Personalized Computational Hemodynamics

Download Personalized Computational Hemodynamics PDF Online Free

Author :
Publisher : Academic Press
ISBN 13 : 0128156546
Total Pages : 282 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!


Book Synopsis Personalized Computational Hemodynamics by : Yuri Vassilevski

Download or read book Personalized Computational Hemodynamics written by Yuri Vassilevski and published by Academic Press. This book was released on 2020-04-19 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized Computational Hemodynamics: Models, Methods, and Applications for Vascular Surgery and Antitumor Therapy offers practices and advances surrounding the multiscale modeling of hemodynamics and their personalization with conventional clinical data. Focusing on three physiological disciplines, readers will learn how to derive a suitable mathematical model and personalize its parameters to account for pathologies and diseases. Written by leading experts, this book mirrors the top trends in mathematical modeling with clinical applications. In addition, the book features the major results of the "Research group in simulation of blood flow and vascular pathologies" at the Institute of Numerical Mathematics of the Russian Academy of Sciences. Two important features distinguish this book from other monographs on numerical methods for biomedical applications. First, the variety of medical disciplines targeted by the mathematical modeling and computer simulations, including cardiology, vascular neurology and oncology. Second, for all mathematical models, the authors consider extensions and parameter tuning that account for vascular pathologies. Examines a variety of medical disciplines targeted by mathematical modeling and computer simulation Discusses how the results of numerical simulations are used to support clinical decision-making Covers hemodynamics relating to various subject areas, including vascular surgery and oncological tumor treatments

Patient-specific Hemodynamic Computations: Application to Personalized Diagnosis of Cardiovascular Pathologies

Download Patient-specific Hemodynamic Computations: Application to Personalized Diagnosis of Cardiovascular Pathologies PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 3319568531
Total Pages : 227 pages
Book Rating : 4.3/5 (195 download)

DOWNLOAD NOW!


Book Synopsis Patient-specific Hemodynamic Computations: Application to Personalized Diagnosis of Cardiovascular Pathologies by : Lucian Mihai Itu

Download or read book Patient-specific Hemodynamic Computations: Application to Personalized Diagnosis of Cardiovascular Pathologies written by Lucian Mihai Itu and published by Springer. This book was released on 2017-05-31 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hemodynamic computations represent a state-of-the-art approach for patient-specific assessment of cardiovascular pathologies. The book presents the development of reduced-order multiscale hemodynamic models for coronary artery disease, aortic coarctation and whole body circulation, which can be applied in routine clinical settings for personalized diagnosis. Specific parameter estimation frameworks are introduced for calibrating the parameters of the models and high performance computing solutions are employed to reduce their execution time. The personalized computational models are validated against patient-specific measurements. The book is written for scientists in the field of biomedical engineering focusing on the cardiovascular system, as well as for research-oriented physicians in cardiology and industrial players in the field of healthcare technologies.

Image-based Computational Approaches for Personalized Cardiovascular Medicine: Improving Clinical Applicability and Reliability through Medical Imaging and Experimental Data

Download Image-based Computational Approaches for Personalized Cardiovascular Medicine: Improving Clinical Applicability and Reliability through Medical Imaging and Experimental Data PDF Online Free

Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832529577
Total Pages : 202 pages
Book Rating : 4.8/5 (325 download)

DOWNLOAD NOW!


Book Synopsis Image-based Computational Approaches for Personalized Cardiovascular Medicine: Improving Clinical Applicability and Reliability through Medical Imaging and Experimental Data by : Selene Pirola

Download or read book Image-based Computational Approaches for Personalized Cardiovascular Medicine: Improving Clinical Applicability and Reliability through Medical Imaging and Experimental Data written by Selene Pirola and published by Frontiers Media SA. This book was released on 2023-07-13 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Patient-Specific Modeling of the Cardiovascular System

Download Patient-Specific Modeling of the Cardiovascular System PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1441966919
Total Pages : 253 pages
Book Rating : 4.4/5 (419 download)

DOWNLOAD NOW!


Book Synopsis Patient-Specific Modeling of the Cardiovascular System by : Roy C.P. Kerckhoffs

Download or read book Patient-Specific Modeling of the Cardiovascular System written by Roy C.P. Kerckhoffs and published by Springer Science & Business Media. This book was released on 2010-09-03 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.

Computational Hemodynamics – Theory, Modelling and Applications

Download Computational Hemodynamics – Theory, Modelling and Applications PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 9401795940
Total Pages : 360 pages
Book Rating : 4.4/5 (17 download)

DOWNLOAD NOW!


Book Synopsis Computational Hemodynamics – Theory, Modelling and Applications by : Jiyuan Tu

Download or read book Computational Hemodynamics – Theory, Modelling and Applications written by Jiyuan Tu and published by Springer. This book was released on 2015-02-24 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses geometric and mathematical models that can be used to study fluid and structural mechanics in the cardiovascular system. Where traditional research methodologies in the human cardiovascular system are challenging due to its invasive nature, several recent advances in medical imaging and computational fluid and solid mechanics modelling now provide new and exciting research opportunities. This emerging field of study is multi-disciplinary, involving numerical methods, computational science, fluid and structural mechanics, and biomedical engineering. Certainly any new student or researcher in this field may feel overwhelmed by the wide range of disciplines that need to be understood. This unique book is one of the first to bring together knowledge from multiple disciplines, providing a starting point to each of the individual disciplines involved, attempting to ease the steep learning curve. This book presents elementary knowledge on the physiology of the cardiovascular system; basic knowledge and techniques on reconstructing geometric models from medical imaging; mathematics that describe fluid and structural mechanics, and corresponding numerical/computational methods to solve its equations and problems. Many practical examples and case studies are presented to reinforce best practice guidelines for setting high quality computational models and simulations. These examples contain a large number of images for visualization, to explain cardiovascular physiological functions and disease. The reader is then exposed to some of the latest research activities through a summary of breakthrough research models, findings, and techniques. The book’s approach is aimed at students and researchers entering this field from engineering, applied mathematics, biotechnology or medicine, wishing to engage in this emerging and exciting field of computational hemodynamics modelling.

Computational Hemodynamics

Download Computational Hemodynamics PDF Online Free

Author :
Publisher :
ISBN 13 : 9789492497420
Total Pages : 0 pages
Book Rating : 4.4/5 (974 download)

DOWNLOAD NOW!


Book Synopsis Computational Hemodynamics by : Jiyuan Tu

Download or read book Computational Hemodynamics written by Jiyuan Tu and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses geometric and mathematical models that can be used to study fluid and structural mechanics in the cardiovascular system. Where traditional research methodologies in the human cardiovascular system are challenging due to its invasive nature, several recent advances in medical imaging and computational fluid and solid mechanics modelling now provide new and exciting research opportunities. This emerging field of study is multi-disciplinary, involving numerical methods, computational science, fluid and structural mechanics, and biomedical engineering. Certainly any new student or researcher in this field may feel overwhelmed by the wide range of disciplines that need to be understood. This unique book is one of the first to bring together knowledge from multiple disciplines, providing a starting point to each of the individual disciplines involved, attempting to ease the steep learning curve. This book presents elementary knowledge on the physiology of the cardiovascular system; basic knowledge and techniques on reconstructing geometric models from medical imaging; mathematics that describe fluid and structural mechanics, and corresponding numerical/computational methods to solve its equations and problems. Many practical examples and case studies are presented to reinforce best practice guidelines for setting high quality computational models and simulations. These examples contain a large number of images for visualization, to explain cardiovascular physiological functions and disease. The reader is then exposed to some of the latest research activities through a summary of breakthrough research models, findings, and techniques. The book?s approach is aimed at students and researchers entering this field from engineering, applied mathematics, biotechnology or medicine, wishing to engage in this emerging and exciting field of computational hemodynamics modelling.

Insights in Cardiac Rhythmology: 2022

Download Insights in Cardiac Rhythmology: 2022 PDF Online Free

Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832538762
Total Pages : 169 pages
Book Rating : 4.8/5 (325 download)

DOWNLOAD NOW!


Book Synopsis Insights in Cardiac Rhythmology: 2022 by : Matteo Anselmino

Download or read book Insights in Cardiac Rhythmology: 2022 written by Matteo Anselmino and published by Frontiers Media SA. This book was released on 2023-11-13 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is part of the Insights in Frontiers in Cardiovascular Medicine series. Following the success of the inaugural series, Frontiers has organized a series of Research Topics to highlight the latest advancements in research across the field of cardiovascular medicine, with articles from the members of our accomplished Editorial Boards. This editorial initiative of particular relevance, led by Professor Matteo Anselmino, Specialty Chief Editor of the Cardiac Rhythmology section, together with Dr. Hung-Fat Tse, is focused on new insights, novel developments, current challenges, latest discoveries, recent advances, and future perspectives in the field of cardiac rhythmology. The Research Topic solicits brief, forward-looking contributions from the editorial board members that describe the state of the art, outlining recent developments and major accomplishments that have been achieved and that need to occur to move the field forward. Authors are encouraged to identify the greatest challenges in the sub-disciplines, and how to address those challenges.

Mathematical Modelling in Biomedicine

Download Mathematical Modelling in Biomedicine PDF Online Free

Author :
Publisher : MDPI
ISBN 13 : 3039434934
Total Pages : 224 pages
Book Rating : 4.0/5 (394 download)

DOWNLOAD NOW!


Book Synopsis Mathematical Modelling in Biomedicine by : Vitaly Volpert

Download or read book Mathematical Modelling in Biomedicine written by Vitaly Volpert and published by MDPI. This book was released on 2021-01-26 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical modelling in biomedicine is a rapidly developing scientific discipline at the intersection of medicine, biology, mathematics, physics, and computer science. Its progress is stimulated by fundamental scientific questions and by the applications to public health. This book represents a collection of papers devoted to mathematical modelling of various physiological problems in normal and pathological conditions. It covers a broad range of topics including cardiovascular system and diseases, heart and brain modelling, tumor growth, viral infections, and immune response. Computational models of blood circulation are used to study the influence of heart arrhythmias on coronary blood flow and on operating modes for left-ventricle-assisted devices. Wave propagation in the cardiac tissue is investigated in order to show the influence of tissue heterogeneity and fibrosis. The models of tumor growth are used to determine optimal protocols of antiangiogenic and radiotherapy. The models of viral hepatitis kinetics are considered for the parameter identification, and the evolution of viral quasi-species is investigated. The book presents the state-of-the-art in mathematical modelling in biomedicine and opens new perspectives in this passionate field of research.

Smart Modelling For Engineering Systems

Download Smart Modelling For Engineering Systems PDF Online Free

Author :
Publisher : Springer Nature
ISBN 13 : 9813347090
Total Pages : 302 pages
Book Rating : 4.8/5 (133 download)

DOWNLOAD NOW!


Book Synopsis Smart Modelling For Engineering Systems by : Margarita N. Favorskaya

Download or read book Smart Modelling For Engineering Systems written by Margarita N. Favorskaya and published by Springer Nature. This book was released on 2021-02-26 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of research papers selected for presentation at the International Conference on Smart Computational Methods in Continuum Mechanics 2021, organized by Moscow Institute of Physics and Technology and the Institute for Computer Aided Design of Russian Academy of Sciences. The work is presented in two volumes. The primary objective of the book is to report the state-of-the-art on smart computational paradigms in continuum mechanics and explore the use of artificial intelligence paradigms such as neural nets, and machine learning for improving the performance of the designed engineering systems. The book includes up-to-date smart computational methods which are used to solve problems in continuum mechanics, engineering, seismic prospecting, non-destructive testing, and so on. The main features of the book are the research papers on the application of novel smart methods including neural nets and machine learning, computational algorithms, smart software systems, and high-performance computer systems for solving complex engineering problems. The case studies pertaining to the real-world applications in the above fields are included. The book presents a collection of best research papers in English language from some of the world leaders in the field of smart system modelling and design of engineering systems.

Current and Future Trends in Health and Medical Informatics

Download Current and Future Trends in Health and Medical Informatics PDF Online Free

Author :
Publisher : Springer Nature
ISBN 13 : 3031421124
Total Pages : 379 pages
Book Rating : 4.0/5 (314 download)

DOWNLOAD NOW!


Book Synopsis Current and Future Trends in Health and Medical Informatics by : Kevin Daimi

Download or read book Current and Future Trends in Health and Medical Informatics written by Kevin Daimi and published by Springer Nature. This book was released on 2023-11-01 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is comprehensive with most of its contents following the recommendations of international health and medical informatics associations and societies. To this extent it covers the areas of healthcare and medical information systems, management of healthcare and medical information systems, healthcare/medical information systems supporting patients and the public, healthcare/medical networking and care sharing, medical imaging and 3D/4D surgical visualization, design and analysis of health/medical records, health/medical data representation and analysis, simulation and modeling in healthcare, and health and medical informatics education. The book provides an excellent professional development resource for educators and practitioners on the state-of-the-art Health and Medical Informatics. It covers many areas and topics of Health and Medical Informatics and contributes toward the enhancement of the community outreach and engagement component of Health and Medical Informatics. Various techniques, methods, and approaches adopted by Health and Medical Informatics experts in the field are introduced. Furthermore, it provides detailed explanation of the Health and Medical Informatics concepts that are aptly reinforced by applications and some practical examples and a road map of future trends that are suitable for innovative Health and Medical Informatics.

Atrial Fibrillation: Technology for Diagnosis, Monitoring, and Treatment

Download Atrial Fibrillation: Technology for Diagnosis, Monitoring, and Treatment PDF Online Free

Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889746909
Total Pages : 537 pages
Book Rating : 4.8/5 (897 download)

DOWNLOAD NOW!


Book Synopsis Atrial Fibrillation: Technology for Diagnosis, Monitoring, and Treatment by : Jose F. Rodriguez Matas

Download or read book Atrial Fibrillation: Technology for Diagnosis, Monitoring, and Treatment written by Jose F. Rodriguez Matas and published by Frontiers Media SA. This book was released on 2022-03-15 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biological Control Systems and Disease Modelling

Download Biological Control Systems and Disease Modelling PDF Online Free

Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889668517
Total Pages : 342 pages
Book Rating : 4.8/5 (896 download)

DOWNLOAD NOW!


Book Synopsis Biological Control Systems and Disease Modelling by : Babatunde Ogunnaike

Download or read book Biological Control Systems and Disease Modelling written by Babatunde Ogunnaike and published by Frontiers Media SA. This book was released on 2021-06-04 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trends in Biomathematics: Chaos and Control in Epidemics, Ecosystems, and Cells

Download Trends in Biomathematics: Chaos and Control in Epidemics, Ecosystems, and Cells PDF Online Free

Author :
Publisher : Springer Nature
ISBN 13 : 303073241X
Total Pages : 395 pages
Book Rating : 4.0/5 (37 download)

DOWNLOAD NOW!


Book Synopsis Trends in Biomathematics: Chaos and Control in Epidemics, Ecosystems, and Cells by : Rubem P. Mondaini

Download or read book Trends in Biomathematics: Chaos and Control in Epidemics, Ecosystems, and Cells written by Rubem P. Mondaini and published by Springer Nature. This book was released on 2021-07-27 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume gathers together selected, peer-reviewed papers presented at the BIOMAT 2020 International Symposium, which was virtually held on November 1-6, 2020, with an organization staff based in Rio de Janeiro, Brazil. Topics covered in this volume include infection modeling, with an emphasis on different aspects of the COVID-19 and novel Coronavirus spread; a description of the effectiveness of quarantine measures via dynamic analysis of SLIR model; hemodynamic simulations in time-dependent domains; an optimal control model for the Ebola disease; and the co-existence of chaos and control in the context of biological models. Texts in agroforestry, economic development, and wastewater treatment processes complete this volume. Held every year since 2001, the BIOMAT International Symposium gathers together, in a single conference, researchers from Mathematics, Physics, Biology, and affine fields to promote the interdisciplinary exchange of results, ideas and techniques, promoting truly international cooperation for problem discussion. The 20th edition of the BIOMAT International Symposium has received contributions by authors from 18 countries: Algeria, Brazil, Cameroon, Canada, Chile, China (Hong Kong), Colombia, Germany, Hungary, India, Italy, Morocco, Nigeria, Russia, Senegal, South Africa, USA, and Uzbekistan. Previous BIOMAT volumes with selected works from 2017, 2018, and 2019 were also published by Springer.

Artificial Intelligence for Computational Modeling of the Heart

Download Artificial Intelligence for Computational Modeling of the Heart PDF Online Free

Author :
Publisher : Academic Press
ISBN 13 : 012817594X
Total Pages : 274 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!


Book Synopsis Artificial Intelligence for Computational Modeling of the Heart by : Tommaso Mansi

Download or read book Artificial Intelligence for Computational Modeling of the Heart written by Tommaso Mansi and published by Academic Press. This book was released on 2019-12 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Artificial Intelligence for Computational Modeling of the Heart presents recent research developments towards streamlined and automatic estimation of the digital twin of a patient's heart by combining computational modeling of heart physiology and artificial intelligence. The book first introduces the major aspects of multi-scale modeling of the heart, along with the compromises needed to achieve subject-specific simulations. Reader will then learn how AI technologies can unlock robust estimations of cardiac anatomy, obtain meta-models for real-time biophysical computations, and estimate model parameters from routine clinical data. Concepts are all illustrated through concrete clinical applications. Presents recent advances in computational modeling of heart function and artificial intelligence technologies for subject-specific applications Discusses AI-based technologies for robust anatomical modeling from medical images, data-driven reduction of multi-scale cardiac models, and estimations of physiological parameters from clinical data Illustrates the technology through concrete clinical applications and discusses potential impacts and next steps needed for clinical translation

Patient-Specific Modeling of the Cardiovascular System

Download Patient-Specific Modeling of the Cardiovascular System PDF Online Free

Author :
Publisher :
ISBN 13 : 9781441966926
Total Pages : 264 pages
Book Rating : 4.9/5 (669 download)

DOWNLOAD NOW!


Book Synopsis Patient-Specific Modeling of the Cardiovascular System by :

Download or read book Patient-Specific Modeling of the Cardiovascular System written by and published by . This book was released on 2011-07-11 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Clinical Application of Computational Mechanics to the Cardiovascular System

Download Clinical Application of Computational Mechanics to the Cardiovascular System PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 4431679219
Total Pages : 440 pages
Book Rating : 4.4/5 (316 download)

DOWNLOAD NOW!


Book Synopsis Clinical Application of Computational Mechanics to the Cardiovascular System by : T. Yamaguchi

Download or read book Clinical Application of Computational Mechanics to the Cardiovascular System written by T. Yamaguchi and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular diseases, particularly atherosclerosis, are the most frequent and critical underlying fatal disorders in the industrialized world. Cardiovascular deaths are the leading cause of death in the Western world. Although cancer or malignant neoplasms recently have topped the list of causes of deaths in Japan, cardiovascular and cerebrovascular diseases bring about more deaths than cancer if they are reclassified into a unified category of diseases of the vascular system. The National Cardiovascular Center was established by the Ministry of Health and Welfare of Japan to combat cardiovascular and cerebrovascular diseases. Since the Center was opened, we have continued to support basic and clinical sturlies of cardiovascular and cerebrovascular diseases within as weil as outside the Center. Clinical studies that we have supported in modern diagnostic and therapeutic measures against cardio- and cerebrovascular diseases have made remarkable advances in recent years, especially in medical imaging technology including CT and MRI, and in interventional measures including balloon angioplasty and other catheter-based treatments. We are proud of the significant improvement in the overall survival rate and the quality of life of patients suffering from vascular disorders. However, there are still many essential difficulties remaining in the diagnosis and treatment of vascular disorders. Such difficulties necessitate further fundamental studies not only from the practical aspect but also from the integrated perspectives of medicine, biology, and engineering.

Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI

Download Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI PDF Online Free

Author :
Publisher : Linköping University Electronic Press
ISBN 13 : 9176852172
Total Pages : 71 pages
Book Rating : 4.1/5 (768 download)

DOWNLOAD NOW!


Book Synopsis Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI by : Belén Casas Garcia

Download or read book Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI written by Belén Casas Garcia and published by Linköping University Electronic Press. This book was released on 2019-02-15 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current diagnostic tools for assessing cardiovascular disease mostly focus on measuring a given biomarker at a specific spatial location where an abnormality is suspected. However, as a result of the dynamic and complex nature of the cardiovascular system, the analysis of isolated biomarkers is generally not sufficient to characterize the pathological mechanisms behind a disease. Model-based approaches that integrate the mechanisms through which different components interact, and present possibilities for system-level analyses, give us a better picture of a patient’s overall health status. One of the main goals of cardiovascular modelling is the development of personalized models based on clinical measurements. Recent years have seen remarkable advances in medical imaging and the use of personalized models is slowly becoming a reality. Modern imaging techniques can provide an unprecedented amount of anatomical and functional information about the heart and vessels. In this context, three-dimensional, three-directional, cine phase-contrast (PC) magnetic resonance imaging (MRI), commonly referred to as 4D Flow MRI, arises as a powerful tool for creating personalized models. 4D Flow MRI enables the measurement of time-resolved velocity information with volumetric coverage. Besides providing a rich dataset within a single acquisition, the technique permits retrospective analysis of the data at any location within the acquired volume. This thesis focuses on improving subject-specific assessment of cardiovascular function through model-based analysis of 4D Flow MRI data. By using computational models, we aimed to provide mechanistic explanations of the underlying physiological processes, derive novel or improved hemodynamic markers, and estimate quantities that typically require invasive measurements. Paper I presents an evaluation of current markers of stenosis severity using advanced models to simulate flow through a stenosis. Paper II presents a framework to personalize a reduced-order, mechanistic model of the cardiovascular system using exclusively non-invasive measurements, including 4D Flow MRI data. The modelling approach can unravel a number of clinically relevant parameters from the input data, including those representing the contraction and relaxation patterns of the left ventricle, and provide estimations of the pressure-volume loop. In Paper III, this framework is applied to study cardiovascular function at rest and during stress conditions, and the capability of the model to infer load-independent measures of heart function based on the imaging data is demonstrated. Paper IV focuses on evaluating the reliability of the model parameters as a step towards translation of the model to the clinic.