Novel Approaches And Strategies For Biologics Vaccines And Cancer Therapies

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Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies

Author : Manmohan Singh
Publisher : Academic Press
ISBN 13 : 012416661X
Total Pages : 520 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies by : Manmohan Singh

Download or read book Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies written by Manmohan Singh and published by Academic Press. This book was released on 2014-12-30 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Cancer Immunotherapy and Biological Cancer Treatments

Author : Hilal Arnouk
Publisher : BoD – Books on Demand
ISBN 13 : 1789848628
Total Pages : 114 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Cancer Immunotherapy and Biological Cancer Treatments by : Hilal Arnouk

Download or read book Cancer Immunotherapy and Biological Cancer Treatments written by Hilal Arnouk and published by BoD – Books on Demand. This book was released on 2019-11-13 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, biological cancer therapies, including immunotherapy, have moved from the bench to mainstream medical treatments of several types of cancer. The success of these treatments relies on innovative approaches to specifically interfere with molecular targets that are involved in the growth, progression, and spread of malignant cells, or to bypass the tumor evasion of the immune system utilizing the latest advances in cancer vaccine development, formulation, and delivery. This book presents an up-to-date overview of novel cancer biological and immunotherapeutic approaches, including cancer vaccines, mimetic vaccines, monoclonal antibodies, adoptive T-cell transfer, chimeric antigen receptor T- cells, tumor infiltrating lymphocytes, dendritic cells, natural killer cells, immune checkpoint inhibitors, laser ablation, and immune stimulating interstitial laser thermotherapy.

Rare Diseases and Orphan Products

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309158060
Total Pages : 442 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Rare Diseases and Orphan Products by : Institute of Medicine

Download or read book Rare Diseases and Orphan Products written by Institute of Medicine and published by National Academies Press. This book was released on 2011-04-03 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.

Cancer Vaccines and Immunotherapy

Author : Peter L. Stern
Publisher : Cambridge University Press
ISBN 13 : 9780521622639
Total Pages : 304 pages
Book Rating : 4.6/5 (226 download)

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Book Synopsis Cancer Vaccines and Immunotherapy by : Peter L. Stern

Download or read book Cancer Vaccines and Immunotherapy written by Peter L. Stern and published by Cambridge University Press. This book was released on 2000-08-17 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid progress in the definition of tumor antigens, and improved immunization methods, bring effective cancer vaccines within reach. In this wide-ranging survey, leading clinicians and scientists review therapeutic cancer vaccine strategies against a variety of diseases and molecular targets. Intended for an interdisciplinary readership, their contributions cover the rationale, development, and implementation of vaccines in human cancer treatment, with specific reference to cancer of the cervix, breast, colon, bladder, and prostate, and to melanoma and lymphoma. They review target identification, delivery vectors and clinical trial design. The book begins and ends with lucid overviews from the editors, that discuss the most recent developments.

Cancer Targeted Drug Delivery

Author : You Han Bae
Publisher : Springer Science & Business Media
ISBN 13 : 1461478766
Total Pages : 717 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Cancer Targeted Drug Delivery by : You Han Bae

Download or read book Cancer Targeted Drug Delivery written by You Han Bae and published by Springer Science & Business Media. This book was released on 2013-08-31 with total page 717 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was conceived from a simple question as to why cancer is so difficult to treat. Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future. This leads the question of whether it is possible to improve current cancer treatment methods, especially from the perspective of enhancing targeted drug delivery to tumors. This volume is designed to provide information related to the difficulties in treating cancers through targeted drug delivery, our current understanding of cancer biology, and potential technologies that might be used to achieve enhanced drug delivery to tumors. An ideal drug delivery system for treating cancers would maximize the therapeutic efficacy with minimal side effects in clinical applications. The seemingly improved anticancer efficacy of the current nanoparticle-based formulations needs to be viewed from the context of very poor success rates for translation to human applications. The results of in vitro cell culture models and small animal in vivo experiments have not been extrapolated to clinical applications. Finding the reasons for the lack of successful translation is required if we are to discover approaches to substantially extend the survival time of cancer patients, and hopefully identify cures. Cancer Targeted Drug Delivery: Elusive Dream describes some answers of achieving the so far elusive dream of treating cancers like other chronic diseases with therapies that focus using improved drug delivery systems designed to better align with the unique biological and physiological properties of cancer.

Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents

Author : Manju Rawat Singh
Publisher : Academic Press
ISBN 13 : 0128199180
Total Pages : 657 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents by : Manju Rawat Singh

Download or read book Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents written by Manju Rawat Singh and published by Academic Press. This book was released on 2020-04-07 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications. Advances information on various bioactive based medications, their sources, clinical consequences and transport strategies Illustrates diverse transport systems for bioactives and derivatives, novel techniques for formulations, targeting strategies and fundamental qualities of developed bioactive carriers, and their safety concerns and standardization Discusses distinctive transport systems, stability, upgraded dissolvability, and enhanced bioavailability of bioactives

Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases

Author : Dinesh Kumar Chellappan
Publisher : Springer Nature
ISBN 13 : 981164392X
Total Pages : 652 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases by : Dinesh Kumar Chellappan

Download or read book Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases written by Dinesh Kumar Chellappan and published by Springer Nature. This book was released on 2022-03-23 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.

Novel Treatment Strategies for Glioblastoma

Author : Stanley Stylli
Publisher : Mdpi AG
ISBN 13 : 9783036525990
Total Pages : 282 pages
Book Rating : 4.5/5 (259 download)

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Book Synopsis Novel Treatment Strategies for Glioblastoma by : Stanley Stylli

Download or read book Novel Treatment Strategies for Glioblastoma written by Stanley Stylli and published by Mdpi AG. This book was released on 2021-12-21 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of articles that brings together current knowledge from an international team of contributors who are dedicated investigators exploring novel strategies for the treatment of glioblastoma. These articles describe some of the latest concepts that will provide students, researchers and clinicians with an overview of the therapeutic approaches being developed in the field of neuro-oncology to combat this deadly disease.

Vaccines for Cancer Immunotherapy

Author : Nima Rezaei
Publisher : Academic Press
ISBN 13 : 0128140402
Total Pages : 198 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Vaccines for Cancer Immunotherapy by : Nima Rezaei

Download or read book Vaccines for Cancer Immunotherapy written by Nima Rezaei and published by Academic Press. This book was released on 2018-10-17 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic cancer vaccines represent a type of active cancer immunotherapy. Clinicians, scientists, and researchers working on cancer treatment require evidence-based and up-to-date resources relating to therapeutic cancer vaccines. Vaccines for Cancer Immunotherapy provides a reference for cancer treatment for clinicians and presents a well-organized resource for determining high-potential research areas. The book considers that this promising modality can be made more feasible as a treatment for cancer. Chapters cover cancer immunology, general approaches to cancer immunotherapy, vaccines, tumor antigens, the strategy of allogeneic and autologous cancer vaccines, personalized vaccines, whole-tumor antigen vaccines, protein and peptide vaccines, dendritic cell vaccines, genetic vaccines, candidate cancers for vaccination, obstacles to developing therapeutic cancer vaccines, combination therapy, future perspectives and concluding remarks on therapeutic cancer vaccines. Introduces the feasible immunotherapeutic vaccines for patients with different types of cancer Presents the status of past and current vaccines for cancer treatment Considers advantages and disadvantages of different therapeutic cancer vaccines Looks at the combination of vaccines and other modalities, including immunotherapeutic and conventional methods Analyzes obstacles to development of therapeutic cancer vaccines Gives a view on future perspectives in the application of therapeutic cancer vaccines

Nanomedicine-Based Approaches for the Treatment of Dementia

Author : Umesh Gupta
Publisher : Academic Press
ISBN 13 : 0323859062
Total Pages : 320 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Nanomedicine-Based Approaches for the Treatment of Dementia by : Umesh Gupta

Download or read book Nanomedicine-Based Approaches for the Treatment of Dementia written by Umesh Gupta and published by Academic Press. This book was released on 2022-10-11 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomedicine-Based Approaches for the Treatment of Dementia explores a wide range of promising approaches for the diagnosis and treatment of dementia. The book begins with introductory sections on dementia and brain ailments that are followed by further chapters that discuss detailed information about challenges of drug delivery across the blood-brain barrier as well as the current status. This book helps readers design and develop novel drug delivery systems and devices for the treatment of dementia that take advantage of recent advances in nanomedical technologies. Numerous drug delivery systems have been developed recently for dementia. Unfortunately, most of them are ineffective since dementia is not a single disease. It is an umbrella term for several neurodegenerative conditions which alter brain functions. Due to this, there is an urgent need for innovative technologies/nano drug delivery systems to improve the targeting and delivery of therapeutic as well as diagnostic agents specifically for treating dementia. Explores promising approaches for the diagnosis and treatment of dementia Discusses advances in cutting-edge nanomedical technologies Focuses on the design, synthesis and application of nanocarriers in drug delivery

Natural Immunomodulators: Promising Therapy for Disease Management

Author : Vandana S. Nikam
Publisher : Bentham Science Publishers
ISBN 13 : 9815123262
Total Pages : 441 pages
Book Rating : 4.8/5 (151 download)

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Book Synopsis Natural Immunomodulators: Promising Therapy for Disease Management by : Vandana S. Nikam

Download or read book Natural Immunomodulators: Promising Therapy for Disease Management written by Vandana S. Nikam and published by Bentham Science Publishers. This book was released on 2023-05-16 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Immunomodulators: Promising Therapy for Disease Management discusses the use of natural immunomodulators as a promising therapy for managing various diseases. The book begins with an introduction to the immune system and the ways in which it can be modulated. This is followed by a discussion on the various diseases and disorders associated with the immune system, including autoimmune disorders, allergies, and immune deficiency conditions. The natural sources of immunomodulators, including plants, herbs, and other natural substances is also explained along with the importance of standardizing natural immunomodulator drugs, including the methods used to ensure their quality and consistency. The book also delves into the chemistry and analytical techniques used to study immunomodulators, clinical and pre-clinical bioassays. The next couple of chapters focus on the use of natural immunomodulators in cancer, the therapy of cancer and infectious diseases. Drug delivery and the strategy and regulatory perspective for natural immunomodulators. The final 2 chapters round up the contents with information about synthetic immunomodulators and the future perspective for the use of immunomodulators in disease management. Natural Immunomodulators: Promising Therapy for Disease Management is a comprehensive guide to the use of natural immunomodulators as a therapy for various diseases, and is a valuable resource for professionals and students interested in this topic. The book is aimed at health care professionals such as medical doctors, nurses, pharmacists, and life science and nutritionist professionals, as well as students.

Epidemiology of Endocrine Tumors

Author : Jahangir Moini
Publisher : Elsevier
ISBN 13 : 0128232668
Total Pages : 570 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Epidemiology of Endocrine Tumors by : Jahangir Moini

Download or read book Epidemiology of Endocrine Tumors written by Jahangir Moini and published by Elsevier. This book was released on 2021-03-03 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiology of Endocrine Tumors brings current data and clinical research into one source for a multidisciplinary audience. The book discusses the prevalence, incidence, etiology, pathology, diagnosis and treatment of various endocrine tumors. With clear and focused writing, it is essential reading for healthcare professionals, endocrinologists, oncologists, and public health professionals. Users will be able to bridge the knowledge gap that exists in the comprehensive coverage surrounding the epidemiology of endocrine tumors. Globally, the prevalence and incidence of endocrine tumors is high. This audience needs a treatise where they can gain a broad overview of endocrine tumors with a focus on epidemiology. Supplies information about the epidemiology of various endocrine tumors, both benign and malignant, to endocrinologists, oncologists and related health care professionals Focuses on the impact upon costs and patient deaths due to complications of these tumors Describes how endocrine tumors affect various age groups and ethnicities, discussing the prevention of endocrine tumors Presents chapters on Cancer Problem, Specific Endocrine Tumors, Prevention, Detection and Diagnosis, and Treatment of Endocrine Tumors Provides review questions with an answer key and detailed glossary

Global Epidemiology of Cancer

Author : Jahangir Moini
Publisher : John Wiley & Sons
ISBN 13 : 1119817188
Total Pages : 676 pages
Book Rating : 4.1/5 (198 download)

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Book Synopsis Global Epidemiology of Cancer by : Jahangir Moini

Download or read book Global Epidemiology of Cancer written by Jahangir Moini and published by John Wiley & Sons. This book was released on 2022-03-22 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: GLOBAL EPIDEMIOLOGY OF CANCER Cancer is the second highest cause of death in the United States, and a leading cause of death globally. Our goals are to discuss the global epidemiology of various cancers, with detailed information on their prevalence, incidence, and clinical considerations. Epidemiology is the key to understanding the mortality and morbidity of cancer, and how we can prevent, diagnose, and treat the disease. Prevention of cancer is essential for saving lives. Prevalence and incidence of cancer are key factors that each government and population must be aware of. Advances in the study of cancer occur on a regular basis, and this book provides the latest insights about relationships between the disease and stem cells, tumorigenesis, molecular interactions, pathways, channels, and immunity. Global Epidemiology of Cancer: Diagnosis and Treatment meets the needs of readers by providing current information about epidemiology (including molecular epidemiology), diagnosis, and treatment. Providing logical, step-by-step information on various cancers, this book consolidates all of the most up-to-date information and data from verified studies on all different types of cancers in the United States and throughout the world. Chapters are presented so that each includes an overview, clinical manifestations, epidemiology, pathophysiology, etiology and risk factors, diagnosis, treatment, prevention, and prognosis. Global Epidemiology of Cancer: Diagnosis and Treatment will be invaluable to graduate and postgraduate students, including medical students; nurses; physician assistants; residents in oncology; public health students and allied health students.

Pharmaceutical Biotechnology

Author : Oliver Kayser
Publisher : John Wiley & Sons
ISBN 13 : 3527329943
Total Pages : 677 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Pharmaceutical Biotechnology by : Oliver Kayser

Download or read book Pharmaceutical Biotechnology written by Oliver Kayser and published by John Wiley & Sons. This book was released on 2012-05-21 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of a very successful book is thoroughly updated with existing chapters completely rewritten while the content has more than doubled from 16 to 36 chapters. As with the first edition, the focus is on industrial pharmaceutical research, written by a team of industry experts from around the world, while quality and safety management, drug approval and regulation, patenting issues, and biotechnology fundamentals are also covered. In addition, this new edition now not only includes biotech drug development but also the use of biopharmaceuticals in diagnostics and vaccinations. With a foreword by Robert Langer, Kenneth J Germeshausen Professor of Chemical and Biomedical Engineering at MIT and member of the National Academy of Engineering and the National Academy of Sciences.

Drug Delivery Systems

Author :
Publisher : Academic Press
ISBN 13 : 0128145080
Total Pages : 792 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug Delivery Systems by :

Download or read book Drug Delivery Systems written by and published by Academic Press. This book was released on 2019-10-23 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Delivery Systems examines the current state of the field within pharmaceutical science and concisely explains the history of drug delivery systems, including key developments. The book translates the physicochemical properties of drugs into drug delivery systems administered via various routes, such as oral, parenteral, transdermal and inhalational. Regulatory and product development topics are also explored. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of drug delivery systems within the pharmaceutical sciences industry and research, as well as in chemical engineering. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists. This book provides a comprehensive examination that is suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnologies, and related industries. Provides up-to-date information on how to translate the physicochemical properties of drugs into drug delivery systems Explores how drugs are administered via various routes, such as oral, parenteral, transdermal and inhalational Contains extensive references and further reading for course and self-study

Drying Technologies for Biotechnology and Pharmaceutical Applications

Author : Satoshi Ohtake
Publisher : John Wiley & Sons
ISBN 13 : 3527802096
Total Pages : 400 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Drying Technologies for Biotechnology and Pharmaceutical Applications by : Satoshi Ohtake

Download or read book Drying Technologies for Biotechnology and Pharmaceutical Applications written by Satoshi Ohtake and published by John Wiley & Sons. This book was released on 2020-02-03 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive source of information about modern drying technologies that uniquely focus on the processing of pharmaceuticals and biologicals Drying technologies are an indispensable production step in the pharmaceutical industry and the knowledge of drying technologies and applications is absolutely essential for current drug product development. This book focuses on the application of various drying technologies to the processing of pharmaceuticals and biologicals. It offers a complete overview of innovative as well as standard drying technologies, and addresses the issues of why drying is required and what the critical considerations are for implementing this process operation during drug product development. Drying Technologies for Biotechnology and Pharmaceutical Applications discusses the state-of-the-art of established drying technologies like freeze- and spray- drying and highlights limitations that need to be overcome to achieve the future state of pharmaceutical manufacturing. The book also describes promising next generation drying technologies, which are currently used in fields outside of pharmaceuticals, and how they can be implemented and adapted for future use in the pharmaceutical industry. In addition, it deals with the generation of synergistic effects (e.g. by applying process analytical technology) and provides an outlook toward future developments. -Presents a full technical overview of well established standard drying methods alongside various other drying technologies, possible improvements, limitations, synergies, and future directions -Outlines different drying technologies from an application-oriented point of view and with consideration of real world challenges in the field of drug product development -Edited by renowned experts from the pharmaceutical industry and assembled by leading experts from industry and academia Drying Technologies for Biotechnology and Pharmaceutical Applications is an important book for pharma engineers, process engineers, chemical engineers, and others who work in related industries.

Viral Vectors in Cancer Immunotherapy

Author :
Publisher : Elsevier
ISBN 13 : 0443192502
Total Pages : 276 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Viral Vectors in Cancer Immunotherapy by :

Download or read book Viral Vectors in Cancer Immunotherapy written by and published by Elsevier. This book was released on 2023-08-02 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Vectors in Cancer Immunotherapy, Volume 379 in the International Review of Cell and Molecular Biology presents the latest on cancer immunotherapy and how it has transformed cancer treatment through advances in immune checkpoint inhibitors and adoptive cell therapy. Chapters in this new release include Past, present and future of viral vectors in cancer immunotherapy, Alphaviruses in cancer immunotherapy, Adenoviral-based cancer gene therapy, Armored modified vaccinia Ankara in cancer immunotherapy, Strategies of Semliki Forest virus in immuno-oncology, Maraba virus in cancer immunotherapy, Oncolytic viruses in hematological malignancies, Oncolytic virus for cancer therapies: Overview and future directions, and more. The use of genetically modified viruses allows the expression of pro-inflammatory molecules, while the immune system receives danger signals from the viruses themselves. In some cases, the virus can also induce tumor cell death. This book will review advances in virus-based cancer immunotherapy in both solid tumors and hematologic malignancies. Provides an overview of the landscape of virotherapy for solid tumors and hematologic malignancies Reviews advances in alphaviruses, adenoviruses, vaccinia viruses and Maraba virus Presents lessons on how to improve viruses to enhance immune responses