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Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 489 In Vivo Mammalian Alkaline Comet Assay
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Book Synopsis Test No. 489: In Vivo Mammalian Alkaline Comet Assay by : OECD
Download or read book Test No. 489: In Vivo Mammalian Alkaline Comet Assay written by OECD and published by OECD Publishing. This book was released on 2014-09-26 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 489: In Vivo Mammalian Alkaline Comet Assay by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 489: In Vivo Mammalian Alkaline Comet Assay written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay written by OECD and published by OECD Publishing. This book was released on 2022-06-30 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro written by OECD and published by OECD Publishing. This book was released on 1986-10-23 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 473: In Vitro Mammalian Chromosomal Aberration Test by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 473: In Vitro Mammalian Chromosomal Aberration Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 486: Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 486: Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo written by OECD and published by OECD Publishing. This book was released on 1997-07-21 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the unscheduled DNA synthesis (UDS) test with mammalian liver cells in vivo is to identify substances that induce DNA repair after excision and removal of a stretch of DNA containing a region of damage induced by chemical substances ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 474: Mammalian Erythrocyte Micronucleus Test by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 474: Mammalian Erythrocyte Micronucleus Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters).
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 487: In Vitro Mammalian Cell Micronucleus Test by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 487: In Vitro Mammalian Cell Micronucleus Test written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl transferase...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 485: Genetic toxicology, Mouse Heritable Translocation Assay by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 485: Genetic toxicology, Mouse Heritable Translocation Assay written by OECD and published by OECD Publishing. This book was released on 1986-10-23 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mouse heritable translocation test detects structural and numerical chromosome changes in mammalian germ cells as recovered in first generation progeny. The types of chromosome changes detected in this test system are reciprocal translocations ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 484: Genetic Toxicology: Mouse Spot Test by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 484: Genetic Toxicology: Mouse Spot Test written by OECD and published by OECD Publishing. This book was released on 1986-10-23 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mouse spot test detects presumed somatic mutations in fetal cells following transplacental absorption of the test substance. This is an in vivo test in mice in which developing embryos are exposed to a chemical (solid, liquid, vapour or ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method written by OECD and published by OECD Publishing. This book was released on 2004-11-23 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells written by OECD and published by OECD Publishing. This book was released on 1986-10-23 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 417: Toxicokinetics by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 417: Toxicokinetics written by OECD and published by OECD Publishing. This book was released on 2010-07-23 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes in vivo studies that provide information on mass balance, absorption, bioavailability, tissue distribution, metabolism, excretion, and basic toxicokinetic parameters [e.g. AUC], as well as supplemental approaches that ...
