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Author : Jean Luc Harousseau
Publisher :
ISBN 13 :
Total Pages : 267 pages
Book Rating : 4.:/5 (486 download)
Download or read book New Insights Into the Biology and Advances in the Management of Multiple Myeloma written by Jean Luc Harousseau and published by . This book was released on 2007 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jean Luc Harousseau
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)
Download or read book New Insights into the Biology and Advances in the Management of Multiple Myeloma - Best in Practice and Research Clinical Haematology - vol 20 n4 December 2007 written by Jean Luc Harousseau and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nikhil C. Munshi
Publisher : Springer Science & Business Media
ISBN 13 : 1461452600
Total Pages : 291 pages
Book Rating : 4.4/5 (614 download)
Download or read book Advances in Biology and Therapy of Multiple Myeloma written by Nikhil C. Munshi and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Author : Nikhil C. Munshi
Publisher : Springer Science & Business Media
ISBN 13 : 146144666X
Total Pages : 322 pages
Book Rating : 4.4/5 (614 download)
Download or read book Advances in Biology and Therapy of Multiple Myeloma written by Nikhil C. Munshi and published by Springer Science & Business Media. This book was released on 2012-11-15 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Author : James R. Berenson
Publisher : Springer Science & Business Media
ISBN 13 : 159259817X
Total Pages : 375 pages
Book Rating : 4.5/5 (925 download)
Download or read book Biology and Management of Multiple Myeloma written by James R. Berenson and published by Springer Science & Business Media. This book was released on 2004-05-14 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert physicians and clinical researchers summarize and explain all the recent advances in the biology and treatment of bone marrow-based malignancy. On the biological side, the authors show the characteristics of the malignant cell and describe the significant roles played by oncogenic changes, chromosomal anomalies, Kaposi's sarcoma herpes virus, and cytokines. New epidemiological findings and prognostic factors are also analyzed. On the clinical side, the authors provide a comprehensive review of conventional treatment regimens, as well as a discussion of newer experimental approaches involving immunologic targeting, inhibitors of drug resistance, and antitumor agents.
Author : Ethan D.
Publisher : Shuttle Systems
ISBN 13 : 1776846567
Total Pages : 233 pages
Book Rating : 4.7/5 (768 download)
Download or read book Multiple Myeloma Cancer written by Ethan D. and published by Shuttle Systems. This book was released on 2024-03-11 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Multiple Myeloma Cancer: A Comprehensive Resource for Patients and Families" is an essential guide for anyone touched by multiple myeloma. This book offers a thorough understanding of this complex cancer, from its biology to the latest in treatments and research advancements, providing invaluable support for patients and their loved ones.Deep Dive into Multiple MyelomaStart your journey with an in-depth look at multiple myeloma, including its types, epidemiology, and the historical perspective on research. Gain crucial insights into the nature of plasma cells and the genetic and molecular factors that contribute to the development of this cancer.Understanding Risk Factors and Early DetectionLearn about the risk factors associated with multiple myeloma and the importance of early detection. This book covers screening methods and the significance of early diagnosis in improving treatment outcomes.Symptoms, Diagnosis, and StagingRecognize the symptoms of multiple myeloma and understand the diagnostic process, including tests and procedures. Grasp the staging system, its role in disease progression, and its impact on treatment and prognosis.Exploring Treatment OptionsNavigate the treatment landscape of multiple myeloma, from conventional chemotherapy and stem cell transplantation to cutting-edge targeted therapies and immunotherapies. This book provides comprehensive information to help make informed decisions about care and treatment.Managing Side Effects and ComplicationsUnderstand and manage the side effects and complications of treatment, including the impact on bone health and strategies for infection management.Nutrition and LifestyleDiscover the importance of nutrition and lifestyle changes in supporting overall health during and after treatment. Get practical advice on diet, exercise, and lifestyle adjustments.Psychological and Emotional SupportFind guidance on coping with the emotional and psychological impacts of multiple myeloma. Learn about the importance of support systems, counseling, and the role of community and support groups.Living with Multiple MyelomaAddress the day-to-day challenges of living with multiple myeloma, including chronic management, quality of life issues, and survivorship care.Advances in ResearchStay informed about the latest in multiple myeloma research and emerging treatments. This section highlights the importance of clinical trials and future possibilities in myeloma care.Special ConsiderationsGain insights into how multiple myeloma affects different populations, including considerations for younger and elderly patients, and the unique aspects of the disease in men and women.Advocacy and Community EngagementUnderstand the role of patient advocacy, find community resources, and learn how to engage in raising awareness about multiple myeloma.The Future of Myeloma CareLook ahead to the innovations and evolving landscape of myeloma therapy, offering hope and a vision for the future of myeloma care."Multiple Myeloma Cancer: A Comprehensive Resource for Patients and Families" is more than just a book; it's a companion and guide through the journey of multiple myeloma. It provides the knowledge, support, and resources needed to navigate this challenging path with confidence and hope.
Author : Shaji Kumar, MD
Publisher : Demos Medical Publishing
ISBN 13 : 1935281453
Total Pages : 240 pages
Book Rating : 4.9/5 (352 download)
Download or read book Multiple Myeloma written by Shaji Kumar, MD and published by Demos Medical Publishing. This book was released on 2010-08-24 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Myeloma: The second issue of Emerging Cancer Therapeutics focuses on multiple myelomas also known as plasma cell myeloma, KahlerÌs Disease and myelomatosis. It is estimated that over 20,000 new cases are diagnosed each year with over 10,000 people dying from these malignancies. Multiple myelomas are highly treatable but rarely curable. Thus it is crucial for the practitioner to be up-to-date on the latest insights regarding their management. Management options and outcomes for individuals with multiple myelomas improved dramatically with the introduction of chemotherapy. Even further improvements in prognosis have occurred because of the introduction of newer therapies such as pulse corticosteroids, thalidomide, bortezomib, and autologous and allogeneic stem cell transplantation. With the increased number of therapeutic options to choose from, the clinician is better placed to offer effective therapy but at the same time is challenged to keep abreast of the rapidly changing treatment landscape and the newly emerging data that is shaping the treatment options today and in the future. Multiple Myeloma provides a comprehensive and in-depth review of this group of malignancies. This volume reviews the current literature, provides critical evaluations of the data and offers evidence-based recommendations. About the Series: Emerging Cancer Therapeutics is an invited review publication providing a through analysis of key clinical research related to cancer therapeutics, including a discussion and assessment of current evidence, current clinical best practice, and likely near future developments. There is an emphasis throughout on multidisciplinary approaches to the specialty, as well as on quality and outcomes analysis. Published three times a year Emerging Cancer Therapeutics provides authoritative, thorough assessments of advances in therapeutics in all major areas of oncology, both solid and hematologic malignancies, with a focus on advances in medical and biological therapies with emerging clinical impact and encompassing new technologies with implications for management such as molecular imaging. Features of Emerging Cancer Therapeutics include: Editorial board of nationally recognized experts across the spectrum of Cancer Therapeutics In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Cancer Therapeutics Issues edited by an authority in specific subject area Focuses on major topics in Cancer Therapeutics with in-depth articles covering advances in clinical and translational research developments, as well as clinical applications and experience Emphasizes multidisciplinary approaches to research and practice
Author : Suzanne Lentzsch
Publisher : Springer Science & Business Media
ISBN 13 : 1461446600
Total Pages : 132 pages
Book Rating : 4.4/5 (614 download)
Download or read book Genetic and Molecular Epidemiology of Multiple Myeloma written by Suzanne Lentzsch and published by Springer Science & Business Media. This book was released on 2013-01-09 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple myeloma is a plasma cell malignancy characterized by complex heterogenous cytogenetic abnormalities that accounts for 1.4% of all cancers, and approximately 10% of hematologic malignancies. The clinical manifestations of multiple myeloma include lytic bone lesions, cytopenia, hypercalcemia, renal dysfunction, hyperviscosity of the blood, immunodeficiency, and peripheral neuropathy. Based on the clinical and genetic data, probably all cases of multiple myeloma arise from an asymptomatic monoclonal gammopathy of unknown significance. The exact mechanism of the transition from MGUS to overt multiple myeloma is still not well understood. Recent oncogenomic studies have further advanced our understanding of the molecular pathogenesis of multiple myeloma. This book will give a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481654276
Total Pages : 290 pages
Book Rating : 4.4/5 (816 download)
Download or read book Multiple Myeloma: New Insights for the Healthcare Professional: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Myeloma: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Multiple Myeloma: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Multiple Myeloma: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Ethan D. Anderson
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.2/5 (24 download)
Download or read book Multiple Myeloma Cancer written by Ethan D. Anderson and published by . This book was released on 2024-01-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Multiple Myeloma Cancer: A Comprehensive Resource for Patients and Families" is an essential guide for anyone touched by multiple myeloma. This book offers a thorough understanding of this complex cancer, from its biology to the latest in treatments and research advancements, providing invaluable support for patients and their loved ones. Deep Dive into Multiple Myeloma Start your journey with an in-depth look at multiple myeloma, including its types, epidemiology, and the historical perspective on research. Gain crucial insights into the nature of plasma cells and the genetic and molecular factors that contribute to the development of this cancer. Understanding Risk Factors and Early Detection Learn about the risk factors associated with multiple myeloma and the importance of early detection. This book covers screening methods and the significance of early diagnosis in improving treatment outcomes. Symptoms, Diagnosis, and Staging Recognize the symptoms of multiple myeloma and understand the diagnostic process, including tests and procedures. Grasp the staging system, its role in disease progression, and its impact on treatment and prognosis. Exploring Treatment Options Navigate the treatment landscape of multiple myeloma, from conventional chemotherapy and stem cell transplantation to cutting-edge targeted therapies and immunotherapies. This book provides comprehensive information to help make informed decisions about care and treatment. Managing Side Effects and Complications Understand and manage the side effects and complications of treatment, including the impact on bone health and strategies for infection management. Nutrition and Lifestyle Discover the importance of nutrition and lifestyle changes in supporting overall health during and after treatment. Get practical advice on diet, exercise, and lifestyle adjustments. Psychological and Emotional Support Find guidance on coping with the emotional and psychological impacts of multiple myeloma. Learn about the importance of support systems, counseling, and the role of community and support groups. Living with Multiple Myeloma Address the day-to-day challenges of living with multiple myeloma, including chronic management, quality of life issues, and survivorship care. Advances in Research Stay informed about the latest in multiple myeloma research and emerging treatments. This section highlights the importance of clinical trials and future possibilities in myeloma care. Special Considerations Gain insights into how multiple myeloma affects different populations, including considerations for younger and elderly patients, and the unique aspects of the disease in men and women. Advocacy and Community Engagement Understand the role of patient advocacy, find community resources, and learn how to engage in raising awareness about multiple myeloma. The Future of Myeloma Care Look ahead to the innovations and evolving landscape of myeloma therapy, offering hope and a vision for the future of myeloma care. "Multiple Myeloma Cancer: A Comprehensive Resource for Patients and Families" is more than just a book; it's a companion and guide through the journey of multiple myeloma. It provides the knowledge, support, and resources needed to navigate this challenging path with confidence and hope.
Author : Morie A. Gertz
Publisher : Springer Science & Business Media
ISBN 13 : 1461485207
Total Pages : 311 pages
Book Rating : 4.4/5 (614 download)
Download or read book Multiple Myeloma written by Morie A. Gertz and published by Springer Science & Business Media. This book was released on 2013-10-01 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.
Author : P. Leif Bergsagel
Publisher : Elsevier
ISBN 13 : 9780443130779
Total Pages : 0 pages
Book Rating : 4.1/5 (37 download)
Download or read book New Developments in Myeloma, an Issue of Hematology/Oncology Clinics of North America written by P. Leif Bergsagel and published by Elsevier. This book was released on 2024-04-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Hematology/Oncology Clinics, guest editor Dr. P. Leif Bergsagel brings his considerable expertise to the topic of New Developments in Myeloma. With the advent of next generation sequencing and immune profiling technologies, marked advances have been made recently in the understanding of the molecular and immune pathogenesis of multiple myeloma. Yet even with these advances, there is a continual search for new therapeutic approaches. In this issue, top experts discuss a full range of clinically relevant topics in this complex and fast-changing field. Contains 16 relevant, practice-oriented topics including molecular pathogenesis of multiple myeloma; monoclonal antibodies in the treatment of multiple myeloma; CAR-T cells in the treatment of multiple myeloma; management of newly diagnosed multiple myeloma today, and in the future; approach to high-risk multiple myeloma; new therapies on the horizon for relapsed refractory multiple myeloma; and more. Provides in-depth clinical reviews on new developments in myeloma, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Author : Hillard M. Lazarus
Publisher : Springer Science & Business Media
ISBN 13 : 1597454788
Total Pages : 885 pages
Book Rating : 4.5/5 (974 download)
Download or read book Allogeneic Stem Cell Transplantation written by Hillard M. Lazarus and published by Springer Science & Business Media. This book was released on 2010-03-02 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.
Author : S. Vincent Rajkumar
Publisher : Cambridge University Press
ISBN 13 : 9780521515030
Total Pages : 214 pages
Book Rating : 4.5/5 (15 download)
Download or read book Treatment of Multiple Myeloma and Related Disorders written by S. Vincent Rajkumar and published by Cambridge University Press. This book was released on 2008-10-27 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to major advances in understanding the biology and pathogenesis of the disease, the management of multiple myeloma is changing rapidly. New diagnostic and prognostic criteria have been introduced, and treatment options are multiplying with high-dose chemotherapy regimens, stem cell transplants, and the development of novel agents and immune-based strategies that target tumor cells directly. This book is aimed at the practitioner who is looking to put these advances into clinical context. It will serve as an up-to-date resource for treatment of myeloma and related disorders. Chapters are written by international authorities and contain color photos, diagrams, and algorithms outlining preferred treatment strategies. Relevant scientific information is integrated throughout, but the focus here is on providing practical therapeutic guidance for oncologists and hematologists caring for myeloma patients. The book covers all myeloma subtypes and related disorders, including amyloidosis, Waldenstrom macroglobulinemia, plasmacytoma, MGUS, and POEMS syndrome.
Author : G. David Roodman
Publisher : Springer Science & Business Media
ISBN 13 : 1607615541
Total Pages : 257 pages
Book Rating : 4.6/5 (76 download)
Download or read book Myeloma Bone Disease written by G. David Roodman and published by Springer Science & Business Media. This book was released on 2010-04-28 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies.
Author : J. S. Malpas
Publisher : Elsevier Health Sciences
ISBN 13 :
Total Pages : 472 pages
Book Rating : 4.3/5 (91 download)
Download or read book Myeloma written by J. S. Malpas and published by Elsevier Health Sciences. This book was released on 2004 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was prompted by a renewed interest in the biology of myeloma, new concepts with regard to its clinical evolution, and options for therapy that have not been available before. Myeloma has always involved many systems and caused many problems for the clinician. It has become a focus of attention for the scientist and clinician.
Author : Thomas Moehler
Publisher : Springer Science & Business Media
ISBN 13 : 3540857729
Total Pages : 349 pages
Book Rating : 4.5/5 (48 download)
Download or read book Multiple Myeloma written by Thomas Moehler and published by Springer Science & Business Media. This book was released on 2011-04-21 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy, including in particular the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.
