Non-canonical Cyclic Nucleotides

Download Non-canonical Cyclic Nucleotides PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 3319526731
Total Pages : 387 pages
Book Rating : 4.3/5 (195 download)

DOWNLOAD NOW!


Book Synopsis Non-canonical Cyclic Nucleotides by : Roland Seifert

Download or read book Non-canonical Cyclic Nucleotides written by Roland Seifert and published by Springer. This book was released on 2017-04-28 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.

Cyclic Nucleotides

Download Cyclic Nucleotides PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (99 download)

DOWNLOAD NOW!


Book Synopsis Cyclic Nucleotides by :

Download or read book Cyclic Nucleotides written by and published by . This book was released on 1982 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Factors Affecting Neurological Aging

Download Factors Affecting Neurological Aging PDF Online Free

Author :
Publisher : Academic Press
ISBN 13 : 0128179910
Total Pages : 688 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!


Book Synopsis Factors Affecting Neurological Aging by : Colin R Martin

Download or read book Factors Affecting Neurological Aging written by Colin R Martin and published by Academic Press. This book was released on 2021-06-01 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with neurological aging and associated disorders. This book discusses the mechanisms underlying neurological aging and provides readers with a detailed introduction to the aging of neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurological aging. Finally, this comprehensive resource examines the use of animal modeling of aging and neurological disease. Provides the most comprehensive coverage on a broad range of topics related to the neuroscience of aging Features sections on the genetic components that influence aging and diseases of aging Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations Includes more than 500 illustrations and tables

Cyclic Nucleotide Signaling and the Cardiovascular System

Download Cyclic Nucleotide Signaling and the Cardiovascular System PDF Online Free

Author :
Publisher : MDPI
ISBN 13 : 3038429899
Total Pages : 307 pages
Book Rating : 4.0/5 (384 download)

DOWNLOAD NOW!


Book Synopsis Cyclic Nucleotide Signaling and the Cardiovascular System by : Thomas Brand

Download or read book Cyclic Nucleotide Signaling and the Cardiovascular System written by Thomas Brand and published by MDPI. This book was released on 2018-07-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Cyclic Nucleotide Signaling and the Cardiovascular System" that was published in JCDD

Microbial Cyclic Di-nucleotide Signaling

Download Microbial Cyclic Di-nucleotide Signaling PDF Online Free

Author :
Publisher :
ISBN 13 : 9783030333096
Total Pages : 640 pages
Book Rating : 4.3/5 (33 download)

DOWNLOAD NOW!


Book Synopsis Microbial Cyclic Di-nucleotide Signaling by :

Download or read book Microbial Cyclic Di-nucleotide Signaling written by and published by . This book was released on 2020 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described. In turn, the various aspects of bacterial physiology affected by these signaling systems- e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis - are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior. Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions.

Cyclic Nucleotide Signaling

Download Cyclic Nucleotide Signaling PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 9780367658809
Total Pages : 288 pages
Book Rating : 4.6/5 (588 download)

DOWNLOAD NOW!


Book Synopsis Cyclic Nucleotide Signaling by : XiaoDong Cheng

Download or read book Cyclic Nucleotide Signaling written by XiaoDong Cheng and published by CRC Press. This book was released on 2021-03-30 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.

The Second Messenger Cyclic Di-GMP

Download The Second Messenger Cyclic Di-GMP PDF Online Free

Author :
Publisher : American Society for Microbiology Press
ISBN 13 : 1555814999
Total Pages : 714 pages
Book Rating : 4.5/5 (558 download)

DOWNLOAD NOW!


Book Synopsis The Second Messenger Cyclic Di-GMP by : Alan J. Wolfe

Download or read book The Second Messenger Cyclic Di-GMP written by Alan J. Wolfe and published by American Society for Microbiology Press. This book was released on 2010-01-05 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference on the state of the science for both experienced researchers and for those who are interested in discovering its many promising applications. • Examines c-di-GMP signaling from a variety of angles, beginning with an introductory chapter that compares c-di-GMP to the better-known second messenger cAMP. • Recounts the discovery of c-di-GMP, explains the important role of bioinformatics in the development and continued evolution of the field, and describes the fundamental structure, function, regulation, and integration of c-di-GMP pathways. • Explores the role of c-di-GMP in such diverse processes as flagellar biogenesis and motility, extracellular polysaccharide biosynthesis, biofilm development, virulence, and innate host immunity.

From Neuroscience to Neurology

Download From Neuroscience to Neurology PDF Online Free

Author :
Publisher : Elsevier
ISBN 13 : 0080506984
Total Pages : 552 pages
Book Rating : 4.0/5 (85 download)

DOWNLOAD NOW!


Book Synopsis From Neuroscience to Neurology by : Stephen Waxman

Download or read book From Neuroscience to Neurology written by Stephen Waxman and published by Elsevier. This book was released on 2004-11-05 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson’s disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders. * Presents the evolution of the field of neurology into a therapeutic discipline * Discusses lessons learned from past successes and applications to ongoing work * Explores the future of this field

The Exocrine Pancreas

Download The Exocrine Pancreas PDF Online Free

Author :
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041389
Total Pages : 66 pages
Book Rating : 4.6/5 (15 download)

DOWNLOAD NOW!


Book Synopsis The Exocrine Pancreas by : Stephen Pandol

Download or read book The Exocrine Pancreas written by Stephen Pandol and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.

Supramolecular Chemistry in Water

Download Supramolecular Chemistry in Water PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 3527814930
Total Pages : 781 pages
Book Rating : 4.5/5 (278 download)

DOWNLOAD NOW!


Book Synopsis Supramolecular Chemistry in Water by : Stefan Kubik

Download or read book Supramolecular Chemistry in Water written by Stefan Kubik and published by John Wiley & Sons. This book was released on 2019-05-16 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides deep insight into the concepts and recent developments in the area of supramolecular chemistry in water Written by experts in their respective field, this comprehensive reference covers various aspects of supramolecular chemistry in water?from fundamental aspects to applications. It provides readers with a basic introduction to the current understanding of the properties of water and how they influence molecular recognition, and examines the different receptor types available in water and the types of substrates that can be bound. It also looks at areas to where they can be applied, such as materials, optical sensing, medicinal imaging, and catalysis. Supramolecular Chemistry in Water offers five major sections that address important topics like water properties, molecular recognition, association and aggregation phenomena, optical detection and imaging, and supramolecular catalysis. It covers chemistry and physical chemistry of water; water-mediated molecular recognition; peptide and protein receptors; nucleotide receptors; carbohydrate receptors; and ion receptors. The book also teaches readers all about coordination compounds; self-assembled polymers and gels; foldamers; vesicles and micelles; and surface-modified nanoparticles. In addition, it provides in-depth information on indicators and optical probes, as well as probes for medical imaging. -Covers, in a timely manner, an emerging area in chemistry that is growing more important every day -Addresses topics such as molecular recognition, aggregation, catalysis, and more -Offers comprehensive coverage of everything from fundamental aspects of supramolecular chemistry in water to its applications -Edited by one of the leading international scientists in the field Supramolecular Chemistry in Water is a one-stop-resource for all polymer chemists, catalytic chemists, biochemists, water chemists, and physical chemists involved in this growing area of research.

Synthetic DNA and RNA Programming

Download Synthetic DNA and RNA Programming PDF Online Free

Author :
Publisher : MDPI
ISBN 13 : 3039217348
Total Pages : 188 pages
Book Rating : 4.0/5 (392 download)

DOWNLOAD NOW!


Book Synopsis Synthetic DNA and RNA Programming by : Patrick O’Donoghue

Download or read book Synthetic DNA and RNA Programming written by Patrick O’Donoghue and published by MDPI. This book was released on 2019-11-19 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dear Colleagues, Synthetic biology is a broad and emerging discipline that capitalizes on recent advances in molecular biology, genetics, protein and RNA engineering and omics technologies. These technologies have transformed our ability to reveal the biology of the cell and the molecular basis of disease. This Special Issue on “Synthetic RNA and DNA Programming” features original research articles and reviews, highlighting novel aspects of basic molecular biology and the molecular mechanisms of disease that were uncovered by the application and development of novel synthetic biology-driven approaches.

Synthesis of Therapeutic Oligonucleotides

Download Synthesis of Therapeutic Oligonucleotides PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 981131912X
Total Pages : 284 pages
Book Rating : 4.8/5 (113 download)

DOWNLOAD NOW!


Book Synopsis Synthesis of Therapeutic Oligonucleotides by : Satoshi Obika

Download or read book Synthesis of Therapeutic Oligonucleotides written by Satoshi Obika and published by Springer. This book was released on 2018-12-08 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC). The aim is to provide new insights and inspire fresh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research.

Toxoplasma Gondii

Download Toxoplasma Gondii PDF Online Free

Author :
Publisher : Academic Press
ISBN 13 : 0128150424
Total Pages : 1244 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!


Book Synopsis Toxoplasma Gondii by : Louis M. Weiss

Download or read book Toxoplasma Gondii written by Louis M. Weiss and published by Academic Press. This book was released on 2020-02-28 with total page 1244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxoplasma gondii: The Model Apicomplexan - Perspectives and Methods, Third Edition, reflects significant advances in the field in the last five years, including new information on the genomics, epigenomics and proteomics of T. gondii, along with a new understanding of the population biology and genetic diversity of this organism. This edition expands information on the effects of T. gondii on human psychiatric disease and new molecular techniques, such as CAS9/CSPR. T gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists. Presents a complete review of molecular and cellar biology and immunology of Toxoplasma gondii combined with methods and resources for working with this pathogen Provides a single source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians and food scientists Covers recent advances in the genomics, related bioinformatics analysis, epigenomics, gene regulation, genetic manipulation and proteomics of T. gondii Details advances in the molecular and cellular biology and immunology of Toxoplasma, and in the epidemiology, diagnosis, treatment and prevention of toxoplasmosis

Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health

Download Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health PDF Online Free

Author :
Publisher : Academic Press
ISBN 13 : 0128013133
Total Pages : 636 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!


Book Synopsis Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health by : Suresh C Sikka

Download or read book Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health written by Suresh C Sikka and published by Academic Press. This book was released on 2017-11-14 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health is structured into two parts related to men’s reproductive and sexual health with eight sections designed to enable a logical flow of such knowledge. The book is focused on the biology of key organs involved in male reproduction and the environmental influences affecting their functions with particular emphasis on clinical aspects. Individual chapters within the book range from basic to translational aspects, but all hold clinical relevance. This is an essential reference for those working and learning in the field of human reproduction, reproductive toxicology and environmental influences on reproductive and sexual health. Brings together the leading authorities working in the field of male reproduction and sexual health and how the environment affects these issues. Provides guidelines and reference values of various reproductive hormones, semen parameters, inclusion/exclusion criteria for clinical trials. Discover the most efficient methods by which to design clinical protocols for sperm safety studies and reproductive toxicology trials.

Cellular Signal Processing

Download Cellular Signal Processing PDF Online Free

Author :
Publisher : Garland Science
ISBN 13 : 1351677217
Total Pages : 982 pages
Book Rating : 4.3/5 (516 download)

DOWNLOAD NOW!


Book Synopsis Cellular Signal Processing by : Friedrich Marks

Download or read book Cellular Signal Processing written by Friedrich Marks and published by Garland Science. This book was released on 2017-05-17 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular Signal Processing offers a unifying view of cell signaling based on the concept that protein interactions act as sophisticated data processing networks that govern intracellular and extracellular communication. It is intended for use in signal transduction courses for undergraduate and graduate students working in biology, biochemistry, bioinformatics, and pharmacology, as well as medical students. The text is organized by three key topics central to signal transduction: the protein network, its energy supply, and its evolution. It covers all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling, and also highlights the clinical aspects of cell signaling in health and disease. This new edition includes expanded coverage of prokaryotes, as well as content on new developments in systems biology, epigenetics, redox signaling, and small, non-coding RNA signaling.

Optical Tweezers

Download Optical Tweezers PDF Online Free

Author :
Publisher : Springer Nature
ISBN 13 : 1071622293
Total Pages : 753 pages
Book Rating : 4.0/5 (716 download)

DOWNLOAD NOW!


Book Synopsis Optical Tweezers by : Arne Gennerich

Download or read book Optical Tweezers written by Arne Gennerich and published by Springer Nature. This book was released on 2022-09-05 with total page 753 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores a wide variety of techniques involving optical tweezers, a technology that has become increasingly more accessible to a broad range of researchers. Beginning with recent technical advances, the book continues by covering the application of optical tweezers to study DNA-protein interactions and DNA motors, protocols to perform protein (un)folding experiments, the application of optical tweezers to study actin- and microtubule-associated motor proteins, and well as protocols for investigating the function and mechanical properties of microtubules and intermediate filaments, and more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Optical Tweezers: Methods and Protocols, Second Edition serves as an ideal resource for expanding the accessibility and use of optical traps by scientists of diverse disciplines.

Cumulated Index Medicus

Download Cumulated Index Medicus PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 1836 pages
Book Rating : 4.3/5 (243 download)

DOWNLOAD NOW!


Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt: