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Author : RICHARD A. SMITH
Publisher : Elsevier
ISBN 13 : 0323907261
Total Pages : 518 pages
Book Rating : 4.3/5 (239 download)
Download or read book NEUROTHERAPEUTICS IN THE ERA OF TRANSLATIONAL MEDICINE. written by RICHARD A. SMITH and published by Elsevier. This book was released on 2021 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joel Dudley
Publisher : CRC Press
ISBN 13 : 131535621X
Total Pages : 299 pages
Book Rating : 4.3/5 (153 download)
Download or read book Drug Repositioning written by Joel Dudley and published by CRC Press. This book was released on 2017-07-14 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet. In the last decades, traditional R&D has failed in identifying new effective therapies in many medical areas and drug repositioning has recently emerged as a promising alternative strategy to de novo drug discovery to improve and accelerate therapeutic development. For the first time, Drug Repositioning: Approaches and Applications for Neurotherapeutics reviews history and advances in drug repositioning, with a special focus on therapeutics for nervous system diseases. International experts from Academia, Industry and Non-profit organisations will provide different views on drug repositioning advantages, challenges and specific applications, which will be covered for nervous system diseases including Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, ischemic stroke, and psychiatric disorders. This book provides a balanced overview and synthesis of drug repositioning concept, methods and applications for neurotherapeutics. It represents a valuable resource for students, scientists and clinicians working in academic settings, industry and government agencies within the fields of neuroscience, pharmacology, neurology, pharmaceutical sciences, drug discovery and development.
Author : P. Michael Conn
Publisher : Academic Press
ISBN 13 : 0128025964
Total Pages : 778 pages
Book Rating : 4.1/5 (28 download)
Download or read book Conn's Translational Neuroscience written by P. Michael Conn and published by Academic Press. This book was released on 2016-09-28 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance Features contributions from leading global basic and clinical investigators in the field Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes Relates and translates the current science to the understanding of neurological disorders and their treatment
Author : Ioan Opris
Publisher : Frontiers Media SA
ISBN 13 : 2889636755
Total Pages : 328 pages
Book Rating : 4.8/5 (896 download)
Download or read book Nanotechnologies in Neuroscience and Neuroengineering written by Ioan Opris and published by Frontiers Media SA. This book was released on 2020-05-05 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lourdes M. DelRosso
Publisher : Springer Nature
ISBN 13 : 3030543595
Total Pages : 309 pages
Book Rating : 4.0/5 (35 download)
Download or read book Sleep Neurology written by Lourdes M. DelRosso and published by Springer Nature. This book was released on 2020-11-12 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical text provides knowledge of the basic neuroscience of sleep and sleep disorders as they interrelate with various neurologic conditions. Chapters in the first section cover neural networks involved in normal sleep processes, including dreams and memory. Also discussed are how these neural networks interact in various sleep stages and sleep disorders, such as sleep related movement disorders. The book's second section explores the pathophysiology of sleep disorders in the spectrum of neurologic conditions in both adults and children. This includes sleep changes in patients with dementia, seizures, headaches, and stroke, and other common neurologic disorders. Sleep Neurology fills an important gap in the sleep medicine literature by providing the underpinnings of sleep disorders and will be of great value to students, residents, and clinicians.
Author : Daniel Laskowitz
Publisher : CRC Press
ISBN 13 : 1498766579
Total Pages : 388 pages
Book Rating : 4.4/5 (987 download)
Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Author : David Robertson
Publisher : Academic Press
ISBN 13 : 012802111X
Total Pages : 812 pages
Book Rating : 4.1/5 (28 download)
Download or read book Clinical and Translational Science written by David Robertson and published by Academic Press. This book was released on 2016-11-25 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs
Author : George G. Nomikos
Publisher : Academic Press
ISBN 13 : 0128031646
Total Pages : 458 pages
Book Rating : 4.1/5 (28 download)
Download or read book Translational Medicine in CNS Drug Development written by George G. Nomikos and published by Academic Press. This book was released on 2019-06-18 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders Includes chapters written by international experts from industry and academia
Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publisher :
ISBN 13 :
Total Pages : 1406 pages
Book Rating : 4.:/5 (319 download)
Download or read book Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2007 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and published by . This book was released on 2006 with total page 1406 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publisher :
ISBN 13 :
Total Pages : 1406 pages
Book Rating : 4.:/5 (8 download)
Download or read book Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2007: Testimony of members of Congress and other interested individuals and organizations written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and published by . This book was released on 2006 with total page 1406 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Elsevier
ISBN 13 : 0444634460
Total Pages : 569 pages
Book Rating : 4.4/5 (446 download)
Download or read book Autoimmune Neurology written by and published by Elsevier. This book was released on 2016-03-11 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities
Author : Anne Harrington
Publisher : W. W. Norton & Company
ISBN 13 : 1324001976
Total Pages : 384 pages
Book Rating : 4.3/5 (24 download)
Download or read book Mind Fixers: Psychiatry's Troubled Search for the Biology of Mental Illness written by Anne Harrington and published by W. W. Norton & Company. This book was released on 2019-04-16 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mind Fixers tells the history of psychiatry’s quest to understand the biological basis of mental illness and asks where we need to go from here. In Mind Fixers, Anne Harrington, author of The Cure Within, explores psychiatry’s repeatedly frustrated struggle to understand mental disorder in biomedical terms. She shows how the stalling of early twentieth century efforts in this direction allowed Freudians and social scientists to insist, with some justification, that they had better ways of analyzing and fixing minds. But when the Freudians overreached, they drove psychiatry into a state of crisis that a new “biological revolution” was meant to alleviate. Harrington shows how little that biological revolution had to do with breakthroughs in science, and why the field has fallen into a state of crisis in our own time. Mind Fixers makes clear that psychiatry’s waxing and waning biological enthusiasms have been shaped not just by developments in the clinic and lab, but also by a surprising range of social factors, including immigration, warfare, grassroots activism, and assumptions about race and gender. Government programs designed to empty the state mental hospitals, acrid rivalries between different factions in the field, industry profit mongering, consumerism, and an uncritical media have all contributed to the story as well. In focusing particularly on the search for the biological roots of schizophrenia, depression, and bipolar disorder, Harrington underscores the high human stakes for the millions of people who have sought medical answers for their mental suffering. This is not just a story about doctors and scientists, but about countless ordinary people and their loved ones. A clear-eyed, evenhanded, and yet passionate tour de force, Mind Fixers recounts the past and present struggle to make mental illness a biological problem in order to lay the groundwork for creating a better future, both for those who suffer and for those whose job it is to care for them.
Author :
Publisher :
ISBN 13 :
Total Pages : 692 pages
Book Rating : 4.:/5 (319 download)
Download or read book Schizophrenia Bulletin written by and published by . This book was released on 2010 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alejandro A. Rabinstein
Publisher : Springer Nature
ISBN 13 : 3030280721
Total Pages : 390 pages
Book Rating : 4.0/5 (32 download)
Download or read book Neurological Emergencies written by Alejandro A. Rabinstein and published by Springer Nature. This book was released on 2019-11-28 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive and up-to-date book covers the common emergencies in neurology, neurosurgery, and psychiatry. Chapters examine a variety of neurological emergencies, and offer pragmatic approaches to treatment and management. High-quality tables, figures, and algorithms supplement expertly written text, and provide readers with clear, rapid answers in an easily accessible format. Additionally, the book includes discussions on less common conditions, and incorporates specific methods for treating specific populations, such as pregnant women and transplant patients. Neurological Emergencies: A Practical Approach is a go-to reference for all medical professions working in emergency treatment settings, and will increase their ability to better care for patients with acute neurological diseases.
Author : Christopher Ari Shaw
Publisher : Routledge
ISBN 13 : 1351444611
Total Pages : 410 pages
Book Rating : 4.3/5 (514 download)
Download or read book Glutathione In The Nervous System written by Christopher Ari Shaw and published by Routledge. This book was released on 2018-10-08 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this text is to focus readers attention on three major areas; the origin and localization of GSH in the nervous system; the multiple effects of GSH on neural health activity; and the potential for alterations on GSH status to lead to neurological damage of the type observed in amyotrophic lateral sclerosis, Parkinson's disease and other neurological disorders. The text also touches upon the additional roles of the antoxidant GSH, including possible neurotransmitter action, redox modulation of ionotropic receptor function, and neuroprotection against exicitoxic actions of glutamate.
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309459575
Total Pages : 483 pages
Book Rating : 4.3/5 (94 download)
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030921954X
Total Pages : 42 pages
Book Rating : 4.3/5 (92 download)
Download or read book Guidance for the Description of Animal Research in Scientific Publications written by National Research Council and published by National Academies Press. This book was released on 2011-09-16 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.
