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Outcome Prediction In Cancer
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Book Synopsis Outcome Prediction in Cancer by : Azzam F.G. Taktak
Download or read book Outcome Prediction in Cancer written by Azzam F.G. Taktak and published by Elsevier. This book was released on 2006-11-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is organized into 4 sections, each looking at the question of outcome prediction in cancer from a different angle. The first section describes the clinical problem and some of the predicaments that clinicians face in dealing with cancer. Amongst issues discussed in this section are the TNM staging, accepted methods for survival analysis and competing risks. The second section describes the biological and genetic markers and the rôle of bioinformatics. Understanding of the genetic and environmental basis of cancers will help in identifying high-risk populations and developing effective prevention and early detection strategies. The third section provides technical details of mathematical analysis behind survival prediction backed up by examples from various types of cancers. The fourth section describes a number of machine learning methods which have been applied to decision support in cancer. The final section describes how information is shared within the scientific and medical communities and with the general population using information technology and the World Wide Web. * Applications cover 8 types of cancer including brain, eye, mouth, head and neck, breast, lungs, colon and prostate* Include contributions from authors in 5 different disciplines* Provides a valuable educational tool for medical informatics
Book Synopsis Outcome Prediction in Head and Neck Cancer Patients Using Machine Learning Methods by : David John Dellsperger
Download or read book Outcome Prediction in Head and Neck Cancer Patients Using Machine Learning Methods written by David John Dellsperger and published by . This book was released on 2014 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt: Head and Neck cancers account for approximately 3.2% of the estimated 1,660,290 new cancer cases for the year 2013 and roughly 1.9% of cancer-related deaths in 2013. In this research, machine learning techniques were employed to predict outcome in cancer patients supporting more objective assessment of the treatments, including surgery, radiation therapy, or chemotherapy. Selection of features capable of distinguishing between the possible outcomes was accomplished by using a highly selective cohort of 61 patients with similar treatment and location of the primary tumor. An accuracy of 80.33% (compared to a baseline majority classifier of 60.66%) was achieved utilizing this cohort. Further, it is shown that this limited cohort has the power to provide valuable information on outcome prediction utilizing as few as four features. Feature selection was drawn from both clinical features and quantitative imaging features including the site of cancer, primary tumor volume, and race.
Book Synopsis Prediction of Cancer Patient Outcomes Based on Artificial Intelligence by : Suk Lee
Download or read book Prediction of Cancer Patient Outcomes Based on Artificial Intelligence written by Suk Lee and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge-based outcome predictions are common before radiotherapy. Because there are various treatment techniques, numerous factors must be considered in predicting cancer patient outcomes. As expectations surrounding personalized radiotherapy using complex data have increased, studies on outcome predictions using artificial intelligence have also increased. Representative artificial intelligence techniques used to predict the outcomes of cancer patients in the field of radiation oncology include collecting and processing big data, text mining of clinical literature, and machine learning for implementing prediction models. Here, methods of data preparation and model construction to predict rates of survival and toxicity using artificial intelligence are described.
Book Synopsis Prognostic Factors in Cancer by : Paul Hermanek
Download or read book Prognostic Factors in Cancer written by Paul Hermanek and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: M. K. Gospodarowicz, P. Hermanek, and D. E. Henson Attention to innovations in cancer treatment has tended to eclipse the importance of prognostic assessment. However, the recognition that prognostic factors often have a greater impact on outcome than available therapies and the proliferation of biochemical, molecular, and genetic markers have resulted in renewed interest in this field. The outcome in patients with cancer is determined by a combination of numerous factors. Presently, the most widely recognized are the extent of disease, histologic type of tumor, and treatment. It has been known for some time that additional factors also influence outcome. These include histologic grade, lymphatic or vascular invasion, mitotic index, performance status, symptoms, and most recently genetic and biochemical markers. It is the aim of this volume to compile those prognostic factors that have emerged as important determinants of outcome for tumors at various sites. This compilation represents the first phase of a more extensive process to integrate all prognostic factors in cancer to further enhance the prediction of outcome following treatment. Certain issues surround ing the assessment and reporting of prognostic factors are also considered. Importance of Prognostic Factors Prognostic factors in cancer often have an immense influence on outcome, while treatment often has a much weaker effect. For example, the influence of the presence of lymph node involvement on survival of patients with metastatic breast cancer is much greater than the effect of adjuvant treatment with tamoxifen in the same group of patients [5].
Book Synopsis Cancer Outcome Prediction with Multiform Medical Data Using Deep Learning by : Zhuoyan Shen
Download or read book Cancer Outcome Prediction with Multiform Medical Data Using Deep Learning written by Zhuoyan Shen and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Improving Breast Cancer Outcome Prediction by Combining Multiple Data Sources by : Martinus Hendrikus van Vliet
Download or read book Improving Breast Cancer Outcome Prediction by Combining Multiple Data Sources written by Martinus Hendrikus van Vliet and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Comprehensive Evaluation Composite Gene Features in Cancer Outcome Prediction by : Dezhi Hou
Download or read book Comprehensive Evaluation Composite Gene Features in Cancer Outcome Prediction written by Dezhi Hou and published by . This book was released on 2014 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been extensive studies of classification and prediction of cancer outcome with composite gene features that combine functionally related genes together as a single feature to improve the classification and prediction accuracy. Various algorithms have been proposed for feature extraction, feature activity inference, and feature selection, which all claim to improve the prediction accuracy. However, due to the limited test data sets used by each independent study, inconsistent test procedures, and conflicting results, it is difficult to obtain a comprehensive understanding of the relative performances of these algorithms. In this study, various algorithms for the three steps in using composite features for cancer outcome prediction were implemented and an extensive comparison and evaluation were performed by applying testing to seven microarray data sets covering two cancer types and three different clinical outcomes. Also by integrating algorithms in all three different steps, we aimed to investigate how to get the best cancer prediction by using different combinations of these techniques.
Book Synopsis Cancer Prediction for Industrial IoT 4.0 by : Meenu Gupta
Download or read book Cancer Prediction for Industrial IoT 4.0 written by Meenu Gupta and published by CRC Press. This book was released on 2021-12-31 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Prediction for Industrial IoT 4.0: A Machine Learning Perspective explores various cancers using Artificial Intelligence techniques. It presents the rapid advancement in the existing prediction models by applying Machine Learning techniques. Several applications of Machine Learning in different cancer prediction and treatment options are discussed, including specific ideas, tools and practices most applicable to product/service development and innovation opportunities. The wide variety of topics covered offers readers multiple perspectives on various disciplines. Features • Covers the fundamentals, history, reality and challenges of cancer • Presents concepts and analysis of different cancers in humans • Discusses Machine Learning-based deep learning and data mining concepts in the prediction of cancer • Offers real-world examples of cancer prediction • Reviews strategies and tools used in cancer prediction • Explores the future prospects in cancer prediction and treatment Readers will learn the fundamental concepts and analysis of cancer prediction and treatment, including how to apply emerging technologies such as Machine Learning into practice to tackle challenges in domains/fields of cancer with real-world scenarios. Hands-on chapters contributed by academicians and other professionals from reputed organizations provide and describe frameworks, applications, best practices and case studies on emerging cancer treatment and predictions. This book will be a vital resource to graduate students, data scientists, Machine Learning researchers, medical professionals and analytics managers.
Book Synopsis Radiation Therapy Outcome Prediction Using Statistical Correlations & Deep Learning by : André Diamant Boustead
Download or read book Radiation Therapy Outcome Prediction Using Statistical Correlations & Deep Learning written by André Diamant Boustead and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Prognosis after cancer treatment is a constant concern for physicians, patients and their surrounding friends and family. This is one of the reasons that treatment outcomes prediction is such a critical field of research. The sheer magnitude of data generated within a typical radiation oncology clinic each year facilitates the development and eventual validation of predictive and prognostic models. Furthermore, the technological advances driven by data science have enabled the usage of advanced machine learning techniques which can far exceed the performance of previously used conventional techniques.Most cancer patients follow a standard radiation oncology workflow, which among other things includes medical imaging (CT/PET) and the creation of a radiation therapy treatment plan. As these sorts of data are (in theory) present for every patient, they are ideal variables to input into a predictive model. The goal of this thesis was to investigate these two types of pre-treatment input data (diagnostic imaging and dosimetric data) along with patient characteristics to identify associations and create models capable of predicting a cancer patient's treatment response following radiation therapy. The first objective was to investigate dose-volume metrics as predictors of clinical outcomes in a cohort of 422 non-small cell lung cancer (NSCLC) patients who received stereotactic body radiation therapy (SBRT). A correlation between the dose delivered to the region outside the tumor and the occurrence of distant metastasis was revealed. In particular, patients who received above a certain threshold dose were shown to have significantly reduced distant metastasis recurrence rates compared to the rest of the population. This was first shown on 217 patients all of whom were treated with conventional SBRT treatment modalities. Next, a similar analysis was done on 205 patients who were treated with a robotic arm linear accelerator (CyberKnife). It was found that the CyberKnife cohort had both superior distant control and local control, suggesting that under current prescription practices, CyberKnife, as a delivery device, could be superior for treating NSCLC patients with SBRT. The second objective of this thesis was to investigate the usage of a deep learning framework applied to raw medical imaging data in order to predict the overall prognosis of head & neck cancer patients post-radiation therapy. A de novo architecture was built incorporating CT images, resulting in comparable performance to a state-of-the-art study. Furthermore, our model was shown to recognize imaging features (`radiomics') previously shown to be predictive without being explicitly presented with their definition. The final portion of this work was the development of a multi-modal deep learning framework which incorporated CT & PET images along with clinical information. This was compared to the previous architecture built, showing substantial increase in prediction performance for both overall survival and local recurrence. It was also shown to function in the presence of missing data, a common occurrence within the medical landscape.This work demonstrates that pre-treatment prediction of a cancer patient's post-radiation therapy outcomes is possible by learning correlations and building models from readily available data. Future efforts should be put towards data sharing & data curation to enable the creation and validation of models that eventually can be used in the clinic. Ultimately, predictive models should evolve into generative models whereupon one's treatment could be automatically created with the explicit intention of statistically optimizing that patient's outcomes"--
Book Synopsis From Correlation to Casuality by : Janine Roy
Download or read book From Correlation to Casuality written by Janine Roy and published by . This book was released on 2014 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Comparison of Diverse Genomic Data for Outcome Prediction in Cancer by : Hugo Gómez Rueda
Download or read book Comparison of Diverse Genomic Data for Outcome Prediction in Cancer written by Hugo Gómez Rueda and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Background. In cancer, large-scale technologies such as next-generation sequencing and microarrays have produced a wide number of genomic features such as DNA copy number alterations (CNA), mRNA expression (EXPR), microRNA expression (MIRNA), and DNA somatic mutations (MUT), among others. Several analyses of a specific type of these genomic data have generated many prognostic biomarkers in many cancer types, and more frequently in breast cancer. However, it is uncertain which of these data is more powerful and whether the best data-type is cancer-type dependent. Objective. Characterize the prognostic power of models obtained from different genomic data types in Breast Cancer (BRCA) from public repositories and to compare the performance of these models with those obtained from data of Mexican patients".
Book Synopsis Fundamentals of Clinical Data Science by : Pieter Kubben
Download or read book Fundamentals of Clinical Data Science written by Pieter Kubben and published by Springer. This book was released on 2018-12-21 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare. Fundamentals of Clinical Data Science is an essential resource for healthcare professionals and IT consultants intending to develop and refine their skills in personalized medicine, using solutions based on large datasets from electronic health records or telemonitoring programmes. The book’s promise is “no math, no code”and will explain the topics in a style that is optimized for a healthcare audience.
Book Synopsis In Search of Improved Outcome Prediction of Prostate Cancer - a Biological and Clinical Approach by : Andrew M. Erickson
Download or read book In Search of Improved Outcome Prediction of Prostate Cancer - a Biological and Clinical Approach written by Andrew M. Erickson and published by . This book was released on 2018 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis From Correlation to Casuality by : Janine Roy
Download or read book From Correlation to Casuality written by Janine Roy and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Developing and Implementing the AJCC Prognostic System for Breast Cancer by :
Download or read book Developing and Implementing the AJCC Prognostic System for Breast Cancer written by and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accurate survival prediction is important for women with breast cancer because a woman's expected survival determines her therapy, provides her with vital outcome information, and is one of the main selection criteria for entry into new therapy clinical trials. For almost forty years breast cancer outcome prediction has been based on the TNM staging system. This system it is relatively inaccurate, its accuracy continues to decline as screening increases the early detection of breast cancer, and its accuracy cannot be significantly improved. The objective of this research program is to replace the TNM staging system with a computer-based clinical decision support system that provides the most accurate survival predictions possible for women with breast cancer.
Book Synopsis Head and Neck Tumor Segmentation by : Vincent Andrearczyk
Download or read book Head and Neck Tumor Segmentation written by Vincent Andrearczyk and published by Springer Nature. This book was released on 2021-01-12 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the First 3D Head and Neck Tumor Segmentation in PET/CT Challenge, HECKTOR 2020, which was held in conjunction with the 23rd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2020, in Lima, Peru, in October 2020. The challenge took place virtually due to the COVID-19 pandemic. The 2 full and 8 short papers presented together with an overview paper in this volume were carefully reviewed and selected form numerous submissions. This challenge aims to evaluate and compare the current state-of-the-art methods for automatic head and neck tumor segmentation. In the context of this challenge, a dataset of 204 delineated PET/CT images was made available for training as well as 53 PET/CT images for testing. Various deep learning methods were developed by the participants with excellent results.
Book Synopsis Artificial Intelligence in Medicine by : David Riaño
Download or read book Artificial Intelligence in Medicine written by David Riaño and published by Springer. This book was released on 2019-06-19 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 17th Conference on Artificial Intelligence in Medicine, AIME 2019, held in Poznan, Poland, in June 2019. The 22 revised full and 31 short papers presented were carefully reviewed and selected from 134 submissions. The papers are organized in the following topical sections: deep learning; simulation; knowledge representation; probabilistic models; behavior monitoring; clustering, natural language processing, and decision support; feature selection; image processing; general machine learning; and unsupervised learning.
