Percutaneous Absorption Mechanisms Methodology Drug Delivery Revised And Expanded

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Percutaneous Absorption : Mechanisms - Methodology - Drug Delivery , Revised and Expanded

Author : Bronaugh RL Ed
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)

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Book Synopsis Percutaneous Absorption : Mechanisms - Methodology - Drug Delivery , Revised and Expanded by : Bronaugh RL Ed

Download or read book Percutaneous Absorption : Mechanisms - Methodology - Drug Delivery , Revised and Expanded written by Bronaugh RL Ed and published by . This book was released on 1989 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The microscopic structure of the epidermis and its derivatives; Mathematical models of percutaneous absorption; Mechanism of percutaneous absorption from physicochemical evidence; Cutaneous metabolism of xenobiotics; Occlusion does not uniformly enhance penetration in vivo; Structure activity correlations in percutaneous absorption; Regional variation in percutaneous absorption; Cutaneous permeation of lipophilic molecules, effects of enhancers; Studies on the permeability of infant skin; Interaction of vehicles with model skin membranes in the permeation process; In vivo relationship between percutaneous absorption and transepidermal water loss; Skin contamination and absorption of chemicals from drinking water while bathing or swimming; Classification of percutaneous penetration enhancers, a conceptional diagram; In vivo methods for percutaneous absorption measurements; In vivo animal models for percutaneous absorption; Determination of percutaneous absorption by in vitro techniques; The influence of metabolism on percutaneous absorption; Localization of compounds in different skin layers and its use as an indicator of percutaneous absorption; Evaporation and penetration from skin; Dermal decontamination and percutaneous absorption; Interrelationships in the dose response of percutaneous absorption; Blood flow as a technology in percutaneous absorption, the assessment of the cutaneous microcirculation by laser doppler and photoplethysmographic techniques; Calculations of body exposure from percutaneous absorption data; Human skin sandwich flap model for percutaneous absorption; Stripping method for measuring percutaneous absorption in vivo; Noninvasive radioisotope counting on skin, surface or external counting; The human skin blanching assay as an indicator of topical corticosteroid bioavailability and potency, an update; Skin absorption from patch test systems, relevance to allergic contact dermatitis and transdermal delivery systems; In vitro systems for the assessment of drug release from topical formulations and transmembrane permeation; Percutaneous penetration as a method of delivery to muscle and other tissue; Optimizing percutaneous absorption; Facilitated percutaneous absorption of charged drugs; Action of penetration enhancers on human stratum corneum as assessed by differential scanning calorimetry; Ultrasound as a transdermal enhancer; Iontophoretic Drug Delivery, Effects of physicochemical factors on the skin uptake of drugs; In vivo percutaneous absorption, effect of repeated application versus single dose; In vitro testing of topical pharmaceutical formulations.

Percutaneous Absorption

Author : Robert L. Bronaugh
Publisher : CRC Press
ISBN 13 : 9781420000948
Total Pages : 992 pages
Book Rating : 4.0/5 (9 download)

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Book Synopsis Percutaneous Absorption by : Robert L. Bronaugh

Download or read book Percutaneous Absorption written by Robert L. Bronaugh and published by CRC Press. This book was released on 1999-05-28 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.

Percutaneous Absorption

Author : Robert L. Bronaugh
Publisher :
ISBN 13 :
Total Pages : 688 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Percutaneous Absorption by : Robert L. Bronaugh

Download or read book Percutaneous Absorption written by Robert L. Bronaugh and published by . This book was released on 1989 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Percutaneous Absorption

Author : Nina Dragićević
Publisher : CRC Press
ISBN 13 : 0429511566
Total Pages : 1008 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Percutaneous Absorption by : Nina Dragićević

Download or read book Percutaneous Absorption written by Nina Dragićević and published by CRC Press. This book was released on 2021-07-30 with total page 1008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fifth Edition supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel. Key Features: Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption

Transdermal Drug Delivery Systems

Author : Jonathan Hadgraft
Publisher : CRC Press
ISBN 13 : 0203909682
Total Pages : 400 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis Transdermal Drug Delivery Systems by : Jonathan Hadgraft

Download or read book Transdermal Drug Delivery Systems written by Jonathan Hadgraft and published by CRC Press. This book was released on 2002-10-29 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulator

Percutaneous Absorption : Mechanisms - Methodology - Drug Delivery , Grew out of the Percutaneous Absorption Symposium, Washington, DC, April 27 1983

Download Percutaneous Absorption : Mechanisms - Methodology - Drug Delivery , Grew out of the Percutaneous Absorption Symposium, Washington, DC, April 27 1983 PDF Online Free

Author : Bronaugh RL Ed
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)

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Book Synopsis Percutaneous Absorption : Mechanisms - Methodology - Drug Delivery , Grew out of the Percutaneous Absorption Symposium, Washington, DC, April 27 1983 by : Bronaugh RL Ed

Download or read book Percutaneous Absorption : Mechanisms - Methodology - Drug Delivery , Grew out of the Percutaneous Absorption Symposium, Washington, DC, April 27 1983 written by Bronaugh RL Ed and published by . This book was released on 1985 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Percutaneous Absorption

Author : Robert L. Bronaugh
Publisher : CRC Press
ISBN 13 : 9781574448696
Total Pages : 920 pages
Book Rating : 4.4/5 (486 download)

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Book Synopsis Percutaneous Absorption by : Robert L. Bronaugh

Download or read book Percutaneous Absorption written by Robert L. Bronaugh and published by CRC Press. This book was released on 2005-07-25 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updating and expanding the scope of topics covered in the previous edition, this Fourth Edition supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology, the percutaneous absorption of chemical mixtures, the penetration of chemicals through the hair follicles, dermal drug delivery, mechanisms of absorption, nanoparticles and dermal absorption, the absorption of drugs and cosmetic ingredients, nail penetration, and other current research.

Mechanisms of Transdermal Drug Delivery

Author : Russel O. Potts
Publisher : CRC Press
ISBN 13 : 9781420002249
Total Pages : 392 pages
Book Rating : 4.0/5 (22 download)

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Book Synopsis Mechanisms of Transdermal Drug Delivery by : Russel O. Potts

Download or read book Mechanisms of Transdermal Drug Delivery written by Russel O. Potts and published by CRC Press. This book was released on 1997-07-15 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an up-to-date and critical examination of biophysical techniques used in the analysis of molecular mechanisms underlying transdermal drug delivery as well as a physical and chemical evaluation of the stratum corneum necessary for the enhancement of percutaneous drug transport. Reflects the hands-on experience of established and novel researchers in the field.

Understanding Drug Release and Absorption Mechanisms

Author : Mario Grassi
Publisher : CRC Press
ISBN 13 : 1420004654
Total Pages : 648 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Understanding Drug Release and Absorption Mechanisms by : Mario Grassi

Download or read book Understanding Drug Release and Absorption Mechanisms written by Mario Grassi and published by CRC Press. This book was released on 2006-12-26 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demand for better reliability from drug delivery systems has caused designers and researchers to move away from trial-and-error approaches and toward model-based methods of product development. Developing such models requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, Under

Oral Drug Absorption

Author : Jennifer B. Dressman
Publisher : CRC Press
ISBN 13 : 1420077341
Total Pages : 432 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Oral Drug Absorption by : Jennifer B. Dressman

Download or read book Oral Drug Absorption written by Jennifer B. Dressman and published by CRC Press. This book was released on 2016-04-19 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an

Compounded Topical Pain Creams

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 030967218X
Total Pages : 353 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Compounded Topical Pain Creams by : National Academies of Sciences, Engineering, and Medicine

Download or read book Compounded Topical Pain Creams written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-21 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is both a symptom and a disease. It manifests in multiple forms and its treatment is complex. Physical, social, economic, and emotional consequences of pain can impair an individual's overall health, well-being, productivity, and relationships in myriad ways. The impact of pain at a population level is vast and, while estimates differ, the Centers for Disease Control and Prevention reported that 50 million U.S. adults are living in pain. In terms of pain's global impact, estimates suggest the problem affects approximately 1 in 5 adults across the world, with nearly 1 in 10 adults newly diagnosed with chronic pain each year. In recent years, the issues surrounding the complexity of pain management have contributed to increased demand for alternative strategies for treating pain. One such strategy is to expand use of topical pain medicationsâ€"medications applied to intact skin. This nonoral route of administration for pain medication has the potential benefit, in theory, of local activity and fewer systemic side effects. Compounding is an age-old pharmaceutical practice of combining, mixing, or adjusting ingredients to create a tailored medication to meet the needs of a patient. The aim of compounding, historically, has been to provide patients with access to therapeutic alternatives that are safe and effective, especially for people with clinical needs that cannot otherwise be met by commercially available FDA-approved drugs. Compounded Topical Pain Creams explores issues regarding the safety and effectiveness of the ingredients in these pain creams. This report analyzes the available scientific data relating to the ingredients used in compounded topical pain creams and offers recommendations regarding the treatment of patients.

Dermatotoxicology

Author : Hongbo Zhai
Publisher : CRC Press
ISBN 13 : 0203426274
Total Pages : 1232 pages
Book Rating : 4.2/5 (34 download)

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Book Synopsis Dermatotoxicology by : Hongbo Zhai

Download or read book Dermatotoxicology written by Hongbo Zhai and published by CRC Press. This book was released on 2004-02-25 with total page 1232 pages. Available in PDF, EPUB and Kindle. Book excerpt: For twenty-five years, Dermatotoxicology has stood as the definitive reference book in the field. A generation of toxicologists and dermatologists has consulted this volume throughout their careers, finding within it a wealth of theoretical and practical guidance. Updated and expanded to reflect the latest developments in skin toxicology, De

Drug Absorption Studies

Author : Carsten Ehrhardt
Publisher : Springer Science & Business Media
ISBN 13 : 0387749012
Total Pages : 711 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Drug Absorption Studies by : Carsten Ehrhardt

Download or read book Drug Absorption Studies written by Carsten Ehrhardt and published by Springer Science & Business Media. This book was released on 2007-12-22 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a well thought-out, highly practical text covering contemporary ‘in vitro’ techniques for drug absorption studies. Starting at the molecular level of investigation, it continues with cell monolayer models (both primary and cell lines) and culminates with in situ techniques as a final testing format. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix consisting of a number of practical protocols is available online, updated as needed, and should prove very helpful to apply the techniques directly to the benchside.

pH of the Skin: Issues and Challenges

Author : C. Surber
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318063851
Total Pages : 214 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis pH of the Skin: Issues and Challenges by : C. Surber

Download or read book pH of the Skin: Issues and Challenges written by C. Surber and published by Karger Medical and Scientific Publishers. This book was released on 2018-08-21 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of expressing acidity as the negative logarithm of the hydrogen ion concentration was defined and termed pH in the beginning of the 20th century. The general usefulness of the pH concept for life science was recognized and later gained importance to analytical research. Reports on results of pH measurements from living skin established the term acid mantle - the skin's own protective shield that maintains a naturally acid pH. It is invisible to the eye but crucial to the overall wellbeing of skin. Chronic alkalization can throw this acid mantle out of balance, leading to inflammation, dermatitis, and atopic skin diseases. It is therefore no surprise, that skin pH shifts have been observed in various skin pathologies. It is also obvious that the pH in topically applied preparations may play an important role. Optimal pH and buffer capacity within topical preparations not only support stability of active ingredients and auxiliary materials, but may also increase absorption of the non-ionized species of an acidic or a basic active ingredient. They may even open up opportunities to modify and "correct" skin pH and hence accelerate barrier recovery and maintain or enhance barrier integrity. Further efforts are needed to standardize and improve pH measurements in biological media or pharmaceutical/cosmetic vehicles to increase and ensure quality, comparability, and relevance of research data. In this volume, we present a unique collection of papers that address past, present and future issues of the pH of healthy and diseased skin. It is hoped that this collection will foster future efforts in clinical and experimental skin research.

Transdermal Drug Delivery

Author : Kevin Ita
Publisher : Academic Press
ISBN 13 : 0128225513
Total Pages : 324 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Transdermal Drug Delivery by : Kevin Ita

Download or read book Transdermal Drug Delivery written by Kevin Ita and published by Academic Press. This book was released on 2020-06-12 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transdermal Drug Delivery: Concepts and Application provides comprehensive background knowledge and documents the most recent advances made in the field of transdermal drug delivery. It provides comprehensive and updated information regarding most technologies and formulation strategies used for transdermal drug delivery. There has been recent growth in the number of research articles, reviews, and other types of publications in the field of transdermal drug delivery. Research in this area is active both in the academic and industry settings. Ironically, only about 40 transdermal products with distinct active pharmaceutical ingredients are in the market indicating that more needs to be done to chronicle recent advances made in this area and to elucidate the mechanisms involved. This book will be helpful to researchers in the pharmaceutical and biotechnological industries as well as academics and graduate students working in the field of transdermal drug delivery and professionals working in the field of regulatory affairs focusing on topical and transdermal drug delivery systems. Researchers in the cosmetic and cosmeceutical industries, as well as those in chemical and biological engineering, will also find this book useful. Captures the most recent advancements and challenges in the field of transdermal drug delivery Covers both passive and active transdermal drug delivery strategies Explores a selection of state-of-the-art transdermal drug delivery systems

Topical and Transdermal Drug Delivery

Author : Heather A. E. Benson
Publisher : John Wiley & Sons
ISBN 13 : 1118140494
Total Pages : 393 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Topical and Transdermal Drug Delivery by : Heather A. E. Benson

Download or read book Topical and Transdermal Drug Delivery written by Heather A. E. Benson and published by John Wiley & Sons. This book was released on 2012-02-03 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development. Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts: Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment. Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics. Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results. With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.

Topical Drug Bioavailability, Bioequivalence, and Penetration

Author : Vinod P. Shah
Publisher : Springer
ISBN 13 : 1493912895
Total Pages : 393 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Topical Drug Bioavailability, Bioequivalence, and Penetration by : Vinod P. Shah

Download or read book Topical Drug Bioavailability, Bioequivalence, and Penetration written by Vinod P. Shah and published by Springer. This book was released on 2015-01-30 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.