Perspectives In Nucleoside And Nucleic Acid Chemistry

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Perspectives in Nucleoside and Nucleic Acid Chemistry

Author : M. Volkan Kisakürek
Publisher : John Wiley & Sons
ISBN 13 : 9783906390215
Total Pages : 440 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Perspectives in Nucleoside and Nucleic Acid Chemistry by : M. Volkan Kisakürek

Download or read book Perspectives in Nucleoside and Nucleic Acid Chemistry written by M. Volkan Kisakürek and published by John Wiley & Sons. This book was released on 2000 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemistry of nucleosides and nucleic acids is a rapidly developing field. Many of the most important recent advances in medicinal chemistry have occured in this field with the development of novel nucleoside– and nucleotide–based antiviral and antitumor drugs. New synthesis strategies involving novel protecting groups have helped spur progress in drug–development and genome–sequencing research. This volume, comprised of contributions written by internationally recognized experts, covers cutting–edge developments in current nucleoside and nucleic acid research. The most recent synthesis innovations, including combinatorial approaches, spectroscopy and structural studies, thermodynamic and computational investigations, stability assessments, and medicinal applications are presented. Synthetic, physical, organic, bioorganic, and medicinal chemists working on all aspects of nucleoside and nucleic acid research will value this comprehensive state–of–the–art overview.

Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives

Author : Jesús Fernández Lucas
Publisher : John Wiley & Sons
ISBN 13 : 3527343768
Total Pages : 348 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives by : Jesús Fernández Lucas

Download or read book Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives written by Jesús Fernández Lucas and published by John Wiley & Sons. This book was released on 2019-04-29 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of innovative tools for creative nucleic acid chemists that open the door to novel probes and therapeutic agents Nucleic acids continue to gain importance as novel diagnostic and therapeutic agents. With contributions from noted scientists and scholars, Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives is a practical reference that includes a wide range of approaches for the synthesis of designer nucleic acids and their derivatives. The book covers enzymatic (including chemo-enzymatic) methods, with a focus on the synthesis and incorporation of modified nucleosides. The authors also offer a review of innovative approaches for the non-enzymatic chemical synthesis of nucleic acids and their analogs and derivatives, highlighting especially challenging species. The book offers a concise review of the methods that prepare novel and heavily modified polynucleotides in sufficient amount and purity for most clinical and research applications. This important book: -Presents a timely and topical guide to the synthesis of designer nucleic acids and their derivatives -Addresses the growing market for nucleotide-derived pharmaceuticals used as anti-infectives and chemotherapeutic agents, as well as fungicides and other agrochemicals. -Covers novel methods and the most recent trends in the field -Contains contributions from an international panel of noted scientistics Written for biochemists, medicinal chemists, natural products chemists, organic chemists, and biotechnologists, Enzymatic and Chemical Synthesis of Nucleic Acid Derivatives is a practice-oriented guide that reviews innovative methods for the enzymatic as well as non-enzymatic synthesis of nucleic acid species.

Modified Nucleic Acids

Author : Kazuhiko Nakatani
Publisher : Springer
ISBN 13 : 3319271113
Total Pages : 280 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Modified Nucleic Acids by : Kazuhiko Nakatani

Download or read book Modified Nucleic Acids written by Kazuhiko Nakatani and published by Springer. This book was released on 2016-04-04 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.

Nucleic Acids in Chemistry and Biology

Author : G Michael Blackburn
Publisher : Royal Society of Chemistry
ISBN 13 : 1782625771
Total Pages : 503 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Nucleic Acids in Chemistry and Biology by : G Michael Blackburn

Download or read book Nucleic Acids in Chemistry and Biology written by G Michael Blackburn and published by Royal Society of Chemistry. This book was released on 2015-11-09 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

Molecular Structure of Nucleic Acids

Author :
Publisher : Ardent Media
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4./5 ( download)

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Book Synopsis Molecular Structure of Nucleic Acids by :

Download or read book Molecular Structure of Nucleic Acids written by and published by Ardent Media. This book was released on 1953 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein-nucleic Acid Interaction

Author : Wolfram Saenger
Publisher :
ISBN 13 :
Total Pages : 230 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Protein-nucleic Acid Interaction by : Wolfram Saenger

Download or read book Protein-nucleic Acid Interaction written by Wolfram Saenger and published by . This book was released on 1989 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a series of essays which describe a range of problems in the field of nucleic-acid interactions, investigated by a variety of techniques. An introductory chapter on DNA-protein interactions in the regulation of gene expression is followed by papers on selected model systems.

Prebiotic Chemistry

Author : Peter Walde
Publisher : Springer Science & Business Media
ISBN 13 : 9783540277590
Total Pages : 248 pages
Book Rating : 4.2/5 (775 download)

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Book Synopsis Prebiotic Chemistry by : Peter Walde

Download or read book Prebiotic Chemistry written by Peter Walde and published by Springer Science & Business Media. This book was released on 2005-10-13 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Click Reactions in Organic Synthesis

Author : Srinivasan Chandrasekaran
Publisher : John Wiley & Sons
ISBN 13 : 3527339167
Total Pages : 360 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Click Reactions in Organic Synthesis by : Srinivasan Chandrasekaran

Download or read book Click Reactions in Organic Synthesis written by Srinivasan Chandrasekaran and published by John Wiley & Sons. This book was released on 2016-09-13 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endlich ein Buch zu Click-Reaktionen mit Schwerpunkt auf der organischen Synthese. Beschrieben werden das Click-Konzept, die zugrunde liegenden Mechanismen und Hauptanwendungsgebiete. NÜTZLICH: Die Click-Chemie ist ein wirkungsvoller Ansatz, um auf einfache Weise komplexe organische Moleküle aus verfügbaren Ausgangsmaterialien zu erzeugen ? der Traum jedes Organikers. EINZIGARTIGER SCHWERPUNKT: Aufgrund des besonderen Schwerpunkts auf der organischen Synthese ist dieses Buch für jeden Synthesechemiker von hohem Interesse. HILFREICH: Click-Reaktionen sind stereospezifisch, einfach durchzuführen, hoch ergiebig und lassen sich in einfach zu entfernenden oder nicht schädlichen Lösungsmitteln durchführen. INTERDISZIPLINÄR: Das Click-Konzept ist bei der Herstellung natürlicher Produkte, bioaktiver Verbindungen, von Kohlenhydraten, Arzneimitteln, Polymeren, supramolekularer Strukturen und Materialien weit verbreitet.

Nucleic Acid Transfection

Author : Wolfgang Bielke
Publisher : Springer Science & Business Media
ISBN 13 : 3642164293
Total Pages : 316 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Nucleic Acid Transfection by : Wolfgang Bielke

Download or read book Nucleic Acid Transfection written by Wolfgang Bielke and published by Springer Science & Business Media. This book was released on 2010-10-21 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene Delivery into Mammalian Cells: An Overview on Existing Approaches Employed In Vitro and In Vivo, by Peter Hahn and Elizabeth Scanlan * Strategies for the Preparation of Synthetic Transfection Vectors, by Asier Unciti-Broceta, Matthew N. Bacon, and Mark Bradley * Cationic Lipids: Molecular Structure/Transfection Activity Relationships and Interactions with Biomembranes, by Rumiana Koynova and Boris Tenchov * Hyperbranched Polyamines for Transfection, by Wiebke Fischer, Marcelo Calderon, and Rainer Haag * Carbohydrate Polymers for Nonviral Nucleic Acid Delivery, by Antons Sizovs, Patrick M. McLendon, Sathya Srinivasachari, and Theresa M. Reineke * Cationic Liposome–Nucleic Acid Complexes for Gene Delivery and Silencing: Pathways and Mechanisms for Plasmid DNA and siRNA, by Kai K. Ewert, Alexandra Zidovska, Ayesha Ahmad, Nathan F. Bouxsein, Heather M. Evans, Christopher S. McAllister, Charles E. Samuel, and Cyrus R. Safinya * Chemically Programmed Polymers for Targeted DNA and siRNA Transfection, by Eveline Edith Salcher and Ernst Wagner * Photochemical Internalization: A New Tool for Gene and Oligonucleotide Delivery, by Kristian Berg, Maria Berstad, Lina Prasmickaite, Anette Weyergang, Pål K. Selbo, Ida Hedfors, and Anders Høgset * Visualizing Uptake and Intracellular Trafficking of Gene Carriers by Single-Particle Tracking, by N. Ruthardt and C. Bräuchle

Nucleic Acid Drugs

Author : Akira Murakami
Publisher : Springer
ISBN 13 : 364230463X
Total Pages : 189 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Nucleic Acid Drugs by : Akira Murakami

Download or read book Nucleic Acid Drugs written by Akira Murakami and published by Springer. This book was released on 2012-07-04 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Antisense Strategies: Chemical Synthesis of RNA Oligomers, by Junichi Yano und Gerald E. Smyth Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application, by Mariana Kiomy Osako, Hironori Nakagami und Ryuichi Morishita Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides, by Ekambar R. Kandimalla und Sudhir Agrawal Delivery of Nucleic Acid Drugs, by Yan Lee und Kazunori Kataoka Aptamer: Biology to Applications, by Yoshikazu Nakamura Development and Clinical Applications of Nucleic Acid Therapeutics, by Veenu Aishwarya, Anna Kalota und Alan M. Gewirtz

Supramolecular Nucleic Acid Chemistry

Author : James Tucker
Publisher : Frontiers Media SA
ISBN 13 : 2889661105
Total Pages : 125 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Supramolecular Nucleic Acid Chemistry by : James Tucker

Download or read book Supramolecular Nucleic Acid Chemistry written by James Tucker and published by Frontiers Media SA. This book was released on 2020-10-28 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Molecular and Cellular Enzymology

Author : Jeannine Yon-Kahn
Publisher : Springer Science & Business Media
ISBN 13 : 3642012299
Total Pages : 809 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Molecular and Cellular Enzymology by : Jeannine Yon-Kahn

Download or read book Molecular and Cellular Enzymology written by Jeannine Yon-Kahn and published by Springer Science & Business Media. This book was released on 2011-07-23 with total page 809 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular and Cellular Enzymology addresses not only experienced enzymologists but also students, teachers and academic and industrial researchers who are confronted with enzymological problems during their fundamental or applied research. In this field there is an urgent need for training in order to meet the requirements of both research and industrial endeavours. This book consists of several levels. Practical aspects and elementary explanations are given for the benefit of non-specialists’ and students’ understanding. In order to facilitate the task of students, two typographies have been adopted. The main text corresponds to basic knowledge, whereas text in a smaller font provides more specialised information. Specialists will also find topics more deeply expounded with the principal bibliographic references cited. The bibliography, however, is not exhaustive; the choice includes general books and review articles as well as some specialised articles. In this book, for the first time, the different molecular and cellular aspects of enzymology are presented together. Until now, there has been no book available in which these different aspects are treated in the same volume. In addition, besides the theoretical developments, this book provides a wealth of practical information for experimentalists.

Handbook of Chemical Biology of Nucleic Acids

Author : Naoki Sugimoto
Publisher : Springer Nature
ISBN 13 : 9811997764
Total Pages : 2847 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Handbook of Chemical Biology of Nucleic Acids by : Naoki Sugimoto

Download or read book Handbook of Chemical Biology of Nucleic Acids written by Naoki Sugimoto and published by Springer Nature. This book was released on 2023-07-29 with total page 2847 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox). The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications.

Methods for Studying Nucleic Acid/Drug Interactions

Author : Meni Wanunu
Publisher : CRC Press
ISBN 13 : 1439839743
Total Pages : 397 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Methods for Studying Nucleic Acid/Drug Interactions by : Meni Wanunu

Download or read book Methods for Studying Nucleic Acid/Drug Interactions written by Meni Wanunu and published by CRC Press. This book was released on 2016-04-19 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess the eff

Reagents for Glycoside, Nucleotide, and Peptide Synthesis

Author : David Crich
Publisher : Wiley
ISBN 13 : 9780470023044
Total Pages : 792 pages
Book Rating : 4.0/5 (23 download)

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Book Synopsis Reagents for Glycoside, Nucleotide, and Peptide Synthesis by : David Crich

Download or read book Reagents for Glycoside, Nucleotide, and Peptide Synthesis written by David Crich and published by Wiley. This book was released on 2005-10-21 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook collects together short, informative articles on approximately 250 of the most widely used reagents in the field, into a single volume. Each of the articles, drawn from the e-EROS database, contains a summary of the most pertinent reactions for every reagent, with references to the original literature. This handbook will have a broad appeal and should find a home in every organic chemistry laboratory and library. Compiles all the essential reagents for syntheses on and with biomolecules Gives key information on protection, bond formation and deprotection An essential resource for all synthetic chemists working in drug development and medicinal chemistry Makes use of the leading reagent database e-EROS

General Organic and Biological Chemistry

Author : Kenneth W. Raymond
Publisher : John Wiley & Sons
ISBN 13 : 0470504765
Total Pages : 1257 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis General Organic and Biological Chemistry by : Kenneth W. Raymond

Download or read book General Organic and Biological Chemistry written by Kenneth W. Raymond and published by John Wiley & Sons. This book was released on 2009-12-14 with total page 1257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This general, organic, and biochemistry text has been written for students preparing for careers in health-related fields such as nursing, dental hygiene, nutrition, medical technology, and occupational therapy. It is also suited for students majoring in other fields where it is important to have an understanding of the basics of chemistry. Students need have no previous background in chemistry, but should possess basic math skills. The text features numerous helpful problems and learning features.

Nucleic Acid Structure and Recognition

Author : Stephen Neidle
Publisher : Oxford University Press, USA
ISBN 13 : 9780198506355
Total Pages : 212 pages
Book Rating : 4.5/5 (63 download)

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Book Synopsis Nucleic Acid Structure and Recognition by : Stephen Neidle

Download or read book Nucleic Acid Structure and Recognition written by Stephen Neidle and published by Oxford University Press, USA. This book was released on 2002 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed view of the molecular structures of DNA and RNA and how they are recognised by small molecules and proteins. Extensive source material is provided, including information on relevant web sites and computer programmes. The major methods of structural investigation for nucleic acids: X-ray crystallography, NMR, and molecular modelling are reviewed and their scope and limitations (in the context of nucleic acids) discussed. Also covered are the conformational features of nucleic acid building blocks, including a description of how base-pair morphologies are analysed; the structures of DNA double helices and helical oligonucleotides, emphasising current ideas on sequence-dependent structure; and DNA-DNA interactions, including triplexes and quadruplexes. The principles of RNA folding, ribosome, and ribozyme structure are also surveyed. Both covalent and non-covalent nucleic acid interactions with small molecules are described, with the emphasis on recognition principles and sequence specific gene recognition. The principles of protein - nucleic acid are covered, focussing on regulatory proteins. Nucleic Acid Structure and Recognition will therefore equip readers with a good understanding of all the important aspects of this major field. The Nucleic Acid Database (NDB) crystallographic and NMR structures for the nucleic acid structures described in the book are freely available through the Nucleic Acid Structure and Recognition website.