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Author : Anders Björklund
Publisher :
ISBN 13 :
Total Pages : 604 pages
Book Rating : 4.3/5 (91 download)
Download or read book Neuropeptides in the CNS, Part II written by Anders Björklund and published by . This book was released on 1990 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Fleur L. Strand
Publisher : MIT Press
ISBN 13 : 9780262194075
Total Pages : 678 pages
Book Rating : 4.1/5 (94 download)
Download or read book Neuropeptides written by Fleur L. Strand and published by MIT Press. This book was released on 1999 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. In recent years there has been increasing interest and, subsequently, active research in neuropeptides. These neuroactive molecules coordinate, integrate, and regulate physiological processes in all organisms, throughout all phases of development. Acting as neurohormones, neurotransmitters, and/or neuromodulators, they maintain physiological homeostasis and influence important behavioral patterns. This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. The book is divided into two parts. In Part I the author defines the basic principles of neuropeptide action, including their biosynthesis, processing, transport, distribution, and interactions with receptors and second messenger systems. Strand also discusses the intimate interaction between the neuropeptides, stress, and the immune system. In Part II she discusses the regulatory functions of the families of neuropeptide in sufficient detail to provide both the advanced student and senior investigator with a thorough understanding of the most important neuropeptides. The text also contains a complete and up-to-date reference/reading list.
Author : Tomas Hokfelt (ed)
Publisher :
ISBN 13 :
Total Pages : 549 pages
Book Rating : 4.:/5 (784 download)
Download or read book Neuropeptides in the CNS, Part Ll written by Tomas Hokfelt (ed) and published by . This book was released on 1990 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Fred Nyberg
Publisher : CRC Press
ISBN 13 : 1439830622
Total Pages : 321 pages
Book Rating : 4.4/5 (398 download)
Download or read book Neuropeptides in Neuroprotection and Neuroregeneration written by Fred Nyberg and published by CRC Press. This book was released on 2012-06-19 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the genomic era is no longer in its infancy, the life sciences are still facing questions about the role of endogenous proteins and peptides in homeostasis and pathologies. Delving into one of the most current fields of interest in biology and medicine, Neuropeptides in Neuroprotection and Neuroregeneration describes the impact of neuropeptides on neuroprotection and neuroregeneration. The book begins with chapters describing important features of the endogenous neuropeptide systems related to their formation, receptor signaling, and inactivation. It includes chapters focused on the design and development of peptide-like drugs (peptidomimetics). In addition, the book covers: General aspects regarding the biosynthesis, structures, and distribution of neuroactive peptides and their receptors Basic mechanisms for neuropeptide action, metabolism, as well as techniques for their detection and aspects essential for the cellular mechanisms underlying brain pathology Neuropeptides known for their impact in neurodegenerative and neuroprotective processes Fundamental aspects as well as recent progress in the development of peptidomimetics of neuroprotective and cognition-enhancing peptides
Author : Remi Quirion
Publisher : Gulf Professional Publishing
ISBN 13 : 0444505407
Total Pages : 442 pages
Book Rating : 4.4/5 (445 download)
Download or read book Peptide Receptors written by Remi Quirion and published by Gulf Professional Publishing. This book was released on 2000 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complement with chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry. Data derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-receptor complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.
Author : A. Bjorklund
Publisher : Elsevier
ISBN 13 : 0080538576
Total Pages : 441 pages
Book Rating : 4.0/5 (85 download)
Download or read book Peptide Receptors, Part II written by A. Bjorklund and published by Elsevier. This book was released on 2002-12-13 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Receptors Part I was published in 2000 (as volume 16 of the Handbook of Chemical Neuroanatomy series). This volume summarized current knowledge on the discrete anatomical distribution of ten families of neuropeptide receptors expressed in the mammalian CNS. Part II is its natural complement with chapters covering six additional families of neuropeptide receptors for ligands ranging from well known peptides such as the opioids and neurotensin to recently isolated ones like the orexins. As in the case of Part I, this volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry and immunocytochemistry. Data derived from transgenic and knock-out animals are also summarized, helping to decipher the possible physiological and Pathophysiological role(s) of a given peptide family. Some chapters also review current knowledge on the profile of internalization of the neuropeptide-receptor complex, an area of intense research activities that should help to better understand mechanisms involved in desensitization and tachyphylaxis.
Author : Anders Björklund
Publisher :
ISBN 13 : 9780444903402
Total Pages : pages
Book Rating : 4.9/5 (34 download)
Download or read book Handbook of Chemical Neuroanatomy written by Anders Björklund and published by . This book was released on 1984 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J.P.H. Burbach
Publisher : CRC Press
ISBN 13 : 9781850704539
Total Pages : 156 pages
Book Rating : 4.7/5 (45 download)
Download or read book Brain Functions of Neuropeptides: A Current View written by J.P.H. Burbach and published by CRC Press. This book was released on 1993-05-15 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Functions of Neuropeptides contains capita selecta on neuropeptides by leading scientists in the neurosciences. As a guide through the wealth of neuropeptide research, the authors here present current and personal views on the roles that neuropeptide functions have in the nervous ystem, and their mode of action. The authors address an audience that includes readers at the undergraduate level in life sciences, but also experts who are intersted in timely issues.
Author : S.H. Parvez
Publisher : Elsevier
ISBN 13 : 1483290220
Total Pages : 436 pages
Book Rating : 4.4/5 (832 download)
Download or read book Methods in Neurotransmitter and Neuropeptide Research written by S.H. Parvez and published by Elsevier. This book was released on 2013-10-22 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-part book provides the most advanced biochemical and histochemical analytical methods on neurotransmitters, neuromodulators, and neuropeptides described by international specialists. The biochemical methods include liquid chromatography/electrochemistry, liquid chromatography/fluorescence and chemiluminescence detection, gas chromatography or liquid chromatography with mass spectrometry, and immunoassays. Morphological and physiological methods are also described, including immunohistochemistry, in situ hybridization, in vivo microdialysis, electrophysiological analysis, microwave irradiation, electrophysiological analysis, micro-anatomical dissection, peptide sequence analysis, quantitative autoradiographic analysis, and isolated CNS preparations. The neurotransmitters and neuropeptides include catecholamines, indoleamines, histamine, polyamines, and various neuropeptides, and their related enzymes. The book is the most comprehensive, advanced and versatile volume on the biochemical, morphological and physiological analysis of neurotransmitters and neuropeptides.
Author : F. Nyberg
Publisher : Elsevier
ISBN 13 : 0444817190
Total Pages : 439 pages
Book Rating : 4.4/5 (448 download)
Download or read book Neuropeptides in the Spinal Cord written by F. Nyberg and published by Elsevier. This book was released on 1995 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book devoted exclusively to examining the role of neuropeptides in the spinal cord. Great progress has been made recently in our understanding of the role of neuropeptides in neurotransmission. New tools have been developed to help study the function of endogenous neuropeptides in health and disease. Because the general organization of the spinal cord is well conserved among species and neuropeptides appear to have a major role in spinal neurotransmission, this book is a timely compendium of recent research in this field. The volume will help to stimulate further research in the field of neuropeptides which will lead to better understanding of this role in health and disease.
Author :
Publisher : Elsevier
ISBN 13 : 0080861970
Total Pages : 363 pages
Book Rating : 4.0/5 (88 download)
Download or read book Neuropeptides and Brain Function written by and published by Elsevier. This book was released on 2011-09-22 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropeptides and Brain Function
Author : H. Yoshida
Publisher : Elsevier
ISBN 13 : 1483148440
Total Pages : 297 pages
Book Rating : 4.4/5 (831 download)
Download or read book CNS Pharmacology Neuropeptides written by H. Yoshida and published by Elsevier. This book was released on 2013-10-22 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Pharmacology and Therapeutics II, Volume 1: CNS Pharmacology Neuropeptides contains the proceedings of the Eighth International Congress of Pharmacology held in Tokyo in 1981. This book is the first of a six-volume compilation of the scientific papers of invited speakers. Separating 26 papers as chapters, this book begins with an invited lecture on opioid peptides and their receptors. Other chapters describe opioid peptides and their relevance to central nervous system mechanisms; neuropeptides and related compounds affecting learning and memory; and pharmacological approaches to the study of sleep regulation. This book also explores the importance of kainic acid and related compounds as a pharmacological tool.
Author : B. Krisch
Publisher : Birkhäuser
ISBN 13 : 3034890109
Total Pages : 358 pages
Book Rating : 4.0/5 (348 download)
Download or read book The Peptidergic Neuron written by B. Krisch and published by Birkhäuser. This book was released on 2012-12-06 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropeptides rank among the phylogenetically oldest interneuronal signal substances. In the concept of neuro-secretion they were identified as neurohormones by which - via the blood - the brain regulates peripheral functions. It is now evident that the neuropeptides act as neurotransmitters/-modulators, as (neuro-)hormones, and paracrine or autocrine signal substances in diverse parts of the body. This book reviews, in several comprehensive articles written by distinguished specialists, the state of the art in the field of neuropeptides and peptidergic neurons. Special topics concern molecular aspects of processing, release and degradation of neuropeptides, receptors and signal transduction, comparative and behavioural aspects, and immunoregulatory effects of neuropeptides and their involvement on pathology of the central nervous system.
Author : Laszlo Prokai
Publisher : Birkhäuser
ISBN 13 : 3034880499
Total Pages : 250 pages
Book Rating : 4.0/5 (348 download)
Download or read book Peptide Transport and Delivery into the Central Nervous System written by Laszlo Prokai and published by Birkhäuser. This book was released on 2012-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS). Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics developed as their agonists or antagonists could be useful in the treatment of these CNS maladies. However, peptides face a formidable obstacle in reaching the intended site of action due to the existence of the blood-brain barrier (BBB), a vital element in the regulation of the internal environment of the brain and the spinal cord. After reviews on the role and neuropharmaceutical potential of peptides, properties of the BBB in the context of peptide transport in the CNS and potential transport mechanisms to cross the BBB, this volume discusses the development, present state-of-the-art and future trends of various strategies to overcome this major obstacle to peptide pharmacotherapy involving the CNS. Chapters are devoted to cover invasive approaches that circumvent the BBB by direct administration into the brain or the spinal cord and by transiently opening the tight junctions of or permeabilizing the endothelial cells separating the systemic circulation from the interstitial fluid of the CNS. Subsequently, physiologically based strategies that utilize biological carriers to gain access to the CNS are discussed in detail, followed by methods encompassing prodrug and chemical delivery/targeting strategies, which aim at altering the properties of the peptide to enhance BBB transport, and drug delivery strategies based on peptide vectors. Finally, a comparative evaluation on the present status and perspectives of the techniques is presented.
Author : Anders Björklund
Publisher : Elsevier Science & Technology
ISBN 13 :
Total Pages : 432 pages
Book Rating : 4.3/5 (91 download)
Download or read book Neuropeptide Receptors in the CNS written by Anders Björklund and published by Elsevier Science & Technology. This book was released on 1992 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hardbound. This volume is complementary to two earlier volumes in the series, Volumes 4 and 9.An excellent group of authors, each expert in their respective areas, address the diversity of neuropeptides and their receptors and have produced an excellent and well-illustrated state-of-the-art report.The number of putative transmitters in the central nervous system has increased dramatically during the last two decades. Extensive mapping studies on these compounds have been carried out in adult brain, especially in the rat. This present volume gives a detailed description of various stages, and comprehensive overviews of the development/ontogenetic profiles of many of these compounds.These well-organized chapters will help utilize and deal with the abundant knowledge on this topic as well as to incorporate this knowledge for future advances.
Author : T. Hokfelt
Publisher : Elsevier Science
ISBN 13 : 9780444812308
Total Pages : pages
Book Rating : 4.8/5 (123 download)
Download or read book Neuropeptides in the CNS written by T. Hokfelt and published by Elsevier Science. This book was released on 1990-12-31 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 9 in the series Handbook of Chemical Neuroanatomy continues the coverage of neuropeptides and neuropeptide receptors which was initiated in Volume 4. In addition, a chapter on DARPP-32, a dopamine and cyclic AMP regulated phosphoprotein, which is present in dopamine receptor bearing cells, is included. In this regard this volume also represents a continuation and extension of Volumes 2 and 3 which dealt with classical transmitters and transmitter receptors in the CNS.
Author : A. Bjorklund
Publisher : Elsevier
ISBN 13 : 0080538584
Total Pages : 537 pages
Book Rating : 4.0/5 (85 download)
Download or read book Peptide Receptors, Part I written by A. Bjorklund and published by Elsevier. This book was released on 2000-06-08 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last few years, the pace of research in the field of neuropeptide receptors has increased steadily: new neuropeptides were discovered, and the classification of receptor subtypes has been refined. It thus appeared essential to update the information. Peptide Receptors Part I summarizes current knowledge on ten distinct peptide families. This volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry, and immunocytochemistry images. Application of these classical techniques and of new approaches such as transgenic and knock-out animals has revealed a distinct species and tissue specific variation in receptor subtypes expression and pharmacology in the mammalian central nervous system. The functional role of neuropeptides and their receptors in the CNS has been investigated thanks to the development of potent and selective receptor antagonists and agonists. The development of specific neuropeptide-related molecules will help to get a better understanding of receptor subtype physiology and neuronal distribution and may lead to innovative treatments in a variety of brain disorders.
