Nitric Oxide In Diabetes And Hypertension

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Nitric Oxide in Diabetes and Hypertension

Author : Shiekh gazalla Ayub
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783659779435
Total Pages : 76 pages
Book Rating : 4.7/5 (794 download)

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Book Synopsis Nitric Oxide in Diabetes and Hypertension by : Shiekh gazalla Ayub

Download or read book Nitric Oxide in Diabetes and Hypertension written by Shiekh gazalla Ayub and published by LAP Lambert Academic Publishing. This book was released on 2015-10-20 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide is one the pivotal molecule released by endothelium and its turnover is vital for proper endothelial function. Various chronic risk factors associated with Type II Diabetes Mellitus and hypertension may disrupt the homeostatic balance in vascular system potentiating endothelial dysfunction. Endothelial dysfunction accompanies all cardiovascular risk factors and presumably plays a prime role in the occurrence of cardiovascular events associated with diabetes and hypertension. Although, it is apparent that NO turnover has a deep influence on the etiology of diabetes and hypertension, much remains to be done to substantiate NO-targeted therapies for the treatment of these disorders. Likewise, a systematic detail of ascertaining the relationship of NO dynamics with such disorders need to be elucidated before NO-targeted therapeutic proposition is considered. Our study is an attempt to quantitate and compare the NO level status in these different pathological conditions and analyse it in relation to the effect of disease.

Diabetes and Hypertension

Author : Samy I. McFarlane
Publisher : Springer Science & Business Media
ISBN 13 : 1603273573
Total Pages : 196 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Diabetes and Hypertension by : Samy I. McFarlane

Download or read book Diabetes and Hypertension written by Samy I. McFarlane and published by Springer Science & Business Media. This book was released on 2012-10-19 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.

The Role of Nitric Oxide/peroxynitrite Imbalance in Diabetes and Salt-induced Hypertension

Author : Salah Alsanussi Mousa Awad
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (86 download)

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Book Synopsis The Role of Nitric Oxide/peroxynitrite Imbalance in Diabetes and Salt-induced Hypertension by : Salah Alsanussi Mousa Awad

Download or read book The Role of Nitric Oxide/peroxynitrite Imbalance in Diabetes and Salt-induced Hypertension written by Salah Alsanussi Mousa Awad and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Role of Nitric Oxide in Type 2 Diabetes

Author : Asghar Ghasemi
Publisher : Bentham Science Publishers
ISBN 13 : 9815079824
Total Pages : 386 pages
Book Rating : 4.8/5 (15 download)

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Book Synopsis The Role of Nitric Oxide in Type 2 Diabetes by : Asghar Ghasemi

Download or read book The Role of Nitric Oxide in Type 2 Diabetes written by Asghar Ghasemi and published by Bentham Science Publishers. This book was released on 2022-12-01 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Type 2 diabetes (T2D) is a complex metabolic disorder characterized by impaired glucose metabolism and pancreatic β-cell dysfunction. No effective treatments are available for T2D, although there have been many developments in the therapeutic arena. Nitric oxide (NO) is an endocrine agent with multiple and important biological roles in most mammalian tissues. NO has emerged as a central regulator of energy metabolism and body composition. NO bioavailability is decreased in T2D. Several of the pharmaceuticals used in T2D affect the NO system and perhaps even more so by the drugs we use to treat diabetic cardiovascular complications. Experimental works in animal models of T2D show promising results with interventions aimed to increase NO signaling. However, translation into human studies has so far been less successful, but more large-scale prolonged studies are clearly needed to understand its role. This book is a collection of reviews that deal with the role of nitric oxide in type 2 diabetes, providing a unique overview of NO signaling, and pointing out key areas for more detailed research. The book includes contributions about the pathophysiology of T2D, a brief history of discovery and timeline of NO research, a comprehensive overview of impaired NO metabolism in T2D, precursors of NO (i.e., L-arginine, L-citrulline, nitrate, nitrites, and NO donors), NO and T2D from genetic points of view, NO and diabetic wound healing, NO and osteoporosis, NO and hyperuricemia, NO and Alzheimer’s Disease, therapeutic applications of NO and NO donors in T2D. The compilation is of great value to anyone interested in the biochemistry of NO and its relationship to diabetes.

Diabetic Dysregulation of Endothelial Glucose Metabolism

Author : Matthew Brent West
Publisher :
ISBN 13 :
Total Pages : 54 pages
Book Rating : 4.:/5 (631 download)

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Book Synopsis Diabetic Dysregulation of Endothelial Glucose Metabolism by : Matthew Brent West

Download or read book Diabetic Dysregulation of Endothelial Glucose Metabolism written by Matthew Brent West and published by . This book was released on 2005 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evident increase in obesity and sedentary lifestyles across the globe is consistent with a rise in the incidence of both non-insulin-dependent diabetes mellitus (type 2 diabetes) and cardiovascular disease (CVD). Type 2 diabetes is a clinically polygenic disease that has become an emergent global problem. Like CVD, diabetes is exaggerated by dyslipidemia, hypertension, obesity, and smoking, and it has been suggested that type 2 diabetes is a cardiovascular disease. Indeed, CVD and diabetes share identical and overlapping risk factors ("common soil hypothesis"). A majority of diabetic complications are a result of both micro and macrovascular changes that either directly or indirectly contribute to these chronic pathologies.

Atherosclerosis, Hypertension and Diabetes

Author : Grant N. Pierce
Publisher : Springer Science & Business Media
ISBN 13 : 1441992324
Total Pages : 528 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Atherosclerosis, Hypertension and Diabetes by : Grant N. Pierce

Download or read book Atherosclerosis, Hypertension and Diabetes written by Grant N. Pierce and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is devoted to atherosclerosis, hypertension, and diabetes, three of the most important disease conditions in the world today. Nutritional intervention, cholesterol lowering agents, lipids themselves, particularly oxidized LDL, protein modification by ADP-ribose, bone marrow study, endothelial cell dysfunction, angiotensin, and the role of infection and inflammation are all discussed in the context of atherosclerotic cardiovascular disease. The hypertension section focuses on factors that may be responsible for high blood pressure, such as genetic predisposition, vascular hyperplasia and remodeling, insulin resistance, neurological aspects such as hypothalamic peptides. Also discussed are the possible contributions of the cellular function of the endothelium, nutrition, kidney dysfunction, leptin, and the brain. Novel routes of drug delivery for treatment of hypertension is also a focus. The risk factors and mechanisms responsible for diabetic vascular and cardiac dysfunction are discussed. Lipid profile changes and fibrinolysis in diabetic patients is detailed, along with adipogenesis, diabetic cardiomyopathy, energy metabolism in the diabetic heart, vanadate as an alternative to insulin, insulin resistance mechanisms, and neurotransmitters as targets for the prevention of cardiovascular disease and diabetes.

Phytotherapy in the Management of Diabetes and Hypertension

Author : Mohamed Eddouks
Publisher : Bentham Science Publishers
ISBN 13 : 1608050149
Total Pages : 258 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Phytotherapy in the Management of Diabetes and Hypertension by : Mohamed Eddouks

Download or read book Phytotherapy in the Management of Diabetes and Hypertension written by Mohamed Eddouks and published by Bentham Science Publishers. This book was released on 2012-11-20 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytotherapy in the Management of Diabetes and Hypertension is a good addition to existing volumes detailing knowledge of hyperglycemia therapy. This e-book emphasizes the basic biochemistry behind diabetes mellitus and hypertension, along with the control or remediation of these conditions through a cost effective, safe, easy-going, easy-adaptable method validated by scientific research. This e-book contains 7 chapters dealing with various aspects of these diseases and their Phytotherapy treatment and life style management. Phytotherapy can give patients long term benefits with less or no side effects. Hence, this e-book is an authentic alternative or complementary therapeutic compendium to physicians and patients. This book will also be useful to students, teachers, researchers, clinicians and general readers interested in learning about applied phytotherapy.

The Endothelium

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041230
Total Pages : 309 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis The Endothelium by : Michel Félétou

Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Diabetes and Cardiovascular Disease

Author : Michael T. Johnstone
Publisher : Springer Science & Business Media
ISBN 13 : 1592599087
Total Pages : 645 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Diabetes and Cardiovascular Disease by : Michael T. Johnstone

Download or read book Diabetes and Cardiovascular Disease written by Michael T. Johnstone and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cause of diabetes mellitus is metabolic in origin. However, its major clinical manifestations, which result in most of the morbidity and mortality, are a result of its vascular pathology. In fact, the American Heart Association has recently stated that, “from the point of view of cardiovascular medicine, it may be appropriate to say, diabetes is a cardiovascular disease” (1). But diabetic vascular disease is not limited to just the macrovasculature. Diabetes mellitus also affects the microcirculation with devastating results, including nephropathy, neuropathy, and retinopathy. Diabetic nephropathy is the leading cause of end-stage renal disease in the United States, while diabetic retinopathy is the leading cause of new-onset blindness in working-age Americans. The importance of this text on Diabetes and Cardiovascular Disease is evident by the magnitude of the population affected by diabetes mellitus. Over 10 million Americans have been diagnosed with diabetes mellitus, while another 5 million remain undiagnosed. The impact from a public health perspective is huge and increasing. As the population of the United States grows older, more sedentary, and obese, the risk of developing diabetes and its complications will increase. Epidemiological studies have identified diabetes mellitus as a major independent risk factor for cardiovascular disease. Over 65% of patients with diabetes mellitus die from a cardiovascular cause. The prognosis of patients with diabetes mellitus who develop overt clinical cardiovascular disease is much worse than those cardiovascular patients free of diabetes mellitus.

Nitric Oxide

Author : Louis J. Ignarro
Publisher : Academic Press
ISBN 13 : 0080525032
Total Pages : 1023 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Nitric Oxide by : Louis J. Ignarro

Download or read book Nitric Oxide written by Louis J. Ignarro and published by Academic Press. This book was released on 2000-09-13 with total page 1023 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense

Hypertension and Cardiovascular Disease

Author : Emmanuel A. Andreadis
Publisher : Springer
ISBN 13 : 3319395998
Total Pages : 392 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Hypertension and Cardiovascular Disease by : Emmanuel A. Andreadis

Download or read book Hypertension and Cardiovascular Disease written by Emmanuel A. Andreadis and published by Springer. This book was released on 2016-09-20 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive analysis into individualized patient care, and applying evidence‐based medicine while integrating basic medical knowledge with applied medicine. The Editor and the contributors not only discuss important issues on hypertension management and its deleterious consequences if it is not well‐controlled, but also highlight the important signaling pathways involved in the pathogenesis of hypertensive heart disease and cardiac hypertrophy.

Hypertension, Insulin Resistance and Nitric Oxide Bioavailability

Author : Mobin Mohteshamzadeh
Publisher :
ISBN 13 :
Total Pages : 212 pages
Book Rating : 4.:/5 (522 download)

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Book Synopsis Hypertension, Insulin Resistance and Nitric Oxide Bioavailability by : Mobin Mohteshamzadeh

Download or read book Hypertension, Insulin Resistance and Nitric Oxide Bioavailability written by Mobin Mohteshamzadeh and published by . This book was released on 2002 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

NO More Heart Disease

Author : Louis Ignarro
Publisher : St. Martin's Press
ISBN 13 : 1429972459
Total Pages : 276 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis NO More Heart Disease by : Louis Ignarro

Download or read book NO More Heart Disease written by Louis Ignarro and published by St. Martin's Press. This book was released on 2006-01-24 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Louis Ignarro discovered "the atom" of cardiovascular health--a tiny molecule called Nitric Oxide. NO, as it is known by chemists, is a signaling molecule produced by the body, and is a vasodilator that helps control blood flow to every part of the body. Dr. Ignarro's findings led to the development of Viagra. Nitric Oxide has a beneficial effect on the cardiovascular system as well. NO relaxes and enlarges the blood vessels, prevents blood clots that trigger strokes and heart attacks, and regulates blood pressure and the accumulation of plaque in the blood vessels. Dr. Ignarro's current research indicates that Nitric Oxide may help lower cholesterol by facilitating the actions of statin drugs like Lipitor. The goal of the regimen presented in NO More Heart Disease is to age proof the cardiovascular system, keeping the vascular network clean and elastic through enhanced NO productivity. The plan is easy-to-follow without extreme lifestyle adjustments, involving taking supplements to stimulate Nitric Oxide production, incorporating NO friendly food into the diet, and a moderate exercise program.

Pediatric Hypertension

Author : Joseph Flynn
Publisher : Springer Science & Business Media
ISBN 13 : 1627034900
Total Pages : 597 pages
Book Rating : 4.6/5 (27 download)

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Book Synopsis Pediatric Hypertension by : Joseph Flynn

Download or read book Pediatric Hypertension written by Joseph Flynn and published by Springer Science & Business Media. This book was released on 2013-06-26 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of pediatric hypertension has undergone important changes in the time since the second edition of Pediatric Hypertension published. Much new information on hypertension in the young has become available. Previous chapters have been fully revised and new chapters have been added to cover important topics of recent interest such as consensus recommendations, the prevalence of hypertension in the young due to the obesity epidemic, studies of antihypertensive agents, and ambulatory blood pressure monitoring. Pediatric Hypertension, Third Edition is a comprehensive volume featuring 38 chapters covering the breadth of the current knowledge. It is divided into four sections: Regulation of Blood Pressure in Children; Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology; and Hypertension in Children: Predictors, Risk Factors, and Special Populations; Evaluation and Management of Pediatric Hypertension. Filled with the most up-to-date information, Pediatric Hypertension, Third Edition is an invaluable resource for clinicians and researchers interested in childhood hypertension.

Endothelial Dysfunction

Author : Helena Lenasi
Publisher : BoD – Books on Demand
ISBN 13 : 1789842530
Total Pages : 432 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Endothelial Dysfunction by : Helena Lenasi

Download or read book Endothelial Dysfunction written by Helena Lenasi and published by BoD – Books on Demand. This book was released on 2018-10-24 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

Report of the Hypertension Task Force

Author : National Heart, Lung, and Blood Institute. Hypertension Task Force
Publisher :
ISBN 13 :
Total Pages : 192 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Report of the Hypertension Task Force by : National Heart, Lung, and Blood Institute. Hypertension Task Force

Download or read book Report of the Hypertension Task Force written by National Heart, Lung, and Blood Institute. Hypertension Task Force and published by . This book was released on 1979 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nitric Oxide Synthase

Author : Seyed Soheil Saeedi Saravi
Publisher : BoD – Books on Demand
ISBN 13 : 953513163X
Total Pages : 250 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Nitric Oxide Synthase by : Seyed Soheil Saeedi Saravi

Download or read book Nitric Oxide Synthase written by Seyed Soheil Saeedi Saravi and published by BoD – Books on Demand. This book was released on 2017-05-17 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric Oxide Synthase - Simple Enzyme-Complex Roles provides information on nitric oxide synthase, a biomolecule of key importance for the different biological systems, including central and peripheral nervous, cardiovascular, and reproductive systems. With recent links to the role of nitric oxide in the reactions that can impact cell signaling, and discoveries surrounding the complex role of nitric oxide synthase that have increased research attention across the fields of cell and molecular biology, physiology, pharmacology, toxicology, neuroscience, cardiology, urology, and endocrinology, this book tries to provide a comprehensive overview of biology/pathobiology of nitric oxide synthases and a perspective from possible therapeutic indication of the enzyme inhibitors.