clearance of dying cells can be divided into several stages, including sensing, r- ognition, binding and signaling, internalization, and immunological responses. In this book, our contributors address these different stages of dead cell cle- ance and examine how impaired clearance of dying cells may lead to human d- eases. We have attempted to provide sufficient cross-referencing and indexing to enable the reader to easily locate the ideas elaborated in the different chapters.
