New Results On The False Discovery Rate

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Recent Advances In Biostatistics: False Discovery Rates, Survival Analysis, And Related Topics

Author : Manish C Bhattacharjee
Publisher : World Scientific
ISBN 13 : 981446242X
Total Pages : 311 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Recent Advances In Biostatistics: False Discovery Rates, Survival Analysis, And Related Topics by : Manish C Bhattacharjee

Download or read book Recent Advances In Biostatistics: False Discovery Rates, Survival Analysis, And Related Topics written by Manish C Bhattacharjee and published by World Scientific. This book was released on 2011-03-18 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique volume provides self-contained accounts of some recent trends in Biostatistics methodology and their applications. It includes state-of-the-art reviews and original contributions.The articles included in this volume are based on a careful selection of peer-reviewed papers, authored by eminent experts in the field, representing a well balanced mix of researchers from the academia, R&D sectors of government and the pharmaceutical industry.The book is also intended to give advanced graduate students and new researchers a scholarly overview of several research frontiers in biostatistics, which they can use to further advance the field through development of new techniques and results.

Statistics Done Wrong

Author : Alex Reinhart
Publisher : No Starch Press
ISBN 13 : 1593276206
Total Pages : 177 pages
Book Rating : 4.5/5 (932 download)

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Book Synopsis Statistics Done Wrong by : Alex Reinhart

Download or read book Statistics Done Wrong written by Alex Reinhart and published by No Starch Press. This book was released on 2015-03-01 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific progress depends on good research, and good research needs good statistics. But statistical analysis is tricky to get right, even for the best and brightest of us. You'd be surprised how many scientists are doing it wrong. Statistics Done Wrong is a pithy, essential guide to statistical blunders in modern science that will show you how to keep your research blunder-free. You'll examine embarrassing errors and omissions in recent research, learn about the misconceptions and scientific politics that allow these mistakes to happen, and begin your quest to reform the way you and your peers do statistics. You'll find advice on: –Asking the right question, designing the right experiment, choosing the right statistical analysis, and sticking to the plan –How to think about p values, significance, insignificance, confidence intervals, and regression –Choosing the right sample size and avoiding false positives –Reporting your analysis and publishing your data and source code –Procedures to follow, precautions to take, and analytical software that can help Scientists: Read this concise, powerful guide to help you produce statistically sound research. Statisticians: Give this book to everyone you know. The first step toward statistics done right is Statistics Done Wrong.

Resampling-Based Multiple Testing

Author : Peter H. Westfall
Publisher : John Wiley & Sons
ISBN 13 : 9780471557616
Total Pages : 382 pages
Book Rating : 4.5/5 (576 download)

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Book Synopsis Resampling-Based Multiple Testing by : Peter H. Westfall

Download or read book Resampling-Based Multiple Testing written by Peter H. Westfall and published by John Wiley & Sons. This book was released on 1993-01-12 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combines recent developments in resampling technology (including the bootstrap) with new methods for multiple testing that are easy to use, convenient to report and widely applicable. Software from SAS Institute is available to execute many of the methods and programming is straightforward for other applications. Explains how to summarize results using adjusted p-values which do not necessitate cumbersome table look-ups. Demonstrates how to incorporate logical constraints among hypotheses, further improving power.

Recent Advances in Biostatistics

Author : Manish Bhattacharjee
Publisher : World Scientific
ISBN 13 : 9814329800
Total Pages : 311 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Recent Advances in Biostatistics by : Manish Bhattacharjee

Download or read book Recent Advances in Biostatistics written by Manish Bhattacharjee and published by World Scientific. This book was released on 2011 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique volume provides self-contained accounts of some recent trends in Biostatistics methodology and their applications. It includes state-of-the-art reviews and original contributions. The articles included in this volume are based on a careful sel

Multiple Comparison Procedures

Author : Yosef Hochberg
Publisher :
ISBN 13 :
Total Pages : 482 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Multiple Comparison Procedures by : Yosef Hochberg

Download or read book Multiple Comparison Procedures written by Yosef Hochberg and published by . This book was released on 1987-10-05 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a balanced, up-to-date view of multiple comparison procedures, this book refutes the belief held by some statisticians that such procedures have no place in data analysis. With equal emphasis on theory and applications, it establishes the advantages of multiple comparison techniques in reducing error rates and in ensuring the validity of statistical inferences. Provides detailed descriptions of the derivation and implementation of a variety of procedures, paying particular attention to classical approaches and confidence estimation procedures. Also discusses the benefits and drawbacks of other methods. Numerous examples and tables for implementing procedures are included, making this work both practical and informative.

Large-Scale Inference

Author : Bradley Efron
Publisher : Cambridge University Press
ISBN 13 : 1139492136
Total Pages : pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Large-Scale Inference by : Bradley Efron

Download or read book Large-Scale Inference written by Bradley Efron and published by Cambridge University Press. This book was released on 2012-11-29 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: We live in a new age for statistical inference, where modern scientific technology such as microarrays and fMRI machines routinely produce thousands and sometimes millions of parallel data sets, each with its own estimation or testing problem. Doing thousands of problems at once is more than repeated application of classical methods. Taking an empirical Bayes approach, Bradley Efron, inventor of the bootstrap, shows how information accrues across problems in a way that combines Bayesian and frequentist ideas. Estimation, testing and prediction blend in this framework, producing opportunities for new methodologies of increased power. New difficulties also arise, easily leading to flawed inferences. This book takes a careful look at both the promise and pitfalls of large-scale statistical inference, with particular attention to false discovery rates, the most successful of the new statistical techniques. Emphasis is on the inferential ideas underlying technical developments, illustrated using a large number of real examples.

Biostatistics

Author : Gerald van Belle
Publisher : John Wiley & Sons
ISBN 13 : 0471602353
Total Pages : 894 pages
Book Rating : 4.4/5 (716 download)

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Book Synopsis Biostatistics by : Gerald van Belle

Download or read book Biostatistics written by Gerald van Belle and published by John Wiley & Sons. This book was released on 2004-10-06 with total page 894 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected introduction to biostatistics, thoroughly updated and revised The first edition of Biostatistics: A Methodology for the Health Sciences has served professionals and students alike as a leading resource for learning how to apply statistical methods to the biomedical sciences. This substantially revised Second Edition brings the book into the twenty-first century for today’s aspiring and practicing medical scientist. This versatile reference provides a wide-ranging look at basic and advanced biostatistical concepts and methods in a format calibrated to individual interests and levels of proficiency. Written with an eye toward the use of computer applications, the book examines the design of medical studies, descriptive statistics, and introductory ideas of probability theory and statistical inference; explores more advanced statistical methods; and illustrates important current uses of biostatistics. New to this edition are discussions of Longitudinal data analysis Randomized clinical trials Bayesian statistics GEE The bootstrap method Enhanced by a companion Web site providing data sets, selected problems and solutions, and examples from such current topics as HIV/AIDS, this is a thoroughly current, comprehensive introduction to the field.

Statistical Parametric Mapping: The Analysis of Functional Brain Images

Author : William D. Penny
Publisher : Elsevier
ISBN 13 : 0080466508
Total Pages : 689 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Statistical Parametric Mapping: The Analysis of Functional Brain Images by : William D. Penny

Download or read book Statistical Parametric Mapping: The Analysis of Functional Brain Images written by William D. Penny and published by Elsevier. This book was released on 2011-04-28 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an age where the amount of data collected from brain imaging is increasing constantly, it is of critical importance to analyse those data within an accepted framework to ensure proper integration and comparison of the information collected. This book describes the ideas and procedures that underlie the analysis of signals produced by the brain. The aim is to understand how the brain works, in terms of its functional architecture and dynamics. This book provides the background and methodology for the analysis of all types of brain imaging data, from functional magnetic resonance imaging to magnetoencephalography. Critically, Statistical Parametric Mapping provides a widely accepted conceptual framework which allows treatment of all these different modalities. This rests on an understanding of the brain's functional anatomy and the way that measured signals are caused experimentally. The book takes the reader from the basic concepts underlying the analysis of neuroimaging data to cutting edge approaches that would be difficult to find in any other source. Critically, the material is presented in an incremental way so that the reader can understand the precedents for each new development. This book will be particularly useful to neuroscientists engaged in any form of brain mapping; who have to contend with the real-world problems of data analysis and understanding the techniques they are using. It is primarily a scientific treatment and a didactic introduction to the analysis of brain imaging data. It can be used as both a textbook for students and scientists starting to use the techniques, as well as a reference for practicing neuroscientists. The book also serves as a companion to the software packages that have been developed for brain imaging data analysis. - An essential reference and companion for users of the SPM software - Provides a complete description of the concepts and procedures entailed by the analysis of brain images - Offers full didactic treatment of the basic mathematics behind the analysis of brain imaging data - Stands as a compendium of all the advances in neuroimaging data analysis over the past decade - Adopts an easy to understand and incremental approach that takes the reader from basic statistics to state of the art approaches such as Variational Bayes - Structured treatment of data analysis issues that links different modalities and models - Includes a series of appendices and tutorial-style chapters that makes even the most sophisticated approaches accessible

Statistical Methods in the Atmospheric Sciences

Author : Daniel S. Wilks
Publisher : Academic Press
ISBN 13 : 0123850231
Total Pages : 697 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Statistical Methods in the Atmospheric Sciences by : Daniel S. Wilks

Download or read book Statistical Methods in the Atmospheric Sciences written by Daniel S. Wilks and published by Academic Press. This book was released on 2011-07-04 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Methods in the Atmospheric Sciences, Third Edition, explains the latest statistical methods used to describe, analyze, test, and forecast atmospheric data. This revised and expanded text is intended to help students understand and communicate what their data sets have to say, or to make sense of the scientific literature in meteorology, climatology, and related disciplines. In this new edition, what was a single chapter on multivariate statistics has been expanded to a full six chapters on this important topic. Other chapters have also been revised and cover exploratory data analysis, probability distributions, hypothesis testing, statistical weather forecasting, forecast verification, and time series analysis. There is now an expanded treatment of resampling tests and key analysis techniques, an updated discussion on ensemble forecasting, and a detailed chapter on forecast verification. In addition, the book includes new sections on maximum likelihood and on statistical simulation and contains current references to original research. Students will benefit from pedagogical features including worked examples, end-of-chapter exercises with separate solutions, and numerous illustrations and equations. This book will be of interest to researchers and students in the atmospheric sciences, including meteorology, climatology, and other geophysical disciplines. - Accessible presentation and explanation of techniques for atmospheric data summarization, analysis, testing and forecasting - Many worked examples - End-of-chapter exercises, with answers provided

The Polygraph and Lie Detection

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309084369
Total Pages : 417 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis The Polygraph and Lie Detection by : National Research Council

Download or read book The Polygraph and Lie Detection written by National Research Council and published by National Academies Press. This book was released on 2003-01-22 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: The polygraph, often portrayed as a magic mind-reading machine, is still controversial among experts, who continue heated debates about its validity as a lie-detecting device. As the nation takes a fresh look at ways to enhance its security, can the polygraph be considered a useful tool? The Polygraph and Lie Detection puts the polygraph itself to the test, reviewing and analyzing data about its use in criminal investigation, employment screening, and counter-intelligence. The book looks at: The theory of how the polygraph works and evidence about how deceptivenessâ€"and other psychological conditionsâ€"affect the physiological responses that the polygraph measures. Empirical evidence on the performance of the polygraph and the success of subjects' countermeasures. The actual use of the polygraph in the arena of national security, including its role in deterring threats to security. The book addresses the difficulties of measuring polygraph accuracy, the usefulness of the technique for aiding interrogation and for deterrence, and includes potential alternativesâ€"such as voice-stress analysis and brain measurement techniques.

Lectures on Biostatistics: An Introduction to Statistics With Applications in Biology and Medicine

Author : D. Colquhoun
Publisher : David Colquhoun
ISBN 13 :
Total Pages : 446 pages
Book Rating : 4./5 ( download)

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Book Synopsis Lectures on Biostatistics: An Introduction to Statistics With Applications in Biology and Medicine by : D. Colquhoun

Download or read book Lectures on Biostatistics: An Introduction to Statistics With Applications in Biology and Medicine written by D. Colquhoun and published by David Colquhoun. This book was released on 1971 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:

False Positive

Author : Theodore Dalrymple
Publisher : Encounter Books
ISBN 13 : 1641770473
Total Pages : 233 pages
Book Rating : 4.6/5 (417 download)

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Book Synopsis False Positive by : Theodore Dalrymple

Download or read book False Positive written by Theodore Dalrymple and published by Encounter Books. This book was released on 2019-06-25 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New England Journal of Medicine is one of the most important general medical journals in the world. Doctors rely on the conclusions it publishes, and most do not have the time to look beyond abstracts to examine methodology or question assumptions. Many of its pronouncements are conveyed by the media to a mass audience, which is likely to take them as authoritative. But is this trust entirely warranted? Theodore Dalrymple, a doctor retired from practice, turned a critical eye upon a full year of the Journal, alert to dubious premises and to what is left unsaid. In False Positive, he demonstrates that many of the papers it publishes reach conclusions that are not only flawed, but obviously flawed. He exposes errors of reasoning and conspicuous omissions apparently undetected by the editors. In some cases, there is reason to suspect actual corruption. When the Journal takes on social questions, its perspective is solidly politically correct. Practically no debate on social issues appears in the printed version, and highly debatable points of view go unchallenged. The Journal reads as if there were only one possible point of view, though the American medical profession (to say nothing of the extensive foreign readership) cannot possibly be in total agreement with the stances taken in its pages. It is thus more megaphone than sounding board. There is indeed much in the New England Journal of Medicine that deserves praise and admiration. But this book should encourage the general reader to take a constructively critical view of medical news and to be wary of the latest medical doctrines.

Combinatorial Library

Author : Lisa B. English
Publisher : Springer Science & Business Media
ISBN 13 : 1592592856
Total Pages : 380 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Combinatorial Library by : Lisa B. English

Download or read book Combinatorial Library written by Lisa B. English and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continued successes of large- and small-scale genome sequencing projects are increasing the number of genomic targets available for drug d- covery at an exponential rate. In addition, a better understanding of molecular mechanisms—such as apoptosis, signal transduction, telomere control of ch- mosomes, cytoskeletal development, modulation of stress-related proteins, and cell surface display of antigens by the major histocompatibility complex m- ecules—has improved the probability of identifying the most promising genomic targets to counteract disease. As a result, developing and optimizing lead candidates for these targets and rapidly moving them into clinical trials is now a critical juncture in pharmaceutical research. Recent advances in com- natorial library synthesis, purification, and analysis techniques are not only increasing the numbers of compounds that can be tested against each specific genomic target, but are also speeding and improving the overall processes of lead discovery and optimization. There are two main approaches to combinatorial library production: p- allel chemical synthesis and split-and-mix chemical synthesis. These approaches can utilize solid- or solution-based synthetic methods, alone or in combination, although the majority of combinatorial library synthesis is still done on solid support. In a parallel synthesis, all the products are assembled separately in their own reaction vessels or microtiter plates. The array of rows and columns enables researchers to organize the building blocks to be c- bined, and provides an easy way to identify compounds in a particular well.

The False Discovery Rate

Author : Nicholas W. Galwey
Publisher : John Wiley & Sons
ISBN 13 : 1119889774
Total Pages : 292 pages
Book Rating : 4.1/5 (198 download)

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Book Synopsis The False Discovery Rate by : Nicholas W. Galwey

Download or read book The False Discovery Rate written by Nicholas W. Galwey and published by John Wiley & Sons. This book was released on 2025-03-10 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential tool for statisticians and data scientists seeking to interpret the vast troves of data that increasingly power our world First developed in the 1990s, the False Discovery Rate (FDR) is a way of describing the rate at which null hypothesis testing produces errors. It has since become an essential tool for interpreting large datasets. In recent years, as datasets have become ever larger, and as the importance of ‘big data‘ to scientific research has grown, the significance of the FDR has grown correspondingly. The False Discovery Rate provides an analysis of the FDR's value as a tool, including why it should generally be preferred to the Bonferroni correction and other methods by which multiplicity can be accounted for. It offers a systematic overview of the FDR, its core claims, and its applications. Readers of The False Discovery Rate will also find: Case studies throughout, rooted in real and simulated data sets Detailed discussion of topics including representation of the FDR on a Q-Q plot, consequences of non-monotonicity, and many more Wide-ranging analysis suited for a broad readership The False Discovery Rate is ideal for Statistics and Data Science courses, and short courses associated with conferences. It is also useful as supplementary reading in courses in other disciplines that require the statistical interpretation of “big data.’ The book will also be of great value to statisticians and researchers looking to learn more about the FDR.

Multiple Testing Problems in Pharmaceutical Statistics

Author : Alex Dmitrienko
Publisher : CRC Press
ISBN 13 : 1584889853
Total Pages : 323 pages
Book Rating : 4.5/5 (848 download)

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Book Synopsis Multiple Testing Problems in Pharmaceutical Statistics by : Alex Dmitrienko

Download or read book Multiple Testing Problems in Pharmaceutical Statistics written by Alex Dmitrienko and published by CRC Press. This book was released on 2009-12-08 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple c

Strengthening Forensic Science in the United States

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309142393
Total Pages : 348 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Strengthening Forensic Science in the United States by : National Research Council

Download or read book Strengthening Forensic Science in the United States written by National Research Council and published by National Academies Press. This book was released on 2009-07-29 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scores of talented and dedicated people serve the forensic science community, performing vitally important work. However, they are often constrained by lack of adequate resources, sound policies, and national support. It is clear that change and advancements, both systematic and scientific, are needed in a number of forensic science disciplines to ensure the reliability of work, establish enforceable standards, and promote best practices with consistent application. Strengthening Forensic Science in the United States: A Path Forward provides a detailed plan for addressing these needs and suggests the creation of a new government entity, the National Institute of Forensic Science, to establish and enforce standards within the forensic science community. The benefits of improving and regulating the forensic science disciplines are clear: assisting law enforcement officials, enhancing homeland security, and reducing the risk of wrongful conviction and exoneration. Strengthening Forensic Science in the United States gives a full account of what is needed to advance the forensic science disciplines, including upgrading of systems and organizational structures, better training, widespread adoption of uniform and enforceable best practices, and mandatory certification and accreditation programs. While this book provides an essential call-to-action for congress and policy makers, it also serves as a vital tool for law enforcement agencies, criminal prosecutors and attorneys, and forensic science educators.

Encyclopedia of Research Design

Author : Neil J. Salkind
Publisher : SAGE
ISBN 13 : 1412961270
Total Pages : 1779 pages
Book Rating : 4.4/5 (129 download)

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Book Synopsis Encyclopedia of Research Design by : Neil J. Salkind

Download or read book Encyclopedia of Research Design written by Neil J. Salkind and published by SAGE. This book was released on 2010-06-22 with total page 1779 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Comprising more than 500 entries, the Encyclopedia of Research Design explains how to make decisions about research design, undertake research projects in an ethical manner, interpret and draw valid inferences from data, and evaluate experiment design strategies and results. Two additional features carry this encyclopedia far above other works in the field: bibliographic entries devoted to significant articles in the history of research design and reviews of contemporary tools, such as software and statistical procedures, used to analyze results. It covers the spectrum of research design strategies, from material presented in introductory classes to topics necessary in graduate research; it addresses cross- and multidisciplinary research needs, with many examples drawn from the social and behavioral sciences, neurosciences, and biomedical and life sciences; it provides summaries of advantages and disadvantages of often-used strategies; and it uses hundreds of sample tables, figures, and equations based on real-life cases."--Publisher's description.