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Optimal Design For Nonlinear Response Models
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Book Synopsis Optimal Design for Nonlinear Response Models by : Valerii V. Fedorov
Download or read book Optimal Design for Nonlinear Response Models written by Valerii V. Fedorov and published by CRC Press. This book was released on 2013-07-15 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors' many years of experience in academia and the pharmaceutical industry. While the focus is on nonlinear models, the book begins with an explanation of
Book Synopsis Optimal Design for Nonlinear Response Models by : Valerii V. Fedorov
Download or read book Optimal Design for Nonlinear Response Models written by Valerii V. Fedorov and published by CRC Press. This book was released on 2013-07-15 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors’ many years of experience in academia and the pharmaceutical industry. While the focus is on nonlinear models, the book begins with an explanation of the key ideas, using linear models as examples. Applying the linearization in the parameter space, it then covers nonlinear models and locally optimal designs as well as minimax, optimal on average, and Bayesian designs. The authors also discuss adaptive designs, focusing on procedures with non-informative stopping. The common goals of experimental design—such as reducing costs, supporting efficient decision making, and gaining maximum information under various constraints—are often the same across diverse applied areas. Ethical and regulatory aspects play a much more prominent role in biological, medical, and pharmaceutical research. The authors address all of these issues through many examples in the book.
Book Synopsis Optimal Design of Experiments by : Friedrich Pukelsheim
Download or read book Optimal Design of Experiments written by Friedrich Pukelsheim and published by SIAM. This book was released on 2006-04-01 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimal Design of Experiments offers a rare blend of linear algebra, convex analysis, and statistics. The optimal design for statistical experiments is first formulated as a concave matrix optimization problem. Using tools from convex analysis, the problem is solved generally for a wide class of optimality criteria such as D-, A-, or E-optimality. The book then offers a complementary approach that calls for the study of the symmetry properties of the design problem, exploiting such notions as matrix majorization and the Kiefer matrix ordering. The results are illustrated with optimal designs for polynomial fit models, Bayes designs, balanced incomplete block designs, exchangeable designs on the cube, rotatable designs on the sphere, and many other examples.
Book Synopsis Optimal Design of Experiments by : Peter Goos
Download or read book Optimal Design of Experiments written by Peter Goos and published by John Wiley & Sons. This book was released on 2011-06-28 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is an engaging and informative book on the modern practice of experimental design. The authors' writing style is entertaining, the consulting dialogs are extremely enjoyable, and the technical material is presented brilliantly but not overwhelmingly. The book is a joy to read. Everyone who practices or teaches DOE should read this book." - Douglas C. Montgomery, Regents Professor, Department of Industrial Engineering, Arizona State University "It's been said: 'Design for the experiment, don't experiment for the design.' This book ably demonstrates this notion by showing how tailor-made, optimal designs can be effectively employed to meet a client's actual needs. It should be required reading for anyone interested in using the design of experiments in industrial settings." —Christopher J. Nachtsheim, Frank A Donaldson Chair in Operations Management, Carlson School of Management, University of Minnesota This book demonstrates the utility of the computer-aided optimal design approach using real industrial examples. These examples address questions such as the following: How can I do screening inexpensively if I have dozens of factors to investigate? What can I do if I have day-to-day variability and I can only perform 3 runs a day? How can I do RSM cost effectively if I have categorical factors? How can I design and analyze experiments when there is a factor that can only be changed a few times over the study? How can I include both ingredients in a mixture and processing factors in the same study? How can I design an experiment if there are many factor combinations that are impossible to run? How can I make sure that a time trend due to warming up of equipment does not affect the conclusions from a study? How can I take into account batch information in when designing experiments involving multiple batches? How can I add runs to a botched experiment to resolve ambiguities? While answering these questions the book also shows how to evaluate and compare designs. This allows researchers to make sensible trade-offs between the cost of experimentation and the amount of information they obtain.
Book Synopsis Non-Linear Theory of Elasticity and Optimal Design by : L.W. Ratner
Download or read book Non-Linear Theory of Elasticity and Optimal Design written by L.W. Ratner and published by Elsevier. This book was released on 2003-11-12 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to select an optimal structure among possible similar structures, one needs to compare the elastic behavior of the structures. A new criterion that describes elastic behavior is the rate of change of deformation. Using this criterion, the safe dimensions of a structure that are required by the stress distributed in a structure can be calculated. The new non-linear theory of elasticity allows one to determine the actual individual limit of elasticity/failure of a structure using a simple non-destructive method of measurement of deformation on the model of a structure while presently it can be done only with a destructive test for each structure. For building and explaining the theory, a new logical structure was introduced as the basis of the theory. One of the important physical implications of this logic is that it describes mathematically the universal domain of the possible stable physical relations.
Book Synopsis Fitting Models to Biological Data Using Linear and Nonlinear Regression by : Harvey Motulsky
Download or read book Fitting Models to Biological Data Using Linear and Nonlinear Regression written by Harvey Motulsky and published by Oxford University Press. This book was released on 2004-05-27 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most biologists use nonlinear regression more than any other statistical technique, but there are very few places to learn about curve-fitting. This book, by the author of the very successful Intuitive Biostatistics, addresses this relatively focused need of an extraordinarily broad range of scientists.
Book Synopsis Response Surface Methodology by : Raymond H. Myers
Download or read book Response Surface Methodology written by Raymond H. Myers and published by John Wiley & Sons. This book was released on 2016-01-04 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the Third Edition: “This new third edition has been substantially rewritten and updated with new topics and material, new examples and exercises, and to more fully illustrate modern applications of RSM.” - Zentralblatt Math Featuring a substantial revision, the Fourth Edition of Response Surface Methodology: Process and Product Optimization Using Designed Experiments presents updated coverage on the underlying theory and applications of response surface methodology (RSM). Providing the assumptions and conditions necessary to successfully apply RSM in modern applications, the new edition covers classical and modern response surface designs in order to present a clear connection between the designs and analyses in RSM. With multiple revised sections with new topics and expanded coverage, Response Surface Methodology: Process and Product Optimization Using Designed Experiments, Fourth Edition includes: Many updates on topics such as optimal designs, optimization techniques, robust parameter design, methods for design evaluation, computer-generated designs, multiple response optimization, and non-normal responses Additional coverage on topics such as experiments with computer models, definitive screening designs, and data measured with error Expanded integration of examples and experiments, which present up-to-date software applications, such as JMP®, SAS, and Design-Expert®, throughout An extensive references section to help readers stay up-to-date with leading research in the field of RSM An ideal textbook for upper-undergraduate and graduate-level courses in statistics, engineering, and chemical/physical sciences, Response Surface Methodology: Process and Product Optimization Using Designed Experiments, Fourth Edition is also a useful reference for applied statisticians and engineers in disciplines such as quality, process, and chemistry.
Book Synopsis Nonlinear Regression Modeling for Engineering Applications by : R. Russell Rhinehart
Download or read book Nonlinear Regression Modeling for Engineering Applications written by R. Russell Rhinehart and published by John Wiley & Sons. This book was released on 2016-09-26 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since mathematical models express our understanding of how nature behaves, we use them to validate our understanding of the fundamentals about systems (which could be processes, equipment, procedures, devices, or products). Also, when validated, the model is useful for engineering applications related to diagnosis, design, and optimization. First, we postulate a mechanism, then derive a model grounded in that mechanistic understanding. If the model does not fit the data, our understanding of the mechanism was wrong or incomplete. Patterns in the residuals can guide model improvement. Alternately, when the model fits the data, our understanding is sufficient and confidently functional for engineering applications. This book details methods of nonlinear regression, computational algorithms,model validation, interpretation of residuals, and useful experimental design. The focus is on practical applications, with relevant methods supported by fundamental analysis. This book will assist either the academic or industrial practitioner to properly classify the system, choose between the various available modeling options and regression objectives, design experiments to obtain data capturing critical system behaviors, fit the model parameters based on that data, and statistically characterize the resulting model. The author has used the material in the undergraduate unit operations lab course and in advanced control applications.
Download or read book Statistica Sinica written by and published by . This book was released on 1998 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Structural and Multidisciplinary Optimization by : Axel Schumacher
Download or read book Advances in Structural and Multidisciplinary Optimization written by Axel Schumacher and published by Springer. This book was released on 2017-12-04 with total page 2101 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume includes papers from the WSCMO conference in Braunschweig 2017 presenting research of all aspects of the optimal design of structures as well as multidisciplinary design optimization where the involved disciplines deal with the analysis of solids, fluids or other field problems. Also presented are practical applications of optimization methods and the corresponding software development in all branches of technology.
Book Synopsis Theory Of Optimal Experiments by : V.V. Fedorov
Download or read book Theory Of Optimal Experiments written by V.V. Fedorov and published by Elsevier. This book was released on 2013-04-20 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theory Of Optimal Experiments
Book Synopsis Explanatory Item Response Models by : Paul de Boeck
Download or read book Explanatory Item Response Models written by Paul de Boeck and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume gives a new and integrated introduction to item response models (predominantly used in measurement applications in psychology, education, and other social science areas) from the viewpoint of the statistical theory of generalized linear and nonlinear mixed models. It also includes a chapter on the statistical background and one on useful software.
Book Synopsis Nonlinear Optimization by : William P. Fox
Download or read book Nonlinear Optimization written by William P. Fox and published by CRC Press. This book was released on 2020-12-08 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimization is the act of obtaining the "best" result under given circumstances. In design, construction, and maintenance of any engineering system, engineers must make technological and managerial decisions to minimize either the effort or cost required or to maximize benefits. There is no single method available for solving all optimization problems efficiently. Several optimization methods have been developed for different types of problems. The optimum-seeking methods are mathematical programming techniques (specifically, nonlinear programming techniques). Nonlinear Optimization: Models and Applications presents the concepts in several ways to foster understanding. Geometric interpretation: is used to re-enforce the concepts and to foster understanding of the mathematical procedures. The student sees that many problems can be analyzed, and approximate solutions found before analytical solutions techniques are applied. Numerical approximations: early on, the student is exposed to numerical techniques. These numerical procedures are algorithmic and iterative. Worksheets are provided in Excel, MATLAB®, and MapleTM to facilitate the procedure. Algorithms: all algorithms are provided with a step-by-step format. Examples follow the summary to illustrate its use and application. Nonlinear Optimization: Models and Applications: Emphasizes process and interpretation throughout Presents a general classification of optimization problems Addresses situations that lead to models illustrating many types of optimization problems Emphasizes model formulations Addresses a special class of problems that can be solved using only elementary calculus Emphasizes model solution and model sensitivity analysis About the author: William P. Fox is an emeritus professor in the Department of Defense Analysis at the Naval Postgraduate School. He received his Ph.D. at Clemson University and has taught at the United States Military Academy and at Francis Marion University where he was the chair of mathematics. He has written many publications, including over 20 books and over 150 journal articles. Currently, he is an adjunct professor in the Department of Mathematics at the College of William and Mary. He is the emeritus director of both the High School Mathematical Contest in Modeling and the Mathematical Contest in Modeling.
Book Synopsis Applied Linear Statistical Models by : Michael H. Kutner
Download or read book Applied Linear Statistical Models written by Michael H. Kutner and published by McGraw-Hill/Irwin. This book was released on 2005 with total page 1396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Linear regression with one predictor variable; Inferences in regression and correlation analysis; Diagnosticis and remedial measures; Simultaneous inferences and other topics in regression analysis; Matrix approach to simple linear regression analysis; Multiple linear regression; Nonlinear regression; Design and analysis of single-factor studies; Multi-factor studies; Specialized study designs.
Book Synopsis Nonlinear System Identification by : Stephen A. Billings
Download or read book Nonlinear System Identification written by Stephen A. Billings and published by John Wiley & Sons. This book was released on 2013-07-29 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonlinear System Identification: NARMAX Methods in the Time, Frequency, and Spatio-Temporal Domains describes a comprehensive framework for the identification and analysis of nonlinear dynamic systems in the time, frequency, and spatio-temporal domains. This book is written with an emphasis on making the algorithms accessible so that they can be applied and used in practice. Includes coverage of: The NARMAX (nonlinear autoregressive moving average with exogenous inputs) model The orthogonal least squares algorithm that allows models to be built term by term where the error reduction ratio reveals the percentage contribution of each model term Statistical and qualitative model validation methods that can be applied to any model class Generalised frequency response functions which provide significant insight into nonlinear behaviours A completely new class of filters that can move, split, spread, and focus energy The response spectrum map and the study of sub harmonic and severely nonlinear systems Algorithms that can track rapid time variation in both linear and nonlinear systems The important class of spatio-temporal systems that evolve over both space and time Many case study examples from modelling space weather, through identification of a model of the visual processing system of fruit flies, to tracking causality in EEG data are all included to demonstrate how easily the methods can be applied in practice and to show the insight that the algorithms reveal even for complex systems NARMAX algorithms provide a fundamentally different approach to nonlinear system identification and signal processing for nonlinear systems. NARMAX methods provide models that are transparent, which can easily be analysed, and which can be used to solve real problems. This book is intended for graduates, postgraduates and researchers in the sciences and engineering, and also for users from other fields who have collected data and who wish to identify models to help to understand the dynamics of their systems.
Book Synopsis Discrete-Time Inverse Optimal Control for Nonlinear Systems by : Edgar N. Sanchez
Download or read book Discrete-Time Inverse Optimal Control for Nonlinear Systems written by Edgar N. Sanchez and published by CRC Press. This book was released on 2017-12-19 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discrete-Time Inverse Optimal Control for Nonlinear Systems proposes a novel inverse optimal control scheme for stabilization and trajectory tracking of discrete-time nonlinear systems. This avoids the need to solve the associated Hamilton-Jacobi-Bellman equation and minimizes a cost functional, resulting in a more efficient controller. Design More Efficient Controllers for Stabilization and Trajectory Tracking of Discrete-Time Nonlinear Systems The book presents two approaches for controller synthesis: the first based on passivity theory and the second on a control Lyapunov function (CLF). The synthesized discrete-time optimal controller can be directly implemented in real-time systems. The book also proposes the use of recurrent neural networks to model discrete-time nonlinear systems. Combined with the inverse optimal control approach, such models constitute a powerful tool to deal with uncertainties such as unmodeled dynamics and disturbances. Learn from Simulations and an In-Depth Case Study The authors include a variety of simulations to illustrate the effectiveness of the synthesized controllers for stabilization and trajectory tracking of discrete-time nonlinear systems. An in-depth case study applies the control schemes to glycemic control in patients with type 1 diabetes mellitus, to calculate the adequate insulin delivery rate required to prevent hyperglycemia and hypoglycemia levels. The discrete-time optimal and robust control techniques proposed can be used in a range of industrial applications, from aerospace and energy to biomedical and electromechanical systems. Highlighting optimal and efficient control algorithms, this is a valuable resource for researchers, engineers, and students working in nonlinear system control.
Book Synopsis Moments, Positive Polynomials and Their Applications by : Jean-Bernard Lasserre
Download or read book Moments, Positive Polynomials and Their Applications written by Jean-Bernard Lasserre and published by World Scientific. This book was released on 2010 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. The generalized moment problem. 1.1. Formulations. 1.2. Duality theory. 1.3. Computational complexity. 1.4. Summary. 1.5. Exercises. 1.6. Notes and sources -- 2. Positive polynomials. 2.1. Sum of squares representations and semi-definite optimization. 2.2. Nonnegative versus s.o.s. polynomials. 2.3. Representation theorems : univariate case. 2.4. Representation theorems : mutivariate case. 2.5. Polynomials positive on a compact basic semi-algebraic set. 2.6. Polynomials nonnegative on real varieties. 2.7. Representations with sparsity properties. 2.8. Representation of convex polynomials. 2.9. Summary. 2.10. Exercises. 2.11. Notes and sources -- 3. Moments. 3.1. The one-dimensional moment problem. 3.2. The multi-dimensional moment problem. 3.3. The K-moment problem. 3.4. Moment conditions for bounded density. 3.5. Summary. 3.6. Exercises. 3.7. Notes and sources -- 4. Algorithms for moment problems. 4.1. The overall approach. 4.2. Semidefinite relaxations. 4.3. Extraction of solutions. 4.4. Linear relaxations. 4.5. Extensions. 4.6. Exploiting sparsity. 4.7. Summary. 4.8. Exercises. 4.9. Notes and sources. 4.10. Proofs -- 5. Global optimization over polynomials. 5.1. The primal and dual perspectives. 5.2. Unconstrained polynomial optimization. 5.3. Constrained polynomial optimization : semidefinite relaxations. 5.4. Linear programming relaxations. 5.5. Global optimality conditions. 5.6. Convex polynomial programs. 5.7. Discrete optimization. 5.8. Global minimization of a rational function. 5.9. Exploiting symmetry. 5.10. Summary. 5.11. Exercises. 5.12. Notes and sources -- 6. Systems of polynomial equations. 6.1. Introduction. 6.2. Finding a real solution to systems of polynomial equations. 6.3. Finding all complex and/or all real solutions : a unified treatment. 6.4. Summary. 6.5. Exercises. 6.6. Notes and sources -- 7. Applications in probability. 7.1. Upper bounds on measures with moment conditions. 7.2. Measuring basic semi-algebraic sets. 7.3. Measures with given marginals. 7.4. Summary. 7.5. Exercises. 7.6. Notes and sources -- 8. Markov chains applications. 8.1. Bounds on invariant measures. 8.2. Evaluation of ergodic criteria. 8.3. Summary. 8.4. Exercises. 8.5. Notes and sources -- 9. Application in mathematical finance. 9.1. Option pricing with moment information. 9.2. Option pricing with a dynamic model. 9.3. Summary. 9.4. Notes and sources -- 10. Application in control. 10.1. Introduction. 10.2. Weak formulation of optimal control problems. 10.3. Semidefinite relaxations for the OCP. 10.4. Summary. 10.5. Notes and sources -- 11. Convex envelope and representation of convex sets. 11.1. The convex envelope of a rational function. 11.2. Semidefinite representation of convex sets. 11.3. Algebraic certificates of convexity. 11.4. Summary. 11.5. Exercises. 11.6. Notes and sources -- 12. Multivariate integration 12.1. Integration of a rational function. 12.2. Integration of exponentials of polynomials. 12.3. Maximum entropy estimation. 12.4. Summary. 12.5. Exercises. 12.6. Notes and sources -- 13. Min-max problems and Nash equilibria. 13.1. Robust polynomial optimization. 13.2. Minimizing the sup of finitely many rational cunctions. 13.3. Application to Nash equilibria. 13.4. Exercises. 13.5. Notes and sources -- 14. Bounds on linear PDE. 14.1. Linear partial differential equations. 14.2. Notes and sources