P27 Drives Pi3k Dependent Cancer Metastasis By Activating Emt Transcription Factors To Induce An Emt Program

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P27 Drives PI3K-dependent Cancer Metastasis by Activating EMT Transcription Factors to Induce an EMT Program

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Author : Alexandra H Besser
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (12 download)

Book Synopsis P27 Drives PI3K-dependent Cancer Metastasis by Activating EMT Transcription Factors to Induce an EMT Program by : Alexandra H Besser

Download or read book P27 Drives PI3K-dependent Cancer Metastasis by Activating EMT Transcription Factors to Induce an EMT Program written by Alexandra H Besser and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In normal cells, p27 regulates cell cycle and functions as an atypical tumor suppressor. Unlike typical tumor suppressors such as p16 and pRb, p27 gene deletions or mutations are rarely observed in human cancers. Instead, p27 is deregulated through either excess degradation or through key C-terminal phosphorylations, in human cancers. Phosphorylation at T157 or T198 by different PI3K effector kinases allows p27 to take on new binding partners and promote oncogenic transformation. This thesis addresses the functional contribution of T157 and T198-phosphorylated, deregulated p27 to cancer progression and metastasis. By studying the effects of a transfected cell cycle defective (CK-) and double phosphomimetic p27 mutant (T157D/T198D) in transformed and non-transformed cells, we found that phosphorylation of p27 at T157 or T198 by PI3K/mTOR directly regulates tumor cell migration and invasion. Targeted inhibition of PI3K/mTOR impairs tumor cell motility and metastasis via modulation of p27. Furthermore, we uncovered a novel oncogenic function of p27 to promote tumor progression. p27CK-DD induced epithelial-mesenchymal transition (EMT) and transformation of human mammary epithelial cells and enhanced the mesenchymal characteristics and metastatic potential of breast cancer cell lines. Knockdown of p27 in highly metastatic EMT-transformed cell lines with enriched p27pT157pT198 (p27pTpT) reverted EMT and impaired metastatic potential. Mechanistically, we showed phosphorylation of p27 at T157 and T198 promotes the activation and induction of several EMT drivers and transcription factors to induce EMT. p27CK-DD activates STAT3 and facilitates its transactivation of TWIST1 to induce EMT. Pharmacological inhibition of STAT3 or dominant negative STAT3 (STAT3DN) decreased TWIST1 expression and reversed p27CK-DD-mediated EMT and tumor progression, while constitutively active STAT3 (STAT3CA) rescued the EMT phenotype and metastatic potential in p27 knockdown cells. We also identified a potential signaling feed-forward loop containing AKT activation, p27 phosphorylation, STAT3 activation and further AKT activation that might contribute to tumor progression. This thesis work also provides novel evidence for p27 as a transcriptional co- regulator of c-Jun. We prove evidence that C-terminally phophorylated p27 binds and activates c-Jun, and forms a complex with c-Jun at an enhancer region upstream of the TGF-B2 gene to upregulate TGF-B2. Not only does p27pTpT upregulate expression of the ligand, TGF-?2, p27pTpT is required for maximal TGF-B2-stimulated SMAD3 activation, SNAI1 induction, and matrigel invasion. Following addition of exogenous TGF-B2 ligand, p27 forms a tripartite complex with c-Jun and SMAD3 on the SNAI1 promoter, thus revealing an additional mechanism by which PI3K-activated, C-terminally phosphorylated p27 drives EMT and metastasis. These findings reveal a novel, oncogenic function of p27 to promote tumor progression through EMT via STAT3-mediated induction of TWIST1, c-Jun-mediated TGF-B2 induction, and c-Jun/SMAD3-mediated SNAI1 induction. Combined inhibition of AKT, STAT3, and TGF-B2 in PI3K/mTOR activated, p27pTpT enriched human cancers may ultimately have therapeutic potential to limit p27-mediated EMT and cancer metastasis.

Inhibition of Epithelial-to-mesenchymal Transition by Anti-tumor Agents in Cancer Cells

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Author : Chih-Chien Chou
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (922 download)

Book Synopsis Inhibition of Epithelial-to-mesenchymal Transition by Anti-tumor Agents in Cancer Cells by : Chih-Chien Chou

Download or read book Inhibition of Epithelial-to-mesenchymal Transition by Anti-tumor Agents in Cancer Cells written by Chih-Chien Chou and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Epithelial-mesenchymal transition (EMT) is a critical process that confers to cancer cells the ability to invade basement membranes and metastasize to distant sites. Here, we report a novel function of the metabolic sensor adenosine monophosphate-activated protein kinase (AMPK) in suppressing EMT by modulating the Akt-MDM2-Foxo3 signaling axis. This mechanistic link was supported by the effects of siRNA-mediated knockdown and pharmacological activation of AMPK on epithelial (E-cadherin) and mesenchymal markers (vimentin, YB-1, Snail) in a panel of breast and prostate cancer cell lines. Exposure of cells to OSU-53, a novel allosteric AMPK activator, as well as metformin and AICAR, reversed their mesenchymal phenotype, which could be abrogated by AMPK silencing. This phenotypic change was mediated through Foxo3a activation as knockdown and ectopic expression of Foxo3a mimicked the effects of AMPK silencing and OSU-53-induced activation on these EMT markers, respectively. Mechanistically, Foxo3a activation led to the transactivation of the E-cadherin gene and repression of genes encoding EMT-inducing transcription factors. Evidence indicates that OSU-53 activated Foxo3a through two Akt-dependent pathways: nuclear localization by blocking Akt- and IKK-mediated phosphorylation, and protein stabilization by cytoplasmic sequestration of MDM2, an E3 ligase responsible for Foxo3a degradation. This mode of activation contrasts with a previously reported in which AMPK increased Foxo3a transcriptional activity through direct phosphorylation without affecting its subcellular localization. Functionally, the suppressive effect of OSU-53 on EMT was demonstrated by its ability to block the invasive phenotypes of MDA-MB-231 and PC-3 cells in vitro and lung metastasis in the 4T1 orthotopic mammary cancer model.

Signal Transduction in Cancer

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Author : David A. Frank
Publisher : Springer Science & Business Media
ISBN 13 : 1402073402
Total Pages : 358 pages
Book Rating : 4.4/5 (2 download)

Book Synopsis Signal Transduction in Cancer by : David A. Frank

Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

The Heterogeneity of Cancer Metabolism

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Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)

Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Intercellular Signaling in Development and Disease

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Author : Edward A. Dennis
Publisher : Academic Press
ISBN 13 : 0123822165
Total Pages : 549 pages
Book Rating : 4.1/5 (238 download)

Book Synopsis Intercellular Signaling in Development and Disease by : Edward A. Dennis

Download or read book Intercellular Signaling in Development and Disease written by Edward A. Dennis and published by Academic Press. This book was released on 2011-04-05 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Required reading for anyone involved in cell signaling research with articles written and edited by experts in the field. This title covers disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, andinflammatory bowel disease, along with up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease. Articles written and edited by experts in the field Thematic volume covering disease states such as lymphoid leukemia, breast cancer, pulmonary fibrosis, systemic sclerosis, and inflammatory bowel disease Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

The Cancer Stem Cell Niche

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Author : Susie Nilsson
Publisher : Academic Press
ISBN 13 : 0323853250
Total Pages : 246 pages
Book Rating : 4.3/5 (238 download)

Book Synopsis The Cancer Stem Cell Niche by : Susie Nilsson

Download or read book The Cancer Stem Cell Niche written by Susie Nilsson and published by Academic Press. This book was released on 2021-02-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche

Handbook of Cell Signaling

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Author : Ralph A. Bradshaw
Publisher : Academic Press
ISBN 13 : 0080920918
Total Pages : 3188 pages
Book Rating : 4.0/5 (89 download)

Book Synopsis Handbook of Cell Signaling by : Ralph A. Bradshaw

Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field

Chromatin Signaling and Diseases

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Author : Olivier Binda
Publisher : Academic Press
ISBN 13 : 012802609X
Total Pages : 468 pages
Book Rating : 4.1/5 (28 download)

Book Synopsis Chromatin Signaling and Diseases by : Olivier Binda

Download or read book Chromatin Signaling and Diseases written by Olivier Binda and published by Academic Press. This book was released on 2016-08-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling. Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored. Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with aging Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling Helps researchers learn about the quickly expanding field of chromatin signaling

PI3K-mTOR in Cancer and Cancer Therapy

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Author : Nandini Dey
Publisher : Humana Press
ISBN 13 : 3319342118
Total Pages : 307 pages
Book Rating : 4.3/5 (193 download)

Book Synopsis PI3K-mTOR in Cancer and Cancer Therapy by : Nandini Dey

Download or read book PI3K-mTOR in Cancer and Cancer Therapy written by Nandini Dey and published by Humana Press. This book was released on 2016-06-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway’s involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area.

The Retinoblastoma Protein

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Author : Pedro G. Santiago-Cardona
Publisher : Humana Press
ISBN 13 : 9781493975648
Total Pages : 200 pages
Book Rating : 4.9/5 (756 download)

Book Synopsis The Retinoblastoma Protein by : Pedro G. Santiago-Cardona

Download or read book The Retinoblastoma Protein written by Pedro G. Santiago-Cardona and published by Humana Press. This book was released on 2018-02-22 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the mechanisms of pRb inactivation detailing repressive mechanisms commonly associated to cancer, and representative of the experimentally relevant tests used in the establishment of cancer diagnosis and prognosis. Chapters contain protocols and in-depth discussions for commonly used experimental approaches to assess the status and function of components of the pRb pathway, including pRb itself, in cell lines and biological samples.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, The Retinoblastoma Protein aims to serve as a guide to assist molecular cancer biologists in their search for understanding of the molecular functions of this preeminent tumor suppressor.

Tumor Suppressor Par-4

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Author : Vivek M. Rangnekar
Publisher : Springer Nature
ISBN 13 : 3030805581
Total Pages : 329 pages
Book Rating : 4.0/5 (38 download)

Book Synopsis Tumor Suppressor Par-4 by : Vivek M. Rangnekar

Download or read book Tumor Suppressor Par-4 written by Vivek M. Rangnekar and published by Springer Nature. This book was released on 2022-01-01 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.

Breast Cancer

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Author : Phuc Van Pham
Publisher : BoD – Books on Demand
ISBN 13 : 9535129996
Total Pages : 570 pages
Book Rating : 4.5/5 (351 download)

Book Synopsis Breast Cancer by : Phuc Van Pham

Download or read book Breast Cancer written by Phuc Van Pham and published by BoD – Books on Demand. This book was released on 2017-04-05 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.

Oxygen Sensing

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Author :
Publisher : Elsevier
ISBN 13 : 0080497195
Total Pages : 867 pages
Book Rating : 4.0/5 (84 download)

Book Synopsis Oxygen Sensing by :

Download or read book Oxygen Sensing written by and published by Elsevier. This book was released on 2004-05-10 with total page 867 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of cells to sense and respond to changes in oxygenation underlies a multitude of developmental, physiological, and pathological processes. This volume provides a comprehensive compendium of experimental approaches to the study of oxygen sensing in 48 chapters that are written by leaders in their fields.

Hypoxia and Cancer Metastasis

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Author : Daniele M. Gilkes
Publisher : Springer
ISBN 13 : 3030127346
Total Pages : 160 pages
Book Rating : 4.0/5 (31 download)

Book Synopsis Hypoxia and Cancer Metastasis by : Daniele M. Gilkes

Download or read book Hypoxia and Cancer Metastasis written by Daniele M. Gilkes and published by Springer. This book was released on 2019-06-14 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.

Systems Biology of Cancer

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Author : Sam Thiagalingam
Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.5/5 (214 download)

Book Synopsis Systems Biology of Cancer by : Sam Thiagalingam

Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Philosophy of Cancer

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Author : Marta Bertolaso
Publisher : Springer
ISBN 13 : 9402408657
Total Pages : 200 pages
Book Rating : 4.4/5 (24 download)

Book Synopsis Philosophy of Cancer by : Marta Bertolaso

Download or read book Philosophy of Cancer written by Marta Bertolaso and published by Springer. This book was released on 2016-08-24 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the 1970s, the origin of cancer is being explored from the point of view of the Somatic Mutation Theory (SMT), focusing on genetic mutations and clonal expansion of somatic cells. As cancer research expanded in several directions, the dominant focus on cells remained steady, but the classes of genes and the kinds of extra-genetic factors that were shown to have causal relevance in the onset of cancer multiplied. The wild heterogeneity of cancer-related mutations and phenotypes, along with the increasing complication of models, led to an oscillation between the hectic search of ‘the’ few key factors that cause cancer and the discouragement in face of a seeming ‘endless complexity’. To tame this complexity, cancer research started to avail itself of the tools that were being developed by Systems Biology. At the same time, anti-reductionist voices began claiming that cancer research was stuck in a sterile research paradigm. This alternative discourse even gave birth to an alternative theory: the Tissue Organization Field Theory (TOFT). A deeper philosophical analysis shows limits and possibilities of reductionist and anti-reductionist positions and of their polarization. This book demonstrates that a radical philosophical reflection is necessary to drive cancer research out of its impasses. At the very least, this will be a reflection on the assumptions of different kinds of cancer research, on the implications of what cancer research has been discovering over 40 years and more, on a view of scientific practice that is most able to make sense of the cognitive and social conflicts that are seen in the scientific community (and in its results), and, finally, on the nature of living entities with which we entertain this fascinating epistemological dance that we call scientific research. The proposed Dynamic and Relational View of carcinogenesis is a starting point in all these directions.

Basic Principles of Cancer Chemotherapy

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Author : Kenneth Charles Calman
Publisher :
ISBN 13 :
Total Pages : 180 pages
Book Rating : 4.:/5 (311 download)

Book Synopsis Basic Principles of Cancer Chemotherapy by : Kenneth Charles Calman

Download or read book Basic Principles of Cancer Chemotherapy written by Kenneth Charles Calman and published by . This book was released on 1980 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: