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Nonalcoholic Fatty Liver Disease Nafld
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Book Synopsis Non-Alcoholic Fatty Liver Disease by : Elisabetta Bugianesi
Download or read book Non-Alcoholic Fatty Liver Disease written by Elisabetta Bugianesi and published by Springer Nature. This book was released on 2020-09-28 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this book is to promote awareness of non-alcoholic fatty liver disease (NAFLD) – which is rapidly replacing viral hepatitis as the leading cause of chronic liver disease in Europe, North and South America and Asia – and to share the latest information on evolving approaches to diagnosis and treatment. The book offers a comprehensive overview of the current topics of interest in the field, and provides clinical guidance on NAFLD through a multidisciplinary approach based on the latest scientific understanding of this multisystemic disease, involving the expertise of specialists including hepatologists, diabetologists, and cardiologists. The respective contributions address various aspects, including the newly released international guidelines, novel diagnostic modalities, and new experimental drugs. The work will appeal to a broad readership, from residents in internal medicine to specialists.
Book Synopsis GI Epidemiology by : Nicholas J. Talley
Download or read book GI Epidemiology written by Nicholas J. Talley and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authoritative new text from the experts in GI populationstudies This book covers both key methodological issues and the mostimportant information in the field, disease by disease. It focuseson population-based information and studies looking at principlesand approaches to diagnosis and treatment of diseases. GI Epidemiology brings together world authorities inmultiple disciplines for the very first time, to create one clearand comprehensive source. The bulk of the chapters are divided intotwo parts, covering methodological issues and the epidemiology ofspecific GI diseases. Each chapter begins with a list of keypoints, followed by a review written in a clear and simplestyle. The methodologic chapters cover evidence-based medicine,meta-analysis, systematic reviews, genetic and molecularepidemiology, clinical trials, questionnaire design, and healtheconomics. The disease-specific chapters note the current gaps inknowledge and suggest areas for further study. GI Epidemiology serves as both a useful refresher and areliable reference on the methods and techniques used inepidemiological studies for consultants and researchers ingastroenterology. It is also an invaluable tool for fellows/trainees ingastroenterology, candidates for recertification in the combineddisciplines of gastroenterology, pediatric gastroenterology andcolorectal surgery, and anyone completing MPH training.
Book Synopsis Liver Disease in Children by : Frederick J. Suchy
Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.
Book Synopsis Alcoholic and Non-Alcoholic Fatty Liver Disease by : Naga Chalasani
Download or read book Alcoholic and Non-Alcoholic Fatty Liver Disease written by Naga Chalasani and published by Springer. This book was released on 2015-12-10 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the first text to concisely yet comprehensively cover developments for both alcoholic and nonalcoholic fatty liver disease in an organized fashion. Aspects of these two diseases covered in the book include global epidemiology and risk factors, pathogenesis, animal models, hepatic and extra-hepatic malignancies, treatment models, and current and emerging therapies. Written by experts in the field, Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside is a valuable resource for gastroenterologists, pathologists, and hepatologists who treat patients with alcoholic and nonalcoholic fatty liver disease.
Book Synopsis The Human Gut-Liver-Axis in Health and Disease by : Aleksander Krag
Download or read book The Human Gut-Liver-Axis in Health and Disease written by Aleksander Krag and published by Springer. This book was released on 2018-11-09 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book brings together the current knowledge and future perspectives of the complex physiology and pathophysiology of gut-liver interactions in health and disease. It provides readers with a unique overview and access to knowledge that cannot be obtained elsewhere. The structure is logical and covers all aspect including the normal physiology, changes in various liver diseases, technology, sample collection and various interventions. Thus suitable for general reading, lookup for specific questions or as a reference book within the area. The book allows the reader to access all the knowledge that has been generated within the last 10 years in this field.
Book Synopsis Nonalcoholic Fatty Liver Disease by : Emad Hamdy Gad
Download or read book Nonalcoholic Fatty Liver Disease written by Emad Hamdy Gad and published by BoD – Books on Demand. This book was released on 2019-11-20 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-alcoholic fatty liver disease (NAFLD) is a major medical challenge because of its increasing prevalence, difficulties in diagnosis, complex pathogenesis, and lack of approved therapies. In the near future, it will become the major form of chronic liver disease in adults and children and the leading indication for liver transplantation. It can be detected by noninvasive and invasive tools, and its treatment depends mainly on lifestyle modification to prevent disease progression and its related sequelae. This book provides information on NAFLD prevalence, etiology, pathogenesis, pathology, diagnosis, and treatment. Chapters cover such topics as experimental work related to the disease, other diseases related to NAFLD, and noninvasive tools for diagnosis.
Book Synopsis Nonalcoholic Fatty Liver Disease (NAFLD) by : Tatjana Ábel
Download or read book Nonalcoholic Fatty Liver Disease (NAFLD) written by Tatjana Ábel and published by Bentham Science Publishers. This book was released on 2017-05-05 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-alcoholic fatty liver disease (NAFLD) is a common cause of elevated liver enzymes and chronic liver disease in Western countries. NAFLD is characterized by elevated liver enzymes in the absence of alcohol consumption and secondary causes of liver disease. It is an independent predictor of future risk of cardiovascular diseases, type 2 diabetes and metabolic syndrome (hypertension, abdominal obesity, dyslipidemia, glucose intolerance). This book is a quick reference guide for medical students and professionals about NAFLD. Readers will find a summary of epidemiology, clinical features, diagnosis, imaging techniques, histopathology, and disease management. The book also presents information about NAFLD linked with hepatocellular carcinoma and guidelines for treating NAFLD in pediatric patients. Each chapter presents information in a simple, structured manner making this text an ideal handbook for supplementing hepatology modules in medical curricula.
Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
Book Synopsis Non-Alcoholic Fatty Liver Disease by : Rodrigo Valenzuela Baez
Download or read book Non-Alcoholic Fatty Liver Disease written by Rodrigo Valenzuela Baez and published by BoD – Books on Demand. This book was released on 2018-03-21 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonalcoholic fatty liver disease (NAFLD) with a prevalence of 20-30% worldwide is characterized by the buildup of fat in the liver (liver steatosis) with no or little alcohol consumption. Its principal causes are modern diet and occidental lifestyle. It is characterized by metabolic disturbances such as insulin resistance, inflammation, and oxidative stress, considered as the hepatic manifestation of metabolic syndrome. There is no effective drug therapy for this disease; therefore, lifestyle interventions remain as the first-line treatment. Nevertheless, the adherence rates to this type of treatment are very low, so great efforts are focused at finding novel therapeutic agents for the prevention of hepatic steatosis and its progression. This book presents a systematic and comprehensive revision about NAFLD, highlighting its epidemiological and molecular aspects, as well as its prevention and treatment.
Book Synopsis Non-Alcoholic Fatty Liver Disease by : Geoffrey C. Farrell
Download or read book Non-Alcoholic Fatty Liver Disease written by Geoffrey C. Farrell and published by John Wiley & Sons. This book was released on 2013-02-06 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sharp rise in cases of Non-alcoholic fatty liver disease is fast becoming one of the major concerns for hepatologists worldwide. This comprehensive clinical guide explains how to diagnose NAFLD and manage patients according to the best standards of care. Contributors from the world's leading institutions concentrate on patient care, drawing on their extensive experience.
Book Synopsis Non-Alcoholic Fatty Liver Disease by : Patrik Nasr
Download or read book Non-Alcoholic Fatty Liver Disease written by Patrik Nasr and published by Linköping University Electronic Press. This book was released on 2019-09-25 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease affecting approximately 25% of the global population and is commonly recognized as the hepatic manifestation of the metabolic syndrome. The histological spectrum of NAFLD ranges from isolated steatosis to non-alcoholic steatohepatitis (NASH), with risk of developing fibrosis and subsequent cirrhosis and hepatocellular carcinoma. The gold standard for diagnosing NAFLD is liver biopsy. However, because of its invasive nature, several non-invasive methods have been developed and validated in evaluating fat and fibrosis in patients with NAFLD. Liver fat content can be assessed using various methods. The conventional histopathological method consists of a visual semiquantitative approach in which the pathologist uses a four-point scale: grade 0 corresponds to fat deposition in <5% of hepatocytes and grade 1?3 (which is needed for the diagnosis of NAFLD) corresponds to ?5%. An alternate approach is to quantitatively assess steatosis using stereological point counting (SPC) – which rely on liver biopsy. However, in vivo proton magnetic resonance spectroscopy (1H-MRS) is a reliable noninvasive method that can be used to quantitatively assess total hepatic lipid content, or proton density fat fraction (PDFF). In Paper I we compared the conventional semiquantitative histological method (grade 0-3) with SPC and 1H-MRS. We found a strong positive correlation between 1H-MRS and SPC, whereas the correlations between 1H-MRS or SPC and histopathological grading were substantially weaker. Using the widely used cut-off value of PDFF ?5%, all participants were found to have steatosis (specificity 100%, sensitivity 53%). Reducing the cut-off value to 3% maintained 100% specificity while increasing sensitivity to 79%. In Paper IV we evaluated quantitative steatosis, by SPC, in 106 biopsy-proven NAFLD patients during a 20-year follow-up. SPC was independently associated with an increased risk of all-cause mortality and development of T2DM. Moreover, in the 59 patients with sequential biopsies (approximately 10 years apart), a reduction of quantitative hepatic steatosis decreased the all-time risk of developing T2DM. NASH is commonly seen as a histological feature portending a worse prognosis in NAFLD. Interestingly, no dual biopsy study has ever shown that NASH predicts fibrosis progression. Yet, NASH is seen as a surrogate marker in pharmaceutical trials – were resolution in NASH is equivalent to future resolution of fibrosis. In Paper II we conducted a long-term follow-up study (20 years) in a large cohort of biopsy-proven NAFLD patients (n=646), in a collaboration with Karolinska Institute. We could not ascertain that NASH had any effect on all-cause, or disease-specific mortality. However, higher stages of fibrosis predicted all-cause and disease specific mortality. In Paper III, we present 129 biopsy-proven NAFLD patients, in which we had prospective, longitudinal data. They were included between 1988 and 1993. All patients alive, were re-invited 2003-2005 and 2013-2015. Dual biopsies were present in 68 patients, and three consecutive biopsies were available in 33 patients. Results showed that NAFLD is a highly heterogeneous disease, with 9.3% developing end-stage liver disease and 16% progressing to advanced stages of fibrosis without any clinically significant baseline data predicting disease progression. In summary, when using 1H-MRS as a diagnostic method for NAFLD, the diagnostic cut-off should be reduced from 5% to 3%. Furthermore, quantitative amount of hepatic steatosis could be used to stratify patients with NAFLD related to future risk of developing T2DM. Moreover, we have shown that NASH does not predict future all-cause or disease-specific mortality nor end-stage liver disease, therefore a different surrogate marker should be used in clinical trials when assessing NAFLD improvement, so to not imbue false reliance in new therapies. Lastly, we have shown that NAFLD has a more dismal prognosis than previously reported, and that it is unexpectedly difficult to predict fibrosis progression in individual NAFLD patients, emphasizing the need for robust non-invasive biomarkers suitable to monitor large number of patients.
Download or read book Drug-Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Book Synopsis Nutritional Intake and the Risk for Non-alcoholic Fatty Liver Disease (NAFLD) by : Ina Bergheim
Download or read book Nutritional Intake and the Risk for Non-alcoholic Fatty Liver Disease (NAFLD) written by Ina Bergheim and published by MDPI. This book was released on 2019-02-13 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Nutritional Intake and the Risk for Non-alcoholic Fatty Liver Disease (NAFLD)" that was published in Nutrients
Download or read book Obesity written by George L. Blackburn and published by Jones & Bartlett Learning. This book was released on 1994 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines the disease of obesity and its metabolic consequences. Explores obesity in relation to physiological and psychological health, and describes the clinical aspects of properly evaluating obese patients. Discusses the roles of dietary factors, appetite, exercise, metabolism, and the endocrine system in obesity, as well as the effects of significant weight loss on long-term health. Also discusses the psychology of obesity, weight loss, and regain. Provides practitioners with detailed guidelines for selecting and implementing multidisciplinary treatment that incorporates dietary intervention, exercise, behavior modification and stress management, and, when necessary, surgery or pharmacotherapy. Emphasizes matching patients with clinical interventions and treatment settings, and presents strategies for maintaining weight loss. Illustrates how to design interventions appropriate for the hospital, physician's office, clinic, home and workplace, and how to integrate different types of interventions in multiple settings. Written for physicians, dietitians, phychiatrists,
Book Synopsis Dietary Interventions in Liver Disease by : Ronald Ross Watson
Download or read book Dietary Interventions in Liver Disease written by Ronald Ross Watson and published by Academic Press. This book was released on 2019-01-10 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dietary Interventions in Liver Disease: Foods, Nutrients, and Dietary Supplements provides valuable insights into the agents that affect metabolism and other health-related conditions in the liver. It provides nutritional treatment options for those suffering from liver disease. Information is presented on a variety of foods, including herbs, fruits, soy and olive oil, thus illustrating that variations in intake can change antioxidant and disease preventing non-nutrients that affect liver health and/or disease promotion. This book is a valuable resource for biomedical researchers who focus on identifying the causes of liver diseases and food scientists targeting health-related product development. Provides information on agents that affect metabolism and other health-related conditions in the liver Explores the impact of composition, including differences based on country of origin and processing techniques Addresses the most positive results from dietary interventions using bioactive foods to impact liver disease, including reduction of inflammation and improved function
Book Synopsis Need-to-Know NAFLD by : Naim Alkhouri
Download or read book Need-to-Know NAFLD written by Naim Alkhouri and published by CRC Press. This book was released on 2023-09-08 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity and metabolic syndrome epidemics, which this up-to-date book deals with comprehensively. The contents outline disease mechanisms, diagnostic tests, management, varying manifestations, and special populations. It covers the mechanistic pathways that contribute to NAFLD development, including the role of genetic variants and the gut microbiome. It elaborates on noninvasive diagnostic tests to screen for NAFLD, determine its severity, and monitor response to lifestyle intervention and pharmacologic treatment. This book helps clinicians diagnose and treat this common and potentially deadly disease. Key Features: Reviews current drugs in development and provides practical advice to clinicians on the diagnosis and management of fatty liver. Proves attractive to primary care providers who are on the front line of managing patients with NAFLD, to gastroenterologists and hepatologists who would benefit from updated data on how to risk-stratify patients and identify those who will be eligible for pharmacologic treatment, and other specialists such as cardiologists, endocrinologists, and nephrologists who will find this book to be a useful reference on the extrahepatic manifestations of NAFLD. Focuses on extrahepatic manifestations and new insights on the mechanistic drivers of the disease.
Book Synopsis Diabetes in Children and Adolescents by : William V. Tamborlane
Download or read book Diabetes in Children and Adolescents written by William V. Tamborlane and published by Springer Nature. This book was released on 2021-02-12 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, available information on pediatric and adolescent diabetes is limited to chapters in larger books covering the broader topic of pediatric endocrinology, and these do not have the space to delve into specific topics. This concise, timely book contains everything that a practicing provider needs to know in order to provide comprehensive, up-to-date care for children and adolescents with diabetes, from the latest methods for diagnosing various types of diabetes to integrating cutting-edge technology in the care of this patient population. Initial management, the use of insulin pumps, continuous glucose monitoring, and automated insulin delivery are discussed in detail, as are nutrition therapy, exercise, psychosocial challenges, acute and long-term complications, and future directions for treatment and research. Further, this book provides clinicians with guidelines for the implementation of best practices as outlined by leading associations such as the American Diabetes Association (ADA) and International Society of Pediatric and Adolescent Diabetes (ISPAD). The Yale Children’s Diabetes Program has been ranked among the best in the United States, including clinicians and researchers who are world-renowned for their efforts in improving the care of children with diabetes. This wealth of knowledge and experience positions the author team well as experts in this field.
