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Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Karsten Weis
Publisher : Springer Science & Business Media
ISBN 13 : 3540446036
Total Pages : 222 pages
Book Rating : 4.5/5 (44 download)
Download or read book Nuclear Transport written by Karsten Weis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bidirectional traffic of macromolecules across the nuclear envelope is an active and essential transport process in all eukaryotic cells. Work on various model systems has led to a tremendous increase in our understanding of nuclear transport in recent years. This volume summarizes our current knowledge of protein and RNA transport into and out of the nucleus. It contains nine up-to-date reviews which cover various aspects of nucleocytoplasmic transport, including the structure and function of the nuclear pore complex, the role of soluble transport factors in protein and RNA transport, and the regulation of protein transport through the nuclear pore.
Author : Weidong Yang
Publisher : Springer
ISBN 13 : 3319773097
Total Pages : 277 pages
Book Rating : 4.3/5 (197 download)
Download or read book Nuclear-Cytoplasmic Transport written by Weidong Yang and published by Springer. This book was released on 2018-07-27 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.
Author : Carl Feldherr
Publisher : Academic Press
ISBN 13 : 0323152988
Total Pages : 385 pages
Book Rating : 4.3/5 (231 download)
Download or read book Nuclear Trafficking written by Carl Feldherr and published by Academic Press. This book was released on 2012-12-02 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Trafficking is a summary of the state of knowledge in nuclear trafficking, and is organized into five parts. The book begins by discussing the diffusion and signal-mediated transport through the pores. It then looks into the detailed accounts of pore structure and composition, nuclear localization signals, signal binding proteins, RNA efflux, and biochemical factors influencing nucleocytoplasmic exchange. This book will be very useful to those people new to this field of interest.
Author : Karsten Weis
Publisher :
ISBN 13 : 9783642536076
Total Pages : 212 pages
Book Rating : 4.5/5 (36 download)
Download or read book Nuclear Transport written by Karsten Weis and published by . This book was released on 2001-11-20 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ralph H. Kehlenbach
Publisher : CRC Press
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.F/5 ( download)
Download or read book Nuclear Transport written by Ralph H. Kehlenbach and published by CRC Press. This book was released on 2009-07-25 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both from a morphological and a functional point of view, the nucleus is central to modern cell biology. Transport of proteins and RNAs between the nucleus and the cytoplasm continues to be a fascinating research topic on its own. Furthermore, it affects many aspects of gene expression and general cellular functions and has far-reaching implications for human health. In this book, we cover a wide range of topics from the nuclear transport field. Individual chapters deal with the general concepts of nucleocytoplasmic transport, with various transport pathways like nuclear protein import, mRNA export and tRNA trafficking, and with the molecular mechanisms that govern macromolecular exchange between the two compartments. Others address new technologies that will help to answer open questions in the future. Together, we hope to provide a collection of reviews that should be useful for experts in the field, as well as for a wider audience.
Author : Reiner Peters
Publisher : Springer Science & Business Media
ISBN 13 : 3642715656
Total Pages : 296 pages
Book Rating : 4.6/5 (427 download)
Download or read book Nucleocytoplasmic Transport written by Reiner Peters and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309164826
Total Pages : 355 pages
Book Rating : 4.3/5 (91 download)
Download or read book Going the Distance? written by National Research Council and published by National Academies Press. This book was released on 2006-06-21 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new report from the National Research Council's Nuclear and Radiation Studies Board (NRSB) and the Transportation Research Board reviews the risks and technical and societal concerns for the transport of spent nuclear fuel and high-level radioactive waste in the United States. Shipments are expected to increase as the U.S. Department of Energy opens a repository for spent fuel and high-level waste at Yucca Mountain, and the commercial nuclear industry considers constructing a facility in Utah for temporary storage of spent fuel from some of its nuclear waste plants. The report concludes that there are no fundamental technical barriers to the safe transport of spent nuclear fuel and high-level radioactive and the radiological risks of transport are well understood and generally low. However, there are a number of challenges that must be addressed before large-quantity shipping programs can be implemented successfully. Among these are managing "social" risks. The report does not provide an examination of the security of shipments against malevolent acts but recommends that such an examination be carried out.
Author : D.G. Walton
Publisher : Springer Science & Business Media
ISBN 13 : 1475700466
Total Pages : 409 pages
Book Rating : 4.4/5 (757 download)
Download or read book Transportation for the Nuclear Industry written by D.G. Walton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: The transport requirements of the nuclear industry are unique in many respects. Thi s is not because cargoes are particularly large or hazardous by compari son wi th other industries but because standards of performance required in every aspect of the activity are so much greater than those required for any other industry. Transport of nuclear materials is subject to existing statutory regulations applied not only nationally but internationally. In addition to this, users of transport demand the highest standards of performance for their own purposes particularly in the area of quality assurance. Similar considerations also apply to the transport of non-nuclear materials where the transport link often has to tie in with project management and quality assurance requirements. Safety and security of nuclear materials are of paramount importance but even when these aspects are of a completely acceptable standard public attitudes to the transport activities have to be addressed adequately. The transport system itself consists of many components. The route, the vehicles, the containers, and the individual packages. The performance of each component determines the performance of the total system: all these factors were presented in the 1988 Conference on Transportation for the Nuclear Industry, giving a broad over-view of current practice together with wide ranging consideration of future requirements and developments.
Author : Ken Sorenson
Publisher : Woodhead Publishing
ISBN 13 : 1782423222
Total Pages : 361 pages
Book Rating : 4.7/5 (824 download)
Download or read book Safe and Secure Transport and Storage of Radioactive Materials written by Ken Sorenson and published by Woodhead Publishing. This book was released on 2015-07-24 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Safe and Secure Transport and Storage of Radioactive Materials reviews best practice and emerging techniques in this area. The transport of radioactive materials is an essential operation in the nuclear industry, without which the generation of nuclear power would not be possible. Radioactive materials also often need to be stored pending use, treatment, or disposal. Given the nature of radioactive materials, it is paramount that transport and storage methods are both safe and secure. A vital guide for managers and general managers in the nuclear power and transport industries, this book covers topics including package design, safety, security, mechanical performance, radiation protection and shielding, thermal performance, uranium ore, fresh fuel, uranium hexafluoride, MOX, plutonium, and more. Uniquely comprehensive and systematic coverage of the packaging, transport, and storage of radioactive materials Section devoted to spent nuclear fuels Expert team of authors and editors
Author : Tzvi Tzfira
Publisher : Springer Science & Business Media
ISBN 13 : 0387277471
Total Pages : 239 pages
Book Rating : 4.3/5 (872 download)
Download or read book Nuclear Import and Export in Plants and Animals written by Tzvi Tzfira and published by Springer Science & Business Media. This book was released on 2007-02-25 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Import and Export in Plants and Animals provides insight into the remarkable mechanisms of nuclear import and export. This book covers a range of topics from the nuclear pore structure, to nuclear import and export of macromolecules in plant and animal cells. In addition, the book covers the special cases of nuclear import of Agrobacterium T-DNA during plant genetic transformation, nuclear import and export of animal viruses, and nuclear intake of foreign DNA. A chapter on research methods to study nuclear transport concludes the book.
Author : Silvana Wolf
Publisher : GRIN Verlag
ISBN 13 : 3668443815
Total Pages : 75 pages
Book Rating : 4.6/5 (684 download)
Download or read book Analysis of Nuclear Transport Signals written by Silvana Wolf and published by GRIN Verlag. This book was released on 2017-05-09 with total page 75 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bachelor Thesis from the year 2015 in the subject Computer Science - Bioinformatics, Technical University of Munich, language: English, abstract: Nuclear transport of proteins is a basic cellular mechanism preceding a lot of biological processes. The classical transport mechanism for nuclear proteins involves karyopherins importing and exporting the proteins. The karyopherins recognize typically nuclear transport signals in the protein sequence. Three main types of nuclear localization signals (NLS) are focused in the scientific field of nuclear protein transport: monopartite, bipartite and PY-NLS. In studies on nuclear export signals (NES) the specific type of leucine-rich signals is often investigated. The first goal of this thesis was to update NLSdb, a database containing 114 experimental and 194 potential NLS, to the current state of available data. Towards this end, a set of 2452 novel signals with published experimental evidence was extracted from the literature and used as development set. An in silico mutagenesis approach was applied to this set to detect 4301 novel potential NLS in nuclear proteins. We matched these potential NLS in protein sequences of unannotated subcellular localization to identify nuclear proteins. We were able to confirm the predicted localization using our potential NLS in literature. Additional to the collection of data, an extensive analysis on protein sequences containing NLS and NES was performed to provide insights into subcellular localization of proteins and their occurrence in various organisms. A clustering of sequences of NLS led to the separation of signals into distinct sub-groups with a clear definition of a consensus sequence for each sub-group. Aligning potential NLS against the sub-groups resulted in a refinement of the consensus sequences. The results from this study reflect the scientific progress, lead to further knowledge in the field of nuclear transport and highlight the usability of bioinformatics methods for the discovery of new insights in biology. Nuclear transport is related to many interesting researches, for example allergic reactions, cancer and other diseases. The outcome of this work provides a good fundament for other studies with nuclear transport signals.
Author :
Publisher : Elsevier
ISBN 13 : 0124171788
Total Pages : 553 pages
Book Rating : 4.1/5 (241 download)
Download or read book Nuclear Pore Complexes and Nucleocytoplasmic Transport - Methods written by and published by Elsevier. This book was released on 2014-05-20 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 122 of Methods in Cell Biology describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (including mammalian cells, Xenopus, C. elegans, yeast). The volume enables investigators to analyze nuclear pore complex structure, assembly, and dynamics; to evaluate protein and RNA trafficking through the nuclear envelope; and to design in vivo or in vitro assays appropriate to their research needs. Beyond the study of nuclear pores and transport as such, these protocols will also be helpful to scientists characterizing gene regulation, signal transduction, cell cycle, viral infections, or aging. The NPC being one of the largest multiprotein complexes in the cell, some protocols will also be of interest for people currently characterizing other macromolecular assemblies. This book is thus designed for laboratory use by graduate students, technicians, and researchers in many molecular and cellular disciplines. Describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (mammalian cells, Xenopus, C. elegans, yeast) Chapters are written by experts in the field Cutting-edge material
Author : Ambikanandan Misra
Publisher : Elsevier
ISBN 13 : 0123849659
Total Pages : 686 pages
Book Rating : 4.1/5 (238 download)
Download or read book Challenges in Delivery of Therapeutic Genomics and Proteomics written by Ambikanandan Misra and published by Elsevier. This book was released on 2010-09-09 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of interest to researchers in both academia and industry Highlights what’s currently known and where further research is needed
Author : Mohamed Mohamed El-Wakil
Publisher :
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.3/5 (91 download)
Download or read book Nuclear Heat Transport written by Mohamed Mohamed El-Wakil and published by . This book was released on 1978 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the processes of energy (heat) generation in nuclear processes, the transport of that energy by the reactor coolant to the power cycle, and the limitations imposed by the transport mechanism on the design of nuclear reactor cores. Homework problems are presented at the end of each chapter.
Author : Dilantha Perera
Publisher : Cuvillier Verlag
ISBN 13 : 3736968477
Total Pages : 136 pages
Book Rating : 4.7/5 (369 download)
Download or read book A toolkit to study nuclear transport pathways: nanobody-mediated inhibition of importin β-related nuclear transport receptors (NTRs) written by Dilantha Perera and published by Cuvillier Verlag. This book was released on 2023-08-07 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eukaryotic cells are divided into a nuclear and a cytoplasmic compartment. This separates transcription from translation and makes gene expression dependent on nucleocytoplasmic transport. The members of the importin β superfamily function as shuttling nuclear transport receptors (NTRs) that recognize and actively transport cargoes through nuclear pores. An estimated 5 000 to 10 000 different human proteins are subject to active nuclear transport. Numerous cargo/NTR pairs have been identified, however, we are still far from a complete understanding as it has been very challenging to setup a systematic in vivo analysis that integrates the impact of all transport pathways. In this study, we obtained anti-NTR nanobodies against TRN1, Xpo4, Xpo7, and CAS. Our aim was to identify nanobodies, and prepare nanobody fusions, that impede nuclear pore-passage of the targeted NTR and thus, interrupt a given transport cycle. These nanobody fusions were observed to inhibit the partition of NTR/cargo complexes into a reconstituted FG phase. We also observed that the nanobodies and nanobody fusions inhibit NTR transport in permeabilized cells.
Author : Samuel E. Sparks
Publisher :
ISBN 13 :
Total Pages : 470 pages
Book Rating : 4.:/5 (1 download)
Download or read book Investigation Into the Dynamic Mechanism of Nuclear Transport Through the Nuclear Pore Complex written by Samuel E. Sparks and published by . This book was released on 2017 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt:
