Nr Coregulators And Human Diseases

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NR Coregulators and Human Diseases

Author : Rakesh Kumar
Publisher : World Scientific
ISBN 13 : 9812705368
Total Pages : 615 pages
Book Rating : 4.8/5 (127 download)

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Book Synopsis NR Coregulators and Human Diseases by : Rakesh Kumar

Download or read book NR Coregulators and Human Diseases written by Rakesh Kumar and published by World Scientific. This book was released on 2008 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a treasure for all those who have an interest in nuclear receptor coregulators and human diseases. Written by experts in the field, each chapter provides comprehensive, up-to-date information on the physiologic and pathologic roles of coregulators in specific organ systems, giving biomedical students; basic and clinical researchers; and educators in diverse sub-specialties a thorough summary of the overall subject. Readers will be able to understand the important current information and views on specific coactivators and corepressors and their roles in the pathogenesis of human diseases in areas outside their own expertise or experience. A special emphasis is placed on the ?classic? papers as well as perspectives on future directions for the field.

Nuclear Receptor Coregulators and Human Diseases

Author :
Publisher :
ISBN 13 : 9814476056
Total Pages : pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Nuclear Receptor Coregulators and Human Diseases by :

Download or read book Nuclear Receptor Coregulators and Human Diseases written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

NR Coregulators and Human Diseases

Author : Rakesh Kumar (Ph. D.)
Publisher : World Scientific
ISBN 13 : 9812819177
Total Pages : 615 pages
Book Rating : 4.8/5 (128 download)

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Book Synopsis NR Coregulators and Human Diseases by : Rakesh Kumar (Ph. D.)

Download or read book NR Coregulators and Human Diseases written by Rakesh Kumar (Ph. D.) and published by World Scientific. This book was released on 2008 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a treasure for all those who have an interest in nuclear receptor coregulators and human diseases. Written by experts in the field, each chapter provides comprehensive, up-to-date information on the physiologic and pathologic roles of coregulators in specific organ systems, giving biomedical students; basic and clinical researchers; and educators in diverse sub-specialties a thorough summary of the overall subject. Readers will be able to understand the important current information and views on specific coactivators and corepressors and their roles in the pathogenesis of human diseases in areas outside their own expertise or experience. A special emphasis is placed on the OC classicOCO papers as well as perspectives on future directions for the field. Sample Chapter(s). Chapter 1: Nuclear Receptor Coregulators in Human Diseases (839 KB). Contents: Nuclear Receptor Coregulators in Human Diseases (R B Lanz et al.); p160 Coactivators: Critical Mediators of Transcriptional Activation by Nuclear Receptors (J H Kim & M R Stallcup); Regulation of Nuclear Hormone Receptor Functions by Ubiquitin-Proteasome Pathway (A Ismail et al.); Coregulators as Oncogenes and Tumor Suppressors (R Kumar & A E Gururaj); A Central Role of SRC-3/AIB1 in Tumorigenesis (J Yan et al.); Thyroid Hormone Receptors, Coregulators, and Disease (M L Privalsky); Androgen Receptor Coactivators in Prostate Cancer (N L Weigel & I U Agoulnik); PGC-1 and Metabolic Control in Skeletal and Cardiac Muscle (Z Arany & B M Spiegelman); Coregulators in Metabolic and Neurodegenerative Diseases (J N Feige et al.); Role of the RIP140 Corepressor in Metabolic Regulation (M G Parker et al.); Nuclear Receptor Corepressors and Metabolism (T Alenghat & M A Lazar); Coregulators in CNS Function and Disease (O C Meijer & E R de Kloet); Tissue Repair and Cancer Control Through PPARs and Their Coregulators (L Michalik & W Wahli); Coregulators and Inflammation (S Ghisletti & W Huang); Nuclear Receptor Coactivators in the Cardiovascular System (J-M Xu); Coregulators as Determinants of Selective Receptor Modulator (SRM) Activity (M C Pace & C L Smith); Coregulators in Toxicology (J Regg et al.); Nuclear Receptor Coactivators Co-ordinate Metabolic Responses to Hormonal and Environmental Stimuli (R M Evans et al.); Nuclear Receptor Cofactor Interactions as Targets for New Drug Discovery (L L Grasfeder & D P McDonnell). Readership: Academic, medical students, residents, fellow and biomedical research students."

Nuclear Receptors in Human Health and Disease

Author : Moray J. Campbell
Publisher : Springer Nature
ISBN 13 : 3031118367
Total Pages : 338 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Nuclear Receptors in Human Health and Disease by : Moray J. Campbell

Download or read book Nuclear Receptors in Human Health and Disease written by Moray J. Campbell and published by Springer Nature. This book was released on 2022-09-15 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.

Gene Regulation, Epigenetics and Hormone Signaling

Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
ISBN 13 : 3527697241
Total Pages : 656 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Gene Regulation, Epigenetics and Hormone Signaling by : Subhrangsu S. Mandal

Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-05-09 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

Nuclear Receptors and Coregulators in Metabolism and Immunity

Author : Rongrong Fan
Publisher : Frontiers Media SA
ISBN 13 : 2889743292
Total Pages : 206 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Nuclear Receptors and Coregulators in Metabolism and Immunity by : Rongrong Fan

Download or read book Nuclear Receptors and Coregulators in Metabolism and Immunity written by Rongrong Fan and published by Frontiers Media SA. This book was released on 2022-02-04 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nuclear Receptor Coregulators

Author :
Publisher : Academic Press
ISBN 13 : 9780080522883
Total Pages : 304 pages
Book Rating : 4.5/5 (228 download)

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Book Synopsis Nuclear Receptor Coregulators by :

Download or read book Nuclear Receptor Coregulators written by and published by Academic Press. This book was released on 2004-08-11 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. *First published in 1943, Vitamins and Hormones is AP's longest running serial *Each volume contains cutting edge reviews by leading contributors

Cancer Research

Author :
Publisher :
ISBN 13 :
Total Pages : 660 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Cancer Research by :

Download or read book Cancer Research written by and published by . This book was released on 2009-11 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nuclear Receptors as Drug Targets

Author : Eckhard Ottow
Publisher : John Wiley & Sons
ISBN 13 : 3527623302
Total Pages : 522 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Nuclear Receptors as Drug Targets by : Eckhard Ottow

Download or read book Nuclear Receptors as Drug Targets written by Eckhard Ottow and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.

Metabolism and Disease

Author : Terri Grodzicker
Publisher :
ISBN 13 : 9781936113569
Total Pages : 0 pages
Book Rating : 4.1/5 (135 download)

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Book Synopsis Metabolism and Disease by : Terri Grodzicker

Download or read book Metabolism and Disease written by Terri Grodzicker and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Symposium aimed to integrate a very broad field of investigative effort, bringing together advances in our understanding of energy intake, consumption, and storage (diet, exercise, and fat), oxygen regulation and hypoxia, circadian rhythms, and life span/aging. The Symposium explored metabolism at molecular (gene expression, posttranslational modifications, protein turnover, cofactors and integrators, hormones, and signals), organellar (mitochondria), cellular, organ system (cardiovascular, bone), and organismal (timing and life span) scales. Diseases impacted by metabolic imbalance or dysregulation that were covered in detail included diabetes, obesity, metabolic syndrome, and cancer. New and emerging technologies were presented for simultaneous monitoring of hundreds of metabolites that allow for sophisticated sampling of the metabolic state of cells. Because the Symposium covered such a broad field, by necessity much excellent work could not be included, and instead, the Proceedings should be viewed as a necessarily eclectic collection of some of the most interesting and stimulating work that came to the organizers' attention during the 18 months before the meeting"--Page XV.

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B

Author :
Publisher : Academic Press
ISBN 13 : 0128226048
Total Pages : 402 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B by :

Download or read book Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B written by and published by Academic Press. This book was released on 2020-08-19 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field

Gene Regulation, Epigenetics and Hormone Signaling

Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
ISBN 13 : 3527322817
Total Pages : 678 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Gene Regulation, Epigenetics and Hormone Signaling by : Subhrangsu S. Mandal

Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

Genetic Steroid Disorders

Author : David M. Lonard
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128072997
Total Pages : 406 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genetic Steroid Disorders by : David M. Lonard

Download or read book Genetic Steroid Disorders written by David M. Lonard and published by Elsevier Inc. Chapters. This book was released on 2013-08-22 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear receptors are transcription factors that bind steroid, retinoid and thyroid hormones, and other ligands to drive hormone-dependent gene expression in conjunction with co-activators and co-repressors, collectively referred to as co-regulators. So far, more than 400 co-regulators have been reported in the literature and they have been implicated in a wide variety of pathological conditions, genetic syndromes, and in cancer. A key feature of co-regulator-based disease is the pleiotropic effects that disruption of normal co-regulator function has on energy metabolism, neurological function, and susceptibility to cancer. Technological advances in proteomics, genomics, and transcriptomics are leading to new ways to understand the pleiotropic actions of co-regulators. We expect that co-regulator ‘omics’ will lead to ways of understanding how co-regulators can be evaluated in the context of other complex genetic factors, hormones, diet, the environment, and stress. The broad role that co-regulators have in human pathological conditions makes it important to consider them as important new drug targets, such as for the treatment of hormone-dependent cancers or for indications related to energy metabolism. Better system-wide knowledge of co-regulator control of transcription and physiology is expected to lead to the best placement for future co-regulator-based therapies.

Nutritional Genomics

Author : Wayne R. Bidlack
Publisher : CRC Press
ISBN 13 : 1439844534
Total Pages : 448 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Nutritional Genomics by : Wayne R. Bidlack

Download or read book Nutritional Genomics written by Wayne R. Bidlack and published by CRC Press. This book was released on 2016-04-19 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The notion of matching diet with an individual's genetic makeup is transforming the way the public views nutrition as a means of managing health and preventing disease. To fulfill the promise of nutritional genomics, researchers are beginning to reconcile the diverse properties of dietary factors with our current knowledge of genome structure and g

Glucocorticoid Signaling

Author : Jen-Chywan Wang
Publisher : Springer
ISBN 13 : 1493928953
Total Pages : 387 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Glucocorticoid Signaling by : Jen-Chywan Wang

Download or read book Glucocorticoid Signaling written by Jen-Chywan Wang and published by Springer. This book was released on 2015-07-27 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.

Diagnosis and Management of Ovarian Disorders

Author : Albert Altchek
Publisher : Elsevier
ISBN 13 : 008049451X
Total Pages : 568 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Diagnosis and Management of Ovarian Disorders by : Albert Altchek

Download or read book Diagnosis and Management of Ovarian Disorders written by Albert Altchek and published by Elsevier. This book was released on 2003-09-04 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. KEY FEATURES * Includes updated information on early diagnosis of ovarian cancer * Reviews new diagnostic techniques for ovarian disorders * Discusses latest information on reproductive technology * Presents translational treatment linking laboratory research with clinical medicine

The Nuclear Receptor Superfamily

Author : Iain J. McEwan, PhD
Publisher : Humana Press
ISBN 13 : 9781603275743
Total Pages : 0 pages
Book Rating : 4.2/5 (757 download)

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Book Synopsis The Nuclear Receptor Superfamily by : Iain J. McEwan, PhD

Download or read book The Nuclear Receptor Superfamily written by Iain J. McEwan, PhD and published by Humana Press. This book was released on 2008-12-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acting principally to control patterns of gene expression, nuclear receptors play vital roles during embryonic development and in the regulation of metabolic and reproductive functions in adult life, which proves this superfamily of ligand-activated transcription factors to be a crucial part of biological life. In The Nuclear Receptor Superfamily: Methods and Protocols, expert researchers describe a range of molecular, structural and cell biological techniques currently used to investigate the structure-function of nuclear receptors, together with experimental approaches that may lead to new therapeutic strategies for treating nuclear receptor-associated diseases. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters in this volume contain brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, as well as notes from the experts to highlight tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, The Nuclear Receptor Superfamily: Methods and Protocols provides beneficial and time-saving guidance for all those undertaking research in this ever-growing field of study.