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Novel Anti Inflammatory Approaches For Cystic Fibrosis Lung Disease Identification Of Molecular Targets And Design Of Innovative Therapies
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Book Synopsis Novel Anti-inflammatory Approaches for Cystic Fibrosis Lung Disease: Identification of Molecular Targets and Design of Innovative Therapies by : Carla Maria Pedrosa Ribeiro
Download or read book Novel Anti-inflammatory Approaches for Cystic Fibrosis Lung Disease: Identification of Molecular Targets and Design of Innovative Therapies written by Carla Maria Pedrosa Ribeiro and published by Frontiers Media SA. This book was released on 2022-01-04 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Treatment of Cystic Fibrosis and Other Rare Lung Diseases by : Arata Azuma
Download or read book Treatment of Cystic Fibrosis and Other Rare Lung Diseases written by Arata Azuma and published by Springer. This book was released on 2017-01-28 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the pathogenesis and pathophysiology of several pulmonary diseases as well as their treatment. It also discusses the underlying genetic and molecular biological basis, which opens the way for new treatments for these conditions. It focuses on the treatment of cystic fibrosis including CFTR (cystic fibrosis transmembrane-conductance regulator) modulator therapies, drug therapies that augment airway surface liquid as well as anti-inflammatory and anti-infective therapies. Further topics include long-term, low-dose macrolide therapy for diffuse panbronchiolitis; novel agents for previously untreatable idiopathic pulmonary fibrosis; possible new treatments for pulmonary alveolar proteinosis (PAP); and multiple novel therapeutic targets for treating lymphangiomyomatosis. Research into these conditions has led to major advances in our understanding of the underlying genetic and molecular basis of this disease, and to dramatic improvements in survival and quality of life for affected individuals.
Book Synopsis Emerging Therapeutic Approaches for Cystic Fibrosis by : Miquéias Lopes-Pacheco
Download or read book Emerging Therapeutic Approaches for Cystic Fibrosis written by Miquéias Lopes-Pacheco and published by Frontiers Media SA. This book was released on 2020-01-27 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immunobiology of IFRD1, a Novel Genetic Modifier of Cystic Fibrosis Lung Disease by : Yuanyuan Gu
Download or read book Immunobiology of IFRD1, a Novel Genetic Modifier of Cystic Fibrosis Lung Disease written by Yuanyuan Gu and published by . This book was released on 2009 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cystic fibrosis is the most common, lethal autosomal recessive disorder in the United States. Lung disease is the major cause of morbidity and mortality in CF. In the CF lung, chronic infection and dysregulated neutrophilic inflammation lead to progressive airway destruction. Despite the molecular insights afforded by identification of disease-causing gene, CFTR, a clear understanding of the pathogenesis of lung disease in CF remains elusive. There is a poor correlation of genotype with phenotype in lung disease in CF, which strongly suggests that the expression of lung disease in CF is influenced by environmental exposures and/or modifier genes. To search for genes modifying CF lung disease, the Karp lab performed a genome-wide association study in collaboration with GMSG cohort, validating top candidates in collaboration with the CFTSS cohort. Using this approach, genetic variation in IFRD1 was identified and verified as a modifier of lung disease severity in CF. IFRD1 is a HDAC-dependent transcriptional co-activator or co-repressor whose expression is particularly enriched in neutrophils. The goal of my dissertation studies was mechanistic insight into the modulation of CF lung disease by IFRD1. This dissertation research provides evidence in favor of the hypothesis that IFRD1 modulates the course of airway disease in CF through regulation of neutrophil effector function. This study also strongly suggests a mechanism by which IFRD1 modulates neutrophil function in a HDAC-dependent manner to co-suppress the expression of ATF3, a transcriptional repressor of NF-[kappa]B activity in neutrophils. Finally, this research emphasizes the translational implications for therapeutic targeting of neutrophils in CF. This study suggests that the IFRD1/HDAC axis may provide a tractable therapeutic target in CF, and the plethora of other diseases in which neutrophils play an important pathogenic role.
Book Synopsis Cystic Fibrosis by : Margarida D. Amaral
Download or read book Cystic Fibrosis written by Margarida D. Amaral and published by Humana Press. This book was released on 2011-05-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the many milestones in cystic fibrosis (CF) research, progress toward curing the disease has been slow, and it is increasingly difficult to grasp and use the already wide and still growing range of diverse methods currently employed to study CF so as to understand it in its multidisciplinary nature. Cystic Fibrosis: Diagnosis and Protocols aims to provide the CF research community and related researchers with a very wide range of high-quality experimental tools, as an easy way to grasp and use classical and novel methods applied to cystic fibrosis. Volume II: Methods and Resources to Understand Cystic Fibrosis focuses on pathophysiology, Omics approaches, and a variety of key resources recently made available for CF research. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Cystic Fibrosis: Diagnosis and Protocols will provide readers with optimal working tools to address pressing questions in the best technical way, while helping all of us, as a research and clinical community, to move faster hand-in-hand toward unravelling the secrets of this challenging disorder and cure it.
Book Synopsis Cystic Fibrosis by : Margarida D. Amaral
Download or read book Cystic Fibrosis written by Margarida D. Amaral and published by Humana Press. This book was released on 2011-08-09 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the many milestones in cystic fibrosis (CF) research, progress towards curing the disease has been slow, and it is increasingly difficult to grasp and use the already wide and still growing range of diverse methods currently employed to study CF so as to understand it in its multidisciplinary nature. Cystic Fibrosis: Diagnosis and Protocols aims to provide the CF research community and related researchers with a very wide range of high-quality experimental tools, as an easy way to grasp and use classical and novel methods applied to cystic fibrosis. Volume I: Approaches to Study and Correct CFTR Defects focuses on the cystic fibrosis transmembrane conductance regulator (CFTR) and its expression, biogenesis, structure, and function in terms of the defects causing CF. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Cystic Fibrosis: Diagnosis and Protocols will provide readers with optimal working tools to address pressing questions in the best technical way, while helping all of us, as a research and clinical community, to move faster hand-in-hand toward unravelling the secrets of this challenging disorder and cure it.
Book Synopsis Interleukin-8 as a Genetic Modifier and Pharmacologic Target for Cystic Fibrosis Pulmonary Disease by : Antoinette D. Hillian
Download or read book Interleukin-8 as a Genetic Modifier and Pharmacologic Target for Cystic Fibrosis Pulmonary Disease written by Antoinette D. Hillian and published by . This book was released on 2009 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary disease is the most significant manifestation of cystic fibrosis (CF) and is primarily due to continuous and exaggerated inflammation stemming from an inherent dysregulation of the inflammatory processes. Specifically, airway inflammation is characterized by a disproportionate neutrophil load, high levels of neutrophilic enzymes, and excessive neutrophil chemokine expression; thus, the airway inflammation and subsequent damage is considered to be neutrophil-mediated. As interleukin-8 (IL-8) is the primary mediator for neutrophil migration and activation, the progression and maintenance of the neutrophilic inflammation is potentially due to elevated expression of IL-8. This dissertation examines how variations in the expression of IL-8 impact pulmonary disease severity.There is considerable phenotypic variation with regards to pulmonary disease progression among CF patients. It has been suggested that the majority of the observed variation is due to genetic heterogeneity, independent of CFTR genotype. To test this hypothesis, variants in a panel of inflammatory genes were evaluated for a statistical association with lung disease severity in a CF patient population. Variants in the IL8 gene were found to associate with lung disease severity. Specifically, a functional IL-8 promoter variant was identified and shown to result in an allele specific expression difference.To minimize damage caused by inflammation, patients are treated with anti-inflammatory drugs, including ibuprofen. High doses of ibuprofen have been shown to inhibit neutrophil migration, reduce the rate of lung function decline, and slow CF lung disease progression although the molecular mechanism has not been identified. Given its role in neutrophil recruitment and activation, IL-8 was tested as a potential molecular target of ibuprofen. In an epithelial cell line, IL-8 protein and message levels were reduced in response ibuprofen at the level of transcription. Furthermore, ibuprofen was found to correlate with reduced IL-8 message in nasal epithelium from CF patients. Therefore, it appears that the overall reduction of CF lung disease associated with ibuprofen is at least partially mediated through a decrease in IL8 expression. Together these data suggest that alterations in the expression of interleukin-8, either through naturally occurring genetic variation or pharmacological manipulation, modify cystic fibrosis pulmonary disease phenotype.
Book Synopsis Molecular Basis and Gene Therapies of Cystic Fibrosis by : John Engelhardt
Download or read book Molecular Basis and Gene Therapies of Cystic Fibrosis written by John Engelhardt and published by . This book was released on 2020 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of Genes. Thirty years ago, the gene responsible for cystic fibrosis (CF), a recessive genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene, was identified. This progress has considerably changed our understanding of the pathophysiology of CF and has paved the way for the development of novel and specific therapies for the disease. The CFTR gene contains 27 exons and is characterized by a frequent three base pair deletion of the p.Phe508del. As a result of collaborative work, today more than 2000 mutations have been reported in the gene, and their impact on protein function is now more evident and useful in designing new strategies to correct the gene defect. The field of gene therapy, as illustrated by Ziying Yan in this book, has worked on identifying an efficient vector system for the delivery of the wild-type CFTR gene to the lung. At the same time, animal models have been developed in mice, rats, rabbits, zebrafish, ferrets, and pigs to establish the efficacity of gene delivery. These animals are also of the utmost importance in testing new molecules as modulators or correctors to improve the CFTR lung function. During the last three decades, the epidemiology of CF has dramatically changed, as today cystic fibrosis is now a chronic adult pulmonary disease.
Book Synopsis Reducing Lung Disease in Cystic Fibrosis: Model Systems and Anti-inflammatory Treatment by : Scotty McGlothlin Buff
Download or read book Reducing Lung Disease in Cystic Fibrosis: Model Systems and Anti-inflammatory Treatment written by Scotty McGlothlin Buff and published by . This book was released on 2007 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: These studies support that inflammation is excessive to bacterial infection in CF and demonstrate AAV-based IL-10 gene transfer is a promising anti-inflammatory therapeutic for CF lung disease.
Download or read book Advances in PET written by Jun Zhang and published by Springer Nature. This book was released on 2020-05-11 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a guide to new and emerging PET technology, instrumentation, and its place in clinical practice. PET technology is currently moving from the conventional photomultiplier tube (PMT) detector based PET to the new generation, solid state light sensor detector. This is a technological leap and holds significant implications for the use of PET imaging. This book introduces and describes the emerging and new generation of PET instrumentations and technologies across manufactures, focusing on solid-state PET detector designs, system characteristics, and clinical practices as well as future advanced Time-of-Flight (TOF) PET technologies. Organized into three sections, the basics of PET imaging; solid state digital PET instrumentation, technology, and clinical practice; and a look to the future of PET imaging, chapters present a full picture of PET imaging, where we are and where we will be. Nuclear medicine physicians, physicists, and technologists can use this book to better understand future PET systems, novel PET technologies, and potential game changes of clinical PET practice.
Book Synopsis Adenoviral Vectors for Gene Therapy by : David T. Curiel
Download or read book Adenoviral Vectors for Gene Therapy written by David T. Curiel and published by Academic Press. This book was released on 2016-03-10 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials
Book Synopsis The Lung Microbiome by : Michael J. Cox
Download or read book The Lung Microbiome written by Michael J. Cox and published by European Respiratory Society. This book was released on 2019-03-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studying the lung microbiome requires a specialist approach to sampling, laboratory techniques and statistical analysis. This Monograph introduces the techniques used and discusses how respiratory sampling, 16S rRNA gene sequencing, metagenomics and the application of ecological theory can be used to examine the respiratory microbiome. It examines the different components of the respiratory microbiome: viruses and fungi in addition to the more frequently studied bacteria. It also considers a range of contexts from the paediatric microbiome and how this develops to disease of all ages including asthma and chronic obstructive pulmonary disease, chronic suppurative lung diseases, interstitial lung diseases, acquired pneumonias, transplantation, cancer and HIV, and the interaction of the respiratory microbiome and the environment.
Download or read book Bacterial Biofilms written by Tony Romeo and published by Springer Science & Business Media. This book was released on 2008-02-26 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout the biological world, bacteria thrive predominantly in surface-attached, matrix-enclosed, multicellular communities or biofilms, as opposed to isolated planktonic cells. This choice of lifestyle is not trivial, as it involves major shifts in the use of genetic information and cellular energy, and has profound consequences for bacterial physiology and survival. Growth within a biofilm can thwart immune function and antibiotic therapy and thereby complicate the treatment of infectious diseases, especially chronic and foreign device-associated infections. Modern studies of many important biofilms have advanced well beyond the descriptive stage, and have begun to provide molecular details of the structural, biochemical, and genetic processes that drive biofilm formation and its dispersion. There is much diversity in the details of biofilm development among various species, but there are also commonalities. In most species, environmental and nutritional conditions greatly influence biofilm development. Similar kinds of adhesive molecules often promote biofilm formation in diverse species. Signaling and regulatory processes that drive biofilm development are often conserved, especially among related bacteria. Knowledge of such processes holds great promise for efforts to control biofilm growth and combat biofilm-associated infections. This volume focuses on the biology of biofilms that affect human disease, although it is by no means comprehensive. It opens with chapters that provide the reader with current perspectives on biofilm development, physiology, environmental, and regulatory effects, the role of quorum sensing, and resistance/phenotypic persistence to antimicrobial agents during biofilm growth.
Download or read book Exhaled Biomarkers written by I. Horvath and published by European Respiratory Society. This book was released on 2010-09-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exhaled air contains numerous substances, often in extremely low concentrations. The development of sensitive detection techniques has made it possible to examine the composition of exhaled air in relation to a variety of airway diseases and other disorders. In this book, an overview of current cutting-edge breath analysis techniques and their clinical applications is provided for the clinician. The various contributions give a fascinating perspective of a future where new, highly sensitive methodologies will enable clinicians to diagnose and monitor a wide variety of diseases merely by taking.
Book Synopsis Microbiome-Host Interactions by : D. Dhanasekaran
Download or read book Microbiome-Host Interactions written by D. Dhanasekaran and published by CRC Press. This book was released on 2021-04-01 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbiota are a promising and fascinating subject in biology because they integrate the microbial communities in humans, animals, plants, and the environment. In humans, microbiota are associated with the gut, skin, and genital, oral, and respiratory organs. The plant microbial community is referred to as "holobiont," and it is influential in the maintenance and health of plants, which themselves play a role in animal health and the environment. The contents of Microbiome-Host Interactions cover all areas as well as new research trends in the fields of plant, animal, human, and environmental microbiome interactions. The book covers microbiota in polar soil environments, in health and disease, in Caenorhabditis elegans, and in agroecosystems, as well as in rice root and actinorhizal root nodules, speleothems, and marine shallow-water hydrothermal vents. Moreover, this book provides comprehensive accounts of advanced next-generation DNA sequencing, metagenomic techniques, high-throughput 16S rRNA sequencing, and understanding nucleic acid sequence data from fungal, algal, viral, bacterial, cyanobacterial, actinobacterial, and archaeal communities using QIIME software (Quantitative Insights into Microbial Ecology). FEATURES Summarizes recent insight in microbiota and host interactions in distinct habitats, including Antarctic, hydrothermal vents, speleothems, oral, skin, gut, feces, reproductive tract, soil, root, root nodules, forests, and mangroves Illustrates the high-throughput amplicon sequencing, computational techniques involved in the microbiota analysis, downstream analysis and visualization, and multivariate analysis commonly used for microbiome analysis Describes probiotics and prebiotics in the composition of the gut microbiota, skin microbiome impact in dermatologic disease prevention, and microbial communities in the reproductive tract of humans and animals Presents information in a reachable way for students, teachers, researchers, microbiologists, computational biologists, and other professionals who are interested in strengthening or enlarging their knowledge about microbiome analysis with next-generation DNA sequencing in the different branches of the sciences
Book Synopsis The Principles of Humane Experimental Technique by : William Moy Stratton Russell
Download or read book The Principles of Humane Experimental Technique written by William Moy Stratton Russell and published by Hyperion Books. This book was released on 1992 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Global Public Health by : Franklin White
Download or read book Global Public Health written by Franklin White and published by Oxford University Press. This book was released on 2013-01-21 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amid ongoing shifts in the world economic and political order, the promise for future public health is tenuous. Will today's economic systems sustain tomorrow's health? Will future generations inherit fair access to health and health care? An important hope for the health of future generations is the establishment of a well-grounded, global public health system. Global Public Health: Ecological Foundations addresses both the challenges and cooperative solutions of contemporary public health, within a framework of social justice, environmental sustainability, and global cooperation. With an emphasis on ecological foundations, this book approaches public health principles-history, foundations, topics, and applications-with a community-oriented perspective. By achieving global reach through cooperative, community-based interventions, this text illustrates that the practical application of public health principles can help maintain the health of the world's people. Blending established wisdom with new perspectives, Global Public Health will stimulate better understanding of how the different streams of public health can work more synergistically to promote global health equity. It is a foundation for future public health measures to be built and to succeed.
