Optimization Of Pharmaceutical Rd Programs And Portfolios

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Optimization of Pharmaceutical R&D Programs and Portfolios

Author : Zoran Antonijevic
Publisher : Springer
ISBN 13 : 3319090755
Total Pages : 204 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Optimization of Pharmaceutical R&D Programs and Portfolios by : Zoran Antonijevic

Download or read book Optimization of Pharmaceutical R&D Programs and Portfolios written by Zoran Antonijevic and published by Springer. This book was released on 2014-10-10 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Very little has been published on optimization of pharmaceutical portfolios. Moreover, most of published literature is coming from the commercial side, where probability of technical success (PoS) is treated as fixed, and not as a consequence of development strategy or design. In this book there is a strong focus on impact of study design on PoS and ultimately on the value of portfolio. Design options that are discussed in different chapters are dose-selection strategies, adaptive design and enrichment. Some development strategies that are discussed are indication sequencing, optimal number of programs and optimal decision criteria. This book includes chapters written by authors with very broad backgrounds including financial, clinical, statistical, decision sciences, commercial and regulatory. Many authors have long held executive positions and have been involved with decision making at a product or at a portfolio level. As such, it is expected that this book will attract a very broad audience, including decision makers in pharmaceutical R&D, commercial and financial departments. The intended audience also includes portfolio planners and managers, statisticians, decision scientists and clinicians. Early chapters describe approaches to portfolio optimization from big Pharma and Venture Capital standpoints. They have stronger focus on finances and processes. Later chapters present selected statistical and decision analysis methods for optimizing drug development programs and portfolios. Some methodological chapters are technical; however, with a few exceptions they require a relatively basic knowledge of statistics by a reader.

Bayesian Methods in Pharmaceutical Research

Author : Emmanuel Lesaffre
Publisher : CRC Press
ISBN 13 : 1351718665
Total Pages : 583 pages
Book Rating : 4.3/5 (517 download)

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Book Synopsis Bayesian Methods in Pharmaceutical Research by : Emmanuel Lesaffre

Download or read book Bayesian Methods in Pharmaceutical Research written by Emmanuel Lesaffre and published by CRC Press. This book was released on 2020-04-15 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the early 2000s, there has been increasing interest within the pharmaceutical industry in the application of Bayesian methods at various stages of the research, development, manufacturing, and health economic evaluation of new health care interventions. In 2010, the first Applied Bayesian Biostatistics conference was held, with the primary objective to stimulate the practical implementation of Bayesian statistics, and to promote the added-value for accelerating the discovery and the delivery of new cures to patients. This book is a synthesis of the conferences and debates, providing an overview of Bayesian methods applied to nearly all stages of research and development, from early discovery to portfolio management. It highlights the value associated with sharing a vision with the regulatory authorities, academia, and pharmaceutical industry, with a view to setting up a common strategy for the appropriate use of Bayesian statistics for the benefit of patients. The book covers: Theory, methods, applications, and computing Bayesian biostatistics for clinical innovative designs Adding value with Real World Evidence Opportunities for rare, orphan diseases, and pediatric development Applied Bayesian biostatistics in manufacturing Decision making and Portfolio management Regulatory perspective and public health policies Statisticians and data scientists involved in the research, development, and approval of new cures will be inspired by the possible applications of Bayesian methods covered in the book. The methods, applications, and computational guidance will enable the reader to apply Bayesian methods in their own pharmaceutical research.

Optimization of Pharmaceutical R&d Programs and Portfolios

Author : Zoran Antonijevic
Publisher :
ISBN 13 : 9783319090764
Total Pages : 212 pages
Book Rating : 4.0/5 (97 download)

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Book Synopsis Optimization of Pharmaceutical R&d Programs and Portfolios by : Zoran Antonijevic

Download or read book Optimization of Pharmaceutical R&d Programs and Portfolios written by Zoran Antonijevic and published by . This book was released on 2014-10-31 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Platform Trial Designs in Drug Development

Author : Zoran Antonijevic
Publisher : CRC Press
ISBN 13 : 1351683934
Total Pages : 323 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Platform Trial Designs in Drug Development by : Zoran Antonijevic

Download or read book Platform Trial Designs in Drug Development written by Zoran Antonijevic and published by CRC Press. This book was released on 2018-12-07 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Platform trials test multiple therapies in one indication, one therapy for multiple indications, or both. These novel clinical trial designs can dramatically increase the cost-effectiveness of drug development, leading to life-altering medicines for people suffering from serious illnesses, possibly at lower cost. Currently, the cost of drug development is unsustainable. Furthermore, there are particular problems in rare diseases and small biomarker defined subsets in oncology, where the required sample sizes for traditional clinical trial designs may not be feasible. The editors recruited the key innovators in this domain. The 20 articles discuss trial designs from perspectives as diverse as quantum computing, patient’s rights to information, and international health. The book begins with an overview of platform trials from multiple perspectives. It then describes impacts of platform trials on the pharmaceutical industry’s key stakeholders: patients, regulators, and payers. Next it provides advanced statistical methods that address multiple aspects of platform trials, before concluding with a pharmaceutical executive’s perspective on platform trials. Except for the statistical methods section, only a basic qualitative knowledge of clinical trials is needed to appreciate the important concepts and novel ideas presented.

Quantitative Decisions in Drug Development

Author : Christy Chuang-Stein
Publisher : Springer Nature
ISBN 13 : 3030797317
Total Pages : 354 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Quantitative Decisions in Drug Development by : Christy Chuang-Stein

Download or read book Quantitative Decisions in Drug Development written by Christy Chuang-Stein and published by Springer Nature. This book was released on 2021-09-03 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on important decision points and evidence needed for making decisions at these points during the development of a new drug. It takes a holistic approach towards drug development by incorporating explicitly knowledge learned from the earlier part of the development and available historical information into decisions at later stages. In addition, the book shares lessons learned from several select examples published in the literature since the publication of the first edition. The second edition reiterates the need for making evidence-based Go/No Go decisions in drug development discussed in the first edition. It substantially expands several topics that have seen great advances since the publication of the first edition. The most noticeable additions include three adaptive trials conducted in recent years that offer excellent learning opportunities, the use of historical data in the design and analysis of clinical trials, and extending decision criteria to the cases when the primary endpoint is binary. The examples used to illustrate the additional materials all come from real trials with some post-trial reflections offered by the authors. The book begins with an overview of product development and regulatory approval pathways. It then discusses how to incorporate prior knowledge into study design and decision making at different stages of drug development. Prior knowledge includes information pertaining to historical controls. To assist decision making, the book discusses appropriate metrics and the formulation of go/no-go decisions for progressing a drug candidate to the next development stage. Using the concept of the positive predictive value in the field of diagnostics, the book leads readers to the assessment of the probability that an investigational product is effective given positive study outcomes. Lastly, the book points out common mistakes made by drug developers under the current drug-development paradigm. The book offers useful insights to statisticians, clinicians, regulatory affairs managers and decision-makers in the pharmaceutical industry who have a basic understanding of the drug-development process and the clinical trials conducted to support drug-marketing authorization. The authors provide software codes for select analytical approaches discussed in the book. The book includes enough technical details to allow statisticians to replicate the quantitative illustrations so that they can generate information to facilitate decision-making themselves.

Operations Research Applications in Health Care Management

Author : Cengiz Kahraman
Publisher : Springer
ISBN 13 : 3319654551
Total Pages : 596 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Operations Research Applications in Health Care Management by : Cengiz Kahraman

Download or read book Operations Research Applications in Health Care Management written by Cengiz Kahraman and published by Springer. This book was released on 2017-12-08 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive reference guide to operations research theory and applications in health care systems. It provides readers with all the necessary tools for solving health care problems. The respective chapters, written by prominent researchers, explain a wealth of both basic and advanced concepts of operations research for the management of operating rooms, intensive care units, supply chain, emergency medical service, human resources, lean health care, and procurement. To foster a better understanding, the chapters include relevant examples or case studies. Taken together, they form an excellent reference guide for researchers, lecturers and postgraduate students pursuing research on health care management problems. The book presents a dynamic snapshot on the field that is expected to stimulate new directions and stimulate new ideas and developments.

Mathematical and Statistical Skills in the Biopharmaceutical Industry

Author : Arkadiy Pitman
Publisher : CRC Press
ISBN 13 : 1498769802
Total Pages : 220 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Mathematical and Statistical Skills in the Biopharmaceutical Industry by : Arkadiy Pitman

Download or read book Mathematical and Statistical Skills in the Biopharmaceutical Industry written by Arkadiy Pitman and published by CRC Press. This book was released on 2019-07-15 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mathematical and Statistical Skills in the Biopharmaceutical Industry: A Pragmatic Approach describes a philosophy of efficient problem solving showcased using examples pertinent to the biostatistics function in clinical drug development. It was written to share a quintessence of the authors’ experiences acquired during many years of relevant work in the biopharmaceutical industry. The book will be useful will be useful for biopharmaceutical industry statisticians at different seniority levels and for graduate students who consider a biostatistics-related career in this industry. Features: Describes a system of principles for pragmatic problem solving in clinical drug development. Discusses differences in the work of a biostatistician in small pharma and big pharma. Explains the importance/relevance of statistical programming and data management for biostatistics and necessity for integration on various levels. Describes some useful statistical background that can be capitalized upon in the drug development enterprise. Explains some hot topics and current trends in biostatistics in simple, non-technical terms. Discusses incompleteness of any system of standard operating procedures, rules and regulations. Provides a classification of scoring systems and proposes a novel approach for evaluation of the safety outcome for a completed randomized clinical trial. Presents applications of the problem solving philosophy in a highly problematic transfusion field where many investigational compounds have failed. Discusses realistic planning of open-ended projects.

Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials

Author : John O'Quigley
Publisher : CRC Press
ISBN 13 : 149874611X
Total Pages : 306 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials by : John O'Quigley

Download or read book Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials written by John O'Quigley and published by CRC Press. This book was released on 2017-04-27 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials gives a thorough presentation of state-of-the-art methods for early phase clinical trials. The methodology of clinical trials has advanced greatly over the last 20 years and, arguably, nowhere greater than that of early phase studies. The need to accelerate drug development in a rapidly evolving context of targeted therapies, immunotherapy, combination treatments and complex group structures has provided the stimulus to these advances. Typically, we deal with very small samples, sequential methods that need to be efficient, while, at the same time adhering to ethical principles due to the involvement of human subjects. Statistical inference is difficult since the standard techniques of maximum likelihood do not usually apply as a result of model misspecification and parameter estimates lying on the boundary of the parameter space. Bayesian methods play an important part in overcoming these difficulties, but nonetheless, require special consideration in this particular context. The purpose of this handbook is to provide an expanded summary of the field as it stands and also, through discussion, provide insights into the thinking of leaders in the field as to the potential developments of the years ahead. With this goal in mind we present: An introduction to the field for graduate students and novices A basis for more established researchers from which to build A collection of material for an advanced course in early phase clinical trials A comprehensive guide to available methodology for practicing statisticians on the design and analysis of dose-finding experiments An extensive guide for the multiple comparison and modeling (MCP-Mod) dose-finding approach, adaptive two-stage designs for dose finding, as well as dose–time–response models and multiple testing in the context of confirmatory dose-finding studies. John O’Quigley is a professor of mathematics and research director at the French National Institute for Health and Medical Research based at the Faculty of Mathematics, University Pierre and Marie Curie in Paris, France. He is author of Proportional Hazards Regression and has published extensively in the field of dose finding. Alexia Iasonos is an associate attending biostatistician at the Memorial Sloan Kettering Cancer Center in New York. She has over one hundred publications in the leading statistical and clinical journals on the methodology and design of early phase clinical trials. Dr. Iasonos has wide experience in the actual implementation of model based early phase trials and has given courses in scientific meetings internationally. Björn Bornkamp is a statistical methodologist at Novartis in Basel, Switzerland, researching and implementing dose-finding designs in Phase II clinical trials. He is one of the co-developers of the MCP-Mod methodology for dose finding and main author of the DoseFinding R package. He has published numerous papers on dose finding, nonlinear models and Bayesian statistics, and in 2013 won the Royal Statistical Society award for statistical excellence in the pharmaceutical industry.

Optimizing Corporate Portfolio Management

Author : Anand Sanwal
Publisher : John Wiley & Sons
ISBN 13 : 0470149604
Total Pages : 220 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Optimizing Corporate Portfolio Management by : Anand Sanwal

Download or read book Optimizing Corporate Portfolio Management written by Anand Sanwal and published by John Wiley & Sons. This book was released on 2007-07-30 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: If where an organization allocates its resources determines its strategy, why is it that so few companies actively manage the resource allocation process? "Optimizing Corporate Portfolio Management: Aligning Investment Proposals with Organizational Strategy" goes beyond platitudes about why you should use corporate portfolio management (CPM) by offering a practical methodology to bring this powerful discipline to your organization. "Optimizing Corporate Portfolio Management" takes an expansive view of where CPM can be utilized by demonstrating that it can be used across any business line, product group or functional area, e.g., IT, R&D, innovation, marketing, salesforce, capital expenditure, etc. CPM is appropriate anywhere discretionary investments are being selected and executed. As a result, other terms used to describe portfolio management such as IT portfolio management, enterprise portfolio management, and project portfolio management are all merely subsets or slices of CPM. The book is written by Anand Sanwal, an expert on CPM, who has led American Express' CPM discipline (referred to as American Express Investment Optimization). American Express' CPM efforts are widely recognized as the most extensive, substantial and progressive deployment of CPM across any organization. Sanwal avoids academic theories and consultant jargon to ultimately deliver pragmatic and proven recommendations on how to make CPM a reality. The book features a foreword by Gary Crittenden, former CFO and EVP of American Express, and several case studies from leading financial services, technology, and government organizations utilizing CPM. Additionally, the book has received significant praise from thought leaders at Google, HP, American Express, The CFO Executive Board, Gartner, Accenture Marketing Sciences, The Wharton School of Business and many others.

Enterprise Project Portfolio Management

Author : Dr. Richard Bayney
Publisher : J. Ross Publishing
ISBN 13 : 1604270608
Total Pages : 305 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Enterprise Project Portfolio Management by : Dr. Richard Bayney

Download or read book Enterprise Project Portfolio Management written by Dr. Richard Bayney and published by J. Ross Publishing. This book was released on 2012-08-11 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique guide and professional reference presents a structured framework for practitioners and students of project, program, and portfolio management to enhance their strategic and analytic capabilities in the evolving discipline of project portfolio management (PPM). It provides a practical, step-by-step approach to building competencies in categorizing, evaluating, optimizing, prioritizing, and managing an IT, pharmaceutical, biotech or other complex R&D-oriented portfolio of investments.

Handbook on Project Management and Scheduling Vol. 2

Author : Christoph Schwindt
Publisher : Springer
ISBN 13 : 3319059157
Total Pages : 768 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Handbook on Project Management and Scheduling Vol. 2 by : Christoph Schwindt

Download or read book Handbook on Project Management and Scheduling Vol. 2 written by Christoph Schwindt and published by Springer. This book was released on 2015-01-13 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the increasing importance of product differentiation and collapsing product life cycles, a growing number of value-adding activities in the industry and service sector are organized in projects. Projects come in many forms, often taking considerable time and consuming a large amount of resources. The management and scheduling of projects represents a challenging task and project performance may have a considerable impact on an organization's competitiveness. This handbook presents state-of-the-art approaches to project management and scheduling. More than sixty contributions written by leading experts in the field provide an authoritative survey of recent developments. The book serves as a comprehensive reference, both, for researchers and project management professionals. The handbook consists of two volumes. Volume 1 is devoted to single-modal and multi-modal project scheduling. Volume 2 presents multi-project problems, project scheduling under uncertainty and vagueness, managerial approaches and a separate part on applications, case studies and information systems.

29th European Symposium on Computer Aided Chemical Engineering

Author : Anton A. Kiss
Publisher : Elsevier
ISBN 13 : 0128186356
Total Pages : 1886 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis 29th European Symposium on Computer Aided Chemical Engineering by : Anton A. Kiss

Download or read book 29th European Symposium on Computer Aided Chemical Engineering written by Anton A. Kiss and published by Elsevier. This book was released on 2019-06-28 with total page 1886 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 29th European Symposium on Computer Aided Process Engineering, contains the papers presented at the 29th European Symposium of Computer Aided Process Engineering (ESCAPE) event held in Eindhoven, The Netherlands, from June 16-19, 2019. It is a valuable resource for chemical engineers, chemical process engineers, researchers in industry and academia, students, and consultants for chemical industries. - Presents findings and discussions from the 29th European Symposium of Computer Aided Process Engineering (ESCAPE) event

Portfolio Decision Analysis

Author : Ahti Salo
Publisher : Springer Science & Business Media
ISBN 13 : 1441999434
Total Pages : 410 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Portfolio Decision Analysis by : Ahti Salo

Download or read book Portfolio Decision Analysis written by Ahti Salo and published by Springer Science & Business Media. This book was released on 2011-08-12 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Portfolio Decision Analysis: Improved Methods for Resource Allocation provides an extensive, up-to-date coverage of decision analytic methods which help firms and public organizations allocate resources to 'lumpy' investment opportunities while explicitly recognizing relevant financial and non-financial evaluation criteria and the presence of alternative investment opportunities. In particular, it discusses the evolution of these methods, presents new methodological advances and illustrates their use across several application domains. The book offers a many-faceted treatment of portfolio decision analysis (PDA). Among other things, it (i) synthesizes the state-of-play in PDA, (ii) describes novel methodologies, (iii) fosters the deployment of these methodologies, and (iv) contributes to the strengthening of research on PDA. Portfolio problems are widely regarded as the single most important application context of decision analysis, and, with its extensive and unique coverage of these problems, this book is a much-needed addition to the literature. The book also presents innovative treatments of new methodological approaches and their uses in applications. The intended audience consists of practitioners and researchers who wish to gain a good understanding of portfolio decision analysis and insights into how PDA methods can be leveraged in different application contexts. The book can also be employed in courses at the post-graduate level.

Innovation and Marketing in the Pharmaceutical Industry

Author : Min Ding
Publisher : Springer Science & Business Media
ISBN 13 : 1461478014
Total Pages : 763 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Innovation and Marketing in the Pharmaceutical Industry by : Min Ding

Download or read book Innovation and Marketing in the Pharmaceutical Industry written by Min Ding and published by Springer Science & Business Media. This book was released on 2013-10-31 with total page 763 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pharmaceutical industry is one of today’s most dynamic and complex industries, involving commercialization of cutting-edge scientific research, a huge web of stakeholders (from investors to doctors), multi-stage supply chains, fierce competition in the race to market, and a challenging regulatory environment. The stakes are high, with each new product raising the prospect of spectacular success—or failure. Worldwide revenues are approaching $1 trillion; in the U.S. alone, marketing for pharmaceutical products is, itself, a multi-billion dollar industry. In this volume, the editors showcase contributions from experts around the world to capture the state of the art in research, analysis, and practice, and covering the full spectrum of topics relating to innovation and marketing, including R&D, promotion, pricing, branding, competitive strategy, and portfolio management. Chapters include such features as: · An extensive literature review, including coverage of research from fields other than marketing · an overview of how practitioners have addressed the topic · introduction of relevant analytical tools, such as statistics and ethnographic studies · suggestions for further research by scholars and students The result is a comprehensive, state-of-the-art resource that will be of interest to researchers, policymakers, and practitioners, alike.

Portfolio, Program, and Project Management in the Pharmaceutical and Biotechnology Industries

Author : Pete Harpum
Publisher : John Wiley & Sons
ISBN 13 : 0470888962
Total Pages : 352 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Portfolio, Program, and Project Management in the Pharmaceutical and Biotechnology Industries by : Pete Harpum

Download or read book Portfolio, Program, and Project Management in the Pharmaceutical and Biotechnology Industries written by Pete Harpum and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the way that pharmaceutical projects and programs are currently managed, and offers views from many highly experienced practitioners from within the industry on future directions for drug program management. The book integrates portfolio, program, and project management processes as fundamental for effective and efficient drug product development. Contributing expert authors provide their view of how the projectization approach can be taken forward by the drug industry over the coming years.

Portfolio Optimization and Performance Analysis

Author : Jean-Luc Prigent
Publisher : CRC Press
ISBN 13 : 142001093X
Total Pages : 451 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Portfolio Optimization and Performance Analysis by : Jean-Luc Prigent

Download or read book Portfolio Optimization and Performance Analysis written by Jean-Luc Prigent and published by CRC Press. This book was released on 2007-05-07 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: In answer to the intense development of new financial products and the increasing complexity of portfolio management theory, Portfolio Optimization and Performance Analysis offers a solid grounding in modern portfolio theory. The book presents both standard and novel results on the axiomatics of the individual choice in an uncertain framework, cont

Women in Industrial and Systems Engineering

Author : Alice E. Smith
Publisher : Springer Nature
ISBN 13 : 3030118665
Total Pages : 599 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Women in Industrial and Systems Engineering by : Alice E. Smith

Download or read book Women in Industrial and Systems Engineering written by Alice E. Smith and published by Springer Nature. This book was released on 2019-09-13 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a diversity of innovative and impactful research in the field of industrial and systems engineering (ISE) led by women investigators. After a Foreword by Margaret L. Brandeau, an eminent woman scholar in the field, the book is divided into the following sections: Analytics, Education, Health, Logistics, and Production. Also included is a comprehensive biography on the historic luminary of industrial engineering, Lillian Moeller Gilbreth. Each chapter presents an opportunity to learn about the impact of the field of industrial and systems engineering and women’s important contributions to it. Topics range from big data analysis, to improving cancer treatment, to sustainability in product design, to teamwork in engineering education. A total of 24 topics touch on many of the challenges facing the world today and these solutions by women researchers are valuable for their technical innovation and excellence and their non-traditional perspective. Found within each author’s biography are their motivations for entering the field and how they view their contributions, providing inspiration and guidance to those entering industrial engineering.