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Part I Development Of Dirhodium Catalyzed Intermolecular C H Amination Part Ii Synthesis And Applications Of Sulfamate Esters
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Book Synopsis Part I: Development of Dirhodium-catalyzed Intermolecular C-H Amination; Part II: Synthesis and Applications of Sulfamate Esters by : Nicholas Derek Chiappini
Download or read book Part I: Development of Dirhodium-catalyzed Intermolecular C-H Amination; Part II: Synthesis and Applications of Sulfamate Esters written by Nicholas Derek Chiappini and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic methods for C(sp3)--H amination are enabling technologies for both the synthesis and late-stage diversification of myriad organic molecules. Contemporary challenges that propel future development of such processes are presented by complex substrates approximating the architectures found in natural products along with polar, functional group-rich active pharmaceutical and agrochemical ingredients. In our efforts to address these limitations, we have established a catalytic system for C--H amination that markedly advances the ability of chemists to efficiently introduce nitrogen into molecules of different structural types. The discovery of pivalonitrile (t-BuCN) as a differential solvent for Rh-catalyzed intermolecular amination of C(sp3)--H bonds and phenyl sulfamate (PhsNH2) as a nitrene precursor has enabled efficient functionalization of a wide variety of complex molecule substrates including natural products and active pharmaceutical ingredients (APIs). Although limitations remain with oxidatively labile functional groups, including basic amines, our disclosure represents a definitive leap forward in the state-of-the-art for C--H bond oxidation. Mechanistic data strongly implicate a pathway for catalyst decomposition that initiates with solvent oxidation, thus providing rationale for the marked influence of pivalonitrile on this reaction process. The phenyl sulfamate nitrogen source can be unmasked under mild conditions using pyridine and water to unveil the corresponding primary amine products. Additionally, through amination of bromoalkane and mesyloxalkane substrates, SN2 cyclization can afford azetidines and other saturated azacycles in good to excellent yield. In pursuit of alternative, modular methods for the installation of sulfamate and sulfamide groups, we have developed pentafluorophenyl sulfamate (PfpsNH2) and trichlorphenyl sulfmatate (TcpsNH2) as bench-stable, versatile reagents for sulfamoylation of alcohol and amine nucleophiles to generate N-unsubstituted sulfamates and sulfamides. This type of 'click' reaction should find widespread use in academic and industrial labs.
Book Synopsis Discovery and Development of Novel Dirhodium Catalysts for Selective Intermolecular Allylic C-H Amination by : Kerry Nicole Betz
Download or read book Discovery and Development of Novel Dirhodium Catalysts for Selective Intermolecular Allylic C-H Amination written by Kerry Nicole Betz and published by . This book was released on 2022 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal-catalyzed C--H functionalization has had an immense impact on streamlining synthesis by enabling previously inaccessible synthetic disconnections in organic synthesis and late-stage diversification of complex molecules. Dirhodium tetracarboxylate catalysts represent the state-of-the-art for intermolecular C(sp3)--H amination, but struggle to functionalize allylic sites due to the competitive reactivity of alkenes. Further advances in dirhodium-mediated C--H amination will require developing catalysts with enhanced stability and different ligand architectures to control selectivity in reactions with substrates bearing reactive functional groups and numerous C--H bonds. However, carboxylate ligands are inherently limited in their electronic, steric, and geometric tunability, which has severely hampered efforts to expand the scope of dirhodium-catalyzed C--H amination. To move beyond dirhodium tetracarboxylate catalysts, we developed a new, modular family of bridging ligands based on 2-pyridones. This work has advanced by capitalizing on a unique combination of computing tools, including molecular dynamics, transition state analysis, and statistical modeling, in a rationally connected feedback loop. These novel dirhodium catalysts mediate intermolecular allylic C−H amination with unprecedented selectivity. The most effective catalyst, Rh2(btz)3(O2CtBu), features one carboxylate and three substituted 2-pyridone ligands that create a spatially complex, conformationally dynamic reactive site. In addition to mediating high yielding amination reactions, these catalysts challenge the paradigm that rigid, well-defined ligand frameworks are optimal for controlling reaction outcomes. Our results demonstrate the versatility of 2-pyridone-derived ligands for optimizing catalyst performance. In addition, this work represents the first successful divergence from dirhodium tetracarboxylate complexes for catalyzing intermolecular C--H amination reactions. More broadly, our design blueprint showcases how data science and computational techniques can be implemented synergistically to help advance reaction design. By capitalizing on the efficiency of dirhodium-catalyzed intermolecular C--H amination reactions, we have developed a novel strategy for constructing saturated azacycles from readily available precursors. The preparation of substituted azetidines and larger ring, nitrogen-containing saturated heterocycles is enabled through efficient and selective intermolecular sp3-C--H amination of alkyl bromide derivatives. A range of substrates are demonstrated to undergo C--H amination and subsequent sulfamate alkylation in good to excellent yield. N-Phenoxysulfonyl-protected products can be unmasked under neutral or mild basic conditions to yield the corresponding cyclic secondary amines. The preparative convenience of this protocol is demonstrated through gram-scale and telescoped multistep procedures. Application of this technology is highlighted in a nine-step total synthesis of an unusual azetidine-containing natural product, penaresidin B.
Book Synopsis The Development and Application of Rhodium-catalyzed C-H Amination Reactions in the Synthesis of Bromopyrrole Alkaloids by : Paul Manning Wehn
Download or read book The Development and Application of Rhodium-catalyzed C-H Amination Reactions in the Synthesis of Bromopyrrole Alkaloids written by Paul Manning Wehn and published by . This book was released on 2005 with total page 1074 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Rhodium-catalyzed C-H Amination by : Kristin Williams Fiori
Download or read book Rhodium-catalyzed C-H Amination written by Kristin Williams Fiori and published by . This book was released on 2007 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chiral Amine Synthesis by : Thomas C. Nugent
Download or read book Chiral Amine Synthesis written by Thomas C. Nugent and published by John Wiley & Sons. This book was released on 2010-01-14 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive presentation of this hot and important topic compiles the most up-to-date methods for chiral amine synthesis. The international list of authors reads like a "Who's Who" of the subject, providing a large array of highly practical information concentrated into the useful and essential methods. Following an introductory chapter devoted to helping readers quickly determine which strategies to choose for their investigation, this handbook and ready reference focuses on the examination of methods that are reliable and simultaneously efficient for the synthesis of structurally diverse aliphatic and aromatic chiral amines. Modern methods and applications found in (pharmaceutical) industry are also covered.
Book Synopsis Catalytic Amination for N-Alkyl Amine Synthesis by : Feng Shi
Download or read book Catalytic Amination for N-Alkyl Amine Synthesis written by Feng Shi and published by Academic Press. This book was released on 2018-03-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic Amination for N-Alkyl Amine Synthesis provides a useful survey of this key type of reaction for chemistry researchers in academia and industry. Beginning with an introduction to amination and the development of the field, the book focuses on useful and high potential methods, such as the catalytic amination of alcohol with homogeneous and heterogeneous catalysts, the coupling reaction of olefin and amine, and the reductive amination of carbon dioxide with different reducing agents. The work also discusses two key examples of one-pot synthesis, the oxidative amination of alkane and amine and synthesis of N-alkyl amine with nitrobenzene and nitrile as starting materials. Valuable for chemists, materials scientists, chemical engineers and others, the book offers a unique overview of this growing area and its future possibilities.
Book Synopsis Modern Rhodium-Catalyzed Organic Reactions by : P. Andrew Evans
Download or read book Modern Rhodium-Catalyzed Organic Reactions written by P. Andrew Evans and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rhodium has proven to be an extremely useful metal due to its ability to catalyze an array of synthetic transformations, with quite often-unique selectivity. Hydrogenation, C-H activation, allylic substitution, and numerous other reactions are catalyzed by this metal, which presumably accounts for the dramatic increase in the number of articles that have recently emerged on the topic. P. Andrew Evans, the editor of this much-needed book, has assembled an internationally renowned team to present the first comprehensive coverage of this important area. The book features contributions from leaders in the field of rhodium-catalyzed reactions, and thereby provides a detailed account of the most current developments, including: Rhodium-Catalyzed Asymmetric Hydrogenation (Zhang) Rhodium-Catalyzed Hydroborations and Related Reactions (Brown) Rhodium-Catalyzed Asymmetric Addition of Organometallic Reagents to Electron Deficient Olefins (Hayashi) Recent Advances in Rhodium(I)-Catalyzed Asymmetric Olefin Isomerization and Hydroacylation Reactions (Fu) Stereoselective Rhodium(I)-Catalyzed Hydroformylation and Silylformylation Reactions and Their Application to Organic Synthesis (Leighton) Carbon-Carbon Bond-Forming Reactions Starting from Rh-H or Rh-Si Species (Matsuda) Rhodium(I)-Catalyzed Cycloisomerization and Cyclotrimerization Reactions (Ojima) The Rhodium(I)-Catalyzed Alder-ene Reaction (Brummond) Rhodium-Catalyzed Nucleophilic Ring Cleaving Reactions of Allylic Ethers and Amines (Fagnou) Rhodium(I)-Catalyzed Allylic Substitution Reactions and their Applications to Target Directed Synthesis (Evans) Rhodium(I)-Catalyzed [2+2+1] and [4+1] Carbocyclization Reactions (Jeong) Rhodium(I)-Catalyzed [4+2] and [4+2+2] Carbocyclizations (Robinson) Rhodium(I)-Catalyzed [5+2], [6+2], and [5+2+1] Cycloadditions: New Reactions for Organic Synthesis (Wender) Rhodium(II)-Stabilized Carbenoids Containing both Donor and Acceptor Substituents (Davies) Chiral Dirhodium(II)Carboxamidates for Asymmetric Cyclopropanation and Carbon-Hydrogen Insertion Reactions (Doyle) Cyclopentane Construction by Rhodium(II)-Mediated Intramolecular C-H Insertion (Taber) Rhodium(II)-Catalyzed Oxidative Amination (DuBois) Rearrangement Processes of Oxonium and Ammonium Ylides Formed by Rhodium(II)-Catalyzed Carbene-Transfer (West) Rhodium(II)-Catalyzed 1,3-Dipolar Cycloaddition Reactions (Austin) "Modern Rhodium-Catalyzed Organic Reactions" is an essential reference text for researchers at all levels in the general area of organic chemistry. This book provides an invaluable overview of the most significant developments in this important area of research, and will no doubt be an essential text for researchers at academic institutions and professionals at pharmaceutical/agrochemical companies.
Book Synopsis Oxidative Cross-Coupling Reactions by : Aiwen Lei
Download or read book Oxidative Cross-Coupling Reactions written by Aiwen Lei and published by John Wiley & Sons. This book was released on 2016-08-12 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first handbook on this emerging field provides a comprehensive overview of transition metal-catalyzed coupling reactions in the presence of an oxidant. Following an introduction to the general concept and mechanism of this reaction class, the team of authors presents chapters on C-C cross-coupling reactions using organometallic partners, C-Heteroatom bond forming reactions via oxidative couplings, and C-H couplings via C-H activation. The text also covers such groundbreaking topics as recent achievements in the fields of C-C and C-X bond formation reactions as well as C-H activation involving oxidative couplings. With its novel and concise approach towards important building blocks in organic chemistry and its focus on synthetic applications, this handbook is of great interest to all synthetic chemists in academia and industry alike.
Book Synopsis The Development of a Method for Rhodium-catalyzed Olefin Aziridination and Its Application to Synthesis of the Welwitindolinones by : Kiran Guthikonda
Download or read book The Development of a Method for Rhodium-catalyzed Olefin Aziridination and Its Application to Synthesis of the Welwitindolinones written by Kiran Guthikonda and published by . This book was released on 2008 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic and Spectroscopic Studies of Dirhodium Complexes Relevant to C-H Functionalization Catalysis by :
Download or read book Synthetic and Spectroscopic Studies of Dirhodium Complexes Relevant to C-H Functionalization Catalysis written by and published by . This book was released on 2014 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dirhodium complexes have a long-standing importance in C8́2H functionalization chemistry, but little is known about the reactive intermediates on which this chemistry relies. The first part of this dissertation focuses on intermediates in catalytic C8́2H amination chemistry: In Chapter 3, the catalyst Rh2(esp)2 (esp = [alpha], [alpha], [alpha]', [alpha]' -tetramethyl- 1,3-benzenedipropanoate) is studied spectroscopically and electrochemically to gain insight into its robust nature. These studies implicate the stability of a one-electron oxidized Rh2II,III state in the high level of activity reported for this catalyst. In Chapter 4, two complexes that are structurally analogous to Rh2(esp)2 with chelating dicarboxylate ligands based on a resorcinol backbone are synthesized. These new complexes are electronically dissimilar to Rh2(esp)2, since the ligands are more readily oxidized than the Rh2 core, as observed by cyclic voltammetry. In catalytic studies, it is shown that these new catalysts perform equally well in intramolecular amination as parent catalyst Rh2(esp)2, but fail to achieve the same level of efficiency in intermolecular amination. The results of this study further implicate the importance of mixed-valency in intermolecular amination. In Chapter 5, the synthesis and catalytic activity of a new purposefully mixed-valent Rh2-amidate catalyst is reported. The new catalyst, Rh2(espn)2Cl (espn = [alpha], [alpha], [alpha]', [alpha]' -tetramethyl-1,3-benzenedipropanamidate), achieves higher turnover numbers in intramolecular amination than parent catalyst Rh2(esp)2. Chapter 6 is focused on the exploration of intermediates in Rh2-mediated carbenoid chemistry. Methods for preparing a metastable solution of a donor/acceptor carbene complex of Rh2(TPA)4 (TPA = triphenylacetate) are described; the carbenoid intermediate is characterized by NMR, resonance Raman and X-ray absorption spectroscopies, all corroborated by DFT analysis. In summary, the work presented in this dissertation establishes the importance of mixed-valency for increased turnover in C8́2H amination catalysts. Isolation of the first Rh2-carbenoid provides experimental support for the previously theoretically-based catalytic reactivity of Rh2-carbenoids.
Book Synopsis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis by : Montserrat Diéguez
Download or read book Artificial Metalloenzymes and MetalloDNAzymes in Catalysis written by Montserrat Diéguez and published by John Wiley & Sons. This book was released on 2018-02-21 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.
Book Synopsis Part I: an Approach to the Synthesis of Plakortethers A--E; Part II: Rhodium-catalyzed Intramolecular C--H Insertion on Diazosulfonates and Its Synthetic Applications by : Duminda Shiromalee Liyanage
Download or read book Part I: an Approach to the Synthesis of Plakortethers A--E; Part II: Rhodium-catalyzed Intramolecular C--H Insertion on Diazosulfonates and Its Synthetic Applications written by Duminda Shiromalee Liyanage and published by . This book was released on 2015 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Copper-catalyzed Carbon-heteroatom Bond Formations by : Saki Ichikawa
Download or read book Copper-catalyzed Carbon-heteroatom Bond Formations written by Saki Ichikawa and published by . This book was released on 2019 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: The studies presented in this dissertation are regarding the development of new methods for copper-catalyzed carbon-heteroatom bond formations, including asymmetric hydroamination and continuous-flow aromatic Finkelstein reaction. The first part of this dissertation focuses on the development of copper-catalyzed asymmetric hydroamination reactions to access various classes of enantioenriched amines. This includes the development of a broadly applicable hydroamination protocol for the synthesis of enantioenriched N-arylamines (Chapter 1) and 1,2- diamines (Chapter 2). The second part of this dissertation describes the development of copper-catalyzed aromatic Finkelstein reaction under continuous-flow conditions (Chapter 3). Part I. Chapter 1. A Modified System for the Synthesis of Enantioenriched N-Arylamines through Copper-Catalyzed Hydroamination Despite significant recent progress in copper-catalyzed enantioselective hydroamination chemistry, the synthesis of chiral N-arylamines, which are frequently found in natural products and pharmaceuticals, has not been realized. Initial experiments with N-arylhydroxylamine ester electrophiles were unsuccessful and instead, their reduction, in the presence of copper hydride (CuH) catalysts, was observed. We detail key modifications of our previously reported hydroamination protocols that led to broadly applicable conditions for the enantioselective net addition of secondary anilines across the double bond of styrenes, 1,1 -disubstituted alkenes, and terminal alkenes. NMR studies suggest that suppression of the undesired reduction pathway is the basis for the dramatic improvements in yield under this new protocol. Chapter 2. Regio- and Enantioselective Synthesis of 1,2-Diamine Derivatives by Copper- Catalyzed Hydroamination A highly regio- and enantioselective synthesis of 1,2-diamines using [gamma]-substituted allylic pivalamides via copper-catalyzed hydroamination is reported. The N-pivaloyl group is essential, both in facilitating the hydrocupration step and in suppressing the unproductive [beta]-elimination from the alkylcopper intermediate. This synthetic approach enables an efficient construction of chiral, differentially protected, vicinal diamines under mild conditions with broad functional group tolerance. Part II. Chapter 3. Rapid and Efficient Copper-Catalyzed Finkelstein Reaction of (Hetero)Aromatics under Continuous-Flow Conditions A general, rapid, and efficient method for the copper-catalyzed Finkelstein reaction of (hetero)aromatics has been developed using continuous flow to generate a variety of aryl iodides. The described method can tolerate a broad range of functional groups, including N-H and O-H groups. Additionally, in lieu of isolation, the aryl iodide products in solution can be directly used in two distinct multistep continuous-flow processes (amidation or Mg-I exchange/nucleophilic addition) to demonstrate the flexibility of this method.
Book Synopsis Modern Catalytic Methods for Organic Synthesis with Diazo Compounds by : Michael P. Doyle
Download or read book Modern Catalytic Methods for Organic Synthesis with Diazo Compounds written by Michael P. Doyle and published by Wiley-Interscience. This book was released on 1998-01-19 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: This much-needed resource brings together a wealth of procedures for the synthesis and practical use of diazocarbonyl compounds. It features methods for the preparation of important catalysts and for applications of diazocarbonyl compounds within each of the main transformation categories-including in-depth coverage of cyclopropanation, C-H and X-H insertion, Wolff rearrangement, ylide formation, aromatic cycloaddition and substitution, and many other useful reactions. Written by leading experts in the field, this book contains cutting-edge material on highly enantioselective transformations, and presents new ways of thinking about diazocarbonyl compounds and their applications, from donor-acceptor cyclopropanes in organic synthesis to macrocyclic cyclopropanation. Complete with illustrative examples of procedures in each chapter, clear diagrams, and a detailed bibliography, this practical reference gives readers the tools they need to put diazocarbonyl compounds to work for their own projects-an invaluable source of guidance for synthetic organic chemists, chemical scientists, and advanced students.
Download or read book Iron Catalysis written by Bernd Plietker and published by Springer Science & Business Media. This book was released on 2011-01-05 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Juan I. Padrón and Víctor S. Martín: Catalysis by means of Fe-based Lewis acids; Hiroshi Nakazawa*, Masumi Itazaki: Fe–H Complexes in Catalysis; Kristin Schröder, Kathrin Junge, Bianca Bitterlich, and Matthias Beller: Fe-catalyzed Oxidation Reactions of Olefins, Alkanes and Alcohols: Involvement of Oxo- and Peroxo Complexes; Chi-Ming Che, Cong-Ying Zhou, Ella Lai-Ming Wong: Catalysis by Fe=X Complexes (X=NR, CR2); René Peters, Daniel F. Fischer and Sascha Jautze: Ferrocene and Half Sandwich Complexes as Catalysts with Iron Participation; Markus Jegelka, Bernd Plietker: Catalysis by Means of Complex Ferrates.
Book Synopsis C-H Activation for Asymmetric Synthesis by : Françoise Colobert
Download or read book C-H Activation for Asymmetric Synthesis written by Françoise Colobert and published by John Wiley & Sons. This book was released on 2019-11-11 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.
Book Synopsis Comprehensive Organometallic Chemistry III by :
Download or read book Comprehensive Organometallic Chemistry III written by and published by Elsevier Science. This book was released on 2006-12-26 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Organometallic Chemistry, (COMC-III), Third Edition, 13 Volume Set is aimed at the specialist and non-specialist alike. It covers the major developments in the field in a carefully presented way with extensive cross-references. COMC-III provides a clear and comprehensive overview of developments since 1993 and attempts to predict trends in the field over the next ten years. Applications of organometallic chemistry continue to expand and this has been reflected by the significant increase in the number of volumes devoted to applications in COMC-III. Organic chemists have edited the volumes on organometallic chemistry towards organic synthesis - this is now organized by reaction type so as to be readily accessible to the organic community. Like its predecessors, COMC (1982) and COMC-II (1995), this new work is the essential reference text for any chemist or technologist who needs to use or apply organometallic compounds. Also available online via ScienceDirect (2006) - featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com. Presents a comprehensive overview of the major developments in the field since 1993 providing general and significant insights Highlights the expansion of applications in organometallic chemistry with a strong organic synthesis focus Provides a structured first point of entry to the key literature and background material for those planning research, teaching and writing about the area
