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Ode Pde A Synuclein Models For Parkinsons Disease
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Book Synopsis ODE/PDE α-synuclein Models for Parkinson’s Disease by : William E. Schiesser
Download or read book ODE/PDE α-synuclein Models for Parkinson’s Disease written by William E. Schiesser and published by Academic Press. This book was released on 2018-02-13 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: ODE/PDE Alpha-Synuclein Models for Parkinson’s Disease discusses a mechanism for the evolution of Parkinson’s Disease (PD) based on the dynamics of the protein a-synuclein, a monomer that has been implicated in this disease. Specifically, a-synuclein morphs and aggregates into a polymer that can interfere with functioning neurons and lead to neurodegenerative pathology. This book first demonstrates computer-based implementation of a prototype ODE/PDE model for the dynamics of the a-synuclein monomer and polymer, and then details the methodology for the numerical integration of ODE/PDE systems which can be applied to computer-based analyses of alternative models based on the reader's interest. This book facilitates immediate computer use for research without the necessity to first learn the basic concepts of numerical analysis for ODE/PDEs and programming algorithms Includes PDE routines based on the method of lines (MOL) for computer-based implementation of ODE/PDE models Offers transportable computer source codes for readers, with line-by-line code descriptions relating to the mathematical model and algorithms Authored by a leading researcher and educator in ODE/PDE models
Book Synopsis ODE / PDE Alpha-Synuclein Models for Parkinson's Disease by : William E. Schiesser
Download or read book ODE / PDE Alpha-Synuclein Models for Parkinson's Disease written by William E. Schiesser and published by Academic Press. This book was released on 2018-02-14 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: ODE/PDE Alpha-Synuclein Models for Parkinson's Disease discusses a mechanism for the evolution of Parkinson's Disease (PD) based on the dynamics of the protein α-synuclein, a monomer that has been implicated in this disease. Specifically, α-synuclein morphs and aggregates into a polymer that can interfere with functioning neurons and lead to neurodegenerative pathology. This book first demonstrates computer-based implementation of a prototype ODE/PDE model for the dynamics of the α-synuclein monomer and polymer, and then details the methodology for the numerical integration of ODE/PDE systems which can be applied to computer-based analyses of alternative models based on the reader's interest. This book facilitates immediate computer use for research without the necessity to first learn the basic concepts of numerical analysis for ODE/PDEs and programming algorithms Includes PDE routines based on the method of lines (MOL) for computer-based implementation of ODE/PDE models Offers transportable computer source codes for readers, with line-by-line code descriptions relating to the mathematical model and algorithms Authored by a leading researcher and educator in ODE/PDE models
Book Synopsis ODE/PDE Α-synuclein Models for Parkinson's Disease by : William E. Schiesser
Download or read book ODE/PDE Α-synuclein Models for Parkinson's Disease written by William E. Schiesser and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biomarkers and Pathogenesis of Alpha-Synuclein in Parkinson's Disease by : Pingyi Xu
Download or read book Biomarkers and Pathogenesis of Alpha-Synuclein in Parkinson's Disease written by Pingyi Xu and published by Frontiers Media SA. This book was released on 2022-01-24 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms in Parkinson's Disease by : Juliana Dushanova
Download or read book Mechanisms in Parkinson's Disease written by Juliana Dushanova and published by BoD – Books on Demand. This book was released on 2012-02-08 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) results primarily from the death of dopaminergic neurons in the substantia nigra. Current PD medications treat symptoms; none halt or retard dopaminergic neuron degeneration. The main obstacle to developing neuroprotective therapies is a limited understanding of the key molecular mechanisms that provoke neurodegeneration. The discovery of PD genes has led to the hypothesis that misfolding of proteins and dysfunction of the ubiquitin-proteasome pathway are pivotal to PD pathogenesis. Previously implicated culprits in PD neurodegeneration, mitochondrial dysfunction, and oxidative stress may also act in part by causing the accumulation of misfolded proteins, in addition to producing other deleterious events in dopaminergic neurons. Neurotoxin-based models have been important in elucidating the molecular cascade of cell death in dopaminergic neurons. PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.
Book Synopsis Parkinson's Disease by : Richard Nass
Download or read book Parkinson's Disease written by Richard Nass and published by Elsevier. This book was released on 2011-04-28 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson’s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery. Comprehensive and critical assessment of the utility of various model systems to identify the molecular components and pathways involved in Parkinson’s disease Describes the power of toxin and genetic models to identify novel therapeutic targets and compounds that can be used in PD Current overviews of current status of PD research and discovery from bench-to-bedside Provides novel insights and views on where the future of PD research may lead Provides a powerful teaching tool and template to explore the utility of model systems to identify molecular pathways, molecular targets, and therapeutics that are applicable to a variety of neurological diseases
Book Synopsis Intracellular Mechanisms of α-Synuclein Processing by : Friederike Zunke
Download or read book Intracellular Mechanisms of α-Synuclein Processing written by Friederike Zunke and published by Frontiers Media SA. This book was released on 2021-11-02 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pathogenicity of Alpha-synuclein in Various Cell Models for Parkinson's Disease by : Thaiany Quevedo Melo
Download or read book Pathogenicity of Alpha-synuclein in Various Cell Models for Parkinson's Disease written by Thaiany Quevedo Melo and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modeling Parkinson's Disease: Bridging the Translational Gap by : Graziella Madeo
Download or read book Modeling Parkinson's Disease: Bridging the Translational Gap written by Graziella Madeo and published by Frontiers Media SA. This book was released on 2019-11-26 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials by : Sarat Chandra Yenisetti
Download or read book Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials written by Sarat Chandra Yenisetti and published by BoD – Books on Demand. This book was released on 2023-12-20 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite being described about 200 years ago, the pathophysiology of Parkinson’s disease (PD) is not well understood due to its complex etiology and heterogeneity of symptoms and progression. Animal models provide a great opportunity to follow the progression of neurodegeneration and to screen potent therapeutic molecules, knowledge of which can be critical for different levels of clinical trials. Contemporary health technologies are coming in handy to accelerate the pace of developing novel and refined therapeutic strategies for PD. This book, Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials, provides a comprehensive overview of PD, presenting information on animal models of PD and contemporary therapeutic strategies, health technologies, clinical trials, and their influence on the quality of life of patients with PD.
Book Synopsis Mechanisms of Alpha-synuclein Spread in Mouse and Human Models of Parkinson's Disease by : Gregor Bieri
Download or read book Mechanisms of Alpha-synuclein Spread in Mouse and Human Models of Parkinson's Disease written by Gregor Bieri and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Parkinson's Disease: Cell Vulnerability and Disease Progression by : Javier Blesa
Download or read book Parkinson's Disease: Cell Vulnerability and Disease Progression written by Javier Blesa and published by Frontiers Media SA. This book was released on 2016-01-04 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Download PDF Download EPUB Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinson's Disease. This e-Book discusses the etiopathogenesis of Parkinson's Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinson's Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinson's Disease.
Book Synopsis Mapping Networks of Alpha-Synuclein Proteostasis in Cellular Models of Parkinson's Disease Pathology by : Rahel Lewin
Download or read book Mapping Networks of Alpha-Synuclein Proteostasis in Cellular Models of Parkinson's Disease Pathology written by Rahel Lewin and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Alpha-synuclein Impairs Normal Dynamics of Mitochondria in Cell and Animal Models of Parkinson's Disease by : Weilin Xie
Download or read book Alpha-synuclein Impairs Normal Dynamics of Mitochondria in Cell and Animal Models of Parkinson's Disease written by Weilin Xie and published by . This book was released on 2011 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Motor Deficits in an Alpha-Synuclein Mouse Model of Parkinson's Disease are Not Exacerbated by Gba1 Mutation by : Megan E. Fitzpatrick
Download or read book Motor Deficits in an Alpha-Synuclein Mouse Model of Parkinson's Disease are Not Exacerbated by Gba1 Mutation written by Megan E. Fitzpatrick and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Experimental Models of Parkinson's Disease by : Yuzuru Imai
Download or read book Experimental Models of Parkinson's Disease written by Yuzuru Imai and published by . This book was released on 2021 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Differential Impact of Multiple Parkinson's Disease Associated Genes on the Toxicity of [alpha]-synuclein in a Yeast Model by : Paul A. Jones
Download or read book Differential Impact of Multiple Parkinson's Disease Associated Genes on the Toxicity of [alpha]-synuclein in a Yeast Model written by Paul A. Jones and published by . This book was released on 2018 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract under embargo.
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