Neutron Beam Design Development And Performance For Neutron Capture Therapy

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Neutron Beam Design, Development, and Performance for Neutron Capture Therapy

Author : Otto K. Harling
Publisher : Springer Science & Business Media
ISBN 13 : 1468458027
Total Pages : 340 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Neutron Beam Design, Development, and Performance for Neutron Capture Therapy by : Otto K. Harling

Download or read book Neutron Beam Design, Development, and Performance for Neutron Capture Therapy written by Otto K. Harling and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: For this Workshop, the organizers have attempted to invite experts from all known centers which are engaged in neutron beam development for neutron capture therapy. The Workshop was designed around a series of nineteen invited papers which dealt with neutron source design and development and beam characterization and performance. Emphasis was placed on epithermal beams because they offer clinical advantages and are more challenging to implement than thermal beams. Fission reactor sources were the basis for the majority of the papers; however three papers dealt with accelerator neutron sources. An additional three invited papers provided a summary of clinical results of Ncr therapy in Japan between 1968 and 1989 and overviews of clinical considerations for neutron capture therapy and of the status of tumor targeting chemical agents for Ncr. Five contributed poster papers dealing with NCT beam design and performance were also presented. A rapporteurs' paper was prepared after the Workshop to attempt to summarize the major aspects, issues, and conclusions which resulted from this Workshop. Many people contributed to both the smooth functioning of the Workshop and to the preparation of these proceedings. Special thanks are reserved for Ms. Dorothy K.

Neutron Capture Therapy

Author : Wolfgang A.G. Sauerwein
Publisher : Springer Science & Business Media
ISBN 13 : 3642313345
Total Pages : 545 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Neutron Capture Therapy by : Wolfgang A.G. Sauerwein

Download or read book Neutron Capture Therapy written by Wolfgang A.G. Sauerwein and published by Springer Science & Business Media. This book was released on 2012-11-05 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter, which in principle allows for tumor cell-selective high-LET particle radiotherapy. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.

Progress in Neutron Capture Therapy for Cancer

Author : B.J. Allen
Publisher : Springer Science & Business Media
ISBN 13 : 1461533848
Total Pages : 641 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Progress in Neutron Capture Therapy for Cancer by : B.J. Allen

Download or read book Progress in Neutron Capture Therapy for Cancer written by B.J. Allen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the many advances made in the diagnosis and therapy of cancer, the mortality rate is still about half that of the incidence rate. However, the odds are not evenly distributed. Prognosis for some cancers is good, but for others, few patients will survive 12 months. This latter group of cancers is characterised by a proclivity to disseminate malignant cells in the host organ. The degree of surgery possible may be limited by the critical nature of the organ, and chemotherapy and radiotherapy are of palliative value only. In some cases systemic metastases occur, but in other cases, failure to achieve local control results in death. First among these cancers are the high grade brain tumours, astrocytoma 3,4 and glioblastoma multiforme. Local control of these tumours should lead to cure. Other cancers melanoma metastatic to the brain, for which a useful palliative therapy is not yet available, and pancreatic cancer for which localised control at an early stage could bring about improved prognosis. Patients with these cancers have little grounds for hope. Our primary objective is to reverse this situation with Neutron Capture Therapy (NCT). The purpose of this fourth symposium is to hasten the day whereby patients with these cancers can reasonably hope for substantial remissions. The first symposium on NCT was held in Boston in 1983, followed by Tokyo in 1985 and Bremen, Germany in 1988.

Advances in Neutron Capture Therapy

Author : R.F. Barth
Publisher : Springer Science & Business Media
ISBN 13 : 1461529786
Total Pages : 776 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Advances in Neutron Capture Therapy by : R.F. Barth

Download or read book Advances in Neutron Capture Therapy written by R.F. Barth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.

Cancer Neutron Capture Therapy

Author : Y. Mishima
Publisher : Springer Science & Business Media
ISBN 13 : 147579567X
Total Pages : 893 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Cancer Neutron Capture Therapy by : Y. Mishima

Download or read book Cancer Neutron Capture Therapy written by Y. Mishima and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 893 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many human cancers which actively synthesize specific characteristic proteins such as melanomas, thyroid cancer and squamous cell carcinoma. Many cancer researchers have of course tried to utilize this specific activity as a key for the selective treatment of cancers. In the past for example, the molecular hybrid compound of DOPA, a substrate of melanin, and nitrogen mustard N-oxide hydrochloride, a ctyotoxic anti-tumor drug, was synthesized as Melphalan and used to treat malignant melanoma. A major problem arose though in that it was soon found to be highly suppressive toward bone marrow and quite toxic while not being remarkably effective. Thus, malignant melanoma could not be cured by it. Such failure led us to develop a novel bimodal therapeutic system which includes the use of non-toxic potentially cytocidal chemicals which selectively accumulate within the cancer cells and which are converted by a controllable modality into an actively cytocidal element in situ. We can now non-surgically cure malignant melanoma and glioblastoma with our selective cancer treatment, neutron capture therapy (NCT); as can be found in this volume. Included are 124 papers on the latest breaking developments discussed at the Sixth International Symposium on NCT for Cancer held in Kobe during the late autumn of 1994.

Frontiers in Neutron Capture Therapy

Author : M. Frederick Hawthorne
Publisher : Springer
ISBN 13 : 1461512859
Total Pages : 1389 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Frontiers in Neutron Capture Therapy by : M. Frederick Hawthorne

Download or read book Frontiers in Neutron Capture Therapy written by M. Frederick Hawthorne and published by Springer. This book was released on 2013-11-11 with total page 1389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.

Boron Neutron Capture Therapy

Author : Detlef Gabel
Publisher : Springer Science & Business Media
ISBN 13 : 1461534089
Total Pages : 274 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Boron Neutron Capture Therapy by : Detlef Gabel

Download or read book Boron Neutron Capture Therapy written by Detlef Gabel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The European Collaboration on Boron Neutron Capture Therapy (BNCT), conceived in 1987 and successful in 1989 in gaining financial support as a Concerted Action through the Medical and Health Research Programme of the Commission ofthe European Communities (CEC) in Brussels, considered it an opportune moment to hold its annual Plenary Meeting on 18-20 Septem ber 1991 as an International Workshop entitled "Towards Clinical Trials of Glioma with BNCT". The background to this consideration was influenced by the world-wide resurgence ofinterest in NCT over the last 2 decades and by the exemplifica tions at the Fourth International Symposium on Neutron Capture Therapy for Cancer held in Sydney in December 1990, where it was strongly indicated that within the next 2 years clinical trials would be started both in Europe and the United States. In particular at the High Flux Reactor of the Joint Research Centre of the CEC at Petten in The Netherlands, an epithermal neutron beam designed and installed in the summer of 1990 recently became operable at full reactor power. An extensive series ofexperiments, including the nuclear and radiobiological characterisation of the beam and a healthy tissue tolerance study on canines has started and has the aim to define the preconditions for clinical trials onpatients with Grade III/IV glioma. However, as with any other new therapy modality, it must be demon strated that BNCT is safe for the patient and has a reasonable chance of being an effective therapy.

Neurosurgical Standards, Cerebral Aneurysms, Malignant Gliomas

Author : Kurt Piscol
Publisher : Springer Science & Business Media
ISBN 13 : 3642771092
Total Pages : 413 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Neurosurgical Standards, Cerebral Aneurysms, Malignant Gliomas by : Kurt Piscol

Download or read book Neurosurgical Standards, Cerebral Aneurysms, Malignant Gliomas written by Kurt Piscol and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Three topics of major interest for neursurgeons are covered in this volume of the Advances in Neurosurgery series, as the title suggests. First, neurosurgical standards of diagnosis and treatment are viewed from several points of view, including the legal one. Second, the many aspects of aneurysm surgery are dealt with: timing and grading, monitoring during the operation, postoperative vasospasm, Doppler sonography and new research in subarachnoid hemorrhage. Third, the diagnosis and treatment of malignant gliomas are discussed; there are preliminary reports on interstitial laser-assisted thermal therapy, immunotherapy and radiopharmaceutical substances as well as the standard forms of neurosurgical and radiation treatment.

High-Grade Gliomas

Author : Gene H. Barnett
Publisher : Springer Science & Business Media
ISBN 13 : 1597451851
Total Pages : 493 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis High-Grade Gliomas by : Gene H. Barnett

Download or read book High-Grade Gliomas written by Gene H. Barnett and published by Springer Science & Business Media. This book was released on 2007-11-21 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is truly an exciting time in the field of neuro-oncology, particularly in the area of hi- grade gliomas. The management of patients with high-grade gliomas has historically been one of the most challenging and disheartening fields in medicine, where failure is the rule and longevity is the exception. The jaded often state that despite purported advances in surgical and radiotherapeutic techniques and a myriad of clinical trials of medical therapies, the s- vival statistics for glioblastoma have not changed in the last three decades. The nihilism associated with these tumors is such that some practitioners still advise against treatment or even biopsy, recommending palliative care with the diagnosis based only on history and an MRI scan. If the current state-of-the-art in the diagnosis and management of high-grade gliomas was truly so bleak, there would be no reason to compile and publish a monograph on the subject. The fact is that we have recently entered an era where real progress is being made in our understanding and treatment of high-grade gliomas that is directly benefiting some patients. We are slowly but surely chipping away at this problem. One approach has exploited correlations between particular molecular markers and therapeutic response. The first such “breakthrough” in high-grade glioma was the observation that loss of chromosomes 1p and 19q uniformly predict chemosensitivity in anaplastic oligodendrogliomas (1).

National Library of Medicine Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1068 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1991 with total page 1068 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 700 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Catalog by : National Library of Medicine (U.S.)

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1991 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

Energy Research Abstracts

Author :
Publisher :
ISBN 13 :
Total Pages : 1470 pages
Book Rating : 4.U/5 (183 download)

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Book Synopsis Energy Research Abstracts by :

Download or read book Energy Research Abstracts written by and published by . This book was released on 1989 with total page 1470 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nuclear Science Applications

Author :
Publisher :
ISBN 13 :
Total Pages : 536 pages
Book Rating : 4.X/5 (6 download)

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Book Synopsis Nuclear Science Applications by :

Download or read book Nuclear Science Applications written by and published by . This book was released on 1981 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Neutron Optics

Author : Maria L. Calvo
Publisher : CRC Press
ISBN 13 : 1000727548
Total Pages : 308 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Advances in Neutron Optics by : Maria L. Calvo

Download or read book Advances in Neutron Optics written by Maria L. Calvo and published by CRC Press. This book was released on 2019-11-11 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutron optics studies the interactions of a beam of slow neutrons with matter. This book updates various advances on neutron optics. There will be a focus on the very active topics of neutron imaging (NI) and neutron spin optics (NSO). The book will also present applications of neutron beams in biomedicine, such as Boron Neutron Capture Therapy (BNCT) and related techniques. Features: Discusses diffraction and interference of slow neutrons, including computational approaches Reviews neutron imaging (NI) and neutron spin optics (NSO) Treats two major sources of slow neutron beams: (1) fission reactions at nuclear reactors and (2) collisions in particle accelerators (small ones, spallation sources) of charged particle beams with targets of heavy atoms Selects subjects on fundamental quantum aspects of slow neutrons and on confined propagation and waveguiding thereof Updates slow neutron beams and BNCT

Proceedings of the 23rd Pacific Basin Nuclear Conference, Volume 2

Author : Chengmin Liu
Publisher : Springer Nature
ISBN 13 : 9811987807
Total Pages : 1238 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Proceedings of the 23rd Pacific Basin Nuclear Conference, Volume 2 by : Chengmin Liu

Download or read book Proceedings of the 23rd Pacific Basin Nuclear Conference, Volume 2 written by Chengmin Liu and published by Springer Nature. This book was released on 2023-05-16 with total page 1238 pages. Available in PDF, EPUB and Kindle. Book excerpt: “This is the second in a series of three volumes of proceedings of the 23rd Pacific Basin Nuclear Conference (PBNC 2022) which was held by Chinese Nuclear Society. As one in the most important and influential conference series of nuclear science and technology, the 23rd PBNC was held in Beijing and Chengdu, China in 2022 with the theme “Nuclear Innovation for Zero-carbon Future”. For taking solid steps toward the goals of achieving peak carbon emissions and carbon neutrality, future-oriented nuclear energy should be developed in an innovative way for meeting global energy demands and coordinating the deployment mechanism. It brought together outstanding nuclear scientists and technical experts, senior industry executives, senior government officials and international energy organization leaders from all across the world. The proceedings highlight the latest scientific, technological and industrial advances in Nuclear Safety and Security, Operations and Maintenance, New Builds, Waste Management, Spent Fuel, Decommissioning, Supply Capability and Quality Management, Fuel Cycles, Digital Reactor and New Technology, Innovative Reactors and New Applications, Irradiation Effects, Public Acceptance and Education, Economics, Medical and Biological Applications, and also the student program that intends to raise students’ awareness in fully engaging in this career and keep them updated on the current situation and future trends. These proceedings are not only a good summary of the frontiers in nuclear science and technology, but also a useful guideline for the researchers, engineers and graduate students.

Computational Medicine, Public Health And Biotechnology: Building A Man In The Machine - Proceedings Of The First World Congress (In 3 Parts)

Download Computational Medicine, Public Health And Biotechnology: Building A Man In The Machine - Proceedings Of The First World Congress (In 3 Parts) PDF Online Free

Author : Diana J Vincent
Publisher : World Scientific
ISBN 13 : 9814548332
Total Pages : 1630 pages
Book Rating : 4.8/5 (145 download)

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Book Synopsis Computational Medicine, Public Health And Biotechnology: Building A Man In The Machine - Proceedings Of The First World Congress (In 3 Parts) by : Diana J Vincent

Download or read book Computational Medicine, Public Health And Biotechnology: Building A Man In The Machine - Proceedings Of The First World Congress (In 3 Parts) written by Diana J Vincent and published by World Scientific. This book was released on 1996-07-03 with total page 1630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This three volume series represents a selected and refereed collection of papers contributed by the participants of the First World Congress on Computational Medicine, Public Health, and Biotechnology, held in 1994 at Austin, Texas. Over 500 individuals, from 30 countries attended this meeting. In addition, this collection contains a number of papers from the Australian CSIRO High Performance Computing Meeting held that same year.

Frontiers In Boron-based Medicinal Chemistry

Author : Yinghuai Zhu
Publisher : World Scientific
ISBN 13 : 9811268045
Total Pages : 233 pages
Book Rating : 4.8/5 (112 download)

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Book Synopsis Frontiers In Boron-based Medicinal Chemistry by : Yinghuai Zhu

Download or read book Frontiers In Boron-based Medicinal Chemistry written by Yinghuai Zhu and published by World Scientific. This book was released on 2023-04-14 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron has long occupied a privileged role in chemistry (as a catalyst component) and human health (as a micronutrient). In 1951, boron science took a momentous leap forward with its application in clinical cancer research. The seventy or so years since have witnessed exciting developments in the technology now known as Boron Nuclear Capture Therapy (BNCT), a binary form of radiotherapy that lethally combines two separately non-lethal constituents: a boron-based radiosensitizer and non-ionizing neutron radiation. Frontiers in Boron-based Medicinal Chemistry is a one-stop resource on the current state of BNCT and promising works in the pipeline. It begins with an introduction to general boron chemistry, with extensive discussion on important boron compounds including boranes, boronic acids, carboranes, and FDA-approved boron drugs. Chapter 2 looks at BNCT in clinical trials, while Chapter 3 describes emerging next-generation agents such as boron-based nanoparticles and dendrimers. The penultimate chapter summarizes the currently used and emerging imaging techniques in BNCT, namely, PET, CT, MRI and fluorescence microscopy. The book concludes with a technically heavy chapter on neutron sources and dosimetry. The cutting-edge information contained in this authoritative volume will be a valuable resource for all those involved in mankind's endless struggle against cancer.