Neutron Protein Crystallography

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Neutron Crystallography in Structural Biology

Author :
Publisher : Academic Press
ISBN 13 : 0128192143
Total Pages : 408 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Neutron Crystallography in Structural Biology by :

Download or read book Neutron Crystallography in Structural Biology written by and published by Academic Press. This book was released on 2020-02-24 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron Crystallography in Structural Biology, Volume 634, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this updated release include Fundamentals of neutron crystallography in structural biology, Large crystal growth for neutron protein crystallography, Prospects for membrane protein crystals in NMX, IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor, The macromolecular neutron diffractometer at the spallation neutron source, Current status and near future plan of neutron protein crystallography at J-PARC, Neutron macromolecular crystallography at the European spallation source, and much more.

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1437 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1437 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Neutron Protein Crystallography

Author : Nobuo Niimura
Publisher : Oxford University Press
ISBN 13 : 0191004812
Total Pages : 250 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Neutron Protein Crystallography by : Nobuo Niimura

Download or read book Neutron Protein Crystallography written by Nobuo Niimura and published by Oxford University Press. This book was released on 2011-02-17 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is one of the first books dedicated to the emerging field of neutron protein crystallography (NPC). The text covers all of the practical aspects of NPC, from the basic background of neutron scattering and diffraction, to the technical details of neutron facilities, growth of high-quality crystals, and data analysis. The final chapter is devoted to providing many examples of using NPC to investigate a wide range of different proteins. It demonstrates how NPC can explore hydrogen bonds, protonation and deprotonation of amino acid residues, hydration structures, and hydrogen-to-deuterium exchange ratios. To avoid redundancy with other textbooks on X-ray protein crystallography (XPC), this book assumes a familiarity with the basics of XPC and strives to highlight and explain the differences between XPC and NPC. It is therefore especially useful for X-ray protein crystallographers who are eager to have a sound, scientific basis for judging if NPC is the right technique for furthering their experimental programs.

Neutron Protein Crystallography

Author : Nobuo Niimura
Publisher : Oxford University Press
ISBN 13 : 0199578869
Total Pages : 250 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Neutron Protein Crystallography by : Nobuo Niimura

Neutron Scattering in Biology

Author : Jörg Fitter
Publisher : Springer Science & Business Media
ISBN 13 : 3540291113
Total Pages : 571 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Neutron Scattering in Biology by : Jörg Fitter

Download or read book Neutron Scattering in Biology written by Jörg Fitter and published by Springer Science & Business Media. This book was released on 2006-05-01 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.

Structure Determination by X-Ray Crystallography

Author : M. F. C. Ladd
Publisher : Springer Science & Business Media
ISBN 13 : 1461579333
Total Pages : 404 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Structure Determination by X-Ray Crystallography by : M. F. C. Ladd

Download or read book Structure Determination by X-Ray Crystallography written by M. F. C. Ladd and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crystallography may be described as the science of the structure of materi als, using this word in its widest sense, and its ramifications are apparent over a broad front of current scientific endeavor. It is not surprising, therefore, to find that most universities offer some aspects of crystallography in their undergraduate courses in the physical sciences. It is the principal aim of this book to present an introduction to structure determination by X-ray crystal lography that is appropriate mainly to both final-year undergraduate studies in crystallography, chemistry, and chemical physics, and introductory post graduate work in this area of crystallography. We believe that the book will be of interest in other disciplines, such as physics, metallurgy, biochemistry, and geology, where crystallography has an important part to play. In the space of one book, it is not possible either to cover all aspects of crystallography or to treat all the subject matter completely rigorously. In particular, certain mathematical results are assumed in order that their applications may be discussed. At the end of each chapter, a short bibliog raphy is given, which may be used to extend the scope of the treatment given here. In addition, reference is made in the text to specific sources of information. We have chosen not to discuss experimental methods extensively, as we consider that this aspect of crystallography is best learned through practical experience, but an attempt has been made to simulate the interpretive side of experimental crystallography in both examples and exercises.

Neutron Crystallography in Structural Biology

Author :
Publisher : Academic Press
ISBN 13 : 0128192151
Total Pages : 410 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Neutron Crystallography in Structural Biology by :

Download or read book Neutron Crystallography in Structural Biology written by and published by Academic Press. This book was released on 2020-02-22 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron Crystallography in Structural Biology, Volume 634, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this updated release include Fundamentals of neutron crystallography in structural biology, Large crystal growth for neutron protein crystallography, Prospects for membrane protein crystals in NMX, IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor, The macromolecular neutron diffractometer at the spallation neutron source, Current status and near future plan of neutron protein crystallography at J-PARC, Neutron macromolecular crystallography at the European spallation source, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on neutron crystallography in structural biology

Elements of Slow-Neutron Scattering

Author : J. M. Carpenter
Publisher : Cambridge University Press
ISBN 13 : 0521857813
Total Pages : 539 pages
Book Rating : 4.5/5 (218 download)

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Book Synopsis Elements of Slow-Neutron Scattering by : J. M. Carpenter

Download or read book Elements of Slow-Neutron Scattering written by J. M. Carpenter and published by Cambridge University Press. This book was released on 2015-09-24 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and up-to-date introduction to the fundamental theory and applications of slow-neutron scattering.

Chemical Crystallography with Pulsed Neutrons and Synchroton X-Rays

Author : Maria Arménia Carrondo
Publisher : Springer Science & Business Media
ISBN 13 : 9400940270
Total Pages : 612 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Chemical Crystallography with Pulsed Neutrons and Synchroton X-Rays by : Maria Arménia Carrondo

Download or read book Chemical Crystallography with Pulsed Neutrons and Synchroton X-Rays written by Maria Arménia Carrondo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: X-ray and neutron crystallography have played an increasingly impor tant role in the chemical and biochemical sciences over the past fifty years. The principal obstacles in this methodology, the phase problem and com puting, have been overcome. The former by the methods developed in the 1960's and just recognised by the 1985 Chemistry Nobel Prize award to Karle and Hauptman, the latter by the dramatic advances that have taken place in computer technology in the past twenty years. Within the last decade, two new radiation sources have been added to the crystallographer's tools. One is synchrotron X-rays and the other is spallation neutrons. Both have much more powerful fluxes than the pre vious sources and they are pulsed rather than continuos. New techniques are necessary to fully exploit the intense continuos radiation spectrum and its pulsed property. Both radiations are only available from particular National Laboratories on a guest-user basis for scientists outside these Na tional Laboratories. Hitherto, the major emphasis on the use of these facilities has been in solid-state physics, and the material, engineering and biological sciences. We believe that there is equivalent potential to applications which are pri marily chemical or biochemical.

Protein Crystallization

Author : Terese M. Bergfors
Publisher : Internat'l University Line
ISBN 13 : 0972077448
Total Pages : 505 pages
Book Rating : 4.9/5 (72 download)

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Book Synopsis Protein Crystallization by : Terese M. Bergfors

Download or read book Protein Crystallization written by Terese M. Bergfors and published by Internat'l University Line. This book was released on 2009 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neutron Scattering in Biology

Author : Jörg Fitter
Publisher : Springer Science & Business Media
ISBN 13 : 9783540291084
Total Pages : 594 pages
Book Rating : 4.2/5 (91 download)

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Book Synopsis Neutron Scattering in Biology by : Jörg Fitter

Download or read book Neutron Scattering in Biology written by Jörg Fitter and published by Springer Science & Business Media. This book was released on 2006-01-10 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.

RNA Spectroscopy

Author : Véronique Arluison
Publisher : Humana
ISBN 13 : 9781071602775
Total Pages : 0 pages
Book Rating : 4.6/5 (27 download)

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Book Synopsis RNA Spectroscopy by : Véronique Arluison

Download or read book RNA Spectroscopy written by Véronique Arluison and published by Humana. This book was released on 2020-02-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume looks at the different spectroscopic and biophysical methods used by researchers to study the structure and folding of RNA, and to follow their interactions with proteins. The chapters in this book cover topics such as single-molecule spectroscopy of multiple RNA species; surface plasmon resonance, MS or microcalorimetry for investigating molecular interactions with RNA; FTIR, SAXS, SANS and SRCD spectroscopies to analyze RNA structure; use of fluorescent nucleotides to map RNA-binding sites on proteins surfaces or CryoEM; and much more. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, RNA Spectroscopy: Methods and Protocols is a valuable resource for anyone interested in learning more about this developing field.

Crystals, X-rays and Proteins

Author : Dennis Sherwood
Publisher : Oxford University Press
ISBN 13 : 019955904X
Total Pages : 640 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Crystals, X-rays and Proteins by : Dennis Sherwood

Download or read book Crystals, X-rays and Proteins written by Dennis Sherwood and published by Oxford University Press. This book was released on 2011 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Information derived from X-ray crystal structures of biological molecules allows us to explain their functions in living organisms in extraordinary detail, and to develop drugs to treat disease. This book describes the principles and practice of X-ray diffraction as a key technique at the forefront of new discoveries in biology and medicine.

Single Crystal Neutron Diffraction from Molecular Materials

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Author : Chick C. Wilson
Publisher : World Scientific
ISBN 13 : 9789810237769
Total Pages : 390 pages
Book Rating : 4.2/5 (377 download)

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Book Synopsis Single Crystal Neutron Diffraction from Molecular Materials by : Chick C. Wilson

Download or read book Single Crystal Neutron Diffraction from Molecular Materials written by Chick C. Wilson and published by World Scientific. This book was released on 2000 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important book presents a comprehensive account of the techniques & applications of single crystal neutron diffraction in the area of chemical crystallography & molecular structure. Beginning with a brief description of the general principles & the reasons for choosing the technique - the "why" - the book covers the methods for both the production of neutrons & the measurement of their scattering by molecular crystals - the "how" - followed by a detailed survey of past, present & future applications - the "what". The coverage of both steady state & pulsed neutron sources & instrumentation is extensive, while the survey of applications is the most comprehensive yet undertaken. The book endeavours to show why the technique is an essential method for studying areas as diverse as hydrogen bonding & weak interactions, organometallics, supramolecular chemistry & crystal engineering, metal hydrides, charge density & pharmaceuticals. It is an ideal reference source for the research worker interested in using neutron diffraction to study the structure of molecules. Contents: Crystallography & the Importance of Structural Information; Neutron Scattering; Neutron Diffractometers; Review of Applications I: The Accurate Location of Atoms; Review of Applications II: Hydrogen Bonding & Other Intermolecular Interactions; Review of Applications III: Probing Vibrations & Disorder; Impact on Material Properties & Design; The Future: New Instruments, New Sources, New Techniques. Readership: Students & researchers involved in structural science, especially chemical crystallography.

Neutron Scattering – Applications in Biology, Chemistry, and Materials Science

Author : Felix Fernandez-Alonso
Publisher : Elsevier
ISBN 13 : 0128092300
Total Pages : 784 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Neutron Scattering – Applications in Biology, Chemistry, and Materials Science by : Felix Fernandez-Alonso

Download or read book Neutron Scattering – Applications in Biology, Chemistry, and Materials Science written by Felix Fernandez-Alonso and published by Elsevier. This book was released on 2017-06-14 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron Scattering: Applications in Chemistry, Materials Science and Biology, Volume 49, provides an in-depth overview of the applications of neutron scattering in the fields of physics, materials science, chemistry, biology, the earth sciences, and engineering. The book describes the tremendous advances in instrumental, experimental, and computational techniques over the past quarter-century. Examples include the coming-of-age of neutron reflectivity and spin-echo spectroscopy, the advent of brighter accelerator-based neutron facilities and associated techniques in the United States and Japan over the past decade, and current efforts in Europe to develop long-pulse, ultra-intense spallation neutron sources. It acts as a complement to two earlier volumes in the Experimental Methods in the Physical Science series, Neutron Scattering: Fundamentals(Elsevier 2013) and Neutron Scattering: Magnetic and Quantum Phenomena (Elsevier 2015). As a whole, the set enables researchers to identify aspects of their work where neutron scattering techniques might contribute, conceive the important experiments to be done, assess what is required, write a successful proposal for one of the major facilities around the globe, and perform the experiments under the guidance of the appropriate instrument scientist. - Completes a three-volume set, providing extensive coverage on emerging and highly topical applications of neutron scattering - Addresses the increasing use of neutrons by chemists, life scientists, material scientists, and condensed-matter physicists - Presents up-to-date reviews of recent results, enabling readers to identify new opportunities and plan neutron scattering experiments in their own field

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118681010
Total Pages : 706 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-02-05 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Neutrons in Biology

Author : Benno P. Schoenborn
Publisher : Springer Science & Business Media
ISBN 13 : 1461558476
Total Pages : 453 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Neutrons in Biology by : Benno P. Schoenborn

Download or read book Neutrons in Biology written by Benno P. Schoenborn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This compendium presents some of the major applications of neutron scattering techniques to problems in biology. It is a record of the papers presented at the Neutrons in Biology Conference, the third in an occasional series held to highlight progress in the field and to provide a focus for future direction. The strength ofthe neutron scattering technique remains principally in the manipula tion of scattering density through hydrogen and deuterium atoms. The development ofad vanced detectors, innovative instrument and beamline components, and sophisticated data acquisition systems through the 1970s and early 1980s provided a sound foundation for the technique. With continued development, some of the exotic and expensive equipment has become affordable by the medium-sized facilities, thereby broadening the user base considerably. Despite problems with the major neutron sources in the late 1980s and early 1990s, some spectacular results have been achieved. Whilst the high and medium flux beam reac tors will continue to make a major impact in the field, the results from the first experi ments, and the planned developments on spallation neutron sources, clearly indicate that the technique has enormous potential.