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Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 453 Combined Chronic Toxicity Carcinogenicity Studies
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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-response relationships following prolonged and repeated exposure. The rat is typically used for ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ...
Book Synopsis OECD Series on Testing and Assessment Guidance Document 116 on the Conduct and Design of Chronic Toxicity and Carcinogenicity Studies, Supporting Test Guidelines 451, 452 and 453 Second edition by : OECD
Download or read book OECD Series on Testing and Assessment Guidance Document 116 on the Conduct and Design of Chronic Toxicity and Carcinogenicity Studies, Supporting Test Guidelines 451, 452 and 453 Second edition written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 484: Genetic Toxicology: Mouse Spot Test by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 484: Genetic Toxicology: Mouse Spot Test written by OECD and published by OECD Publishing. This book was released on 1986-10-23 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mouse spot test detects presumed somatic mutations in fetal cells following transplacental absorption of the test substance. This is an in vivo test in mice in which developing embryos are exposed to a chemical (solid, liquid, vapour or ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 451: Carcinogenicity Studies by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 451: Carcinogenicity Studies written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test substance by an appropriate route of ...
Book Synopsis OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Notes for Analysis and Evaluation of Chronic Toxicity and Carcinogenicity Studies by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Notes for Analysis and Evaluation of Chronic Toxicity and Carcinogenicity Studies written by OECD and published by OECD Publishing. This book was released on 2002-12-12 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: These Guidance Notes outline core concepts in order to obviate the need to consult large numbers of text books, while still pointing the reader to sources of more detailed or specific information.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been obtained from acute or repeated dose ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 403: Acute Inhalation Toxicity by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 403: Acute Inhalation Toxicity written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 413: Subchronic Inhalation Toxicity: 90-day Study by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 413: Subchronic Inhalation Toxicity: 90-day Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised Test Guideline has been designed to fully characterize test article toxicity by the inhalation route for a subchronic duration (90 days), and to provide robust data for quantitative inhalation risk assessments. Groups of 10 male and 10 ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 409: Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 409: Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents written by OECD and published by OECD Publishing. This book was released on 1998-09-21 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from short-term exposure to test substance. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure written by OECD and published by OECD Publishing. This book was released on 2002-02-08 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 414: Prenatal Developmental Toxicity Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 411: Subchronic Dermal Toxicity: 90-day Study by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 411: Subchronic Dermal Toxicity: 90-day Study written by OECD and published by OECD Publishing. This book was released on 1981-05-12 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study relates to the analysis, via dermal application, of the health hazards of solid or liquid test substance. It may be carried out after initial information obtained by acute testing. This method is composed of the main test and the limit ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 412: Subacute Inhalation Toxicity: 28-Day Study by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 412: Subacute Inhalation Toxicity: 28-Day Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data for quantitative inhalation risk ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 433: Acute Inhalation Toxicity: Fixed Concentration Procedure by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 433: Acute Inhalation Toxicity: Fixed Concentration Procedure written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from short-term exposure to a test chemical by inhalation. It is a principle of the method that only moderately toxic concentrations are used so that ‘evident toxicity’, rather than death/moribundity is used as an endpoint, and ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 402: Acute Dermal Toxicity by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 402: Acute Dermal Toxicity written by OECD and published by OECD Publishing. This book was released on 2017-10-09 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents written by OECD and published by OECD Publishing. This book was released on 2008-10-16 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The method is based on the repeated oral administration of the substance of interest during one limited period (one dose level ...
