Numerical Characterization Of Mechanical Stress And Flow Patterns In Stirred Tank Bioreactors

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Numerical Characterization of Mechanical Stress and Flow Patterns in Stirred Tank Bioreactors

Author : Manely Eslahpazir Esfandabadi
Publisher : Cuvillier Verlag
ISBN 13 : 3736944497
Total Pages : 146 pages
Book Rating : 4.7/5 (369 download)

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Book Synopsis Numerical Characterization of Mechanical Stress and Flow Patterns in Stirred Tank Bioreactors by : Manely Eslahpazir Esfandabadi

Download or read book Numerical Characterization of Mechanical Stress and Flow Patterns in Stirred Tank Bioreactors written by Manely Eslahpazir Esfandabadi and published by Cuvillier Verlag. This book was released on 2013-06-24 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Das Ziel der Arbeit bestand darin, die lokalen und globalen mechanischen Beanspruchungsparameter in einem Rührkesselbioreaktor mit Hilfe der numerischen Strömungssimulation (CFD) nachzubilden und die Ergebnisse mit experimentellen Daten der Pellet-kultivierung bzgl. Fluiddynamik und Rheolgie des rekombinanten Stammes A. niger SKAn1015 zu validieren. Ausgehend von der einphasigen Strömungssimulation eines 2L-Bioreaktors werden zunächst Simultionsdaten über Strömungsgeschwindigkeit und mechanische Beanspruchung diskutiert. Aßerdem erfolgt eine Validierung der einphasigen Simulationsdaten mit der Particle Image Velocimetry. In weiteren Untersuchungen wird die Strömungssimulation auch auf nicht-newtonsche Flüssigkeiten, so wie sie bei der Kultivierung filamentöser Pilze üblicherweise auftreten, mit dem Ostwald - de Waele-Ansatz erweitert und die mechanische Beanspruchung in Abhängigkeit zu den rheologischen Prozessparametern korreliert. Die Untersuchung des Einflusses unterschiedlicher Rührergeometrien auf die Strömungsfelder und die mechanische Beanspruchung mittels CFD bildet den Abschluss, so dass die Auswahl eines geeigneten Rührers für den Kultivierungsprozess mit schesensitiven biologischen Systemen eindeutig getroffen wird. Die Arbeit validiert die numerische Strömungssimulation in einem Bioreaktor mit experimentell gnerierten biologischen und fluiddynamischen Prozessdaten und gibt praktische Hinweise darüber, wie biotechnologische Prozesse mit filamentösen Mikroorganismen hinsichtlich der Minimierung der mechanischen Beanspruchung zu betreiben sind.

Production of labyrinthopeptin A1 with Actinomadura namibiensis

Author : Sebastian Tesche
Publisher : Cuvillier Verlag
ISBN 13 : 3736963432
Total Pages : 130 pages
Book Rating : 4.7/5 (369 download)

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Book Synopsis Production of labyrinthopeptin A1 with Actinomadura namibiensis by : Sebastian Tesche

Download or read book Production of labyrinthopeptin A1 with Actinomadura namibiensis written by Sebastian Tesche and published by Cuvillier Verlag. This book was released on 2020-12-21 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: The filamentous actinomycete Actinomadura namibiensis is the only known producer of labyrinthopeptins, a class of ribosomally synthesized and posttranslationally modified peptides (RiPPs) displaying highly attractive bioactive properties. In order to increase the labyrinthopeptin A1 productivity in shaking flask cultivations of A. namibiensis, a new cultivation method called salt-enhanced cultivation was used. Compared to the unsupplemented control, labyrinthopeptin A1 productivity was enhanced the most by addition of 50 mM (NH4)2SO4, reaching a 7-fold higher yield of 325 mg L-1 within 10 cultivation days. Salt-enhanced cultivation affected growth and product formation mechanisms, cell morphology characteristics and rheological characteristics of cultivation broth. An image analysis method was developed to quantify both the macro-morphology (pellet size and shape) and the micro-morphology (hyphal network structure) of the heterogeneous filamentous biomass in detail. Productivity-related morphological parameters were in particular the size and circularity of pellets and the degree of hyphal interweaving (hyphal network spacing). It was shown that the time-dependent change in morphology linked to the rheological properties of the cultivation broth. The results presented in this work provide new insights into the cultivation aspects of A. namibiensis and illustrate the challenges on the way to a comprehensive understanding of the complex relationship between productivity, morphology and rheology in filamentous cultivations.

Chemical Synergies

Author : Nuno A.G. Bandeira
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110482061
Total Pages : 324 pages
Book Rating : 4.1/5 (14 download)

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Book Synopsis Chemical Synergies by : Nuno A.G. Bandeira

Download or read book Chemical Synergies written by Nuno A.G. Bandeira and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-05-07 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an overview of recent integrated and inter-disciplinary approaches between chemical experiment and theory in a variety of fields, from polymer science to materials chemistry and ranging from the design of tailored properties to catalysis and reactivity, building on the well-established success of Density Functional Theory as the foremost quantum chemical method to provide qualitative and quantitative interpretation of results from the chemical laboratory. The combination of several characterization techniques with an understanding at the molecular level of chemical and physical phenomena are the main focal point of the subject matter.

Bioreaction Engineering

Author : K. Schügerl
Publisher : Springer Science & Business Media
ISBN 13 : 3642597351
Total Pages : 639 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Bioreaction Engineering by : K. Schügerl

Download or read book Bioreaction Engineering written by K. Schügerl and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alongside presenting the fundamentals, this book reviews the state of the art of mathematical modeling and control of bioprocesses, while demonstrating the application in various biological systems important to industry. At the same time, the application of different types of models and control strategies are illustrated, taking into account the recent developments in reactor modeling. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.

Environmental Impact of Mining and Mineral Processing

Author : Ravi Jain
Publisher : Butterworth-Heinemann
ISBN 13 : 0128040920
Total Pages : 323 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Environmental Impact of Mining and Mineral Processing by : Ravi Jain

Download or read book Environmental Impact of Mining and Mineral Processing written by Ravi Jain and published by Butterworth-Heinemann. This book was released on 2015-08-03 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Impact of Mining and Mineral Processing: Management, Monitoring, and Auditing Strategies covers all the aspects related to mining and the environment, including environmental assessment at the early planning stages, environmental management during mine operation, and the identification of major impacts. Technologies for the treatment of mining, mineral processing, and metallurgical wastes are also covered, along with environmental management of mining wastes, including disposal options and the treatment of mining effluents. - Presents a systematic approach for environmental assessment of mining and mineral processing projects - Provides expert advice for the implementation of environmental management systems that are unique to the mining industry - Effectively addresses a number of environmental challenges, including air quality, water quality, acid mine drainage, and land and economic impacts - Explains the latest in environmental monitoring and control systems to limit the environmental impact of mining and processing operations

Disposable Bioreactors II

Author : Dieter Eibl
Publisher : Springer
ISBN 13 : 3642451586
Total Pages : 296 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Disposable Bioreactors II by : Dieter Eibl

Download or read book Disposable Bioreactors II written by Dieter Eibl and published by Springer. This book was released on 2013-12-17 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamic Single-Use Bioreactors Used in Modern Liter- and m3- Scale Biotechnological Processes: Engineering Characteristics and Scaling Up, by Christian Löffelholz, Stephan C. Kaiser, Matthias Kraume, Regine Eibl , Dieter Eibl. Orbitally Shaken Single-Use Bioreactors, by Wolf Klöckner, Sylvia Diederichs, Jochen Büchs. Therapeutic Human Cells: Manufacture for Cell Therapy/Regenerative Medicine by Christian van den Bos, Robert Keefe, Carmen Schirmaier, Michael McCaman. Fast Single-Use VLP Vaccine Productions Based on Insect Cells and the Baculovirus Expression Vector System: Influenza as Case Study by Regine Eibl, Nina Steiger, Sabine Wellnitz, Tiago Vicente, Corinne John, Dieter Eibl. Microbial High Cell Density Fermentations in a Stirred Single-Use Bioreactor by Thomas Dreher, Bart Walcarius, Ute Husemann, Franziska Klingenberg, Christian Zahnow, Thorsten Adams, Davy de Wilde, Peter Casteels, Gerhard Greller. Quorus Bioreactor: A New Perfusion-Based Technology for Microbial Cultivation by Sheena J. Fraser, Christian Endres. Cultivation of Marine Microorganisms in Single-Use Systems by Friederike Hillig, Maciej Pilarek, Stefan Junne, Peter Neubauer. Flexible Biomanufacturing Processes that Address the Needs of the Future by Bernhard Diel, Christian Manzke, Thorsten Peuker. An Approach to Quality and Security of Supply for Single-Use Bioreactors by Magali Barbaroux, Susanne Gerighausen, Heiko Hackel. A Risk Analysis for Production Processes with Disposable Bioreactors by Tobias Merseburger, Ina Pahl, Daniel Müller, Markus Tanner.

Airlift Bioreactors

Author : M. Y. Chisti
Publisher : Springer
ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Airlift Bioreactors by : M. Y. Chisti

Download or read book Airlift Bioreactors written by M. Y. Chisti and published by Springer. This book was released on 1989-02-28 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bioreactors

Author : Carl-Fredrik Mandenius
Publisher : John Wiley & Sons
ISBN 13 : 3527683372
Total Pages : 520 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Bioreactors by : Carl-Fredrik Mandenius

Download or read book Bioreactors written by Carl-Fredrik Mandenius and published by John Wiley & Sons. This book was released on 2016-02-16 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.

Bioprocess Engineering Principles

Author : Pauline M. Doran
Publisher : Elsevier
ISBN 13 : 0080528120
Total Pages : 455 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Bioprocess Engineering Principles by : Pauline M. Doran

Download or read book Bioprocess Engineering Principles written by Pauline M. Doran and published by Elsevier. This book was released on 1995-04-03 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: The emergence and refinement of techniques in molecular biology has changed our perceptions of medicine, agriculture and environmental management. Scientific breakthroughs in gene expression, protein engineering and cell fusion are being translated by a strengthening biotechnology industry into revolutionary new products and services. Many a student has been enticed by the promise of biotechnology and the excitement of being near the cutting edge of scientific advancement. However, graduates trained in molecular biology and cell manipulation soon realise that these techniques are only part of the picture. Reaping the full benefits of biotechnology requires manufacturing capability involving the large-scale processing of biological material. Increasingly, biotechnologists are being employed by companies to work in co-operation with chemical engineers to achieve pragmatic commercial goals. For many years aspects of biochemistry and molecular genetics have been included in chemical engineering curricula, yet there has been little attempt until recently to teach aspects of engineering applicable to process design to biotechnologists.This textbook is the first to present the principles of bioprocess engineering in a way that is accessible to biological scientists. Other texts on bioprocess engineering currently available assume that the reader already has engineering training. On the other hand, chemical engineering textbooks do not consider examples from bioprocessing, and are written almost exclusively with the petroleum and chemical industries in mind. This publication explains process analysis from an engineering point of view, but refers exclusively to the treatment of biological systems. Over 170 problems and worked examples encompass a wide range of applications, including recombinant cells, plant and animal cell cultures, immobilised catalysts as well as traditional fermentation systems.* * First book to present the principles of bioprocess engineering in a way that is accessible to biological scientists* Explains process analysis from an engineering point of view, but uses worked examples relating to biological systems* Comprehensive, single-authored* 170 problems and worked examples encompass a wide range of applications, involving recombinant plant and animal cell cultures, immobilized catalysts, and traditional fermentation systems* 13 chapters, organized according to engineering sub-disciplines, are groupled in four sections - Introduction, Material and Energy Balances, Physical Processes, and Reactions and Reactors* Each chapter includes a set of problems and exercises for the student, key references, and a list of suggestions for further reading* Includes useful appendices, detailing conversion factors, physical and chemical property data, steam tables, mathematical rules, and a list of symbols used* Suitable for course adoption - follows closely curricula used on most bioprocessing and process biotechnology courses at senior undergraduate and graduate levels.

Comprehensive Biotechnology

Author :
Publisher : Newnes
ISBN 13 : 0080885047
Total Pages : 5304 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Comprehensive Biotechnology by :

Download or read book Comprehensive Biotechnology written by and published by Newnes. This book was released on 2011-08-26 with total page 5304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comprehensive Biotechnology, Six Volume Set continues the tradition of the first inclusive work on this dynamic field with up-to-date and essential entries on the principles and practice of biotechnology. The integration of the latest relevant science and industry practice with fundamental biotechnology concepts is presented with entries from internationally recognized world leaders in their given fields. With two volumes covering basic fundamentals, and four volumes of applications, from environmental biotechnology and safety to medical biotechnology and healthcare, this work serves the needs of newcomers as well as established experts combining the latest relevant science and industry practice in a manageable format. It is a multi-authored work, written by experts and vetted by a prestigious advisory board and group of volume editors who are biotechnology innovators and educators with international influence. All six volumes are published at the same time, not as a series; this is not a conventional encyclopedia but a symbiotic integration of brief articles on established topics and longer chapters on new emerging areas. Hyperlinks provide sources of extensive additional related information; material authored and edited by world-renown experts in all aspects of the broad multidisciplinary field of biotechnology Scope and nature of the work are vetted by a prestigious International Advisory Board including three Nobel laureates Each article carries a glossary and a professional summary of the authors indicating their appropriate credentials An extensive index for the entire publication gives a complete list of the many topics treated in the increasingly expanding field

Single-Use Technology in Biopharmaceutical Manufacture

Author : Regine Eibl
Publisher : John Wiley & Sons
ISBN 13 : 1119477786
Total Pages : 368 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Single-Use Technology in Biopharmaceutical Manufacture by : Regine Eibl

Download or read book Single-Use Technology in Biopharmaceutical Manufacture written by Regine Eibl and published by John Wiley & Sons. This book was released on 2019-07-18 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authoritative guide to the principles, characteristics, engineering aspects, economics, and applications of disposables in the manufacture of biopharmaceuticals The revised and updated second edition of Single-Use Technology in Biopharmaceutical Manufacture offers a comprehensive examination of the most-commonly used disposables in the manufacture of biopharmaceuticals. The authors—noted experts on the topic—provide the essential information on the principles, characteristics, engineering aspects, economics, and applications. This authoritative guide contains the basic knowledge and information about disposable equipment. The author also discusses biopharmaceuticals’ applications through the lens of case studies that clearly illustrate the role of manufacturing, quality assurance, and environmental influences. This updated second edition revises existing information with recent developments that have taken place since the first edition was published. The book also presents the latest advances in the field of single-use technology and explores topics including applying single-use devices for microorganisms, human mesenchymal stem cells, and T-cells. This important book: • Contains an updated and end-to-end view of the development and manufacturing of single-use biologics • Helps in the identification of appropriate disposables and relevant vendors • Offers illustrative case studies that examine manufacturing, quality assurance, and environmental influences • Includes updated coverage on cross-functional/transversal dependencies, significant improvements made by suppliers, and the successful application of the single-use technologies Written for biopharmaceutical manufacturers, process developers, and biological and chemical engineers, Single-Use Technology in Biopharmaceutical Manufacture, 2nd Edition provides the information needed for professionals to come to an easier decision for or against disposable alternatives and to choose the appropriate system.

Handbook of Industrial Mixing

Author : Edward L. Paul
Publisher : John Wiley & Sons
ISBN 13 : 0471451444
Total Pages : 1450 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Handbook of Industrial Mixing by : Edward L. Paul

Download or read book Handbook of Industrial Mixing written by Edward L. Paul and published by John Wiley & Sons. This book was released on 2004-02-17 with total page 1450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Industrial Mixing will explain the difference and uses of a variety of mixers including gear mixers, top entry mixers, side entry mixers, bottom entry mixers, on-line mixers, and submerged mixers The Handbook discusses the trade-offs among various mixers, concentrating on which might be considered for a particular process. Handbook of Industrial Mixing explains industrial mixers in a clear concise manner, and also: * Contains a CD-ROM with video clips showing different type of mixers in action and a overview of their uses. * Gives practical insights by the top professional in the field. * Details applications in key industries. * Provides the professional with information he did receive in school

Selected Water Resources Abstracts

Author :
Publisher :
ISBN 13 :
Total Pages : 742 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Selected Water Resources Abstracts by :

Download or read book Selected Water Resources Abstracts written by and published by . This book was released on 1979 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Agrindex

Author :
Publisher :
ISBN 13 :
Total Pages : 1390 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Agrindex by :

Download or read book Agrindex written by and published by . This book was released on 1995 with total page 1390 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Numerical Simulation of Multiphase Reactors with Continuous Liquid

Author : Chao Yang
Publisher : Academic Press
ISBN 13 : 9780080999197
Total Pages : 309 pages
Book Rating : 4.9/5 (991 download)

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Book Synopsis Numerical Simulation of Multiphase Reactors with Continuous Liquid by : Chao Yang

Download or read book Numerical Simulation of Multiphase Reactors with Continuous Liquid written by Chao Yang and published by Academic Press. This book was released on 2014-06-13 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerical simulation of multiphase reactors with continuous liquid phase provides current research and findings in multiphase problems, which will assist researchers and engineers to advance this field. This is an ideal reference book for readers who are interested in design and scale-up of multiphase reactors and crystallizers, and using mathematical model and numerical simulation as tools. Yang and Mao's book focuses on modeling and numerical applications directly in the chemical, petrochemical, and hydrometallurgical industries, rather than theories of multiphase flow. The content will help you to solve reacting flow problems and/or system design/optimization problems. The fundamentals and principles of flow and mass transfer in multiphase reactors with continuous liquid phase are covered, which will aid the reader's understanding of multiphase reaction engineering. Provides practical applications for using multiphase stirred tanks, reactors, and microreactors, with detailed explanation of investigation methods. Presents the most recent research efforts in this highly active field on multiphase reactors and crystallizers. Covers mathematical models, numerical methods and experimental techniques for multiphase flow and mass transfer in reactors and crystallizers.

Assessment of Treatment Plant Performance and Water Quality Data: A Guide for Students, Researchers and Practitioners

Author : Marcos von Sperling
Publisher : IWA Publishing
ISBN 13 : 1780409311
Total Pages : 668 pages
Book Rating : 4.7/5 (84 download)

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Book Synopsis Assessment of Treatment Plant Performance and Water Quality Data: A Guide for Students, Researchers and Practitioners by : Marcos von Sperling

Download or read book Assessment of Treatment Plant Performance and Water Quality Data: A Guide for Students, Researchers and Practitioners written by Marcos von Sperling and published by IWA Publishing. This book was released on 2020-01-15 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the basic principles for evaluating water quality and treatment plant performance in a clear, innovative and didactic way, using a combined approach that involves the interpretation of monitoring data associated with (i) the basic processes that take place in water bodies and in water and wastewater treatment plants and (ii) data management and statistical calculations to allow a deep interpretation of the data. This book is problem-oriented and works from practice to theory, covering most of the information you will need, such as (a) obtaining flow data and working with the concept of loading, (b) organizing sampling programmes and measurements, (c) connecting laboratory analysis to data management, (e) using numerical and graphical methods for describing monitoring data (descriptive statistics), (f) understanding and reporting removal efficiencies, (g) recognizing symmetry and asymmetry in monitoring data (normal and log-normal distributions), (h) evaluating compliance with targets and regulatory standards for effluents and water bodies, (i) making comparisons with the monitoring data (tests of hypothesis), (j) understanding the relationship between monitoring variables (correlation and regression analysis), (k) making water and mass balances, (l) understanding the different loading rates applied to treatment units, (m) learning the principles of reaction kinetics and reactor hydraulics and (n) performing calibration and verification of models. The major concepts are illustrated by 92 fully worked-out examples, which are supported by 75 freely-downloadable Excel spreadsheets. Each chapter concludes with a checklist for your report. If you are a student, researcher or practitioner planning to use or already using treatment plant and water quality monitoring data, then this book is for you! 75 Excel spreadsheets are available to download.

Chemical Reactor Modeling

Author : Hugo A. Jakobsen
Publisher : Springer Science & Business Media
ISBN 13 : 3319050923
Total Pages : 1589 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Chemical Reactor Modeling by : Hugo A. Jakobsen

Download or read book Chemical Reactor Modeling written by Hugo A. Jakobsen and published by Springer Science & Business Media. This book was released on 2014-04-02 with total page 1589 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Reactor Modeling closes the gap between Chemical Reaction Engineering and Fluid Mechanics. The second edition consists of two volumes: Volume 1: Fundamentals. Volume 2: Chemical Engineering Applications In volume 1 most of the fundamental theory is presented. A few numerical model simulation application examples are given to elucidate the link between theory and applications. In volume 2 the chemical reactor equipment to be modeled are described. Several engineering models are introduced and discussed. A survey of the frequently used numerical methods, algorithms and schemes is provided. A few practical engineering applications of the modeling tools are presented and discussed. The working principles of several experimental techniques employed in order to get data for model validation are outlined. The monograph is based on lectures regularly taught in the fourth and fifth years graduate courses in transport phenomena and chemical reactor modeling and in a post graduate course in modern reactor modeling at the Norwegian University of Science and Technology, Department of Chemical Engineering, Trondheim, Norway. The objective of the book is to present the fundamentals of the single-fluid and multi-fluid models for the analysis of single and multiphase reactive flows in chemical reactors with a chemical reactor engineering rather than mathematical bias. Organized into 13 chapters, it combines theoretical aspects and practical applications and covers some of the recent research in several areas of chemical reactor engineering. This book contains a survey of the modern literature in the field of chemical reactor modeling.