Neural Mechanisms Of Anesthesia

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Neural Mechanisms of Anesthesia

Author : Joseph E. Antognini
Publisher : Springer Science & Business Media
ISBN 13 : 1592593224
Total Pages : 464 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Neural Mechanisms of Anesthesia by : Joseph E. Antognini

Download or read book Neural Mechanisms of Anesthesia written by Joseph E. Antognini and published by Springer Science & Business Media. This book was released on 2002-08-22 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading investigators critically evaluate the latest information on how anesthetics work at the molecular, cellular, organ, and whole animal level. These distinguished experts review anesthetic effects on memory, consciousness, and movement and spell out in detail both the anatomic structures and physiological processes that are their likely targets, as well as the cellular and molecular mechanisms by which they operate. Comprehensive and authoritative, Neural Mechanisms of Anesthesia draws together and critically reviews all the recent research on anesthetic mechanisms, highlighting the precise routes along which these substances operate, and how this deeper understanding will lead to the design of effective drugs free ofundesirable side effects.

Sleep and Anesthesia

Author : Axel Hutt
Publisher : Springer Science & Business Media
ISBN 13 : 1461401739
Total Pages : 268 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Sleep and Anesthesia by : Axel Hutt

Download or read book Sleep and Anesthesia written by Axel Hutt and published by Springer Science & Business Media. This book was released on 2011-07-12 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sleep and anesthesia resemble in many ways at a first glance. The most prominent common feature of course is the loss of consciousness, i.e. the loss of awareness of external stimuli. However a closer look at the loss of consciousness reveals already a difference between sleep and anesthesia: anesthesia is induced by an anesthetic drug whereas we may fall asleep without external cause. Other questions may arise about the difference of the two effects: do we dream during surgery under anesthesia, do we feel pain during sleep? Essentially, we may ask: what is common and what are the differences between sleep and anesthesia? To answer these questions, we may take a look at the neural origin of both effects and the involved physiological pathways. In which way do they resemble? Moreover, we ask what are the detailed features of normal sleep and general anesthesia as applied during surgery and which features exist in both phenomena? If yes in which way? To receive answers to these questions, it is necessary to consider several experimental techniques that reveal underlying neural mechanisms of sleep and anesthesia. Moreover, theoretical models of neural activity may model both phenomena and comes up with predictions or even theories on the underlying mechanisms. Such models may attack several different description levels, from the microscopic level of single neurons to the macroscopic level of neural populations. Such models may give deeper insight into the phenomena if their assumptions are based on experimental findings and their predictions can be compared to experimental results. This comparison step is essential for valuable theoretical models. The book is motivated by two successful workshops on anesthesia and sleep organized during the Computational Neuroscience Conferences in Toronto in 2007 and in Berlin 2009. It aims to cover all the previous aspects with a focus on the link to experimental findings. It elucidates important issues in theoretical models that at the same time reflect some current major research interests. Moreover it considers some diverse issues which are very important to get an overview of the fields. For instance, the book discusses not only neural activity in the brain but also the effects of general anesthesia on the cardio-vascular system and the spinal cord in the context of analgesia. In addition, it considers different experimental techniques on various spatial scales, such as fMRI and EEG-experiments on the macroscopic scale and single neuron and LFP-measurements on the microscopic scale. In total all book chapters reveal aspects of the neural correlates of sleep and anesthesia motivated by experimental data. This focus on the neural mechanism in the light of experimental data is the common feature of the topics and the chapters. In addition, the book aims to clarify the shared physiological mechanisms of both phenomena, but also reveal their physiological differences.

General Anesthesia: From Theory to Experiments

Author : Axel Hutt
Publisher : Frontiers Media SA
ISBN 13 : 2889197492
Total Pages : 140 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis General Anesthesia: From Theory to Experiments by : Axel Hutt

Download or read book General Anesthesia: From Theory to Experiments written by Axel Hutt and published by Frontiers Media SA. This book was released on 2016-01-15 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: General anesthesia is a standard medical procedure in today's hospital practice. Although in most cases the administration of anesthetics does not affect severely the patients health, side effects of anesthesia are well-known, such as nausea or cognitive impairment. Moreover 1-2 out of 1000 patients under surgery report a partial wake up from anesthesia during the operation. The reason for such a partial lack of control of depth of anesthesia is that medical procedures are highly optimized based on experience but the neural dynamics during general anesthesia is far from being understood. One reason for this lack of understanding is both the complex neural interactions of neurons on different spatial and temporal scales and the poorly understood action of anesthetics on neural populations. For instance, anesthetic agents act on synaptic receptors on a microscopic scale essentially evoking a macroscopic change of population activity, such as Local Field Potentials, EEG/MEG or resulting change of cerebral blood flow. This population effect then triggers the loss of consciousness in patients. This Research Topic aims to address recent theoretical and experimental advances in the field. The theoretical and experimental studies represent a good overview over the current state of research in the field and provides a deeper insight into the underlying neural mechanisms. Each article in the issue focusses on a specific current research topic in general anesthesia research and several articles introduce to the topic in a pedagogical way. The issue covers various types of anaesthesia and the most important topics in the field, such as (but not limited to) recent advances in theoretical models and states of consciousness reflected in experimental data, the connectivity changes observed during anesthesia or effects of specific drugs on brain activity. The introduction style of the papers facilitates the reader to understand the background of the research aspect and even allows readers not familiar with general anesthesia research to enter the research domain. Hence the Research Topic aims to provide on one hand an overview of the current state of the art and on the other hand a good starting point for new researchers in the field.

Suppressing the Mind

Author : Anthony Hudetz
Publisher : Springer Science & Business Media
ISBN 13 : 1607614626
Total Pages : 256 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis Suppressing the Mind by : Anthony Hudetz

Download or read book Suppressing the Mind written by Anthony Hudetz and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anesthetics produce a reversible state of unconsciousness accompanied by ante- grade amnesia. This remarkable phenomenon brings great relief to surgical patients and wonder to clinicians and scientists. To date, we do not fully understand the mechanisms by which anesthetics ablate conscious sensation and memory. We are, however, making progress. This book presents original results as well as overviews of the current state of knowledge of the problem. It is authored by investigators who know the ?eld well; their research at a number of levels has contributed substantially to our c- rent understanding of anesthetic modulation of memory and consciousness. Most of the contributors were presenters at two workshops organized by Dr. Pearce and Dr. Hudetz at the 40th Annual Winter Conference on Brain Research, held at Snowmass Village, Colorado, from January 27 through February 2, 2007. One workshop focused on anesthetic modulation of consciousness and another on an- thetic modulation of memory. Seven of the chapters are based on material presented at these symposia – appropriately updated with new relevant ?ndings. This infor- tion is supplemented by chapters on anesthesia and sleep, computational analysis of the state of anesthesia, and the clinical phenomenon of “anesthesia awareness,” a topic that has recently received much public attention. With these three additional contributions, the book thus includes 10 chapters.

Molecular and Cellular Mechanisms of Anesthetics

Author : S.H. Roth
Publisher : Springer
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.:/5 (5 download)

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Book Synopsis Molecular and Cellular Mechanisms of Anesthetics by : S.H. Roth

Download or read book Molecular and Cellular Mechanisms of Anesthetics written by S.H. Roth and published by Springer. This book was released on 1986-03-31 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: B. Raymond Fink Sheldon Roth and Keith Miller have asked me to record that the Third Conference on Molecular and Cellular Mechanisms of Anesthesia was held in Calgary last May "in my honor. " Such was my dear friends' gracious way of continuing a series that began at the University of Washington, where I hosted two, four, or five previous ones, 1,3-6 depending 2 on how far back one wishes to count. At that, Seattle took up where Paris left off in 1951. These occasions create their own unforgettable memories. This book captures the fine, invigorating ambience of the University of Calgary and the exciting explorations and com panionship of a gathering in a frontier territory of neuroscience. So, floreant symposia. They have progressively refined the quarry, from pathway to synapse to lipoprotein membrane to receptor and single channel, in heuristic convergences of neuronal physiology, biochemistry, and pharmacology. Nevertheless, the anesthesiologist in me senses a certain disquiet, a certain claustrophobia provoked by the narrow confines of micropipettes. How much more tubular must tunnel vision become before the desired broad view emerges? At present, the advances in molecular neurobiology seem continually to increase the apparent complexity of the total problem and the conceptual distance between the reductionists in the laboratories and the holists in the operating rooms. Happily, what is also growing is the excitement in trying to bridge the gap. Perhaps it would be timely to regard general anesthesia not as a state but as a syndrome.

Oxford Textbook of Neuroscience and Anaesthesiology

Author : George A. Mashour
Publisher : Oxford University Press
ISBN 13 : 0191063541
Total Pages : 351 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Oxford Textbook of Neuroscience and Anaesthesiology by : George A. Mashour

Download or read book Oxford Textbook of Neuroscience and Anaesthesiology written by George A. Mashour and published by Oxford University Press. This book was released on 2019-01-10 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: The perioperative care of individuals with neurologic compromise is critically important, yet it is only one dimension of the rich relationship between anaesthesiology and the neurosciences. The mechanism of everyday therapeutic interventions such as anaesthesia and analgesia is exciting neuroscience in its own right. At the new frontier of outcomes studies lies the question of how the perioperative period might impact the brain. For example, questions related to anaesthetic neurotoxicity, delirium, and cognitive dysfunction pose critical challenges for the field. The Oxford Textbook in Neuroscience and Anaesthesiology addresses the exciting field of neuroanaesthesiology in a new and stimulating way. In twenty eight chapters, the neuroscientific basis of anaesthesiology, the full spectrum of clinical neuroanaesthesia, and the care of neurologic patients undergoing non-neurologic surgery are explored in one comprehensive textbook for the first time. The first section considers the neural mechanisms of general anaesthetics, cerebral physiology, the neurobiology of pain, and more. The second section explores the care of patients with neurologic disease in the operating room or intensive care unit. These clinical chapters systematically treat the perioperative considerations of both brain and spine surgery, and provide introductions to neurocritical care and pediatric neuroanaesthesia. The final section outlines the care of neurologic patients undergoing non-neurologic surgery. It examines key connections of neurology and anaesthesiology, examining how conditions such as dementia, stroke, or epilepsy interface with the perioperative period. Each chapter has been carefully crafted to be concise yet highly informative, reflecting the cutting edge of neuroscience and neuroanaesthesiology. This international textbook gathers the best available expertise of authors and leaders worldwide. Includes access to online-only content, including more than 20 cases and more than 90 questions that can be used in presentations and teaching sessions. By activating your unique access code, you can access and use the material.

Anesthetic Pharmacology

Author : Alex S. Evers
Publisher : Cambridge University Press
ISBN 13 : 1139497022
Total Pages : 2902 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Anesthetic Pharmacology by : Alex S. Evers

Download or read book Anesthetic Pharmacology written by Alex S. Evers and published by Cambridge University Press. This book was released on 2011-03-10 with total page 2902 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

Neuroscientific Foundations of Anesthesiology

Author : George A. Mashour
Publisher : Oxford University Press
ISBN 13 : 0199875464
Total Pages : 296 pages
Book Rating : 4.1/5 (998 download)

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Book Synopsis Neuroscientific Foundations of Anesthesiology by : George A. Mashour

Download or read book Neuroscientific Foundations of Anesthesiology written by George A. Mashour and published by Oxford University Press. This book was released on 2011-10-05 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the perioperative care of patients by anesthesiologists draws on diverse clinical skills, the principles of anesthesiology and pain management are rooted in the neurosciences. The Neuroscientific Foundations of Anesthesiology thoroughly examines the anesthetic modulation of the central, peripheral, and autonomic nervous systems and will help redefine anesthesiology as a fundamentally neuroscientific field. The book is organized by sections, with each focusing on a different part of the nervous system. State-of-the-art chapters written by thought-leaders in anesthesiology and neuroscience provide a novel and invaluable resource.

Local Anesthetics

Author : Benjamin G. Covino
Publisher :
ISBN 13 :
Total Pages : 200 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Local Anesthetics by : Benjamin G. Covino

Download or read book Local Anesthetics written by Benjamin G. Covino and published by . This book was released on 1976 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemical and Biochemical Approaches for the Study of Anesthetic Function

Author :
Publisher : Academic Press
ISBN 13 : 0128145757
Total Pages : 336 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Chemical and Biochemical Approaches for the Study of Anesthetic Function by :

Download or read book Chemical and Biochemical Approaches for the Study of Anesthetic Function written by and published by Academic Press. This book was released on 2018-04-16 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part B, Volume 603, presents a coherent description of the campaign towards understanding anesthesia. It includes a variety of highly debated topics, including sections on computational approaches, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, the kinetic modeling of electrophysiology data, evolving biophysical technologies, fluorescent anesthetics, lipids, membranes and pressure reversal, in vivo technologies, and more. Helps readers understand the wide array of topics surrounding anesthesia Includes sections on Pharmacophore QSAR, QM, ONIOM, and the kinetic modeling of electrophysiology data Broaches genetics, model organisms and general genetic strategies

Suppressing the Mind

Author : Anthony Hudetz
Publisher : Humana Press
ISBN 13 : 9781607614678
Total Pages : 252 pages
Book Rating : 4.6/5 (146 download)

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Book Synopsis Suppressing the Mind by : Anthony Hudetz

Download or read book Suppressing the Mind written by Anthony Hudetz and published by Humana Press. This book was released on 2011-05-27 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anesthetics produce a reversible state of unconsciousness accompanied by ante- grade amnesia. This remarkable phenomenon brings great relief to surgical patients and wonder to clinicians and scientists. To date, we do not fully understand the mechanisms by which anesthetics ablate conscious sensation and memory. We are, however, making progress. This book presents original results as well as overviews of the current state of knowledge of the problem. It is authored by investigators who know the ?eld well; their research at a number of levels has contributed substantially to our c- rent understanding of anesthetic modulation of memory and consciousness. Most of the contributors were presenters at two workshops organized by Dr. Pearce and Dr. Hudetz at the 40th Annual Winter Conference on Brain Research, held at Snowmass Village, Colorado, from January 27 through February 2, 2007. One workshop focused on anesthetic modulation of consciousness and another on an- thetic modulation of memory. Seven of the chapters are based on material presented at these symposia – appropriately updated with new relevant ?ndings. This infor- tion is supplemented by chapters on anesthesia and sleep, computational analysis of the state of anesthesia, and the clinical phenomenon of “anesthesia awareness,” a topic that has recently received much public attention. With these three additional contributions, the book thus includes 10 chapters.

Molecular Mechanisms of Anesthesia

Author : B. Raymond Fink
Publisher :
ISBN 13 :
Total Pages : 682 pages
Book Rating : 4.:/5 (43 download)

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Book Synopsis Molecular Mechanisms of Anesthesia by : B. Raymond Fink

Download or read book Molecular Mechanisms of Anesthesia written by B. Raymond Fink and published by . This book was released on 1975 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neural Blockade in Clinical Anesthesia and Management of Pain

Author : Michael J. Cousins
Publisher : Lippincott Williams & Wilkins
ISBN 13 :
Total Pages : 1220 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Neural Blockade in Clinical Anesthesia and Management of Pain by : Michael J. Cousins

Download or read book Neural Blockade in Clinical Anesthesia and Management of Pain written by Michael J. Cousins and published by Lippincott Williams & Wilkins. This book was released on 1988 with total page 1220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Essential Clinical Anesthesia

Author : Charles Vacanti
Publisher : Cambridge University Press
ISBN 13 : 1139498401
Total Pages : 1191 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Essential Clinical Anesthesia by : Charles Vacanti

Download or read book Essential Clinical Anesthesia written by Charles Vacanti and published by Cambridge University Press. This book was released on 2011-07-11 with total page 1191 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clinical practice of anesthesia has undergone many advances in the past few years, making this the perfect time for a new state-of-the-art anesthesia textbook for practitioners and trainees. The goal of this book is to provide a modern, clinically focused textbook giving rapid access to comprehensive, succinct knowledge from experts in the field. All clinical topics of relevance to anesthesiology are organized into 29 sections consisting of more than 180 chapters. The print version contains 166 chapters that cover all of the essential clinical topics, while an additional 17 chapters on subjects of interest to the more advanced practitioner can be freely accessed at www.cambridge.org/vacanti. Newer techniques such as ultrasound nerve blocks, robotic surgery and transesophageal echocardiography are included, and numerous illustrations and tables assist the reader in rapidly assimilating key information. This authoritative text is edited by distinguished Harvard Medical School faculty, with contributors from many of the leading academic anesthesiology departments in the United States and an introduction from Dr S. R. Mallampati. This book is your essential companion when preparing for board review and recertification exams and in your daily clinical practice.

Cousins and Bridenbaugh's Neural Blockade in Clinical Anesthesia and Pain Medicine

Author : Michael J. Cousins
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9781451166064
Total Pages : 1328 pages
Book Rating : 4.1/5 (66 download)

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Book Synopsis Cousins and Bridenbaugh's Neural Blockade in Clinical Anesthesia and Pain Medicine by : Michael J. Cousins

Download or read book Cousins and Bridenbaugh's Neural Blockade in Clinical Anesthesia and Pain Medicine written by Michael J. Cousins and published by Lippincott Williams & Wilkins. This book was released on 2015-04-24 with total page 1328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, authoritative text presents the scientific foundations and clinical practice of neural blockade in both regional anesthesia and the management of pain. The descriptions and illustrations of pain mechanisms are considered classic examples.

Brain States and Neural Mechanisms of Consciousness

Author : Olivia Gosseries
Publisher : Frontiers Media SA
ISBN 13 : 2832501230
Total Pages : 510 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Brain States and Neural Mechanisms of Consciousness by : Olivia Gosseries

Download or read book Brain States and Neural Mechanisms of Consciousness written by Olivia Gosseries and published by Frontiers Media SA. This book was released on 2022-09-30 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pharmacology and Physiology for Anesthesia E-Book

Author : Hugh C. Hemmings
Publisher : Elsevier Health Sciences
ISBN 13 : 0323568866
Total Pages : 986 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Pharmacology and Physiology for Anesthesia E-Book by : Hugh C. Hemmings

Download or read book Pharmacology and Physiology for Anesthesia E-Book written by Hugh C. Hemmings and published by Elsevier Health Sciences. This book was released on 2018-10-19 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology and physiology are the foundation of every anesthesia provider’s training and clinical competency. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application, 2nd Edition, delivers the information you need in pharmacology, physiology, and molecular-cellular biology, keeping you current with contemporary training and practice. This thoroughly updated edition is your one-stop, comprehensive overview of physiology, and rational anesthetic drug selection and administration, perfect for study, review, and successful practice. Contains new chapters on Special Populations (anesthetic pharmacology in obesity, geriatrics, and pediatrics), Oral and Non-IV Opioids, Thermoregulation, Physiology and Pharmacology of Obstetric Anesthesia, Chemotherapeutic and Immunosuppresive Drugs, and Surgical Infection and Antimicrobial Drugs. Incorporates entirely new sections on Physics, Anatomy, and Imaging. Includes new information on consciousness and cognition, pharmacodynamics, the immune system, and anti-inflammatory drugs. Features user-friendly tables, figures, and algorithms (including 100 new illustrations), all presented in full color and designed to help explain complex concepts. Helps you understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these areas.