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Author : Sigrid A. Langhans
Publisher : Frontiers Media SA
ISBN 13 : 2889457117
Total Pages : 265 pages
Book Rating : 4.8/5 (894 download)
Download or read book P-type ATPases in Health and Disease written by Sigrid A. Langhans and published by Frontiers Media SA. This book was released on 2019-01-11 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)
Download or read book P-type ATPases in Health and Disease written by and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: P-type ATPases are a large group of evolutionary related ion and lipid pumps that have in common that they catalyze a transient phosphorylated intermediate at a key conserved aspartate residue within the pump in order to function. While all the P-type ATPases perform active transport across cellular membranes, they have different transport specificities and serve diverse physiological functions. The ion pumps of the P-type ATPase family create electrochemical gradients that are essential for transepithelial transport, nutrient uptake and membrane potential. They mediate cellular signaling and provide the ligands for metalloenzymes. Phospholipid flippases, also members of the P-type ATPase superfamily, regulate the asymmetric lipid distribution across the lipid bilayer and are critical for the biogenesis of cell membranes. Since all of these ATPases serve fundamental cellular functions, malfunctioning is associated with various pathophysiological processes and dysfunctions of P-type ATPases are known to contribute to cardiovascular, neurological, renal and metabolic diseases. However, with the ever growing knowledge about the diseases associated with the malfunction of P-type ATPases, they are also promising targets for future drug development. In eukaryotes the most prominent examples of P-type ATPases are the Na+,K+-ATPase (sodium pump), the H+-ATPase (proton pump), the H+,K+-ATPase (proton-potassium pump) and the Ca2+-ATPases (calcium pumps). Mutations in the alpha2 and alpha3 subunit of Na,K-ATPase have been associated with neurological diseases, including rapid-onset dystonia-parkinsonism, familial hemiplegic migraine and alternating hemiplegia of childhood. Dysregulation and loss of expression of Na,K-ATPase and plasma membrane Ca-ATPases may be involved in cancer progression. Malfunctioning of the Ca-ATPases is also thought to contribute to hypertension and neurodegenerative diseases and mutations can cause cardiac dysfunction, deafness, hypertension and cerebellar ataxia. Mutations in the SERCA calcium pumps can cause heart failure, Brody myopathy and Darier disease and mutations in the Cu-ATPase genes cause Menkes and Wilson disease. Deficiencies in phospholipid flippases have been linked to progressive familial intrahepatic cholestasis, obesity, diabetes, hearing loss and neurological diseases.
Author : Jens Peter Andersen
Publisher :
ISBN 13 :
Total Pages : 213 pages
Book Rating : 4.:/5 (488 download)
Download or read book Na,K-ATPase and Related Transport ATPases of P-type written by Jens Peter Andersen and published by . This book was released on 2008 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jose M. Arguello
Publisher : Academic Press
ISBN 13 : 0123943906
Total Pages : 478 pages
Book Rating : 4.1/5 (239 download)
Download or read book Metal Transporters written by Jose M. Arguello and published by Academic Press. This book was released on 2012-10-25 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise
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Publisher :
ISBN 13 :
Total Pages : 1724 pages
Book Rating : 4.E/5 ( download)
Download or read book Environmental Health Perspectives written by and published by . This book was released on 2000 with total page 1724 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kwang W. Jeon
Publisher : Elsevier
ISBN 13 : 0080464823
Total Pages : 281 pages
Book Rating : 4.0/5 (84 download)
Download or read book International Review of Cytology written by Kwang W. Jeon and published by Elsevier. This book was released on 2006-10-06 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address cell biology of membrane trafficking in human disease; the biology of the gaucher cell; intracellular signals and events activated by cytokines of the TNF superfamily; cellular and molecular biology of orphan G-protein coupled receptors; organization and function of the actin; cytoskeleton in developing root cells.
Author : Sajal Chakraborti
Publisher : Springer
ISBN 13 : 3319247808
Total Pages : 582 pages
Book Rating : 4.3/5 (192 download)
Download or read book Regulation of Ca2+-ATPases,V-ATPases and F-ATPases written by Sajal Chakraborti and published by Springer. This book was released on 2015-12-10 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biological membranes of cellular organization enfold an important group of membrane proteins called the ATPases, which are not only versatile in maintaining chemical gradient and electrical potential across the membrane but also bring metabolites necessary for cell metabolism and drive out toxins, waste products and solutes that otherwise can curb cell functions. ATPases are distributed virtually in all live forms starting from unicellular to multicellular and also in viruses. There are different types of ATPases, which differ in function and structure and in the type of ions they transport. The three main types of the ion pump ATPase family are: (i) P-type ATPases that transport different ions across membranes and Ca2+ATPases belongs to this catagory (ii) F-type ATPase in mitochondria, chloroplasts and bacterial plasma membranes produce ATP using the proton gradient; and (iii) V-type ATPase catalyzes ATP hydrolysis to transport solutes and maintains acidic pH in organelles like lysosomes. Genetic defects in either of the ATPases cause several diseases and a number of researches have demonstrated the involvement of the members of ATPases in the cell pathology and diseases, thereby penetrating exciting new areas of our understanding. In this book, the authors summarize recent knowledge about the molecular mechanisms associated with Ca2+-ATPase, V-ATPase and F-ATPase in intracellular and extracellular Ca2+ transport, mitochondrial ATP synthase, vesicular H+ transport, and lysosomal pH regulation. This book thereby bridges the gap between fundamental research and biomedical and pharmaceutical applications. The book provides an informative resource to improve ATPase research and modern therapeutic approaches toward different life threatening diseases that are associated with dysregulation of the ATPases.
Author : Sajal Chakraborti
Publisher : Springer
ISBN 13 : 3319247506
Total Pages : 434 pages
Book Rating : 4.3/5 (192 download)
Download or read book Regulation of Membrane Na+-K+ ATPase written by Sajal Chakraborti and published by Springer. This book was released on 2015-12-16 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Na+-K+ ATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s α- and β- subunits. At present four different α- (α-1,α-2,α-3 and α-4) and three β- (β-1, β-2, and β-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na+-K+ ATPase activity is an important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na+-K+ ATPase is either mediated by changes in intracellular Na+ concentrations that directly affect the Na+-pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na+-K+ ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of α- and β- subunits leading to an increased expression in the level of Na+-pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra ne domain adjacent to the isoform(s) of α-β subunits of Na+-K+ ATPase. Considering the extraordinary importance of Na+-K+ ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled “Regulation of Membrane Na+-K+ ATPase” for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na+-K+ ATPase regulation in health and disease.
Author : Astrid Sigel
Publisher : Springer
ISBN 13 : 3319217569
Total Pages : 663 pages
Book Rating : 4.3/5 (192 download)
Download or read book The Alkali Metal Ions: Their Role for Life written by Astrid Sigel and published by Springer. This book was released on 2016-02-09 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements lithium (Li+), rubidium, and cesium are rare and the radioactive francium occurs only in traces. Since the intra- and extracellular, as well as the compartmental concentrations of Na+ and K+ differ significantly, homeostasis and active transport of these ions are important; this involves transporters/carriers and pore-forming ion channel proteins. Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters are thoroughly discussed. The role of K+ in photosynthesis and the role of Na+ in charging the "battery of life" are pointed out. Also, the relationships between alkali metal ions and diseases (e.g., Parkinson or traumatic brain injury) are covered and the relevance of Li+ salts in medicine (pharmacology and mechanism) is reviewed. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 16, The Alkali Metal Ions: Their Role for Life, which are written by 44 internationally recognized experts from 12 nations. The impact of this vibrant research area is manifested in nearly 3000 references, over 30 tables and more than 150 illustrations (two thirds in color). MILS-16 also provides excellent information for teaching. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.
Author : Nicholas Sperelakis
Publisher : Elsevier
ISBN 13 : 0080574556
Total Pages : 1262 pages
Book Rating : 4.0/5 (85 download)
Download or read book Cell Physiology Source Book written by Nicholas Sperelakis and published by Elsevier. This book was released on 2012-12-02 with total page 1262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. - Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors - Includes broad coverage of both animal and plant cells - Appendixes review basics of the propagation of action potentials, electricity, and cable properties - Authored by leading experts in the field - Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics
Author : Olle Selinus
Publisher : Academic Press
ISBN 13 : 0126363412
Total Pages : 828 pages
Book Rating : 4.1/5 (263 download)
Download or read book Essentials of Medical Geology written by Olle Selinus and published by Academic Press. This book was released on 2005-01-25 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative reference volume emphasizes the importance and interrelationships of geological processes to the health and diseases of humans and animals. Its accessible format fosters better communication between the health and geoscience communities by elucidating the geologic origins and flow of toxic elements in the environment that lead to human exposure through the consumption of food and water. For example, problems of excess intake from drinking water have been encountered for several inorganic compounds, including fluoride in Africa and India; arsenic in certain areas of Argentina, Chile, and Taiwan; selenium in seleniferous areas in the U.S., Venezuela, and China; and nitrate in agricultural areas with heavy use of fertilizers. Environmental influences on vector borne diseases and stormflow water quality influences are also featured. Numerous examples of the environmental influences on human health from across the globe are also presented and discussed in this volume. * Covers recent advances and future research topics at the intersection of environmental science and public health * Developed by 60 experts from 20 countries and edited by professionals from the International Working Group on Medical Geology * Includes 200+ color photographs and illustrations * Organizes information in a highly structured format for easy reference * Written for a broad audience, ranging from students, researchers, and medical professionals to policymakers and the general public
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309172209
Total Pages : 161 pages
Book Rating : 4.3/5 (91 download)
Download or read book Copper in Drinking Water written by National Research Council and published by National Academies Press. This book was released on 2000-04-12 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: The safety of the nation's drinking water must be maintained to ensure the health of the public. The U.S. Environmental Protection Agency (EPA) is responsible for regulating the levels of substances in the drinking water supply. Copper can leach into drinking water from the pipes in the distribution system, and the allowable levels are regulated by the EPA. The regulation of copper, however, is complicated by the fact that it is both necessary to the normal functioning of the body and toxic to the body at too high a level. The National Research Council was requested to form a committee to review the scientific validity of the EPA's maximum contaminant level goal for copper in drinking water. Copper in Drinking Water outlines the findings of the committee's review. The book provides a review of the toxicity of copper as well as a discussion of the essential nature of this metal. The risks posed by both short-term and long-term exposure to copper are characterized, and the implications for public health are discussed. This book is a valuable reference for individuals involved in the regulation of water supplies and individuals interested in issues surrounding this metal.
Author :
Publisher :
ISBN 13 :
Total Pages : 2160 pages
Book Rating : 4.:/5 (319 download)
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author : Nader Rifai
Publisher : Elsevier Health Sciences
ISBN 13 : 0323548482
Total Pages : 4785 pages
Book Rating : 4.3/5 (235 download)
Download or read book Tietz Textbook of Clinical Chemistry and Molecular Diagnostics - E-Book written by Nader Rifai and published by Elsevier Health Sciences. This book was released on 2017-01-16 with total page 4785 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 6th Edition provides the most current and authoritative guidance on selecting, performing, and evaluating the results of new and established laboratory tests. This classic clinical chemistry reference offers encyclopedic coverage detailing everything you need to know, including: analytical criteria for the medical usefulness of laboratory tests, variables that affect tests and results, laboratory medicine, applications of statistical methods, and most importantly clinical utility and interpretation of laboratory tests. It is THE definitive reference in clinical chemistry and molecular diagnostics, now fully searchable and with quarterly content updates, podcasts, clinical cases, animations, and extended content online through Expert Consult. - Analytical criteria focus on the medical usefulness of laboratory procedures. - Reference ranges show new approaches for establishing these ranges — and provide the latest information on this topic. - Lab management and costs gives students and chemists the practical information they need to assess costs, allowing them to do their job more efficiently and effectively. - Statistical methods coverage provides you with information critical to the practice of clinical chemistry. - Internationally recognized chapter authors are considered among the best in their field. - Two-color design highlights important features, illustrations, and content to help you find information easier and faster. - NEW! Internationally recognized chapter authors are considered among the best in their field. - NEW! Expert Consult features fully searchable text, quarterly content updates, clinical case studies, animations, podcasts, atlases, biochemical calculations, multiple-choice questions, links to Medline, an image collection, and audio interviews. You will now enjoy an online version making utility of this book even greater. - UPDATED! Expanded Molecular Diagnostics section with 12 chapters that focus on emerging issues and techniques in the rapidly evolving and important field of molecular diagnostics and genetics ensures this text is on the cutting edge and of the most value. - NEW! Comprehensive list of Reference Intervals for children and adults with graphic displays developed using contemporary instrumentation. - NEW! Standard and international units of measure make this text appropriate for any user — anywhere in the world. - NEW! 22 new chapters that focus on applications of mass spectrometry, hematology, transfusion medicine, microbiology, biobanking, biomarker utility in the pharmaceutical industry and more! - NEW! Expert senior editors, Nader Rifai, Carl Wittwer and Rita Horvath, bring fresh perspectives and help ensure the most current information is presented. - UPDATED! Thoroughly revised and peer-reviewed chapters provide you with the most current information possible.
Author : Yu Cao
Publisher : Springer
ISBN 13 : 9811305323
Total Pages : 183 pages
Book Rating : 4.8/5 (113 download)
Download or read book Advances in Membrane Proteins written by Yu Cao and published by Springer. This book was released on 2018-06-28 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book summarizes advances in biochemical and biophysical property of membrane proteins as well as their applications in biomedicine. It is organised into 2 themed parts. This part focuses on mass processing and transportation and provides deep and comprehensive information on specific groups of membrane proteins including channels and transporters, nuclear and cytoplasmic membrane proteins, and membrane embedded enzymes. Their structures, functions, related diseases as well as their roles in drug discovery are fully discussed. Interesting topics cover fundamental concepts, latest progress and critical puzzles yet to be solved. This work will appeal to a wide readership within the membrane structural and functional biology field. Junior scientists could use it to fast track into the field. Advanced scientists will find it helpful to gain a broader view of the field beyond their area of specialization.
Author : Bernard F. Szuchaj
Publisher : The American Oil Chemists Society
ISBN 13 : 9781893997424
Total Pages : 260 pages
Book Rating : 4.9/5 (974 download)
Download or read book Nutrition and Biochemistry of Phospholipids written by Bernard F. Szuchaj and published by The American Oil Chemists Society. This book was released on 2003-05-30 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phospholipids are involved in many intrinsic applications within the cell and are part of all major tissue and concentrated in vital organs that require neuronal interactions. This book contains the program presented at the 8th International Congress of ILPS and includes sessions covering phospholipids metabolism in brain function, choline and galactosphingolipids in health and disease, phospholipids in cardiovascular, liver, and muscle health, and finally, phospholipids in infant nutrition. This book, which contains these current research activities and updates, should stimulate the scientific community to continue working on phospholipids in biochemistry and nutrition.
Author : Isabelle Mus-Veteau
Publisher : Springer
ISBN 13 : 1493906623
Total Pages : 441 pages
Book Rating : 4.4/5 (939 download)
Download or read book Membrane Proteins Production for Structural Analysis written by Isabelle Mus-Veteau and published by Springer. This book was released on 2014-06-20 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book updates the latest development in production, stabilization and structural analysis techniques of membrane proteins. This field has made significant advances since the elucidation of the first 3-D structure of a recombinant G Protein Coupled Receptor (GPCR), rhodopsin, with the structure of several more GPCRs having been solved in the past five years. In fact, the 2012 Nobel Prize in Chemistry was awarded for groundbreaking discoveries on the inner workings of GPCRs. This book is essential reading for all researchers, biochemists and crystallographers working with membrane proteins, who are interested by the structural characterization of their favorite protein and who wish to follow the expression, migration, modifications and recycling of a membrane protein.
