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Neutron Protein Crystallography
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Book Synopsis Neutron Protein Crystallography by : Nobuo Niimura
Download or read book Neutron Protein Crystallography written by Nobuo Niimura and published by Oxford University Press. This book was released on 2011-02-17 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the first books dedicated to the emerging field of neutron protein crystallography (NPC). It covers all of the practical aspects of NPC and demonstrates how NPC can explore protein features such as hydrogen bonds, protonation and deprotonation of amino acid residues, and hydration structures.
Book Synopsis Neutron Crystallography in Structural Biology by :
Download or read book Neutron Crystallography in Structural Biology written by and published by Academic Press. This book was released on 2020-03-09 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron Crystallography in Structural Biology, Volume 634, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this updated release include Fundamentals of neutron crystallography in structural biology, Large crystal growth for neutron protein crystallography, Prospects for membrane protein crystals in NMX, IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor, The macromolecular neutron diffractometer at the spallation neutron source, Current status and near future plan of neutron protein crystallography at J-PARC, Neutron macromolecular crystallography at the European spallation source, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on neutron crystallography in structural biology
Book Synopsis Neutron Protein Crystallography by : Nobuo Niimura
Download or read book Neutron Protein Crystallography written by Nobuo Niimura and published by . This book was released on 2011 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is dedicated to the emerging field of neutron protein crystallography (NPC). It covers all of the practical aspects of NPC and demonstrates how NPC can explore protein features such as hydrogen bonds, protonation and deprotonation of amino acid residues, and hydration structures.
Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud
Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Book Synopsis Area Detectors for Neutron Protein Crystallography by :
Download or read book Area Detectors for Neutron Protein Crystallography written by and published by . This book was released on 1992 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neutron Scattering in Biology by : Jörg Fitter
Download or read book Neutron Scattering in Biology written by Jörg Fitter and published by Springer Science & Business Media. This book was released on 2006-05-01 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.
Book Synopsis Structure Determination by X-ray Crystallography by : Mark Ladd
Download or read book Structure Determination by X-ray Crystallography written by Mark Ladd and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advances in and applications of x-ray and neutron crystallography form the essence of this new edition of this classic textbook, while maintaining the overall plan of the book that has been well received in the academic community since the first edition in 1977. X-ray crystallography is a universal tool for studying molecular structure, and the complementary nature of neutron diffraction crystallography permits the location of atomic species in crystals which are not easily revealed by X-ray techniques alone, such as hydrogen atoms or other light atoms in the presence of heavier atoms. Thus, a chapter discussing the practice of neutron diffraction techniques, with examples, broadens the scope of the text in a highly desirable way. As with previous editions, the book contains problems to illustrate the work of each chapter, and detailed solutions are provided. Mathematical procedures related to the material of the main body of the book are not discussed in detail, but are quoted where needed with references to standard mathematical texts. To address the computational aspect of crystallography, the suite of computer programs from the fourth edition has been revised and expanded. The programs enable the reader to participate fully in many of the aspects of x-ray crystallography discussed in the book. In particular, the program system XRAY* is interactive, and enables the reader to follow through, at the monitor screen, the computational techniques involved in single-crystal structure determination, albeit in two dimensions, with the data sets provided. Exercises for students can be found in the book, and solutions are available to instructors.
Book Synopsis Applications of Neutron Diffraction Protein Crystallography by :
Download or read book Applications of Neutron Diffraction Protein Crystallography written by and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Data Processing in Neutron Protein Crystallography Using Position-sensitive Detectors by :
Download or read book Data Processing in Neutron Protein Crystallography Using Position-sensitive Detectors written by and published by . This book was released on 1982 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutrons provide a unique probe for localizing hydrogen atoms and for distinguishing hydrogen from deuterons. Hydrogen atoms largely determine the three-dimensional structure of proteins and are responsible for many catalytic reactions. The study of hydrogen bonding and hydrogen exchange will therefore give insight into reaction mechanisms and conformational fluctuations. In addition, neutrons provide the ability to distinguish N from C and O and to allow correct orientation of groups such as histidine and glutamine. To take advantage of these unique features of neutron crystallography, one needs accurate Fourier maps depicting atomic structure to a high precision. In this paper, techniques are described for minimizing error in the observed structure factors by optimizing data collection and analysis procedures. Special attention is given to subtraction of the high background associated with hydrogen-containing molecules, which produces a disproportionately large statistical error.
Book Synopsis Determination of Structural Water by Neutron Protein Crystallography by :
Download or read book Determination of Structural Water by Neutron Protein Crystallography written by and published by . This book was released on 1979 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: An ideal technique for studying the water structure of proteins using neutron crystallography is discussed. The advantages of using deuterons (D2O) instead of hydrogen (H2O) are explained. The results of an early unrefined met myoglobin neutron analysis are presented. More recent high resolution x-ray analysis of met myoglobin and refined neutron analysis of carbon monoxide myoglobin water structure were compared. Neutron maps were included.
Book Synopsis Large-volume Protein Crystal Growth for Neutron Macromolecular Crystallography by :
Download or read book Large-volume Protein Crystal Growth for Neutron Macromolecular Crystallography written by and published by . This book was released on 2015 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Practical Neutron Protein Crystallography by : Marc-Michael Blum
Download or read book Practical Neutron Protein Crystallography written by Marc-Michael Blum and published by Wiley-VCH. This book was released on 2013-02-27 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time, this promising technology is presented in a readily accessible manner. The two editors, a method developer and a method user, have tailored the book to the needs of occasional or first-time users, providing ample practical advice at every stage, and including a detailed walk-through example of a real-life protein study. The result is a hands-on guide starting with basic considerations of the advantages and disadvantages of this relatively new technology, before going on to discuss in practical terms the course of the diffraction study, from sample preparation via the actual measurement to the collection and analysis of the diffraction data. For biochemists, biophysicists, crystallographers, medicinal chemists, and radiation physicists.
Book Synopsis Area Detectors for Neutron Protein Crystallography by :
Download or read book Area Detectors for Neutron Protein Crystallography written by and published by . This book was released on 1992 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main problem in neutron protein crystallography is the low flux of present reactor based or pulsed neutron sources. This low flux is however well matched with presently available multiwire area detectors. One way to increase the flux at the sample is to increase the wavelength bandwidth. The conventional technique uses a monochromator with a bandwidth of the order of 1%. This bandwidth can be increased by using a multilayer monochromator composed of different ''d'' spacings. This provides a large delta lambda increasing the flux manifold. In this case a reflection in diffraction condition is scanned by the wavelength bandwidth and not by rotation of the reciprocal lattice point through the Ewald sphere. In order to collect most of the simultaneous diffraction a large cylindrical area detector covering an angular width of 120° with a height of approximately 20cm is needed. Such a detector should have a spacial resolution of 1.1mm, an efficiency of 80% at 2.0A and a counting rate of one million events per second. This detector will be subdivided into 4 sectors that will be decoded simultaneously into a Motorola based computer system. This data acquisition system allows time slicing and this detector is therefore useful for similar experiments using pulsed neutron sources.
Book Synopsis Structure Determination by X-ray Crystallography by : Mark Ladd
Download or read book Structure Determination by X-ray Crystallography written by Mark Ladd and published by Springer. This book was released on 2013-05-01 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advances in and applications of x-ray and neutron crystallography form the essence of this new edition of this classic textbook, while maintaining the overall plan of the book that has been well received in the academic community since the first edition in 1977. X-ray crystallography is a universal tool for studying molecular structure, and the complementary nature of neutron diffraction crystallography permits the location of atomic species in crystals which are not easily revealed by X-ray techniques alone, such as hydrogen atoms or other light atoms in the presence of heavier atoms. Thus, a chapter discussing the practice of neutron diffraction techniques, with examples, broadens the scope of the text in a highly desirable way. As with previous editions, the book contains problems to illustrate the work of each chapter, and detailed solutions are provided. Mathematical procedures related to the material of the main body of the book are not discussed in detail, but are quoted where needed with references to standard mathematical texts. To address the computational aspect of crystallography, the suite of computer programs from the fourth edition has been revised and expanded. The programs enable the reader to participate fully in many of the aspects of x-ray crystallography discussed in the book. In particular, the program system XRAY* is interactive, and enables the reader to follow through, at the monitor screen, the computational techniques involved in single-crystal structure determination, albeit in two dimensions, with the data sets provided. Exercises for students can be found int the book, and solutions are available to instructors.
Book Synopsis Structure Determination by X-Ray Crystallography by : M. F. C. Ladd
Download or read book Structure Determination by X-Ray Crystallography written by M. F. C. Ladd and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crystallography may be described as the science of the structure of materi als, using this word in its widest sense, and its ramifications are apparent over a broad front of current scientific endeavor. It is not surprising, therefore, to find that most universities offer some aspects of crystallography in their undergraduate courses in the physical sciences. It is the principal aim of this book to present an introduction to structure determination by X-ray crystal lography that is appropriate mainly to both final-year undergraduate studies in crystallography, chemistry, and chemical physics, and introductory post graduate work in this area of crystallography. We believe that the book will be of interest in other disciplines, such as physics, metallurgy, biochemistry, and geology, where crystallography has an important part to play. In the space of one book, it is not possible either to cover all aspects of crystallography or to treat all the subject matter completely rigorously. In particular, certain mathematical results are assumed in order that their applications may be discussed. At the end of each chapter, a short bibliog raphy is given, which may be used to extend the scope of the treatment given here. In addition, reference is made in the text to specific sources of information. We have chosen not to discuss experimental methods extensively, as we consider that this aspect of crystallography is best learned through practical experience, but an attempt has been made to simulate the interpretive side of experimental crystallography in both examples and exercises.
Book Synopsis Neutrons in Biology by : Benno P. Schoenborn
Download or read book Neutrons in Biology written by Benno P. Schoenborn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This compendium presents some of the major applications of neutron scattering techniques to problems in biology. It is a record of the papers presented at the Neutrons in Biology Conference, the third in an occasional series held to highlight progress in the field and to provide a focus for future direction. The strength ofthe neutron scattering technique remains principally in the manipula tion of scattering density through hydrogen and deuterium atoms. The development ofad vanced detectors, innovative instrument and beamline components, and sophisticated data acquisition systems through the 1970s and early 1980s provided a sound foundation for the technique. With continued development, some of the exotic and expensive equipment has become affordable by the medium-sized facilities, thereby broadening the user base considerably. Despite problems with the major neutron sources in the late 1980s and early 1990s, some spectacular results have been achieved. Whilst the high and medium flux beam reac tors will continue to make a major impact in the field, the results from the first experi ments, and the planned developments on spallation neutron sources, clearly indicate that the technique has enormous potential.
Book Synopsis Multilayer Monochromators and Supermirrors for Neutron Protein Crystallography Using a Quasi Laue Technique by :
Download or read book Multilayer Monochromators and Supermirrors for Neutron Protein Crystallography Using a Quasi Laue Technique written by and published by . This book was released on 1992 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt:
