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Author : Zeev B. Alfassi
Publisher :
ISBN 13 :
Total Pages : 554 pages
Book Rating : 4.3/5 (91 download)
Download or read book Peroxyl Radicals written by Zeev B. Alfassi and published by . This book was released on 1997 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael Simic
Publisher : Springer Science & Business Media
ISBN 13 : 1468455680
Total Pages : 1064 pages
Book Rating : 4.4/5 (684 download)
Download or read book Oxygen Radicals in Biology and Medicine written by Michael Simic and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.
Author : Clemens von Sonntag
Publisher : Springer Science & Business Media
ISBN 13 : 9783540261209
Total Pages : 554 pages
Book Rating : 4.2/5 (612 download)
Download or read book Free-Radical-Induced DNA Damage and Its Repair written by Clemens von Sonntag and published by Springer Science & Business Media. This book was released on 2005-12-02 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.
Author : P. D. Lightfoot
Publisher :
ISBN 13 :
Total Pages : 5 pages
Book Rating : 4.:/5 (246 download)
Download or read book Organic Peroxy Radicals written by P. D. Lightfoot and published by . This book was released on 1992 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David Jollow
Publisher : Springer Science & Business Media
ISBN 13 : 1461341248
Total Pages : 513 pages
Book Rating : 4.4/5 (613 download)
Download or read book Biological Reactive Intermediates written by David Jollow and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept that detoxication is the inevitable result of biotransformation of xenobiotic compounds by mammalian systems has undergone modification since it was first described. Indeed, despite the fact that R. T. Williams popularized the notion, he was among the first to caution that it was not possible to predict the biological activities of the resulting metabolites. It has become increasingly apparent in recent years that not only do many metabolites of drugs and other chemicals display biological activity but also in many instances these metabolites play an important role in initiating several forms of cancer and are the cause of a variety of types of toxicity. Thus it seems appropriate to collect in one volume a series of reports outlining advances in the study of the formation of chemically active intermediary metabolic products of chemicals, mechanisms of toxicity or carcinogenesis, and pathways for true detoxication of these chemicals. The work of R. T. Williams, beginning in the late 1920s and early 1930s, marked the first concerted effort to understand the biotransformation of foreign chemicals in animals. He investigated the metabolic pathway of numerous compounds in a wide variety of animal species while training large numbers of our colleagues who have been responsible for further advances in biochemistry, pharmacology, and toxicology. Another pioneer in the study of drug metabo lism, B. B.
Author : Clemens Sonntag
Publisher : Springer Science & Business Media
ISBN 13 : 3540305920
Total Pages : 528 pages
Book Rating : 4.5/5 (43 download)
Download or read book Free-Radical-Induced DNA Damage and Its Repair written by Clemens Sonntag and published by Springer Science & Business Media. This book was released on 2006-03-20 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.
Author : Christopher S. Foote
Publisher : Springer Science & Business Media
ISBN 13 : 9400708742
Total Pages : 355 pages
Book Rating : 4.4/5 (7 download)
Download or read book Active Oxygen in Chemistry written by Christopher S. Foote and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taking an interdisciplinary approach, this book and its counterpart, Active Oxygen in Biochemistry, explore the active research area of the chemistry and biochemistry of oxygen. Complementary but independent, the two volumes integrate subject areas including medicine, biology, chemistry, engineering, and environmental studies.
Author :
Publisher : Elsevier
ISBN 13 : 0080549063
Total Pages : 611 pages
Book Rating : 4.0/5 (85 download)
Download or read book Vitamin E written by and published by Elsevier. This book was released on 2007-07-16 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
Author : Richard G. Cutler
Publisher : World Scientific
ISBN 13 : 9812775730
Total Pages : 872 pages
Book Rating : 4.8/5 (127 download)
Download or read book Critical Reviews of Oxidative Stress and Aging written by Richard G. Cutler and published by World Scientific. This book was released on 2003 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume reference examines the translational research field of oxidative stress and ageing. It focuses on understanding the molecular basis of oxidative stress and its associated age-related diseases, with the goal of developing new methods for treating the human ageing processes.
Author : Carol Colton
Publisher : Springer Science & Business Media
ISBN 13 : 0306468069
Total Pages : 703 pages
Book Rating : 4.3/5 (64 download)
Download or read book Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach written by Carol Colton and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactive oxygen species (ROS) which include free radicals, peroxides, singlet oxygen, ozone, and nitrogen monoxide and dioxide free radicals, is an area of intense research. This volume covers (1) the destruction of cellular function by ROS resulting in pathological states; (2) the protection by ROS of an organism against invading organisms that cause infections; and (3) the role of ROS in normal physiological processes. Designed for beginning graduate students, this book gives a concise overview of the field.
Author : Kendall B Wallace
Publisher : CRC Press
ISBN 13 : 9781439805701
Total Pages : 458 pages
Book Rating : 4.8/5 (57 download)
Download or read book Free Radical Toxicology written by Kendall B Wallace and published by CRC Press. This book was released on 1997-06-19 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides insight into the involvement of free radicals in the pathogenesis of chemical-induced toxic tissue injury. The text addresses the fundamentals of free radical chemistry and the theoretical basis for electron transfer reaction leading to free radical generation. It describes the various subcellular sources of free radicals, the biological reactivity with lipid, protein and nucleic acids, and the physiochemical determinants of free radical-induced cell injury and the various antioxidant defence systems. The book focuses on target organ toxicity, and the concluding section offers an overview of the evidence implicating free radicals in the aetiology of various chemical toxicities, challenging the possibility of misguided use of biomarkers for oxidative damage.
Author : Peter Cerutti
Publisher : Springer Science & Business Media
ISBN 13 : 146156462X
Total Pages : 489 pages
Book Rating : 4.4/5 (615 download)
Download or read book Anticarcinogenesis and Radiation Protection written by Peter Cerutti and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the invited and contributed papers presented at the 2nd International Conference on Anticarcinogenesis and Radiation Protection held at the National Bureau of Standards, Gaithersburg, Maryland, USA, on March 8-12, 1987. The conference documented developments that have taken place in areas that were addressed during the first conference in 1982. A number of new topics, such as biological response modifiers, were included because of their emerging relevance to anticarcinogenesis and radiation protection. The organization of the material in this book does not follow the conference program; rather, we have attempted to provide a different sequence for didactic reasons. The aim of the conference, which is reflected in this book, was to promote further development of mechanistic approaches to cancer prevention and treatment based on recent progress in molecular biology and free radical chemistry. At the basis of carcinogenesis lie changes in the dynamics of growth and differentiation of specific cell subpopulations in the target tissue. 'These changes are brought about by selective toxicity and modulation of gene expression that are induced by xenobiotic carcinogens and affected by physiological and genetic factors. The book deals with oxidative stress and molecular damage caused by radiation and chemical pro-oxidants and their role in carcinogenesis, and it discusses mechanisms of deregulation of the expression of oncogenes and other genes involved in carcinogenic initiation and promotion.
Author : D. Schulte-Frohlinde
Publisher : CRC Press
ISBN 13 : 9783718648740
Total Pages : 138 pages
Book Rating : 4.6/5 (487 download)
Download or read book Free-Radical and Radiation-Induced Damage to DNA written by D. Schulte-Frohlinde and published by CRC Press. This book was released on 1989 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Evgeny T. Denisov
Publisher : CRC Press
ISBN 13 : 142003085X
Total Pages : 1020 pages
Book Rating : 4.4/5 (2 download)
Download or read book Oxidation and Antioxidants in Organic Chemistry and Biology written by Evgeny T. Denisov and published by CRC Press. This book was released on 2005-03-29 with total page 1020 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a comprehensive review of reactions of oxidation for different classes of organic compounds and polymers, and biological processes mediated by free radicals, Oxidation and Antioxidants in Organic Chemistry and Biology puts the data and bibliographical information you need into one easy-to-use resource. You will find up-to-date information
Author : Resat Apak
Publisher : John Wiley & Sons
ISBN 13 : 1119135362
Total Pages : 355 pages
Book Rating : 4.1/5 (191 download)
Download or read book Measurement of Antioxidant Activity and Capacity written by Resat Apak and published by John Wiley & Sons. This book was released on 2017-11-30 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference for assessing the antioxidant potential of foods and essential techniques for developing healthy food products Measurement of Antioxidant Activity and Capacity offers a much-needed resource for assessing the antioxidant potential of food and includes proven approaches for creating healthy food products. With contributions from world-class experts in the field, the text presents the general mechanisms underlying the various assessments, the types of molecules detected, and the key advantages and disadvantages of each method. Both thermodynamic (i.e. efficiency of scavenging reactive species) and kinetic (i.e. rates of hydrogen atom or electron transfer reactions) aspects of available methods are discussed in detail. A thorough description of all available methods provides a basis and rationale for developing standardized antioxidant capacity/activity methods for food and nutraceutical sciences and industries. This text also contains data on new antioxidant measurement techniques including nanotechnological methods in spectroscopy and electrochemistry, as well as on innovative assays combining several principles. Therefore, the comparison of conventional methods versus novel approaches is made possible. This important resource: Offers suggestions for assessing the antioxidant potential of foods and their components Includes strategies for the development of healthy functional food products Contains information for identifying antioxidant activity in the body Presents the pros and cons of the available antioxidant determination methods, and helps in the selection of the most appropriate method Written for researchers and professionals in the nutraceutical and functional food industries,academia and government laboratories, this text includes the most current knowledge in order to form a common language between research groups and to contribute to the solution of critical problems existing for all researchers working in this field.
Author : Patrick M. Dansette
Publisher : Springer Science & Business Media
ISBN 13 : 1461506670
Total Pages : 716 pages
Book Rating : 4.4/5 (615 download)
Download or read book Biological Reactive Intermediates Vi written by Patrick M. Dansette and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a discussion of the biological effects produced following the metabolism of xenobiotic chemicals to chemically reactive metabolites, i.e., toxic and carcinogenic effects, which have been the basis of all five earlier volumes in this series. In particular, this volume devotes sections to structure-activity relationships, recent advances in the understanding of the chemistry of reactive metabolites, and the generation and activity of reactive oxygen species with special emphasis on nitric oxide. There are also segments on DNA damage by reactive metabolites and DNA repair, tissue specific responses to BRIs, and human health effects of BRIs. The papers that comprise this volume were submitted by world class scientists who were in attendance at The Symposium on Biological Reactive Intermediates VI at the Université René Descartes, July 16-20, 2000.
Author : Evgeny T. Denisov
Publisher : CRC Press
ISBN 13 : 9780849390043
Total Pages : 318 pages
Book Rating : 4.3/5 (9 download)
Download or read book Handbook of Antioxidants written by Evgeny T. Denisov and published by CRC Press. This book was released on 1999-11-11 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for scientists and engineers involved in the chemistry and technology of antioxidants, the Second Edition of this popular handbook continues to provide comprehensive data on the thermodynamics and reactivity of antioxidants. Fully revised and updated, the Second Edition provides the latest data on antioxidants and polymer stabilizers, new data for biological antioxidants, a corrected list of bond dissociation energies, and a full bibliography. Additions and changes in the New Edition: The latest data on O-H bond dissociation energies of phenols and the new scale these values Thermodynamic functions of antioxidants and their intermediate presented in tables A table with current data on dissociation energies of C-H bonds of hydrocarbons and oxygen-containing compounds Rate constants and activation energies of reactions of antioxidants with ozone, nitrogen dioxide, and hydroperoxide Kinetic characteristics of benzoquinine reactions with antioxidants Rate constants of free radical generation through biomolecular reactions with ozone, nitrogen dioxide, and hydroperoxide All calculated data from the first edition has been recalculated in accordance with new data on dissociation energies and parameters of reactivity Data on thermodynamics of hydrogen bond formation of antioxidants All data on cyclic mechanisms of chain termination by antioxidants collected into a special chapter Special chapters on bioantioxidants and stabilization of polymers The Handbook of Antioxidants puts essential data at your fingertips. Its comprehensive nature and ease-of-use make it the resource for scientific researchers and engineers working in the field of physical chemistry of antioxidants.
