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Opioid Hormones
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Download or read book Opioid Hormones written by Gerald Litwack and published by Academic Press. This book was released on 2019-08-13 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vassopressin, Volume 111, the latest release in the Vitamins and Hormones series, first published in 1943, covers the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms, with this release focusing on topics relating to hepcidin, bacterial infection, and iron overload, the role of heparan sulfates in hepcidin regulation, hepcidin CDNA and human gene sex hormones, growth factors and hepcidin, HFE gene polymorphisms and hereditary hemochromatosis, hepcidin and il-1beta, hepcidin-ferroportin axis, cardiomyocyte hepcidin, adipocyte iron, leptin and hepcidin, regulators of hepcidin expression, and much more. Focuses on the newest aspects of hormone action in connection with diseases Lays the groundwork for the focus of new chemotherapeutic targets Represents reviews on emerging areas in hormone action, cellular regulators and signaling pathways
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309459575 Total Pages :483 pages Book Rating :4.3/5 (94 download)
Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Download or read book Opioid Peptides written by Rao S. Rapaka and published by . This book was released on 1986 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This monograph is based upon papers and discussion from the technical review on the medicinal chemistry and molecular pharmacology of opioid peptides and the opiates which took place on September 4-6, 1984, at Bethesda, Maryland. The meeting was sponsored by the Office of Science and the Division of Preclinical Research, National Institute on Drug Abuse. The papers on molecular pharmacology, biosynthesis, and analysis of opioid peptides are presented in this volume. Those on the medical chemistry of opioid peptides appear in NIDA Research Monograph 69" [entitled Opioid peptides : medicinal chemistry] -- page iv.
Book Synopsis Multiple Sclerosis by : Ian S. Zagon
Download or read book Multiple Sclerosis written by Ian S. Zagon and published by . This book was released on 2017 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nociceptin Opioid written by and published by Academic Press. This book was released on 2015-02-06 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on nociceptin opioid. Expertise of the contributors Coverage of a vast array of subjects In depth current information at the molecular to the clinical levels Three-dimensional structures in color Elaborate signaling pathways
Book Synopsis Cholecystokinin and Opioid Receptors by : Clair Bruce Eckersell
Download or read book Cholecystokinin and Opioid Receptors written by Clair Bruce Eckersell and published by . This book was released on 1998 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neurobiology of Opioids by : Osborne F.X. Almeida
Download or read book Neurobiology of Opioids written by Osborne F.X. Almeida and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dedicated to Professor Albert Herz, a leading investigator in opioid research, this book provides comprehensive information on the biology of exogenous and endogenous opioids. Contributions by experts in the field discuss recent advances and provide systematic, up-to-date reviews of the physiology and pharmacology of opioids, as well as on the cellular and molecular mechanisms underlying opioid actions. In recognition of the diverse methodologies now available to researchers, each chapter details the approaches used to address a specific issue and provides an in-depth analysis of the data obtained by these various experimental approaches. The clinical relevance of recent findings, as well as future directions, in opioid research are also discussed. This volume thus represents a timely and invaluable sourcebook for researchers, clinicians, and students interested in opioids and peptidergic systems.
Book Synopsis Advanced Therapeutics in Pain Medicine by : Sahar Swidan
Download or read book Advanced Therapeutics in Pain Medicine written by Sahar Swidan and published by CRC Press. This book was released on 2020-12-17 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic pain places a tremendous burden on both the patient and the healthcare system. The use of opioids to address pain has resulted in negative impacts. As practitioners work to undo the current opioid crisis, options to manage pain need a new approach. Advanced Therapeutics in Pain Medicine offers pioneering approaches to this intransigent problem providing a functional medicine approach toward treating pain. This book is dedicated to the advancement of non-opioid therapeutic options that offer real progress in reaching a future of better pain management. With an emphasis on pathophysiology, chapters review various types of pain and propose comprehensive treatment plans. These include manual therapies, novel pharmacologic and plant-based approaches, hormonal effects on pain pathways, as well as psychological and lifestyle interventions. Features · Written by a multi-discplinary team, the book provides clinicians with multiple non-opioid treatment considerations. · Enables practitioners to shift from a “one size fits all’ treatment approach toward individualized patient care. · Includes case studies to help educate the provider on how to implement treatment plans in practice. Written by a team of physicians, pharmacists, psychologists and researchers, this important book offers a much needed step forward in optimizing pain care and benefits practitioners who care for patients experiencing chronic pain.
Book Synopsis Opioid Receptors by : Santi M. Spampinato
Download or read book Opioid Receptors written by Santi M. Spampinato and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Function of the [mu]-opioid Receptor in Gonadotropin-releasing Hormone Neurons by : Laura Cui
Download or read book Function of the [mu]-opioid Receptor in Gonadotropin-releasing Hormone Neurons written by Laura Cui and published by . This book was released on 2019 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the emergence of the opioid epidemic, it is becoming increasingly important to understand the various off target effects caused by opioids. One such side effect is a decrease in sex steroid production, a phenomenon called opioid-induced hypogonadism (OIH). OIH can occur in both males and females and is thought to develop through opioid suppression of the hypothalamic-pituitary-gonadal (HPG) axis. Previous studies have shown the hypothalamus to be the main target of opioid action; however, the exact mechanism is still unknown. This paper aims to illustrate the function of the [mu]-opioid receptor ([mu]OR) in gonadotropin-releasing hormone neurons of the hypothalamus and how that may relate to the development of OIH. We have found that immortalized GnRH neurons (GT1-7 cells) express function [mu]OR, allowing us to use GT1-7 cells as the ideal in vitro model to test for cellular changes in GnRH neurons after opioid exposure. Using a cAMP Response Element luciferase (CRE-luc) reporter vector to measure transcription, we were able to illustrate that isoproterenol (ISO) and forskolin (FSK) activate CRE-luc in a dose-dependent manner. After morphine treatment, we saw an attenuation of ISO and FSK-induced CRE-luc activation. In addition, overexpression of the [mu]OR caused an enhanced inhibition of CRE-luc activation. These findings suggest that morphine may alter GnRH expression through [mu]OR activation to induce OIH via altered CRE binding-incidence. In addition, we found that morphine pretreatment in vivo alters GnRH neuron responsiveness to KISS1, as measured via luteinizing hormone (LH) output, but morphine pretreatment does not change pituitary responsiveness to GnRH. In mutant mice, where [mu]OR is selectively deleted from GnRH neurons, morphine pretreatment is unable to suppress KISS1 activation of GnRH neurons. These results suggest that [mu]OR activation in GnRH neurons is needed for morphine-mediated suppression of the HPG axis. Furthermore, chronic morphine treatment in female mice did not significantly alter gene expression in the hypothalamus, pituitary, or ovaries. This illustrates that chronic morphine use may not permanently alter expression of key reproductive genes. Overall, these findings suggest that opioid action via the [mu]OR in GnRH neurons plays a key role in the suppression of the HPG axis. Future studies must be conducted to fully define altered GnRH expression and secretion in the development of OIH.
Book Synopsis The Opiate Receptors by : Gavril Pasternak
Download or read book The Opiate Receptors written by Gavril Pasternak and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The growth of the opiate field over the past decade has been enor mous. Initial interest focused upon the strategic clinical impor tance of morphine and its analogs, but the discovery of the enkephalins and the other endogenous opioid peptides with their widespread actions within brain has expanded the field to investi gators in almost all areas of neuroscience as well as pharmacol ogy. Unfortunately, this field of research with its vast literature has become progressively more complex. The receptors are no longer limited to opiates, but include many subtypes selective for the opioid peptides. Indeed, they might be better termed opioid, rather than opiate, receptors. Many controversies have emerged and been settled; others remain. Early studies must now be inter preted on the basis of current information. Thousands of papers examining various aspects of opiates and the endogenous opioids present separate pieces of a large puzzle. The goal of this volume is to put the pieces together to give a coherent overview of opiate receptor pharmacology and to provide insights into both the mo lecular and classical pharmacology of opiates and the opioid pep tides. The issue of multiple classes of opiate and opioid peptide re ceptors and their importance in understanding mechanisms of ac tion provides the major focus of the book. The study of opiates and opioid peptides provides a unique research opportunity in the neuropharmacology of drug receptors.
Book Synopsis Opioid Peptides by : National Institute on Drug Abuse
Download or read book Opioid Peptides written by National Institute on Drug Abuse and published by . This book was released on 1988 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309486483 Total Pages :175 pages Book Rating :4.3/5 (94 download)
Book Synopsis Medications for Opioid Use Disorder Save Lives by : National Academies of Sciences, Engineering, and Medicine
Download or read book Medications for Opioid Use Disorder Save Lives written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-06-16 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: The opioid crisis in the United States has come about because of excessive use of these drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use disorder (OUD). More than 2 million people in the United States are estimated to have OUD, which is caused by prolonged use of prescription opioids, heroin, or other illicit opioids. OUD is a life-threatening condition associated with a 20-fold greater risk of early death due to overdose, infectious diseases, trauma, and suicide. Mortality related to OUD continues to escalate as this public health crisis gathers momentum across the country, with opioid overdoses killing more than 47,000 people in 2017 in the United States. Efforts to date have made no real headway in stemming this crisis, in large part because tools that already existâ€"like evidence-based medicationsâ€"are not being deployed to maximum impact. To support the dissemination of accurate patient-focused information about treatments for addiction, and to help provide scientific solutions to the current opioid crisis, this report studies the evidence base on medication assisted treatment (MAT) for OUD. It examines available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.
Download or read book Blitzed written by Norman Ohler and published by HarperCollins. This book was released on 2017-03-07 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: A New York Times bestseller, Norman Ohler's Blitzed is a "fascinating, engrossing, often dark history of drug use in the Third Reich” (Washington Post). The Nazi regime preached an ideology of physical, mental, and moral purity. Yet as Norman Ohler reveals in this gripping history, the Third Reich was saturated with drugs: cocaine, opiates, and, most of all, methamphetamines, which were consumed by everyone from factory workers to housewives to German soldiers. In fact, troops were encouraged, and in some cases ordered, to take rations of a form of crystal meth—the elevated energy and feelings of invincibility associated with the high even help to account for the breakneck invasion that sealed the fall of France in 1940, as well as other German military victories. Hitler himself became increasingly dependent on injections of a cocktail of drugs—ultimately including Eukodal, a cousin of heroin—administered by his personal doctor. Thoroughly researched and rivetingly readable, Blitzed throws light on a history that, until now, has remained in the shadows. “Delightfully nuts.”—The New Yorker
Book Synopsis Role of Endogenous Opioid Peptide in Regulation of Phasic and Pulsatile Release of Gonadotropins. Relation of Hormones and Food Intake to Development and Hormone Dependency of Carcinogen-induced Mammary Tumors by : Paul William Sylvester
Download or read book Role of Endogenous Opioid Peptide in Regulation of Phasic and Pulsatile Release of Gonadotropins. Relation of Hormones and Food Intake to Development and Hormone Dependency of Carcinogen-induced Mammary Tumors written by Paul William Sylvester and published by . This book was released on 1982 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacology of Opioid Peptides by : L F Tseong
Download or read book Pharmacology of Opioid Peptides written by L F Tseong and published by CRC Press. This book was released on 1995-09-01 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is being published at a time when opioid receptors have recently been cloned. The structural characteristics of opioid receptors and the recent advances in their molecular cloning and expression are explicated. Connecting these cloned opioid receptors with the pharmacology of opioid receptor actions is of particular importance. The use of antisense oligodeoxynucleotides to opioid receptors to elucidate the neural mechanisms of opioid action is detailed. As analgesia is one of the most important clinical functions for opioids and opioid peptides, this book concentrates on the detailed mechanisms of action of opioids and opioid peptides for the production of analgesia. The significant pharmacologic actions of opioids and opioid peptides in gastrointestinal function, immune function, cardiovascular and respiratory regulation, addiction and the cellular mechanisms involved in tolerance and dependence of opioids are also described. The book will be of interest both to researchers investigating the neural mechanisms of the pharmacologic and physiologic functions of the endogenous opioid system and to clinicians who are involved in pain management and assessment.
Author :World Health Organization. Department of Mental Health and Substance Abuse Publisher :World Health Organization ISBN 13 :9241547545 Total Pages :133 pages Book Rating :4.2/5 (415 download)
Book Synopsis Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence by : World Health Organization. Department of Mental Health and Substance Abuse
Download or read book Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence written by World Health Organization. Department of Mental Health and Substance Abuse and published by World Health Organization. This book was released on 2009 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: "These guidelines were produced by the World Health Organization (WHO), Department of Mental Health and Substance Abuse, in collaboration with the United Nations Office on Drugs and Crime (UNODC) a Guidelines Development Group of technical experts, and in consultation with the International Narcotics Control Board (INCB) secretariat and other WHO departments. WHO also wishes to acknowledge the financial contribution of UNODC and the Joint United Nations Programme on HIV/AIDS (UNAIDS) to this project. " - p. iv
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