Nanostructured Drug Delivery Systems In Infectious Disease Treatment

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Nanostructured Drug Delivery Systems in Infectious Disease Treatment

Author : Sarwar Beg
Publisher : Elsevier
ISBN 13 : 0443133360
Total Pages : 484 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Nanostructured Drug Delivery Systems in Infectious Disease Treatment by : Sarwar Beg

Download or read book Nanostructured Drug Delivery Systems in Infectious Disease Treatment written by Sarwar Beg and published by Elsevier. This book was released on 2024-07-12 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutting edge technology-based drug delivery systems have been rapidly growing and are being applied to various sections of biomedicine. The current scenario of global burden due to infectious disorders can take advantage of nanoparticulate based carriers to advance the cure efficiency. Nanostructured Drug Delivery Systems in Infectious Disease Treatment explores a broad range of promising approaches for the treatment of infectious diseases using the latest advancements in nanomedical technologies. The book opens with introduction about infectious diseases and its global burden. There is also specific discussion and assessment of the global impact of viruses with an emphasis on COVID-19, Zika, and Ebola. Subsequent chapters provide detailed information about various novel nanotherapeutic strategies used for delivering drugs for the treatment of various types of viral, bacterial, and fungal disorders. Nanostructured Drug Delivery Systems in Infectious Disease Treatment is a valuable resource for graduates, researchers, industry professionals, and anyone working to tackle the challenges of delivering drugs in a more targeted and efficient manner for the treatment of infectious diseases. Focuses on the application of different nanotechnology-based drug delivery systems Offers information on how to design and develop the nanotechnology-based drug delivery systems and devices for the treatment of infectious disorders Explores challenges and regulatory concerns of nanomedicine in infectious disorders

Nanostructures for Antimicrobial Therapy

Author : Anton Ficai
Publisher : Elsevier
ISBN 13 : 0323461514
Total Pages : 724 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Nanostructures for Antimicrobial Therapy by : Anton Ficai

Download or read book Nanostructures for Antimicrobial Therapy written by Anton Ficai and published by Elsevier. This book was released on 2017-05-29 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. Shows how nanoantibiotics can be used to more effectively treat disease Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area

Viral Drug Delivery Systems

Author : Ranjita Shegokar
Publisher : Springer
ISBN 13 : 9783031205361
Total Pages : 0 pages
Book Rating : 4.2/5 (53 download)

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Book Synopsis Viral Drug Delivery Systems by : Ranjita Shegokar

Download or read book Viral Drug Delivery Systems written by Ranjita Shegokar and published by Springer. This book was released on 2023-05-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY). Infectious diseases are one of the major to cause significant losses of DALY and QALY. Human infectious diseases are disorders that are triggered by the micro-organisms such as bacteria, fungi, viruses, or parasites. The majority of such diseases are contagious and create a public health menace. There are several reasons why infectious diseases are deadly diseases, and one of the primary reasons is the drug resistance developed over time. Drug resistance-associated mutations are linked to increasing drug efflux, modifications of the drugs, or their targets. Every year, new drugs are being approved by FDA to treat infectious diseases. Nonetheless, the infectious diseases will undoubtedly persist as permanent and main threats to humanity for now and in the future, primarily due to increased longevity that almost always comes at a cost of impaired immunity. A total of four books are covered under the series of Infectious drug diseases. - Malarial drug delivery systems - Tubercular drug delivery systems - Viral drug delivery systems - Infectious disease drug delivery systems The third volume of series is focused on viral drug delivery systems. Typically, virus attaches to the cells (referred as host cell) and releases its DNA or RNA inside the cell. In second stage, virus’s genetic material takes control of the cell and forces it to replicate the virus leading to onset of disease symptoms. DNA class of viruses include Herpes, Papilloma and Adeno viruses. RNA class of viruses include retroviruses, such as HIV immunodeficiency virus and SARS COV – 2 / Corona virus. This book addresses recent developments in viral drug delivery systems. It covers many different aspects of viral infections, ways to treat them using modern drug delivery systems like nano particulate carriers. The choice of viral delivery systems mainly depends upon the type of virus, duration of life cycle, presence of drug resistance, cellular and mucosal interaction of virus, accordingly gene or non-gene drug delivery systems are selected. Besides that, this book also reports global dynamics of viral diseases, future predictions of infection rate, current treatment options, details of drug carriers like nanoemulsions, polymeric nanoparticles, role of biofunctionalization, and phyto-molecules in treatment of viral infections particularly herpes, Covid-19, Ebola, HIV/AIDS, influenza and viral hepatitis. Audiences from a broad range of groups, from researchers, academicians, and public health bodies to regulatory experts, can benefit from the compiled information to learn more about patient needs and current research advances in the field of viral drug delivery research.

Application of Nanotechnology in Drug Delivery

Author : Rodolph Donovan
Publisher :
ISBN 13 : 9781681172385
Total Pages : 0 pages
Book Rating : 4.1/5 (723 download)

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Book Synopsis Application of Nanotechnology in Drug Delivery by : Rodolph Donovan

Download or read book Application of Nanotechnology in Drug Delivery written by Rodolph Donovan and published by . This book was released on 2016-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuing improvement in the pharmacological and therapeutic properties of drugs is driving the revolution in novel drug delivery systems. In fact, a wide spectrum of therapeutic nanocarriers has been extensively investigated to address this emerging need. Nanotechnology involves the engineering of functional systems at the molecular scale. Recent years have witnessed unprecedented growth of research and applications in the area of nanoscience and nanotechnology. There is increasing optimism that nanotechnology, as applied to medicine, will bring signiﬁcant advances in the diagnosis and treatment of disease. Anticipated applications in medicine include drug delivery, both in vitro and in vivo diagnostics, nutraceuticals and production of improved biocompatible materials. As such, nanomaterials are poised to take advantage of existing cellular machinery to facilitate the delivery of drugs. The use of nanotechnology in medicine and more speciﬁcally drug delivery is set to spread rapidly. Currently many substances are under investigation for drug delivery and more speciﬁcally for cancer therapy. anoparticles (NPs) containing encapsulated, dispersed, absorbed or conjugated drugs have unique characteristics that can lead to enhanced performance in a variety of dosage forms. When formulated correctly, drug particles are resistant to settling and can have higher saturation solubility, rapid dissolution and enhanced adhesion to biological surfaces, thereby providing rapid onset of therapeutic action and improved bioavailability. In addition, the vast majority of molecules in a nanostructure reside at the particle surface, which maximizes the loading and delivery of cargos, such as therapeutic drugs, proteins and polynucleotides, to targeted cells and tissues. Highly eﬃcient drug delivery, based on nanomaterials, could potentially reduce the drug dose needed to achieve therapeutic beneﬁt, which, in turn, would lower the cost and/or reduce the side eﬀects associated with particular drugs. This book, Application of Nanotechnology in Drug Delivery, deals with the new and ongoing potentialities of nanotechnology application of drug delivery. In addition, it discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Advances in Nanotechnology-Based Drug Delivery Systems

Author : Anupam Das Talukdar
Publisher : Elsevier
ISBN 13 : 0323904149
Total Pages : 672 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Advances in Nanotechnology-Based Drug Delivery Systems by : Anupam Das Talukdar

Download or read book Advances in Nanotechnology-Based Drug Delivery Systems written by Anupam Das Talukdar and published by Elsevier. This book was released on 2022-06-06 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Nanotechnology-Based Drug Delivery Systems covers the core concepts and latest research regarding the use of nanoscale materials for the development and application of drug delivery systems. The book introduces the reader to nanotechnology in drug delivery, covering the synthesis, encapsulation techniques, characterization and key properties of nanoscale drug delivery systems. Later chapters review the broad range of target applications, including site-specific delivery of drugs for cardiovascular disease, cancer, bacterial infection, bone regeneration. and much more. This book helps translate advanced research into a clinical setting, analyzing the toxicity and health and safety challenges associated with utilizing nanotechnology in biomedicine. This will be a useful reference for those interested in nano-sized drug delivery in biomedicine, including academics and researchers in materials science, biomedical engineering, pharmaceutical science and related disciplines. Provides a clear introduction to nanotechnology in drug delivery, covering key principles, synthesis, characterization and unique properties of nanoscale materials for drug delivery systems“/li> Discusses preclinical, clinical and patented nano-drug delivery systems, enabling the reader to grasp the current state-of-the-art and market Covers a broad range of targets for nanoscale drug delivery systems, such as in neurological disorders, oral disease, renal disease, cancer, skin protection, and much more

Nanoparticle Based Drug Delivery Systems for Treatment of Infectious Diseases

Author : Mojtaba Salouti
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (115 download)

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Book Synopsis Nanoparticle Based Drug Delivery Systems for Treatment of Infectious Diseases by : Mojtaba Salouti

Download or read book Nanoparticle Based Drug Delivery Systems for Treatment of Infectious Diseases written by Mojtaba Salouti and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticle based Drug Delivery Systems for Treatment of Infectious Diseases.

Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance

Author : Muthupandian Saravanan
Publisher : Elsevier
ISBN 13 : 0323998100
Total Pages : 790 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance by : Muthupandian Saravanan

Download or read book Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance written by Muthupandian Saravanan and published by Elsevier. This book was released on 2022-06-22 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance focuses on recent and emerging trends surrounding nanomaterials and nano-drug delivery approaches to combat antimicrobial resistance. The relationship between nanomaterials and antimicrobial activity needs to be deeply explored to meet the challenges of combating antimicrobial resistance. The content of this book is divided into three main topic areas, including (i) how to overcome the existing traditional approaches to combat antimicrobial resistance, (ii) applying multiple drug delivery mechanisms to target multi-drug resistant microbes, and (iii) how nanomaterials can be used as drug carriers. This is an important reference source for those looking to understand how nanotechnology plays an important role in combatting disease and infection. As antimicrobial resistance threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi, this is a timely resource. Outlines how to overcome existing traditional approaches to combatting antimicrobial resistance Explains how to apply multiple drug delivery mechanisms (MDR) to the target area in order to better combat antimicrobial resistance Shows how nanomaterials are used as drug carriers in this context

Drug Delivery Approaches and Nanosystems, Volume 2

Author : Raj K. Keservani
Publisher : CRC Press
ISBN 13 : 1351846663
Total Pages : 248 pages
Book Rating : 4.3/5 (518 download)

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Book Synopsis Drug Delivery Approaches and Nanosystems, Volume 2 by : Raj K. Keservani

Download or read book Drug Delivery Approaches and Nanosystems, Volume 2 written by Raj K. Keservani and published by CRC Press. This book was released on 2017-11-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a thorough presentation of the state-of-the-art research and developments in drug delivery systems using nanotechnology and its applications. The second of this two-volume set, it addresses the applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. This volume includes 11 chapters that focus on the targeting facet of drug delivery systems. Targeting is a focused maneuver to achieve the specified goals, including achieving the desired result and reaching the specific location. Targeting has now been successfully achieved for several diseases/disorders; however, its role is noteworthy in cancer treatment where chemotherapy is a main course of approach. Nanotechnology-based products have great potential by virtue of their inherent features. This edited book provides a detailed application of nanotechnology in drug delivery systems in health care. The book discusses general principles of drug targeting, material of construction and technological concerns of nanoparticles, and different drug delivery systems and their preparation. Taken together, the informative chapters will provide researchers and scientists as well as faculty and students with valuable research on the effective use of new approaches in advanced drug delivery nanosystems. Volume 1 of the two-volume series is subtitled Novel Drug Carriers. The volumes are available separately or as a set.

Application of Nanotechnology in Drug Delivery

Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
ISBN 13 : 9535116282
Total Pages : 556 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Application of Nanotechnology in Drug Delivery by : Ali Demir Sezer

Download or read book Application of Nanotechnology in Drug Delivery written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2014-07-25 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of nanotechnology use in drug delivery. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of nanotechnology application of drug delivery. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Nanostructures for Drug Delivery

Author : Ecaterina Andronescu
Publisher : Elsevier
ISBN 13 : 0323461492
Total Pages : 1026 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Nanostructures for Drug Delivery by : Ecaterina Andronescu

Download or read book Nanostructures for Drug Delivery written by Ecaterina Andronescu and published by Elsevier. This book was released on 2017-03-24 with total page 1026 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Drug Delivery extensively covers the various nanostructured products that have been tested as carriers in target drug delivery systems. In addition, the book analyses the advantages of, and issues related to, using nanostructured materials in drug delivery systems, also detailing various nanocarrier preparation techniques. As delivering the drug to the target site is a major problem in providing effective treatment for many diseases, this book covers the latest advancements in numerous nanotechnological products that are being used in disease detection, controlled drug delivery, as biosensors, and in tissue engineering that have been developed for more efficient patient healthcare. Due to the versatility of nanostructured materials, it is now possible to deliver a drug at its target site in a more accurate and efficient way. This volume is an up-to-date, state-of-the-art work that highlights the principal mechanistic aspects related to the delivery of active nanoscale therapeutic agents (natural or synthetic) and their release profile in different environmental media. It highlights nanoscale encapsulation strategies and discusses both organic and inorganic nanomaterials as carriers and delivery platforms. Demonstrates how nanostructures are successfully employed in drug delivery stems and as drug delivery agents, allowing biomaterials scientists and biochemists to create more effective drug delivery systems Offers an overview of recent research into the use of nanostructures in drug delivery techniques in a cogent, synthesized way, allowing readers to quickly familiarize themselves with this area Includes examples of how the application of nanostructures have improved the efficiency of drug delivery systems, showing medical scientists how they are beneficial

Nano- and Microscale Drug Delivery Systems

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
ISBN 13 : 0323527280
Total Pages : 516 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Nano- and Microscale Drug Delivery Systems by : Alexandru Mihai Grumezescu

Download or read book Nano- and Microscale Drug Delivery Systems written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2017-03-27 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nano- and Microscale Drug Delivery Systems: Design and Fabrication presents the developments that have taken place in recent years in the field of micro- and nanoscale drug delivery systems. Particular attention is assigned to the fabrication and design of drug delivery systems in order to i) reduce the side effects of therapeutic agents, ii) increase their pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. This book is designed to offer a cogent, concise overview of current scholarship in this important area of research through its focus on the characterization and fabrication of a variety of nanomaterials for drug delivery applications. It is an invaluable reference source for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems. Shows how micro- and nanomaterials can be engineered to create more effective drug delivery systems Summarizes current nanotechnology research in the field of drug delivery systems Explores the pros and cons of using particular nanomaterials as therapeutic agents Serves as a valuable reference for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems

Nanomedicine for the Treatment of Disease

Author : Sarwar Beg
Publisher : CRC Press
ISBN 13 : 0429758820
Total Pages : 547 pages
Book Rating : 4.4/5 (297 download)

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Book Synopsis Nanomedicine for the Treatment of Disease by : Sarwar Beg

Download or read book Nanomedicine for the Treatment of Disease written by Sarwar Beg and published by CRC Press. This book was released on 2019-09-25 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume, Nanomedicine for the Treatment of Disease: From Concept to Application, looks at the application of nanomedicines with a particular focus on their use in the treatment of diseases. The chapters in this volume, contributed by eminent scientists, researchers, and nanotechnologists from across the globe, highlight key advancements, challenges, and opportunities in the area of application of nanomedicines for disease treatment. They explore the design and development of therapeutic nanocarriers for targeting drugs for satiating the demands of disease treatment process. The volume explores the use nanomedicines for the diagnosis and treatment of a multitude various diseases and health conditions, including respiratory diseases, neurological disorders, genetic diseases, pulmonary fungal infections, neuroAIDS, cardiovascular disorders, gastric and colonic diseases, skin disorders, cancer, brain tumors, leishmaniasis and other visceral diseases, hypertension, and ocular diseases.

Nanotechnology Based Approaches for Tuberculosis Treatment

Author : Prashant Kesharwani
Publisher : Academic Press
ISBN 13 : 0128226110
Total Pages : 284 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Nanotechnology Based Approaches for Tuberculosis Treatment by : Prashant Kesharwani

Download or read book Nanotechnology Based Approaches for Tuberculosis Treatment written by Prashant Kesharwani and published by Academic Press. This book was released on 2020-06-10 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology Based Approaches for Tuberculosis Treatment discusses multiple nanotechnology-based approaches that may help overcome persisting limitations of conventional and traditional treatments. The book summarizes the types of nano drugs, their synthesis, formulation, characterization and applications, along with the most important administration routes. It also explores recent advances and achievements regarding therapeutic efficacy and provides possible future applications in this field. It will be a useful resource for investigators, pharmaceutical researchers, innovators and scientists working on technology advancements in the areas of targeted therapies, nano scale imaging systems, and diagnostic modalities in tuberculosis. Addresses the gap between nanomedicine late discovery and early development of tuberculosis therapeutics Explores tuberculosis nanomedicine standardization and characterization with newly developed treatment, diagnostic and treatment monitoring modalities Covers the field thoroughly, from the pathogenesis of tuberculosis and multi-drug resistant mycobacterium tuberculosis, to treatment approaches using nanotechnology and different nanocarriers

Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
ISBN 13 : 0323527264
Total Pages : 374 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics by : Alexandru Mihai Grumezescu

Download or read book Multifunctional Systems for Combined Delivery, Biosensing and Diagnostics written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2017-05-03 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional Systems for Combined Delivery, Biosensing, and Diagnostics explores how multifunctional nanocarriers are being used in combined delivery and diagnostics in contemporary medicine. Particular attention is given to efforts to i) reduce the side effects of therapeutic agents, ii) increase the pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. The chapters focus on applications of nanostructured materials and nanocarriers, highlighting how these can be used effectively in both diagnosis and delivery. This applied focus makes the book an important reference source for those wanting to learn more about how specific nanomaterials and nanotechnology systems can help to solve drug delivery and diagnostics problems. This book is a valuable resource for materials scientists, bioengineers, and medical researchers who are looking for an applications-oriented guide on how nanotechnology and nanomaterials can be used effectively throughout the medical treatment process, from diagnosis to treatment. Explores the benefits of using a variety of nanomaterials as drug delivery agents Explains how nanocarriers can reduce the side effects of therapeutic agents Provides an analysis of the pros and cons of using specific nanocarriers to solve particular diagnosis and delivery problems

Novel Carrier Systems for Targeted and Controlled Drug Delivery

Author : Awesh K. Yadav
Publisher : Springer
ISBN 13 : 9789819749690
Total Pages : 0 pages
Book Rating : 4.7/5 (496 download)

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Book Synopsis Novel Carrier Systems for Targeted and Controlled Drug Delivery by : Awesh K. Yadav

Download or read book Novel Carrier Systems for Targeted and Controlled Drug Delivery written by Awesh K. Yadav and published by Springer. This book was released on 2024-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents novel carrier systems for the targeted and controlled drug delivery for the treatment of various diseases which are difficult to be treated with conventional drug delivery systems like cancer, autoimmune disorders, and emerging infectious diseases. It also reviews the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The book also explores the potential applications of the parenteral route of administration for the delivery of active pharmaceutical substances with a narrow therapeutic index and poor bioavailability. Further, the book presents common routes of administration for the systemic delivery of peptides and proteins. It also examines the applications of various implantable systems in drug delivery. The book also covers the important colloidal drug delivery systems, including liposomes and niosomes and solid lipid nanoparticles, and nanostructured lipid carriers. Towards,the end, the book discusses the therapeutic potential of biodegradable polymeric nanoparticles for controlled drug delivery. Authoritative and thorough, this book is a valuable resource for researchers working on a multidisciplinary approach to employing drug delivery systems.

Rational Design and Synthesis of Mesoporous Silica Nanostructure-based Drug Delivery Systems

Author : Lauren Chlebanowski
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Rational Design and Synthesis of Mesoporous Silica Nanostructure-based Drug Delivery Systems by : Lauren Chlebanowski

Download or read book Rational Design and Synthesis of Mesoporous Silica Nanostructure-based Drug Delivery Systems written by Lauren Chlebanowski and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the most threatening diseases in the world, cancer and multi-drug resistant bacteria infections are two of the most serious. Mesoporous silica nanoparticles or nanostructures (MSNs) provide nanovesicles for transporting anti-cancer or anti-microbial drugs. The MSNs can easily be functionalized with gatekeepers to ensure that these drugs are released when and where they are needed. It is known that membrane disruption is more difficult for bacteria to gain resistance. For this reason, a small surfactant library was designed with potential of having significant activity toward both gram-positive and gram-negative bacteria. Once the surfactants were synthesized, they were characterized using NMR, IR, and mass spectroscopy. Their activity was then tested against Micrococcus luteus and Methicillin Resistant-Staphylococcus aureus. The surfactants with best activity were then successfully incorporated into MSN structures. Benzalkonium chloride (BAC), a commercially available antiseptic, had the lowest minimum inhibitory concentration (MIC) of the surfactants tested, thus making it the best candidate for use in the proof of study for the designed delivery system. The MSN-based system for treatment of bacterial infections consisted of BAC loaded, amine functionalized MSNs anchored to a vancomycin gatekeeper via a protease cleavable peptide linker. The peptide was designed to have two cleavage positions by proteases for optimal cleaving. Vancomycin was chosen for its bulky size and activity toward bacteria. The system designed for treatment of cancer was focused on the non-specific nature of the therapeutic peptide SA-D-K6L9-AS. The peptide needed to be "gift-wrapped" and sent to the exact location of the tumor to minimize systemic toxicity. The proposed system for this was to use MSNs built directly around a self-assembling version of D-K6L9, then embedding iron oxide nanoparticles on the surface of the MSN, and finally enveloping the MSN in a lipid membrane. The drug would be released when the iron oxide particles were heated via radio-wave mediated hyperthermia. As proof of concept, MSNs built around a rhodamine-B labeled, self-assembling version of D-K6L9 were used and tested against GL26 (glioma), B16F10 (melanoma), and NSC (neural stem cells) cell lines, both with and without the gatekeeping system. The outcome was as anticipated, the gatekeeper kept the peptide inside and the cell viabilities remained high. The next steps of these projects will be to continue in-vitro testing before moving on to mouse model studies. The MSNs in both projects were characterized using DLS, Zeta potential, TGA, and TEM. Overall, the proposed MSN-based drug delivery systems appear to exhibit promising potential for new approaches towards treatment of both antibiotic resistance and cancer.

Nanomedicine and Cancer

Author : Rajaventhan Srirajaskanthan
Publisher : CRC Press
ISBN 13 : 1578087279
Total Pages : 462 pages
Book Rating : 4.5/5 (78 download)

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Book Synopsis Nanomedicine and Cancer by : Rajaventhan Srirajaskanthan

Download or read book Nanomedicine and Cancer written by Rajaventhan Srirajaskanthan and published by CRC Press. This book was released on 2011-12-20 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nanosciences are a rapidly expanding field of research with a wide applicability to all areas of health. They encompass a variety of technologies ranging from particles to networks and nanostructures. This book focuses on the application of nanomedicine and nanotechnology to cancer. It introduces nanocarriers, nanorods, nanoprobes nanoplatforms, nanorings, nanotubes nanowires, nano-sensor arrays and a variety of methodological techniques. This is done within the framework of numerous cancer types. Contributors are all leading experts and are carrying out groundbreaking work. The book is essential reading for oncologists, research scientists, doctors, health care professionals, pathologists, biologists, biochemists, chemists and physicists as well as those interested in disease and nanosciences or cancer in general.