New Perspectives In Neurosteroids Action A Special Player Allopregnanolone

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New Perspectives in Neurosteroids action: a Special Player Allopregnanolone

Author : Valerio Magnaghi
Publisher : Frontiers Media SA
ISBN 13 : 2889195554
Total Pages : 88 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis New Perspectives in Neurosteroids action: a Special Player Allopregnanolone by : Valerio Magnaghi

Download or read book New Perspectives in Neurosteroids action: a Special Player Allopregnanolone written by Valerio Magnaghi and published by Frontiers Media SA. This book was released on 2015-07-01 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early in the 80’s date the first observations on the existence of hormonal steroids that may be synthesized and act in the nervous system. In order to refer to these endogenous steroids, proved important to control both central and peripheral nervous system, it was proposed the term “neurosteroids” (NSs). Over the years, their importance in regulating the physiological functions of neuronal and glial cells increased progressively. These steroids can be involved in several pathophysiological conditions such as depression, anxiety, premenstrual syndrome (PMS), schizophrenia and Alzheimer disease. Among the different classes of NSs, the progestagens revealed particularly important. The progesterone metabolite 5a-pregnan-3a-ol-20-one, also named tetrahydroprogesterone or allopregnanolone (ALLO) was one of the first most important steroid that was originally shown to act as neurosteroid. ALLO is synthesized through the action of the 5aR-3a-HSD, which converts P into DHP and subsequently, via a bidirectional reaction, into ALLO. NSs exert complex effects in the nervous system through ‘classic’, genomic, and ‘non-classic’, non-genomic actions. ALLO displays a rapid ‘non-genomic’ effect, which mainly involves the potent modulation of the GABA type A (GABA-A) receptor function. Recently a membrane receptor has been identified as target for ALLO effects, i.e. the membrane progesterone receptors (mPRs) that are able to activate a signalling cascade through G protein dependent mechanisms. By these ways, ALLO is able to modulate several cell functions, acting as neurogenic molecule on neural progenitor cells, as well as by activating proliferation and differentiation of glial cells in the central and peripheral nervous system. In this topic, we review the most recent acquisitions in the field of neurosteroids, focusing our attention on ALLO because its effects on the physiology of neurons and glial cells of the central and peripheral nervous system are intriguing and could potentially lead to the development of new strategies for neuroprotection and/or regeneration of injured nervous tissues and for the treatment of neuropsychiatric disorders.

Fluoxetine

Author : Graziano Pinna
Publisher :
ISBN 13 : 9781634820769
Total Pages : 412 pages
Book Rating : 4.8/5 (27 download)

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Book Synopsis Fluoxetine by : Graziano Pinna

Download or read book Fluoxetine written by Graziano Pinna and published by . This book was released on 2015-04-01 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluoxetine, best known by the trade name Prozac®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.

Sex Differences in the Central Nervous System

Author : Rebecca M. Shansky
Publisher : Academic Press
ISBN 13 : 0128021985
Total Pages : 428 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Sex Differences in the Central Nervous System by : Rebecca M. Shansky

Download or read book Sex Differences in the Central Nervous System written by Rebecca M. Shansky and published by Academic Press. This book was released on 2015-09-14 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sex Differences in the Central Nervous System offers a comprehensive examination of the current state of sex differences research, from both the basic science and clinical research perspectives. Given the current NIH directive that funded preclinical research must consider both females and males, this topic is of interest to an increasing percentage of the neuroscience research population. The volume serves as an invaluable resource, offering coverage of a wide range of topics: sex differences in cognition, learning, and memory, sex hormone signaling mechanisms, neuroimmune interactions, epigenetics, social behavior, neurologic disease, psychological disorders, and stress. Discussions of research in both animal models and human patient populations are included. Details how sex hormones have widespread effects on the nervous system and influence the way males and females function Assists readers in determining how sex impacts their research and practice, and assists in determining how to adjust research programs to incorporate sex influences Includes discussions of research in both animal models and human patient populations, and at various developmental stages Features revised and updated chapters by leaders in the field around the globe—the broadest, most expert coverage available

Sex Hormones in Neurodegenerative Processes and Diseases

Author : Gorazd Drevensek
Publisher : BoD – Books on Demand
ISBN 13 : 1789230144
Total Pages : 360 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Sex Hormones in Neurodegenerative Processes and Diseases by : Gorazd Drevensek

Download or read book Sex Hormones in Neurodegenerative Processes and Diseases written by Gorazd Drevensek and published by BoD – Books on Demand. This book was released on 2018-05-02 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.

Anesthesia and Analgesia in Laboratory Animals

Author : Richard Fish
Publisher : Academic Press
ISBN 13 : 0080559832
Total Pages : 677 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Anesthesia and Analgesia in Laboratory Animals by : Richard Fish

Download or read book Anesthesia and Analgesia in Laboratory Animals written by Richard Fish and published by Academic Press. This book was released on 2011-04-28 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anesthesia and Analgesia in Laboratory Animals focuses on the special anesthetic, analgesic, and postoperative care requirements associated with experimental surgery. Fully revised and updated this new edition provides the reader with agents, methods, and techniques for anesthesia and analgesia that ensure humane and successful procedural outcomes. Provides researchers with the most comprehensive and up-to-date review of the use of anesthesia and analgesia in laboratory animals Thoroughly updated with new material on ferrets, birds, reptiles, amphibians, fish, and invertebrates Includes hot topic areas such as pain research, ethical issues, legal issues, and imaging studies

Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders

Author : Maurizio Popoli
Publisher : Springer
ISBN 13 : 1493910566
Total Pages : 363 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders by : Maurizio Popoli

Download or read book Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders written by Maurizio Popoli and published by Springer. This book was released on 2014-07-28 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies show that changes in Glutamate/GABA synapses and related pathways may determine whether the synaptic plasticity that occurs as a response to stress is adaptive or maladaptive. Findings have shed new light on the mechanisms that determine the effects of stress on cognitive and affective function. Researchers have brought a wide range of techniques to bear on the study of this problem, including cutting-edge live imaging techniques, electrophysiology, glutamate release from isolated live synaptic terminals, development of transgenic and animal models and new behavioral methods. This book provides an overview of these recent findings and of the techniques used as well as a discussion of how the molecular, cellular, and functional effects of stress may trigger or precipitate neuropsychiatric disorders such as depression, schizophrenia, anxiety and PTSD.

The Human Hypothalamus

Author : Dick F. Swaab
Publisher : Elsevier
ISBN 13 : 9780128199732
Total Pages : 745 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis The Human Hypothalamus by : Dick F. Swaab

Download or read book The Human Hypothalamus written by Dick F. Swaab and published by Elsevier. This book was released on 2021-09-06 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbooks of Neurology provide comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer's, Parkinson's, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more. Summarizes research on how the hypothalamus relates to neurological disorders Contains neuropsychiatric, neurodegenerative, periodic, and autonomic disorders Includes the neurobiology of, and treatment for, each disorder Covers depression, anxiety, OCD, PTSD, schizophrenia, autism, aggression, addiction and more Provides coverage of sleep and pain

The Neurobiological Basis of Suicide

Author : Yogesh Dwivedi
Publisher : CRC Press
ISBN 13 : 143983881X
Total Pages : 485 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis The Neurobiological Basis of Suicide by : Yogesh Dwivedi

Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi and published by CRC Press. This book was released on 2012-06-25 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Attention Deficit Hyperactivity Disorder in Children and Adolescents

Author : Somnath Banerjee
Publisher : BoD – Books on Demand
ISBN 13 : 9535110861
Total Pages : 330 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Attention Deficit Hyperactivity Disorder in Children and Adolescents by : Somnath Banerjee

Download or read book Attention Deficit Hyperactivity Disorder in Children and Adolescents written by Somnath Banerjee and published by BoD – Books on Demand. This book was released on 2013-06-27 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: ADHD in children and adolescents is a neurodevelopmental disorder, which is recognized by the clinicians all over the world. ADHD is a clinical diagnosis based on reliable history, reports from home and school and a physical examination to rule out any other underlying medical conditions. ADHD can cause low self-esteem in the child and impair quality of life for the child and the family. It is known that ADHD is a chronic illness and that clinicians needed to use chronic illness principles in treating it. The last 10 years have seen an increase in the number of medications that have been approved for the treatment of ADHD. This book has tried to address some of the issues in ADHD.

Multiple Sigma and PCP Receptor Ligands

Author : Jean-Marc Kamenka
Publisher :
ISBN 13 :
Total Pages : 1016 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Multiple Sigma and PCP Receptor Ligands by : Jean-Marc Kamenka

Download or read book Multiple Sigma and PCP Receptor Ligands written by Jean-Marc Kamenka and published by . This book was released on 1992 with total page 1016 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Extrasynaptic GABAA Receptors

Author : Adam C. Errington
Publisher : Springer
ISBN 13 : 149391426X
Total Pages : 301 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Extrasynaptic GABAA Receptors by : Adam C. Errington

Download or read book Extrasynaptic GABAA Receptors written by Adam C. Errington and published by Springer. This book was released on 2014-09-22 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

Hormones and Brain Plasticity

Author : Luis Miguel Garcia-Segura
Publisher : Oxford University Press
ISBN 13 : 019532661X
Total Pages : 505 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Hormones and Brain Plasticity by : Luis Miguel Garcia-Segura

Download or read book Hormones and Brain Plasticity written by Luis Miguel Garcia-Segura and published by Oxford University Press. This book was released on 2009-05-05 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proposing that hormones modulate metaplasticity in the brain, the author covers a wide variety of hormones, brain regions, and neuroplastic events, and also provides a new theoretical background with which to interpret the interaction of hormones and brain remodeling throughout the entire life of the organism.--[Source inconnue].

Neurotransmitters, Drugs and Brain Function

Author : Roy Webster
Publisher : John Wiley & Sons
ISBN 13 : 9780471978190
Total Pages : 550 pages
Book Rating : 4.9/5 (781 download)

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Book Synopsis Neurotransmitters, Drugs and Brain Function by : Roy Webster

Download or read book Neurotransmitters, Drugs and Brain Function written by Roy Webster and published by John Wiley & Sons. This book was released on 2001-11-28 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.

Steroids and the Nervous System

Author : GianCarlo Panzica
Publisher :
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.X/5 (4 download)

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Book Synopsis Steroids and the Nervous System by : GianCarlo Panzica

Download or read book Steroids and the Nervous System written by GianCarlo Panzica and published by . This book was released on 2003 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers emerging and intriguing topics related to research into steroids and the nervous system, with a major focus on glucocorticoids, non-classical mechanism of action, regulation of reproduction, steroids and glial cells, behavioural effects and pathological correlations.

Sex Differences in the Human Brain, their underpinnings and implications

Author :
Publisher : Elsevier
ISBN 13 : 9780444536310
Total Pages : 216 pages
Book Rating : 4.5/5 (363 download)

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Book Synopsis Sex Differences in the Human Brain, their underpinnings and implications by :

Download or read book Sex Differences in the Human Brain, their underpinnings and implications written by and published by Elsevier. This book was released on 2010-12-03 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Progress in Brain Research documents recent developments and research findings in relation to sex and how the brain’s function and behavior differs from men to women. Specific areas include cerebral function, morphology and organization, sexual dimorphism, neural origins,and genetics and epigenetics, as well as potential causes/affects of stress, pain, sexual orientation and identity and other social issues such as distribution of disorders across the sexes and autism. * Informs and updates on all the latest developments in the field * Highlights areas for future research * Contributions from leading authorities and industry experts

Practical Psychopharmacology

Author : Joseph F. Goldberg
Publisher : Cambridge University Press
ISBN 13 : 1108450741
Total Pages : 611 pages
Book Rating : 4.1/5 (84 download)

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Book Synopsis Practical Psychopharmacology by : Joseph F. Goldberg

Download or read book Practical Psychopharmacology written by Joseph F. Goldberg and published by Cambridge University Press. This book was released on 2021-04-29 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide translating clinical trials findings, across major psychiatric disorders, to devise tailored, evidence-based treatments.

Textbook of Female Sexual Function and Dysfunction

Author : Irwin Goldstein
Publisher : John Wiley & Sons
ISBN 13 : 1119266092
Total Pages : 398 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Textbook of Female Sexual Function and Dysfunction by : Irwin Goldstein

Download or read book Textbook of Female Sexual Function and Dysfunction written by Irwin Goldstein and published by John Wiley & Sons. This book was released on 2018-07-02 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive text on female sexual function and dysfunction that offers a multi-disciplinary, biopsychosocial approach to diagnosis and treatment Textbook of Female Sexual Function and Dysfunction offers a multi-disciplinary, biopsychosocial approach and provides guidance for the safe and effective diagnosis and treatment of various sexual health issues. With contributions from an international panel of experts, the text provides the scientific basis of the clinical recommendations for dealing with problems of sexual, desire, arousal, orgasm and pain. The text is clearly organised around the four major disease states in female sexual dysfunction (FSD) and is officially endorsed by the International Society for the Study of Women's Sexual Health (ISSWSH). The authors cover a wealth of topics such as hypoactive sexual desire disorder, psychological management of sexual disorders, anatomy and physiology of sexual dysfunction and pain and information on future developments and research. In addition, the text reviews all FDA approved medications for sexual dysfunction and contains consideration of off-label treatments for FSDs. This important text: • Offers the only textbook to highlight female sexual dysfunction in light of recently approved FDA medications • Contains a unique biopsychosocial approach from a collaborative team of physicians, psychologists, physical therapists as well as other sexual health professionals • Presents a comprehensive text led by one of the foremost global experts in Women's Sexual Health, Irwin Goldstein, founder of ISSWSH, with three other past presidents and one president-elect Written for any professional dealing with women's sexual health, Textbook of Female Sexual Function and Dysfunction offers an invaluable guide to the most safe and effective diagnosis and treatment.