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Neuronal Calcium Sensor Proteins
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Book Synopsis Neuronal Calcium Sensor Proteins by : Pavel P. Philippov
Download or read book Neuronal Calcium Sensor Proteins written by Pavel P. Philippov and published by Nova Publishers. This book was released on 2006 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium signalling is an astonishing example how a simple caption can trigger and regulate an enormous variety of cellular and physiological responses. Ca2+-signalling routes very often involve Ca2+-binding proteins that sense changes in intracellular [Ca2+] and trigger cellular responses by regulating specific targets. One fascinating group among these Ca2+-sensors are the neuronal calcium sensor (NCS) proteins, named for their localisation in neuronal tissue (although there are reports of their expression in non-neuronal tissues as well). While recent excellent reviews have covered key aspects of this protein group, the field expanded in recent years making it more and more difficult to represent every facet of this ongoing research endeavour. This book is intended to represent properties of NCS proteins.
Book Synopsis Neuronal Calcium Sensors in Health and Disease by : Karl-Wilhelm Koch
Download or read book Neuronal Calcium Sensors in Health and Disease written by Karl-Wilhelm Koch and published by Frontiers Media SA. This book was released on 2020-01-16 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Neuronal Functions of EF-hand Ca(2+)-binding Proteins 2nd Edition by : Michael R. Kreutz
Download or read book The Neuronal Functions of EF-hand Ca(2+)-binding Proteins 2nd Edition written by Michael R. Kreutz and published by Frontiers Media SA. This book was released on 2016-11-01 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ca2+ signaling in neurons is characterized by highly restricted and dynamic gradients called Ca2+ waves, spikes, transients and puffs depending upon their corresponding spatial and temporal features. Based on this strict segmentation the Ca2+ ion provides a versatile basis for complex signaling in neuronal subcompartments with a spatial resolution of micro- and nanodomains. The multitude of Ca2+-regulated processes requires specialized downstream processing machinery, translating the Ca2+ signal into alterations of cellular processes. The broad range of different Ca2+-triggered phenomena in neurons, ranging from neurotransmission to gene expression, is reflected by the existence of a multitude of different Ca2+-binding proteins (CaBPs) from which numerous belong to the EF-hand super-family. EF-hand proteins can be subdivided into Ca2+ buffer and Ca2+ sensor proteins. Whereas the first group has a very high affinity for Ca2+, exhibits little conformational change in the Ca2+-bound state and is thought to mainly chelate Ca2+, the second group has a lower affinity for Ca2+ and shows considerable conformational changes upon Ca2+-binding, which usually triggers a target interaction. Neuronal calcium sensor (NCS) proteins and the related Caldendrin/CaBP/Calneuron (nCaBPs) proteins are members of this latter group. They resemble the structure of their common ancestor Calmodulin (CaM) with four EF-hand Ca2+-binding motifs, of which not all are functional. However, despite their structural homology with CaM, NCS as well as nCaBPs are quite diverse in amino acid sequence. It is therefore surprising that relatively few binding partners have been identified that are not CaM targets and this raises the question of the specificity and function of these interactions. In terms of function, binding of NCS and nCaBP has frequently different consequences than binding of CaM, which substantially increases the versatility of the Ca2+ tool kit. The general idea of this special issue is to provide an overview on the function of neuronal EF-hand calcium-binding proteins in health and disease. But we will not just provide a mere collection of articles to stress the function of each protein. The issue will mainly deal with emerging concepts on Ca2+-signaling/buffering mediated by EF-hand Ca2+-binding proteins. This includes questions like features that define the functional role of a EF-hand calcium sensor in neurons, the conditions that make physiological relevance of a given interaction of a CaBP with its target plausible, the emerging synaptic role of these proteins, and mounting evidence for their role in the regulation of protein trafficking. Structural aspects and biophysical studies will be covered. Another aspect will be the role of CaBPs in brain disease states. This aspect includes studies showing that CaBPs are targets of drugs in clinical use, studies showing that expression levels of calcium-binding proteins are frequently altered in brain disease states as well as reports on mutations in EF-hand calcium sensors linked to human disease.
Book Synopsis Interaction Between Neuronal Calcium Sensor Protein 1 and Lithium in Pedunculopontine Neurons by :
Download or read book Interaction Between Neuronal Calcium Sensor Protein 1 and Lithium in Pedunculopontine Neurons written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis NMR Structures of Neuronal Calcium Sensor Proteins (CaBP1 and CaBP4) by : Sae Bo Mi Park
Download or read book NMR Structures of Neuronal Calcium Sensor Proteins (CaBP1 and CaBP4) written by Sae Bo Mi Park and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal calcium binding proteins (CaBPs, CaBP1-CaBP5) are a subclass of the calmodulin (CaM) superfamily that regulate specific Ca2+ channel targets in the brain and retina. Calcium-binding protein 1 (CaBP1), is a relatively small Ca2+-binding protein (18.7 kDa) that regulates the Ca2+-dependent activity of inositol 1,4,5-triphosphate receptor (InsP3s) and various voltage-gated Ca2+ channels (Ca[v] 1.2, Ca[v]1.3 and Ca[v] 2.1). In the first project of this study, I present the NMR structure of full-length CaBP1 (18.7 kDa) with Ca2+ bound at EF1, EF3, and EF4-hand, calculated by 1250 nuclear overhauser effect (NOE) distance restraints and 70 residual dipolar coupling (RDC) restraints with a root-mean-squared deviation (RMSD) of 0.54 [angstrom] (N-domain) and 0.48 [angstrom] (C-domain). The Ca2+-saturated CaBP1 structure contains two independent domains separated by a flexible central linker. The N-domain structure of CaBP1 contains two EF-hands (EF1 and EF2) both in a closed conformation, and the C-domain contains EF3 and EF4 in the familiar Ca2+-bound open conformation. The N-domain adopts the same closed conformation in the presence or absence of Ca2+ bound at EF1, in contrast to CaM and other Ca2+ sensor proteins that typically undergo a Ca2+-induced closed-to-open transition. In the second project, I performed a structural study on the calcium binding protein 4 (CaBP4), a somewhat larger Ca2+-binding protein (30 kDa), that serves as a critical regulator of L-type voltage gated Ca2+ channels (Cav1.4) in retinal photoreptors. Accoding to isothermal titration calorimetry (ITC) data and NMR spectra, CaBP4 binds to Mg2+ at EF1 and EF3 in the basal resting state of the cell, in which the cytosolic Ca2+ concentration is 100 nM. CaBP4 binds to Ca2+ at EF1, EF3, and EF4 in the activated cell state, in which the cytosolic Ca2+ concentration increases above 1 [mu]M. I solved the NMR structure of the Ca2+ bound activated and truncated form of CaBP4 (residues 100-271), which excludes unstructured N-terminal residues (1-100). A total of 1443 NOE distance restraints and 176 dihedral angles restraints were used to define overall main chain structure of CaBP4 with RMSD of 0.54 [angstrom] (N-domain) and 0.48 [angstrom] (C-domain). CaBP4 contains two independent domains (N-domain and C-domain) separated by a flexible central linker similar to those of CaBP1, calmodulin (CaM), and troponin C (TnC). The NMR structure of CaBP4 reveals an unusual closed conformation for the Ca2+-bound N-domain in contrast to an open conformation for the C-domain, suggesting that the two domains might have different functional roles in regulating target proteins. The Ca2+-bound C-domain (in both CaBP1 and CaBP4) exposes extensive hydrophobic patches during the Ca2+-induced closed to open conformational transition, which is similar to Ca2+-induced opening in CaM or other calcim sensor proteins. I performed a series of biophysical studies to characterize the binding of CaBP4 to the IQ motif of Cav1.4. These studies demonstrate that the Ca2+-bound C-domain (with an open conformation) interacts with a helical IQ motif similar to that seen previously for CaM. For the N-domain which adopts a Ca2+-bound closed conformation, I propose that the closed N-domain (for both CaBP1 and CaBP4) might undergo an induced-fit opening only in the presence of a particular target protein. Thus, this unique Ca2+-bound closed conformation of CaBP1 and CaBP4 may prevent the accidental binding to CaM target motifs and explain why both CaBP1 and CaBP4 have much higher target specificity than CaM.
Book Synopsis Investigation of the Neuronal Calcium Sensor Protein Neurocalcin #delta# by :
Download or read book Investigation of the Neuronal Calcium Sensor Protein Neurocalcin #delta# written by and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Neuronal Calcium Sensor Protein KChIP1 and Its Role in the Traffic of Kv4.2 Potassium Channels to the Plasma Membrane by : Burcu Hasdemir
Download or read book The Neuronal Calcium Sensor Protein KChIP1 and Its Role in the Traffic of Kv4.2 Potassium Channels to the Plasma Membrane written by Burcu Hasdemir and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Expression and Regulation of the Neuronal Calcium Sensor Protein VILIP-1 and Effect on the Alpha 4 Beta 2 NAChR in Rat Hippocampal Neurons and Cell Lines by : CongJian Zhao
Download or read book Expression and Regulation of the Neuronal Calcium Sensor Protein VILIP-1 and Effect on the Alpha 4 Beta 2 NAChR in Rat Hippocampal Neurons and Cell Lines written by CongJian Zhao and published by . This book was released on 2008 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Expression and Regulation of the Neuronal Calcium Sensor Protein VILIP-1 and Effect on the [alpha]4[beta]2 [alpha 4 Beta 2] NAChR in Rat Hippocampal Neurons and Cell Lines by : Cong Jian Zhao
Download or read book Expression and Regulation of the Neuronal Calcium Sensor Protein VILIP-1 and Effect on the [alpha]4[beta]2 [alpha 4 Beta 2] NAChR in Rat Hippocampal Neurons and Cell Lines written by Cong Jian Zhao and published by . This book was released on 2007 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Structural and Functional Divergence Between Two Neuronal Calcium Sensor Proteins, Neurocalcin [delta] and Hippocalcin by : Liron Shiri
Download or read book Structural and Functional Divergence Between Two Neuronal Calcium Sensor Proteins, Neurocalcin [delta] and Hippocalcin written by Liron Shiri and published by . This book was released on 2007 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis From Protein to Signalplex by : Daniel A. De Cotiis
Download or read book From Protein to Signalplex written by Daniel A. De Cotiis and published by . This book was released on 2010 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Expression and Regulation of the Neuronal Calcium Sensor Protein VILIP-1 and Effect on the Α4β2 [alpha 4 Beta 2] NAChR in Rat Hippocampal Neurons and Cell Lines by : Cong Jian Zhao
Download or read book Expression and Regulation of the Neuronal Calcium Sensor Protein VILIP-1 and Effect on the Α4β2 [alpha 4 Beta 2] NAChR in Rat Hippocampal Neurons and Cell Lines written by Cong Jian Zhao and published by . This book was released on 2007 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of Hippocalcin-like Protein 1 (HPCAL1), a Neuronal Calcium Sensor Protein in the Retina by : Aleeza Hoi Ting Tam
Download or read book Characterization of Hippocalcin-like Protein 1 (HPCAL1), a Neuronal Calcium Sensor Protein in the Retina written by Aleeza Hoi Ting Tam and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Marco R. Celio Publisher :Sambrook and Tooze Publication at Oxford University Press ISBN 13 : Total Pages :264 pages Book Rating :4.3/5 (91 download)
Book Synopsis Guidebook to the Calcium-binding Proteins by : Marco R. Celio
Download or read book Guidebook to the Calcium-binding Proteins written by Marco R. Celio and published by Sambrook and Tooze Publication at Oxford University Press. This book was released on 1996 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each entry includes data on isolation/identification, alternative names, genes and sequences, proteins, antibodies, and biological activities.
Book Synopsis Calcium-Binding Proteins in the Human Developing Brain by : N. Ulfig
Download or read book Calcium-Binding Proteins in the Human Developing Brain written by N. Ulfig and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book is primarily written for neuroscientists who will always be interested in the role of calcium in the internal neuronal environment. The objectives are well met. The authors are credible authorities in the field and are the most appropriate to discuss calcium in neuronal development...Through multiple excellent quality pictures, this book shows evidence of the potential roles of calcium in the modulation of development as well as on the determination of programmed cell death. " Review from Doody's Notes
Book Synopsis Neuronal Calcium Sensors in Health and Disease by : Karl-Wilhelm Koch
Download or read book Neuronal Calcium Sensors in Health and Disease written by Karl-Wilhelm Koch and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis Encyclopedia of Molecular Pharmacology by : Stefan Offermanns
Download or read book Encyclopedia of Molecular Pharmacology written by Stefan Offermanns and published by Springer Science & Business Media. This book was released on 2008-08-14 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.