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Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 455 Performance Based Test Guideline For Stably Transfected Transactivation In Vitro Assays To Detect Estrogen Receptor Agonists And Antagonists
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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists written by OECD and published by OECD Publishing. This book was released on 2021-06-17 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).
Book Synopsis Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists by : OECD
Download or read book Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).
Book Synopsis Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists by : OECD
Download or read book Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists written by OECD and published by OECD Publishing. This book was released on 2012-10-02 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provides the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists (ER TAs). It comprises mechanistically and functionally similar test ...
Book Synopsis Handbook of Cosmetic Science and Technology by : Frank Dreher
Download or read book Handbook of Cosmetic Science and Technology written by Frank Dreher and published by CRC Press. This book was released on 2022-08-11 with total page 997 pages. Available in PDF, EPUB and Kindle. Book excerpt: With chapters from experienced and internationally renowned contributors holding positions in research, industry, and clinical practice, this is the fifth edition of what has become the standard reference for cosmetic scientists and dermatologists seeking the latest innovations and technology for the formulation, design, testing, use, and production of cosmetic products for the skin. *Offers in-depth analysis of specific topics in cosmetic science and research *Presents the latest in international research and its translation to practice *Gives an indispensable guide to a hotly competitive area for research and practice
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 250: EASZY assay - Detection of Endocrine Active Substances, acting through estrogen receptors, using transgenic tg(cyp19a1b:GFP) Zebrafish embrYos by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 250: EASZY assay - Detection of Endocrine Active Substances, acting through estrogen receptors, using transgenic tg(cyp19a1b:GFP) Zebrafish embrYos written by OECD and published by OECD Publishing. This book was released on 2021-06-17 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: The EASZY assay is a mechanism-based in vivo screening assay designed to detect endocrine active chemicals acting as agonist through estrogen receptors (ERs), by inducing the expression of the green fluorescent protein (GFP) driven by the cyp19a1b promoter. The EASZY assay allows for the detection of estrogenic activity of chemicals on transgenic tg(cyp19a1b:GFP) Zebrafish embryos exposed for 96 hours during the embryonic stages of development.
Book Synopsis OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP) by : OECD
Download or read book OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP) written by OECD and published by OECD Publishing. This book was released on 2018-12-10 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...
Book Synopsis Reproductive and Developmental Toxicology by : Ramesh C Gupta
Download or read book Reproductive and Developmental Toxicology written by Ramesh C Gupta and published by Academic Press. This book was released on 2022-02-11 with total page 1558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis Includes new chapters on developments in systems toxicology and predictive modeling of male developmental toxicity, adverse outcome pathways in reproductive and developmental toxicology, ovarian and endometrial toxicity, developmental neurotoxicity of air pollution, and more
Book Synopsis In vitro Environmental Toxicology - Concepts, Application and Assessment by : Georg Reifferscheid
Download or read book In vitro Environmental Toxicology - Concepts, Application and Assessment written by Georg Reifferscheid and published by Springer. This book was released on 2017-05-16 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science.Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification.In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
Book Synopsis Hayes' Principles and Methods of Toxicology, Sixth Edition by : A. Wallace Hayes
Download or read book Hayes' Principles and Methods of Toxicology, Sixth Edition written by A. Wallace Hayes and published by CRC Press. This book was released on 2014-10-10 with total page 2186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442E: In Vitro Skin Sensitisation In Vitro Skin Sensitisation assays addressing the Key Event on activation of dendritic cells on the Adverse Outcome Pathway for Skin Sensitisation by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442E: In Vitro Skin Sensitisation In Vitro Skin Sensitisation assays addressing the Key Event on activation of dendritic cells on the Adverse Outcome Pathway for Skin Sensitisation written by OECD and published by OECD Publishing. This book was released on 2024-06-25 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present Key Event based Test Guideline (TG) addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This TG is proposed to address the activation of dendritic cells, which is one Key Event on the Adverse Outcome Pathway (AOP) for Skin Sensitisation. It provides four in vitro test methods addressing the same Key Event on the AOP: (i) the human cell Line Activation Test or h-CLAT method, (ii) the U937 Cell Line Activation Test or U-SENS, (iii) the Interleukin-8 Reporter Gene Assay or IL-8 Luc assay and (iv) the Genomic Allergen Rapid Detection for assessment of skin sensitisers (GARDTMskin). All of them are used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. The test methods described in this TG either quantify the change in the expression of cell surface marker(s) CD54 and CD86, the cytokine IL-8, or a series of genes (genomic biomarker signature) that are associated with the process of activation of monocytes and DC following exposure to sensitisers.
Book Synopsis Current Topics in Nonclinical Drug Development by : Philip Bentley
Download or read book Current Topics in Nonclinical Drug Development written by Philip Bentley and published by CRC Press. This book was released on 2023-11-03 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume in the CURRENT TOPICS IN NONCLINICAL DRUG DEVELOPMENT SERIES explores the critical issues and current topics in nonclinical drug development. This second volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed. Select topics include: Evolution of Artificial Intelligence (AI) technologies and the impact on toxicologic pathology. Current approaches to carcinogenicity testing. Predicting drug-drug interactions. Current understanding of idiosyncratic drug reaction. Assessing cardiovascular risks beyond QT interval. Use of 3D cell cultures in toxicology and ADME. Development of small molecule-antibody complexes. Differentiating adverse from non-adverse findings in nonclinical studies. Current Topics in Nonclinical Drug Development: Volume 2 will aid toxicologists, toxicologic pathologists, consultants, regulators, study directors, and nonclinical scientists dealing with day-to-day issues encountered in drug development and assist in formulating strategies for resolution of these issues. In addition, the book will be a valuable reference for academicians and graduate students pursuing research related to nonclinical drug development.
Book Synopsis Bioanalytical Tools in Water Quality Assessment by : Beate Escher
Download or read book Bioanalytical Tools in Water Quality Assessment written by Beate Escher and published by IWA Publishing. This book was released on 2011-12-15 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of Water Quality Set - Buy all four books and save over 30% on buying separately! Bioanalytical Tools in Water Quality Assessment reviews the application of bioanalytical tools to the assessment of water quality including surveillance monitoring. The types of water included range from wastewater to drinking water, including recycled water, as well as treatment processes and advanced water treatment. Bioanalytical Tools in Water Quality Assessment not only demonstrates applications but also fills in the background knowledge in toxicology/ecotoxicology needed to appreciate these applications. Each chapter summarises fundamental material in a targeted way so that information can be applied to better understand the use of bioanalytical tools in water quality assessment. Bioanalytical tools in Water Quality Assessment can be used by lecturers teaching academic and professional courses and also by risk assessors, regulators, experts, consultants, researchers and managers working in the water sector. It can also be a reference manual for environmental engineers, analytical chemists, and toxicologists. Authors: Beate Escher, National Research Centre for Environmental Toxicology (EnTox), The University of Queensland, Australia, Frederic Leusch, Smart Water Research Facility (G51), Griffith University Gold Coast Campus, Australia. With contributions by Heather Chapman and Anita Poulsen
Book Synopsis Alternative Toxicological Methods by : Harry Salem
Download or read book Alternative Toxicological Methods written by Harry Salem and published by CRC Press. This book was released on 2003-03-26 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist
Book Synopsis Ecotoxicology of Antifouling Biocides by : Takaomi Arai
Download or read book Ecotoxicology of Antifouling Biocides written by Takaomi Arai and published by Springer Science & Business Media. This book was released on 2009-01-29 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organotin compounds, used as antifouling biocides since 1960, are chemical compounds that act as endocrine disrupters. It is not known how organotin compounds cause hormone disturbance, however, and many questions remain about their effect on aquatic organisms. Studies on organotin compounds have recently evolved, with many new findings reported. Following a worldwide ban on organotin compounds in 2008, alternative compounds will mainly be used, with the potential for coastal areas to become contaminated, causing, among other effects, cholinesterase inhibition in aquatic organisms. Use of alternative compounds must be controlled to avoid such errors. These and other findings are described and concisely summarized in this book, providing a useful reference in countries where alternative biocides are being considered. Included are studies on the effects on marine organisms, making this book an excellent aid to experts in environmental chemistry, to government organizations, and to students.
Book Synopsis Clinical Safety and Efficacy Testing of Cosmetics by : William Waggoner
Download or read book Clinical Safety and Efficacy Testing of Cosmetics written by William Waggoner and published by CRC Press. This book was released on 1989-11-27 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 423: Acute Oral toxicity - Acute Toxic Class Method by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 423: Acute Oral toxicity - Acute Toxic Class Method written by OECD and published by OECD Publishing. This book was released on 2002-02-08 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method.
Book Synopsis Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis by : Jussi Meriluoto
Download or read book Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis written by Jussi Meriluoto and published by John Wiley & Sons. This book was released on 2017-01-30 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: A valuable handbook containing reviews, practical methods and standard operating procedures. A valuable and practical working handbook containing introductory and specialist content that tackles a major and growing field of environmental, microbiological and ecotoxicological monitoring and analysis Includes introductory reviews, practical analytical chapters and a comprehensive listing of almost thirty Standard Operating Procedures (SOPs) For use in the laboratory, in academic and government institutions and industrial settings Those readers will appreciate the research that validates and updates cyanotoxin monitoring and analysis plus adding to approaches for setting standard methods that can be applied worldwide. Wayne Carmichael, Analytical and Bioanalytical Chemistry (2018)
