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Neural Transplantation Methods
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Book Synopsis Neural Transplantation Methods by : Stephen B. Dunnett
Download or read book Neural Transplantation Methods written by Stephen B. Dunnett and published by Springer Science & Business Media. This book was released on 1999-10-20 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: we might seek alternative sources of donor tissues. Genetic en- neering, expansion of precursor cells, generation of immortalized cell lines, and transplantation between species are all under active investigation. Although significant difficulties remain for each of these alternatives, the problems appear soluble and relevant knowledge is expanding rapidly. As we enter the twenty-first century, the place of neural tra- plantation in experimental neuroscience is continuing to evolve. Rather than being a topic in its own right, neural transplantation increasingly serves as just another technique in the researcher's armory--alongside lesions, pharmaceuticals, gene transfer, and a variety of other techniques--for the experimental manipulation of brain structure and function. This is particularly true for studies of degeneration, plasticity, regeneration, and recovery of function in the nervous system, topics of increasing importance as experimental neurobiology is required to serve the higher needs of neurological and mental health in aging societies. Within this evolving context, Neural Transplantation Methods seeks to serve a particular need: to provide experimental neu- scientists with a source book of information to enable them to select and adapt transplantation techniques to their own expe- mental programs. All authors have been asked to address prac- cal issues, to enable the reader to assess what is available, what are the alternatives, what are the practical issues to be resolved in applying a particular protocol and getting it to work reliably in their unique experimental context.
Book Synopsis Functional Neural Transplantation IV by :
Download or read book Functional Neural Transplantation IV written by and published by Academic Press. This book was released on 2017-05-25 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science, providing an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair. - Comprehensive set of critical reviews covering the field - Presents state-of-the-art topics in science and translational medicine - Written by international leaders in the field of neural transplantation
Book Synopsis Neural Cell Transplantation by : Neil J. Scolding
Download or read book Neural Cell Transplantation written by Neil J. Scolding and published by Humana Press. This book was released on 2009-05-07 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the dramatic and rapidly developing field of neural transplantation for CNS repair, the most powerful contributor has been the vital research focusing on stem cells. In Neural Cell Transplantation: Methods and Protocols, leading experts in the field examine tried-and-true laboratory techniques in order to supply scientists with a firm foundation upon which further advancements can be based. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters of this volume include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and Notes sections, which examine tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy to use, Neural Cell Transplantation: Methods and Protocols provides the most thorough and essential protocols that will allow new generations of neuroscientists to enter and contribute to this uniquely inspiring field.
Book Synopsis Neural Transplantation by : William J. Freed
Download or read book Neural Transplantation written by William J. Freed and published by MIT Press. This book was released on 2000 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: After providing basic background on transplantation, brain structure, and development, the book discusses Parkinson's disease, the use of transplants to influence localized brain functions, circuit reconstruction, and genetic engineering and other future technologies.
Book Synopsis Functional Neural Transplantation III by :
Download or read book Functional Neural Transplantation III written by and published by Newnes. This book was released on 2012-12-31 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery. - Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research - Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Book Synopsis Neural Transplants by : John R. Sladek
Download or read book Neural Transplants written by John R. Sladek and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: The story of mammalian neural transplantation really begins eighty-one years ago. In Chicago in December of 1903, a 34-year-old physician, Elizabeth Hopkins Dunn, working as a research assistant in neurology, initiated a series of experiments to examine the ability of neonatal rat cerebral tissue to survive transplantation into the brain of matched littermates. Out of 46 attempts, four clearly successful grafts were identified. The publication of Dunn's results in 1917, the first credible report to demonstrate the feasibility of mammalian CNS transplants, generated little interest. In fact, the next significant experiment in this field did not appear until 1930. The field continued to grow slowly and quietly as investigators gradually realized the value of neural trans plantation to study problems of development and plasticity in the mammalian nervous system. With the discovery in 1979 that grafted neurons were capable of appropriate and functional interactions with the host brain, interest in neural transplantation esca lated sharply. The extraordinary opportunities created by using functional neural trans plants in investigating basic issues in neurobiology, as well as the clinical implications, excited both scientists and the public. The popularity of neural transplantation has been growing rapidly in the past five years and shows no signs of abating. The present volume was designed to meet two needs created by the rapid growth of this subdiscipline of neurobiology. The first was to provide a thorough review of the experimental foundations of neural transplantation.
Book Synopsis Cell Transplantation for Neurological Disorders by : Thomas B. Freeman
Download or read book Cell Transplantation for Neurological Disorders written by Thomas B. Freeman and published by Springer Science & Business Media. This book was released on 1998-05-29 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Distinguished medical researchers from around the world review novel neural reconstructive techniques that appear to be beneficial for Parkinson's disease and hold promise for treating Huntington's disease, pain, demyelinating diseases, and stroke. The contributors focus on those diseases for which clinical trials are either ongoing or likely to occur in the near future. Among the topics reviewed are results and rationale for some of the leading transplant programs for the treatment of Parkinson's disease, the use of PET scanning for patient evaluation, autopsy studies of transplant recipients, transplant immunology, fetal tissue transplantation for Huntington's disease, cellular transplantation for the treatment of pain and stroke, and transplantation of myelinating cells. A full discussion of the important ethical issues surrounding the use of fetal tissue for transplantation purposes is also included.
Book Synopsis Neural Tissue Transplantation Research by : R.B. Wallace
Download or read book Neural Tissue Transplantation Research written by R.B. Wallace and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last decade research on neural transplantation in mammals has grown extensively, and has attracted the attention of many young inquisitive scientists. This growth, as the critics point out, has been somewhat random, and has resulted neither in the formulation of basic concepts nor in any other significant achievement. For instance, they question-how is it possible to jump into functional research with clinical bearing when the basic morphological work has not yet been conducted? The criticism, objectively speaking, is valid and is supported by the fact that every investigator who has stepped into this unex plored field of neurosciences has formulated questions in his own way, has followed his own "model" oftransplantation, and has arrived at his own unique conclusions. The potential danger, as the critics emphasize, in this type of approach lies in that instead of evolving into a scientifically solid and valuable field of research, it may end in a confusing and conflicting mass of questionable claims and subjective opinions. The present situation, very likely, is a reflection of unrestrained enthusiasm and imaginativeness of the investigators, and the demands of the times for the so-called "newsworthy" and "breakthrough" publications. Despite these limitations, two important facts have been estab lished in this field. First, as far as transplantation of neural tissues per se is concerned, what was considered impossible by some critics about 10-12 years ago has been shown to be possible.
Book Synopsis Development of Intrastriatal Neural Transplantation Techniques by : Eric Mayer
Download or read book Development of Intrastriatal Neural Transplantation Techniques written by Eric Mayer and published by . This book was released on 1992 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Functional Neural Transplantation III by :
Download or read book Functional Neural Transplantation III written by and published by Elsevier. This book was released on 2012-12-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.
Book Synopsis Functional Neural Transplantation IV by :
Download or read book Functional Neural Transplantation IV written by and published by Academic Press. This book was released on 2017-05-26 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Neural Transplantation IV: Translation to Clinical Application, Part B, Volume 231 provides the current status of cell transplantation in the nervous system, focusing on the conditions for achieving structural repair and functional recovery. New to this edition are chapters on Plasticity and Regeneration in the Injured Spinal Cord After Cell Transplantation Therapy, Transplantation of GABAergic Interneurons for Cell-Based Therapy, Rebuilding CNS Inhibitory Circuits to Control Chronic Neuropathic Pain and Itch, From Transplanting Schwann Cells in Experimental Rat Spinal Cord Injury to their Transplantation into Human Injured Spinal Cord in Clinical Trials, and the Recruitment of Endogenous CNS Stem Cells for Regeneration in Demyelinating Disease. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments in cellular and molecular science, providing the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, while also addressing the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair. - Provides a comprehensive set of critical reviews covering the field - Presents state-of-the-art topics in science and translational medicine - Written by international leaders in the field of neural transplantation
Book Synopsis Neural Transplantation and Regeneration by : Gopal D. Das
Download or read book Neural Transplantation and Regeneration written by Gopal D. Das and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Four years ago the first international symposium dealing with neural transplan tation was organized as a satellite conference to the annual meeting of the Society for Neuroscience in Los Angeles, California. The expanded proceed ings of that symposium were published by Springer-Verlag in 1983 in a volume entitled Neural Tissue Transplantation Research. We were sufficiently pleased with the results of that effort to organize a second satellite international sympo sium on Neural Transplantation and Regeneration in conjunction with the 13th Annual Meeting of the Society for Neuroscience in Boston in the fall of 1983. Paralleling the growing body of research dealing with various aspects of neural transplantation, the scope of this second symposium was broadened to include not only transplantation but also regeneration. Additionally, topics of clinical interest were addressed as well as issues of basic research. The promise apparent in that first conference is still seen in the second as more and more investigators apply their talents in an attempt to understand this infant field of research. The present volume represents an expanded version of the material presented at the second symposium. We wish to thank all of the contributors to the conference and to this volume for their insight and their assistance.
Book Synopsis Neural Transplantation in Neurodegenerative Disease by : Derek J. Chadwick
Download or read book Neural Transplantation in Neurodegenerative Disease written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2003-10-31 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed. This timely book brings together leading neuroscientists, clinicians, and cell and developmental biologists to discuss the use of neural transplants in neurodegenerative disorders, such as Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential alternatives to freshly derived fetal tissue as the source of transplants, for example xenografts, encapsulated cells and immortalized stem cells. With authoritative contributions and lively discussion sections, this book presents much new and exciting work in this field and identifies promising new research directions.
Book Synopsis Neural Transplantation, CNS Neuronal Injury, and Regeneration by : Joe Marwah
Download or read book Neural Transplantation, CNS Neuronal Injury, and Regeneration written by Joe Marwah and published by CRC Press. This book was released on 1994-02-23 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique reference presents studies from leading laboratories that are studying the effects of CNS transplants on neuronal plasticity and recovery of function after CNS injury. Topics covered include tropic influences, reinnervation patterns, and prevention of cell death that range from pre-clinical models of Parkinson's disease in primates to studies of restoration of circadian rhythms in rats. Techniques of neurotransplantation are presented, including current limitations and future projections of advancement.
Book Synopsis Neural Transplantation by : Stephen B. Dunnett
Download or read book Neural Transplantation written by Stephen B. Dunnett and published by Irl Press. This book was released on 1992 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a practical introduction to the techniques of neural transplantation in mammalian brain tissue. It provides a detailed description of the techniques, written by acknowledged experts in the field, with practical details and hints complementing the underlying principles. Each chapter identifies the equipment needed, the preparations to be made in advance, and step-by-step protocols for each procedure. All aspects of neural transplantation surgery are covered, from staging and dissection of embryonic CNS tissues, through the preparation of tissues for implantation, to the transplant surgery itself. A variety of different methods for solid and cell suspension transplantation are covered. Specialized chapters consider genetic engineering of cells, labelling of grafts, and other aspects of tissue manipulation of PNS and gilal tissues; transplantation in neonatal animals, including primates; handling of human embryonic tissues for transplantation; and immunological considerations. The book will be of interest to neuroscientists studying neural development, anatomical plasticity, functional organization, and recovery in the mammalian CNS, and to neurologists and neurosurgeons interested in developing clinical applications of neural transplantation. It should be stressed that these techniques are experimental and not yet for clinical use.
Book Synopsis Transplantation of Neural Tissue Into the Spinal Cord by : Gerta Vrbová
Download or read book Transplantation of Neural Tissue Into the Spinal Cord written by Gerta Vrbová and published by R G Landes Company. This book was released on 1994-01-01 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The spinal cord, if damaged, normally has a very limited ability to restore itself to normal function. However, a new technique of tissue transplantation has led to significant advances in this area. This book briefly describes the structure and function of the mammalian spinal cord. It then reviews the latest results of experiments where grafts of embryonic tissue were used to encourage regeneration of the host spinal cord, or to replace different cell population. Methods of restoration using foetal grafts are discussed, as is the contribution made by this controversial approach toward understanding problems of developmental neuroscience.
Book Synopsis Neural Repair, Transplantation, and Rehabilitation by : Roger A. Barker
Download or read book Neural Repair, Transplantation, and Rehabilitation written by Roger A. Barker and published by Psychology Press. This book was released on 1999 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book begins with a synopsis of experimental work underlying degeneration and recovery in the nervous system, which is then discussed in the context of strategies to repair the central nervous system (CNS) and peripheral nervous system (PNS). The major part of the book is given over to the approach involving the use of transplanted tissues to replace and restore disrupted neural networks. This experimental work has formed the basis for the emerging clinical trials employing neural grafts for diseases such as Parkinson's and Huntington's, which are discussed in detail. The book then goes on to discuss newer cellular strategies involving the manipulation of neural cells both in culture and genetically, an approach that may ultimately be employed in the clinical situation. Neural Repair, Transplantation and Rehabilitation is unique in bridging the gap from experimental studies to clinical trials, whilst also providing the non-specialist with a background in rehabilitation strategies as well as basic neuroscience. It is recommended for all those involved in the management of patients with degenerative and traumatic injuries to the nervous system.
