Novel Therapeutic Targets And Emerging Treatments For Fibrosis

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Novel Therapeutic Targets and Emerging Treatments for Fibrosis

Author : Chrishan S. Samuel
Publisher : Frontiers Media SA
ISBN 13 : 2889453723
Total Pages : 162 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Novel Therapeutic Targets and Emerging Treatments for Fibrosis by : Chrishan S. Samuel

Download or read book Novel Therapeutic Targets and Emerging Treatments for Fibrosis written by Chrishan S. Samuel and published by Frontiers Media SA. This book was released on 2018-01-12 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades we have known that the overgrowth, hardening and scarring of tissues (so-called fibrosis) represents the final common pathway and best histological predictor of disease progression in most organs. Fibrosis is the culmination of both excess extracellular matrix deposition due to ongoing or severe injury, and a failure to regenerate. An inadequate wound repair process ultimately results in organ failure through a loss of function, and is therefore a major cause of morbidity and mortality in disease affecting both multiple and individual organs. Whilst the pathology of fibrosis and its significance are well understood, until recently we have known little about its molecular regulation. Current therapies are often indirect and non-specific, and only slow progression by a matter of months. The recent identification of novel therapeutic targets, and the development of new treatment strategies based on them, offers the exciting prospect of more efficacious therapies to treat this debilitating disorder. This Research Topic therefore compromises several up-to-date mini-reviews on currently known and emerging therapeutic targets for fibrosis including: the Transforming Growth Factor (TGF)-family; epigenetic factors; Angiotensin II type 2 (AT2) receptors; mineralocorticoid receptors; adenosine receptors; caveolins; and the sphingosine kinase/sphingosine 1-phosphate and notch signaling pathways. In each case, mechanistic insights into how each of these factors contribute to regulating fibrosis progression are described, along with how they can be targeted (by existing drugs, small molecules or other mimetics) to prevent and/or reverse fibrosis and its contribution to tissue dysfunction and failure. Two additional reviews will discuss various anti-fibrotic therapies that have demonstrated efficacy at the experimental level, but are not yet clinically approved; and the therapeutic potential vs limitations of stem cell-based therapies for reducing fibrosis while facilitating tissue repair. Finally, this Research Topic concludes with a clinical perspective of various anti-fibrotic therapies for cardiovascular disease (CVD), outlining limitations of currently used therapies, the pipeline of anti-fibrotics for CVD and why so many anti-fibrotic drugs have failed at the clinical level.

Rare Diseases and Orphan Products

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309158060
Total Pages : 442 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Rare Diseases and Orphan Products by : Institute of Medicine

Download or read book Rare Diseases and Orphan Products written by Institute of Medicine and published by National Academies Press. This book was released on 2011-04-03 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.

Emerging Therapeutic Approaches for Cystic Fibrosis

Author : Miquéias Lopes-Pacheco
Publisher : Frontiers Media SA
ISBN 13 : 2889633675
Total Pages : 281 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Emerging Therapeutic Approaches for Cystic Fibrosis by : Miquéias Lopes-Pacheco

Download or read book Emerging Therapeutic Approaches for Cystic Fibrosis written by Miquéias Lopes-Pacheco and published by Frontiers Media SA. This book was released on 2020-01-27 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fibrosis in Disease

Author : Monte S. Willis
Publisher : Springer
ISBN 13 : 3319981439
Total Pages : 474 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Fibrosis in Disease by : Monte S. Willis

Download or read book Fibrosis in Disease written by Monte S. Willis and published by Springer. This book was released on 2018-11-10 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fibroproliferative diseases are a broad spectrum of entities from organ-specific involvement (e.g., pulmonary, heart, liver, and kidney fibrosis) to multi-system diseases such as systemic sclerosis and sclerodermatous graft vs. host disease. These diseases also encompass pathophysiologies not readily recognizably related, such as macular degeneration and cancer metastasis. Fibroproliferative diseases are a leading cause of morbidity and mortality and can affect all tissues and organ systems. Remarkable progress in elucidating the pathogenesis of these common diseases with fibrotic components, including the critical roles of myofibroblasts and the molecular mechanisms driving the transcriptional activation involved in the induction of fibrosis. As the importance of these processes is realized in the long-term recovery and treatment of diseases, effective anti-fibrotic therapies targeting the underlying ongoing disease processes are lacking. The complexity of discovering and applying therapies to fibroproliferative disease may be due to the diversity of the systems the pathogenesis of disease itself involves. By nature, fibroproliferative diseases are interdisciplinary, involving multiple cell types (organ-specific epithelial cells), immune cells, endothelial cells, and fibroblasts. Bone marrow, cytokines, and organ-specific pathologies further speckle both the clinical and scientific disciplines in such a way that communication is often limited to the clinical or scientific tribes we live in, despite the greatest access to information known to man available today. Therefore, the primary focus of this text is to bring together authors from a diversity of both clinical, scientific, and therapeutic backgrounds for readers to more fully appreciate that fantastic platform that is available to build upon to lessen the isolation of the clinical and scientific disciplines. With advances in the discovery of pre-clinical therapeutic targets (at least 20+ to date) involving TGF-beta (and other cytokines), transcription factors, and downstream kinases, it’s important to both recognize the broader impact and potential opportunities that exist even today. This book will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of fibroproliferative diseases. The book will provide new insight into the fundamental mechanisms of classic fibrotic pathophysiologic processes like myocardial infarction, idiopathic pulmonary fibrosis, chronic kidney disease, wound healing, and systemic sclerosis. It will also highlight the many new areas of therapeutic investigation currently underway. Lastly, we will touch upon newly emerging fields investigating the role of fibrosis in macular degeneration and cancer metastasis. The chapters will be written by established experts in their fields, including clinicians (cardiologists, cardiovascular surgeons, pathologists, and general practitioners) and translational biomedical researchers in a wide range of disciplines. However, the material will certainly have a broader audience including medical residents, fellows, and general practitioners as well as M.D. or Ph.D. post-doctoral research fellows. While comprehensive, we'll attempt to present the material in a manner that simplifies the complex pathophysiologic mechanisms that underlie common fibroproliferative diseases while making it appealing to a broad audience.

Emerging Therapeutic Targets and Drug Delivery Approaches in IBD

Author :
Publisher : Elsevier
ISBN 13 : 0443313598
Total Pages : 402 pages
Book Rating : 4.4/5 (433 download)

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Book Synopsis Emerging Therapeutic Targets and Drug Delivery Approaches in IBD by :

Download or read book Emerging Therapeutic Targets and Drug Delivery Approaches in IBD written by and published by Elsevier. This book was released on 2024-12-01 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Therapeutic Targets and Drug Delivery Approaches in IBD, Volume 101 in this ongoing series, highlights new advances, with this volume presenting interesting chapters on timely topics, including Fibrosis in IBD – AXL as a Promising Therapeutic Target, Developing a pathway to test anti-fibrotic drugs in Crohn's disease, Emerging therapeutics for the management of intestinal fibrosis and strictures, GCPII for IBD, Fistulas/stem cell products for IBD/Crohn's, The landscape of new therapeutic opportunities for IBD, TL1A : A Model For The Use Of Precision Medicine For The Treatment of Crohn's Disease and Ulcerative Colitis, Dectin-1 as a therapeutic target for IBD, and more.Additional sections cover BRD4 as an Emerging Epigenetic Therapeutic Target for Inflammatory Bowel Diseases, Scripps - S1P, The potential of targeting TREM-1 in Inflammatory Bowel Disease, and Microbiome therapies. - Provides the latest information on emerging therapeutic targets and drug research - Offers outstanding and original reviews on a range of emerging therapeutic targets and drug research topics - Serves as an indispensable reference for researchers and students alike

Chronic Liver Disease: New Targets and New Mechanisms

Author : Jinhang Gao
Publisher : Frontiers Media SA
ISBN 13 : 2889767760
Total Pages : 186 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Chronic Liver Disease: New Targets and New Mechanisms by : Jinhang Gao

Download or read book Chronic Liver Disease: New Targets and New Mechanisms written by Jinhang Gao and published by Frontiers Media SA. This book was released on 2022-08-16 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Textbook on Scar Management

Author : Luc Téot
Publisher : Springer Nature
ISBN 13 : 3030447669
Total Pages : 553 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Textbook on Scar Management by : Luc Téot

Download or read book Textbook on Scar Management written by Luc Téot and published by Springer Nature. This book was released on 2020-12-07 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text book is open access under a CC BY 4.0 license. Written by a group of international experts in the field and the result of over ten years of collaboration, it allows students and readers to gain to gain a detailed understanding of scar and wound treatment – a topic still dispersed among various disciplines. The content is divided into three parts for easy reference. The first part focuses on the fundamentals of scar management, including assessment and evaluation procedures, classification, tools for accurate measurement of all scar-related elements (volume density, color, vascularization), descriptions of the different evaluation scales. It also features chapters on the best practices in electronic-file storage for clinical reevaluation and telemedicine procedures for safe remote evaluation. The second section offers a comprehensive review of treatment and evidence-based technologies, presenting a consensus of the various available guidelines (silicone, surgery, chemical injections, mechanical tools for scar stabilization, lasers). The third part evaluates the full range of emerging technologies offered to physicians as alternative or complementary solutions for wound healing (mechanical, chemical, anti-proliferation). Textbook on Scar Management will appeal to trainees, fellows, residents and physicians dealing with scar management in plastic surgery, dermatology, surgery and oncology, as well as to nurses and general practitioners

Inflammation and Fibrosis in the Gastrointestinal Tract and Liver: Mechanisms and Targets

Author : Ralf Weiskirchen
Publisher : Frontiers Media SA
ISBN 13 : 2889716260
Total Pages : 421 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Inflammation and Fibrosis in the Gastrointestinal Tract and Liver: Mechanisms and Targets by : Ralf Weiskirchen

Download or read book Inflammation and Fibrosis in the Gastrointestinal Tract and Liver: Mechanisms and Targets written by Ralf Weiskirchen and published by Frontiers Media SA. This book was released on 2023-04-04 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt:

New insights into renal fibrosis and therapeutic effects of natural products, volume II

Author : Dan-Qian Chen
Publisher : Frontiers Media SA
ISBN 13 : 2832514286
Total Pages : 227 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis New insights into renal fibrosis and therapeutic effects of natural products, volume II by : Dan-Qian Chen

Download or read book New insights into renal fibrosis and therapeutic effects of natural products, volume II written by Dan-Qian Chen and published by Frontiers Media SA. This book was released on 2023-04-19 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Idiopathic Pulmonary Fibrosis

Author : Ulrich Costabel
Publisher : European Respiratory Society
ISBN 13 : 1849840687
Total Pages : 292 pages
Book Rating : 4.8/5 (498 download)

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Book Synopsis Idiopathic Pulmonary Fibrosis by : Ulrich Costabel

Download or read book Idiopathic Pulmonary Fibrosis written by Ulrich Costabel and published by European Respiratory Society. This book was released on 2016-03-01 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Idiopathic pulmonary fibrosis (IPF) is a steadily progressive and ultimately fatal disease of unknown origin. Recent years have seen advances in our understanding of IPF and a number of guidelines have been published. But many questions remain unanswered, particularly surrounding probable versus definite IPF. This Monograph aims to discuss the latest achievements in IPF, and covers key diagnostic issues, staging of the disease, complications and comorbidities, treatment, unmet patient needs and perspectives for the future. This book will be of interest to all clinicians and researchers in this area.

Textbook of Vascular Medicine

Author : Rhian M. Touyz
Publisher : Springer
ISBN 13 : 3030164810
Total Pages : 497 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Textbook of Vascular Medicine by : Rhian M. Touyz

Download or read book Textbook of Vascular Medicine written by Rhian M. Touyz and published by Springer. This book was released on 2019-08-02 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.

Anti-fibrotic Drug Discovery

Author : Jehrod Brenneman
Publisher : Royal Society of Chemistry
ISBN 13 : 1839160519
Total Pages : 364 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Anti-fibrotic Drug Discovery by : Jehrod Brenneman

Download or read book Anti-fibrotic Drug Discovery written by Jehrod Brenneman and published by Royal Society of Chemistry. This book was released on 2020-02-17 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various tissues, comprehensively covering recent success and future perspectives on emerging therapeutic intervention points. The book highlights significant pre-clinical and clinical drugs currently being developed globally for this disorder. This book is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.

Therapeutic Targets For Inflammation And Cancer: Novel Therapies For Digestive Diseases

Author : Chi-hin Cho
Publisher : World Scientific
ISBN 13 : 9813148586
Total Pages : 458 pages
Book Rating : 4.8/5 (131 download)

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Book Synopsis Therapeutic Targets For Inflammation And Cancer: Novel Therapies For Digestive Diseases by : Chi-hin Cho

Download or read book Therapeutic Targets For Inflammation And Cancer: Novel Therapies For Digestive Diseases written by Chi-hin Cho and published by World Scientific. This book was released on 2017-04-20 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book deals with both inflammation and cancer in a single source of publication. They are seldom grouped together although it has been known that both diseases are closely associated, particularly in the gastrointestinal tract and liver. As the book touches on two such major areas of diseases in humans, it should be of interest to a wider audience of researchers and readers. It is noted that the book combines the effort of both basic scientists and clinicians from different countries with extensive experiences in molecular biology and clinical practice to unveil the most updated picture of the pathogenesis and therapeutic strategies in the treatment of inflammation and cancer in the digestive tract. In this regard, potential pathogenic modulators and also therapeutic options are widely discussed. These types of information would definitely broaden our knowledge in better understanding these diseases.

Exploring Novel Clinical Trial Designs for Gene-Based Therapies

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309672988
Total Pages : 127 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Exploring Novel Clinical Trial Designs for Gene-Based Therapies by : National Academies of Sciences, Engineering, and Medicine

Download or read book Exploring Novel Clinical Trial Designs for Gene-Based Therapies written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-08-27 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognizing the potential design complexities and ethical issues associated with clinical trials for gene therapies, the Forum on Regenerative Medicine of the National Academies of Sciences, Engineering, and Medicine held a 1-day workshop in Washington, DC, on November 13, 2019. Speakers at the workshop discussed patient recruitment and selection for gene-based clinical trials, explored how the safety of new therapies is assessed, reviewed the challenges involving dose escalation, and spoke about ethical issues such as informed consent and the role of clinicians in recommending trials as options to their patients. The workshop also included discussions of topics related to gene therapies in the context of other available and potentially curative treatments, such as bone marrow transplantation for hemoglobinopathies. This publication summarizes the presentation and discussion of the workshop.

Mechanisms of Chronic Liver Diseases: Identifying New Therapeutic Targets

Author : Gianfranco Danilo Alpini
Publisher : Frontiers Media SA
ISBN 13 : 2889741567
Total Pages : 279 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Mechanisms of Chronic Liver Diseases: Identifying New Therapeutic Targets by : Gianfranco Danilo Alpini

Download or read book Mechanisms of Chronic Liver Diseases: Identifying New Therapeutic Targets written by Gianfranco Danilo Alpini and published by Frontiers Media SA. This book was released on 2022-01-25 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition (EMT) and Fibrosis

Author : Cecilia Battistelli
Publisher : Frontiers Media SA
ISBN 13 : 2889635023
Total Pages : 219 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition (EMT) and Fibrosis by : Cecilia Battistelli

Download or read book Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition (EMT) and Fibrosis written by Cecilia Battistelli and published by Frontiers Media SA. This book was released on 2020-02-10 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Lung Microbiome

Author : Michael J. Cox
Publisher : European Respiratory Society
ISBN 13 : 1849841020
Total Pages : 261 pages
Book Rating : 4.8/5 (498 download)

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Book Synopsis The Lung Microbiome by : Michael J. Cox

Download or read book The Lung Microbiome written by Michael J. Cox and published by European Respiratory Society. This book was released on 2019-03-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studying the lung microbiome requires a specialist approach to sampling, laboratory techniques and statistical analysis. This Monograph introduces the techniques used and discusses how respiratory sampling, 16S rRNA gene sequencing, metagenomics and the application of ecological theory can be used to examine the respiratory microbiome. It examines the different components of the respiratory microbiome: viruses and fungi in addition to the more frequently studied bacteria. It also considers a range of contexts from the paediatric microbiome and how this develops to disease of all ages including asthma and chronic obstructive pulmonary disease, chronic suppurative lung diseases, interstitial lung diseases, acquired pneumonias, transplantation, cancer and HIV, and the interaction of the respiratory microbiome and the environment.