Novel Therapeutic Approaches For Biliary Tract Cancer And Hepatocellular Carcinoma

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Novel Therapeutic Approaches for Biliary Tract Cancer and Hepatocellular Carcinoma

Author : Daniel Neureiter
Publisher : Frontiers Media SA
ISBN 13 : 2832539661
Total Pages : 138 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Novel Therapeutic Approaches for Biliary Tract Cancer and Hepatocellular Carcinoma by : Daniel Neureiter

Download or read book Novel Therapeutic Approaches for Biliary Tract Cancer and Hepatocellular Carcinoma written by Daniel Neureiter and published by Frontiers Media SA. This book was released on 2023-11-24 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatobiliary cancers, encompassing biliary tract cancer (BTC) and hepatocellular carcinoma (HCC) are highly lethal. Biliary tract cancer is a deadly disease with a very low five-year survival rate. BTC is assumed to be the fifth most common gastrointestinal malignancy and can be categorized into extrahepatic cholangiocarcinoma (EHC), intrahepatic cholangiocarcinoma (IHC) and gallbladder cancer (GBC), based on the anatomic location. Patients suffering from BTC can be currently treated with radiation therapy, palliative or with a combination of two chemotherapeutics, cisplatin and gemcitabine. Hepatocellular carcinoma is the most prevalent form of liver cancers and was responsible for over 830,000 deaths related to cancer worldwide in 2020. HCC is therefore the second most leading cause of cancer deaths globally. Current treatment options encompass targeted therapy with sorafenib, immunotherapy and post-surgery adjuvant chemotherapy. Factors that might contribute to these dismal outcomes are diagnosis at an already late stage, due to unspecific symptoms, limited therapeutic options, lack of targets and understanding of molecular processes during carcinogenesis as well as resistance to current chemotherapy/treatment. Therefore, these current issues need to be further addressed and solutions and alternative approaches must be provided in order to detect these illnesses at an early stage, prolong the survival time of patients suffering from HCC and BTC and overcome general resistance to available treatment options. The aim of this research topic is to provide an overview about mechanisms of therapy resistance, the identification of therapeutic relevant targets and finally, innovative and alternative approaches for treating BTC and HCC successfully.

Biliary Tract and Gallbladder Cancer

Author : Joseph M. Herman
Publisher : Springer Science & Business Media
ISBN 13 : 3642405584
Total Pages : 345 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Biliary Tract and Gallbladder Cancer by : Joseph M. Herman

Download or read book Biliary Tract and Gallbladder Cancer written by Joseph M. Herman and published by Springer Science & Business Media. This book was released on 2014-03-21 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this book is intended as a definitive text on biliary tract and gallbladder cancers. Specifically, it will serve as a single-source reference on the current knowledge base for the multidisciplinary management of such cancers and thus covers epidemiological, surgical, radiotherapy, and chemotherapy approaches. A key feature is the demonstration of the impact of cutting-edge technical knowledge on treatment; for example, interventional radiology techniques, novel surgical approaches, and image-guided radiation therapy are all extensively discussed. Diagnosis is also considered in detail, with coverage of novel serum biomarkers, pathologic staging, molecular profiling, and the full range of current and emerging imaging strategies. This book will be an invaluable source of information on new techniques for experienced practitioners, yet is sufficiently concise to offer an introduction to the field for students and community practitioners.

Diagnosis and Management of Cholangiocarcinoma

Author : James H. Tabibian
Publisher : Springer Nature
ISBN 13 : 3030709361
Total Pages : 589 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Diagnosis and Management of Cholangiocarcinoma by : James H. Tabibian

Download or read book Diagnosis and Management of Cholangiocarcinoma written by James H. Tabibian and published by Springer Nature. This book was released on 2021-05-28 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive, state-of-the-art overview of cholangiocarcinoma (CCA). The text is structured to effectively present a broad yet concise overview of bile duct cancer, its relevant definitions, classification schemata, clinical management tenets, translational (including molecular and cellular) facets, and future directions. The book features numerous high-yield illustrations and is authored by an eclectic range of renowned experts in various areas of CCA, reflecting the multidisciplinary nature of the field. Filling a critical gap in the field, Diagnosis and Management of Cholangiocarcinoma: A Multidisciplinary Approach is a valuable resource for clinicians and practitioners who treat patients with bile duct cancer.

Hepatobiliary Cancer

Author : Paul H. Sugarbaker
Publisher :
ISBN 13 : 9781461526056
Total Pages : 348 pages
Book Rating : 4.5/5 (26 download)

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Book Synopsis Hepatobiliary Cancer by : Paul H. Sugarbaker

Download or read book Hepatobiliary Cancer written by Paul H. Sugarbaker and published by . This book was released on 2014-09-01 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Liver Cancers

Author : Tim Cross
Publisher : Springer
ISBN 13 : 3319922165
Total Pages : 312 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Liver Cancers by : Tim Cross

Download or read book Liver Cancers written by Tim Cross and published by Springer. This book was released on 2018-12-12 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in detail the primary liver cancers of hepatocellular carcinoma and cholangiocarcinoma examining the pathogenesis of disease along with diagnosis and current management options together with exploration of future treatment strategies and areas of controversy. Furthermore, the book highlights management of the common secondary malignancies and touches on benign liver tumours and how to best manage these. Written in a clear and didactic style, this volume includes summaries of the key learning points and questions so that the reader can gauge their knowledge and understanding. This book is aimed to broaden the knowledge base of primary care physicians, general physicians along with specialists in hepatology, oncology and hepato-biliary surgery

Hepatocellular Carcinoma

Author : Yujin Hoshida
Publisher : Springer
ISBN 13 : 3030215407
Total Pages : 366 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Hepatocellular Carcinoma by : Yujin Hoshida

Download or read book Hepatocellular Carcinoma written by Yujin Hoshida and published by Springer. This book was released on 2019-08-05 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Surgical Treatment

Author : René Holzheimer
Publisher :
ISBN 13 :
Total Pages : 880 pages
Book Rating : 4.6/5 (211 download)

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Book Synopsis Surgical Treatment by : René Holzheimer

Download or read book Surgical Treatment written by René Holzheimer and published by . This book was released on 2001 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Novel therapeutic approaches for gastrointestinal malignancies

Author : Ganji Purnachandra Nagaraju
Publisher : Springer Nature
ISBN 13 : 9811554714
Total Pages : 259 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Novel therapeutic approaches for gastrointestinal malignancies by : Ganji Purnachandra Nagaraju

Download or read book Novel therapeutic approaches for gastrointestinal malignancies written by Ganji Purnachandra Nagaraju and published by Springer Nature. This book was released on 2020-10-01 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.

Drug Repurposing in Cancer Therapy

Author : Kenneth K.W. To
Publisher : Academic Press
ISBN 13 : 0128199032
Total Pages : 460 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug Repurposing in Cancer Therapy by : Kenneth K.W. To

Download or read book Drug Repurposing in Cancer Therapy written by Kenneth K.W. To and published by Academic Press. This book was released on 2020-07-29 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. - Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research - Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences - Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Immunotherapy of Hepatocellular Carcinoma

Author : Tim F. Greten
Publisher : Springer
ISBN 13 : 9783319879116
Total Pages : 0 pages
Book Rating : 4.8/5 (791 download)

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Book Synopsis Immunotherapy of Hepatocellular Carcinoma by : Tim F. Greten

Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2018-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.

The Heterogeneity of Cancer Metabolism

Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Diseases of the Gallbladder and Bile Ducts

Author : Pierre-Alain Clavien
Publisher : John Wiley & Sons
ISBN 13 : 0470986972
Total Pages : 448 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Diseases of the Gallbladder and Bile Ducts by : Pierre-Alain Clavien

Download or read book Diseases of the Gallbladder and Bile Ducts written by Pierre-Alain Clavien and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: An interdisciplinary reference book for the diagnosis and treatment of gallbladder and bile duct diseases With recent developments in the management of hepatobiliary diseases including liver transplantation, this new edition aids all members of the team by addressing both the biliary indications for and biliary complications of these procedures. It's divided into three sections on anatomy, pathophysiology, and epidemiology; diagnostic and therapeutic approaches including the latest therapeutic modalities; and specific conditions. Includes more than 250 illustrations for rapid reference. Each chapter now has a Q&A section and begins with a list of objectives outlining the chapter’s goals. In addition, a number of new imaging modalities are presented in this new edition. It takes an integrated medical, surgical and radiological approach, making this invaluable to all members of the team who deal with complications of liver transplantation and the management of patients.

Liver Transplantation

Author : James Neuberger
Publisher : John Wiley & Sons
ISBN 13 : 1119633990
Total Pages : 592 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Liver Transplantation by : James Neuberger

Download or read book Liver Transplantation written by James Neuberger and published by John Wiley & Sons. This book was released on 2021-02-25 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore this practical and step-by-step guide to managing liver transplant patients from leading international clinicians in Hepatology The newly revised Second Edition of Liver Transplantation: Clinical Assessment and Management delivers expert clinical guidance on best practices in managing the care of liver transplant patients. Authors are all experts in their field and cover a world-wide perspective. Organized in an accessible, stepwise fashion and packed with text features such as key points, the book covers all critical areas of each stage of the liver transplant journey, from assessment, to management on the list, to long term care. Readers will learn when to refer a patient for liver transplantation, how to assess a potential liver transplant recipient, learn the principles of the procedure and the long term management of the transplant recipient. Liver Transplantation provides the entire hepatology and surgical team the information required for a sound understanding of the entire procedure, from pre- to post-operative care and management. Clinically oriented and management-focused, the book is far more accessible than the liver transplant sections in traditional hepatology textbooks. Readers will also enjoy: A thorough discussion of when to refer a patient for liver transplantation, including general considerations and the use and abuse of prognostic models An exploration of the selection, assessment, and management of patients on the transplant list, including how to manage a patient with chronic liver disease while on the waiting list A treatment of liver transplantation for acute liver failure (ALF), including assessment and management of ALF patients on the transplant waiting list A discussion of care of the liver transplant recipient after the procedure in the short and long term Perfect for gastroenterologists, hepatologists, and surgeons and other health care professionals managing patients with liver disease who are awaiting, undergoing and following liver transplantation, Liver Transplantation: Clinical Assessment and Management will also earn a place in the libraries of medical students, residents, internal medicine physicians, and GI/Hepatology trainees and all health care professionals providing clinical care to people with liver disease, before, during and after transplantation.

Cholangiocarcinoma

Author : Dario Ribero
Publisher : Nova Science Publishers
ISBN 13 : 9781634834889
Total Pages : 0 pages
Book Rating : 4.8/5 (348 download)

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Book Synopsis Cholangiocarcinoma by : Dario Ribero

Download or read book Cholangiocarcinoma written by Dario Ribero and published by Nova Science Publishers. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cholangiocarcinoma is a heterogeneous group of neoplasms, which has a rising worldwide incidence. Therefore, it is now a major cause of cancer mortality. Diagnosis, staging, treatment approaches and outcomes differ significantly based on the location of the tumor. Given the challenges of remaining up-to-date in a rapidly expanding field, the aim of this monograph is to provide a comprehensive, fully referenced presentation of the state-of-the-art medical and surgical aspects relevant to the management of cholangiocarcinoma divided by the site of origin (i.e. intrahepatic, hilar and distal). The division of the book into these sections reflects the biological and clinical differences between these tumor types and will permit the authors to address the diagnostic, interventional or treatment issues specific to each tumor type. By presenting all medical and surgical aspects of cholangiocarcinoma in a systematic manner, this monograph will be a ready-to-use instrument for those interested in cholangiocarcinoma, including practicing physicians, residents, fellows and specialists. A list of 66 world-renowned experts contributed to the book, offering the readers the unique opportunity to have a broad perspective on these diseases, practical indications on patient selection and treatment that can be easily applied to both Eastern and Western clinical settings.

Cancer Medicine

Author : James F. Holland
Publisher :
ISBN 13 : 9780683040951
Total Pages : 3467 pages
Book Rating : 4.0/5 (49 download)

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Book Synopsis Cancer Medicine by : James F. Holland

Download or read book Cancer Medicine written by James F. Holland and published by . This book was released on 1997 with total page 3467 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hepatocellular Carcinoma: Novel Treatment Strategies - Volume II

Author : Fan Feng
Publisher : Frontiers Media SA
ISBN 13 : 2832535917
Total Pages : 291 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Hepatocellular Carcinoma: Novel Treatment Strategies - Volume II by : Fan Feng

Download or read book Hepatocellular Carcinoma: Novel Treatment Strategies - Volume II written by Fan Feng and published by Frontiers Media SA. This book was released on 2023-10-17 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hepatobiliary and Pancreatic Radiology

Author : G. Scott Gazelle
Publisher : Thieme
ISBN 13 : 9780865777163
Total Pages : 934 pages
Book Rating : 4.7/5 (771 download)

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Book Synopsis Hepatobiliary and Pancreatic Radiology by : G. Scott Gazelle

Download or read book Hepatobiliary and Pancreatic Radiology written by G. Scott Gazelle and published by Thieme. This book was released on 1998 with total page 934 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, advanced imaging and interventional techniques have greatly improved the treatment of all forms of liver, biliary, and pancreatic disease. They have also transformed hepatobiliary and pancreatic radiology into an increasingly useful and sought-after specialty. Organized by anatomic region, this book is designed to help specialists develop a comprehensive approach to disorders of the liver, pancreas, and biliary tract. Special features include: Detailed instruction in all radiologic techniques, including ultrasound, computed tomography, MRI, angiography, nuclear medicine, ERC, and transhepatic cholangiography Full information on a wide range of hepatobiliary and pancreatic disorders, and the techniques used in their treatment. Complete coverage of interventional procedures Special chapters on the treatment of trauma, postoperative, and pediatric patients Practical and comprehensive, HEPATOBILIARY AND PANCREATIC RADIOLOGY is a must for both newcomers and experienced radiologists!