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Essential Genetics

Author : Daniel Hartl
Publisher : Jones & Bartlett Learning
ISBN 13 : 0763773646
Total Pages : 600 pages
Book Rating : 4.7/5 (637 download)

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Book Synopsis Essential Genetics by : Daniel Hartl

Download or read book Essential Genetics written by Daniel Hartl and published by Jones & Bartlett Learning. This book was released on 2011 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated to reflect the latest discoveries in the field, the Fifth Edition of Hartl's classic text provides an accessible, student-friendly introduction to contemporary genetics. Designed for the shorter, less comprehensive introductory course, Essential Genetics: A Genomic Perspective, Fifth Edition includes carefully chosen topics that provide a solid foundation to the basic understanding of gene mutation, expression, and regulation. New and updated sections on genetic analysis, molecular genetics, probability in genetics, and pathogenicity islands ensure that students are kept up-to-date on current key topics. The text also provides students with a sense of the social and historical context in which genetics has developed. The updated companion web site provides numerous study tools, such as animated flashcards, crosswords, practice quizzes and more! New and expanded end-of-chapter material allows for a mastery of key genetics concepts and is ideal for homework assignments and in-class discussion.

Pathologic Conditions of the Human Nervous and Muscular Systems Associated with Mutant Chaperones: Molecular and Mechanistic Aspects

Download Pathologic Conditions of the Human Nervous and Muscular Systems Associated with Mutant Chaperones: Molecular and Mechanistic Aspects PDF Online Free

Author : Alberto J. L. Macario
Publisher : Frontiers Media SA
ISBN 13 : 2889454576
Total Pages : 111 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Pathologic Conditions of the Human Nervous and Muscular Systems Associated with Mutant Chaperones: Molecular and Mechanistic Aspects by : Alberto J. L. Macario

Download or read book Pathologic Conditions of the Human Nervous and Muscular Systems Associated with Mutant Chaperones: Molecular and Mechanistic Aspects written by Alberto J. L. Macario and published by Frontiers Media SA. This book was released on 2018-04-12 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.

A Journey Towards Bio-inspired Techniques in Software Engineering

Author : Jagannath Singh
Publisher : Springer Nature
ISBN 13 : 3030409287
Total Pages : 214 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis A Journey Towards Bio-inspired Techniques in Software Engineering by : Jagannath Singh

Download or read book A Journey Towards Bio-inspired Techniques in Software Engineering written by Jagannath Singh and published by Springer Nature. This book was released on 2020-03-11 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a range of basic and advanced topics in software engineering. The field has undergone several phases of change and improvement since its invention, and there is significant ongoing research in software development, addressing aspects such as analysis, design, testing and maintenance. Rather than focusing on a single aspect of software engineering, this book provides a systematic overview of recent techniques, including requirement gathering in the form of story points in agile software, and bio-inspired techniques for estimating the effort, cost, and time required for software development. As such it is a valuable resource for new researchers interested in advances in software engineering — particularly in the area of bio-inspired techniques.

Mutant p53 in Cancer Progression and Personalized Therapeutic Treatments

Author : Marco Cordani
Publisher : Frontiers Media SA
ISBN 13 : 288971537X
Total Pages : 174 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Mutant p53 in Cancer Progression and Personalized Therapeutic Treatments by : Marco Cordani

Download or read book Mutant p53 in Cancer Progression and Personalized Therapeutic Treatments written by Marco Cordani and published by Frontiers Media SA. This book was released on 2021-10-22 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Discovery & Character of Transposable Elements

Author : Barbara McClintock
Publisher : Taylor & Francis
ISBN 13 : 1040292879
Total Pages : 652 pages
Book Rating : 4.0/5 (42 download)

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Book Synopsis The Discovery & Character of Transposable Elements by : Barbara McClintock

Download or read book The Discovery & Character of Transposable Elements written by Barbara McClintock and published by Taylor & Francis. This book was released on 2024-11-15 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume holds a collection of papers around the discovery of transposable elements in maize and chomosome behaviour. They were selected because of their relevance to this topic. For the discovery of "Mobile genetic elements" Barbara McClintock received the Nobel Prize for Physiology or Medicine in 1983.

Advances in Protein Chemistry

Author :
Publisher : Academic Press
ISBN 13 : 0080582036
Total Pages : 502 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Advances in Protein Chemistry by :

Download or read book Advances in Protein Chemistry written by and published by Academic Press. This book was released on 1976-07-09 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Protein Chemistry

Therapeutic Strategies in EGFR Mutant Lung Cancer

Author : Yaxiong Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2832503802
Total Pages : 239 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Therapeutic Strategies in EGFR Mutant Lung Cancer by : Yaxiong Zhang

Download or read book Therapeutic Strategies in EGFR Mutant Lung Cancer written by Yaxiong Zhang and published by Frontiers Media SA. This book was released on 2022-11-03 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins

Author : Ygal Haupt
Publisher : Frontiers Media SA
ISBN 13 : 2889199614
Total Pages : 99 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins by : Ygal Haupt

Download or read book Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins written by Ygal Haupt and published by Frontiers Media SA. This book was released on 2016-08-10 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastasize. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome. Over the past 3 decades, the regulation of p53 has been extensively studied. However, the regulation of mutant p53 remained largely unexplored. This snapshot focuses on recent discovery of mutant p53 GOF and regulation.

CARMA Proteins: Playing a Hand of Four CARDs

Author : Frédéric Bornancin
Publisher : Frontiers Media SA
ISBN 13 : 2889630560
Total Pages : 179 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis CARMA Proteins: Playing a Hand of Four CARDs by : Frédéric Bornancin

Download or read book CARMA Proteins: Playing a Hand of Four CARDs written by Frédéric Bornancin and published by Frontiers Media SA. This book was released on 2019-10-18 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some twenty years ago, the search began for B-cell lymphoma (BCL)-10 binding partners that connect via homophilic interaction with its N-terminal caspase recruitment domain (CARD) to induce nuclear factor-kappa B (NF-κB) activation. This effort led first to the identification of the protein CARD9. Soon afterwards, similar searches identified CARD10 (aka CARMA3), CARD11 (aka CARMA1) and CARD14 (aka CARMA2), as further BCL10 interactors. These discoveries paved the way for landmark progress in our understanding of NF-κB activation pathways downstream of several cell surface receptors on multiple cell types, focused particularly on antigen receptors on lymphocytes. An additional binding partner, called Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), was also implicated in the CARD-BCL10 pathway. Since then, the resulting “CBM” complex has been recognized as a key node in signaling cascades leading to NF-κB activation, particularly in immune cells. Mouse models of genetic deficiencies for each CBM component provided the first evidence for their critical role in cell signaling. More recently, studies of human lymphoid malignancies and novel genetic disorders have revealed important new insights. Both gain- and loss-of-function mutations were identified, establishing these CARMA/CARD proteins as key regulators of proliferation and differentiation of immune and non-immune cells, and linking them to human disease. According to the genetic defect involved, dysregulation of CARMA/CARD pathways can lead to a broad spectrum of immune disorders, including severe immune deficiencies, lymphoproliferative disorders, psoriasis and atopy. The aim of this Research Topic is to summarize and update our current understanding of CARMA/CARD protein biology, from initial discoveries to the most recent insights. It focuses on CARD9 and the CARMA proteins CARD10, CARD11 and CARD14, from genetic, signaling and disease perspectives. BCL10 and MALT1 are also reviewed in this context as critical nodes for CBM signal relay and regulation. This Research Topic also aims to delineate the next key questions in the field to guide future research efforts.

Encyclopedia of Cancer

Author :
Publisher : Academic Press
ISBN 13 : 0128124857
Total Pages : 1906 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Cancer by :

Download or read book Encyclopedia of Cancer written by and published by Academic Press. This book was released on 2018-10-12 with total page 1906 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Cancer, Third Edition, Three Volume Set provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition. Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented. Comprises 180 contributions from renowned experts who present the latest in mechanisms, hallmarks of cancer, causes, prevention and control, diagnosis and therapy, pathology and genetics Presents a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health

Pathology of Genetically Engineered and Other Mutant Mice

Author : John P. Sundberg
Publisher : John Wiley & Sons
ISBN 13 : 1119624576
Total Pages : 564 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Pathology of Genetically Engineered and Other Mutant Mice by : John P. Sundberg

Download or read book Pathology of Genetically Engineered and Other Mutant Mice written by John P. Sundberg and published by John Wiley & Sons. This book was released on 2022-01-26 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

Teenage Mutant Ninja Turtles Classics, Vol. 8

Author : Jim Lawson
Publisher : IDW Publishing
ISBN 13 : 1623025605
Total Pages : 135 pages
Book Rating : 4.6/5 (23 download)

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Book Synopsis Teenage Mutant Ninja Turtles Classics, Vol. 8 by : Jim Lawson

Download or read book Teenage Mutant Ninja Turtles Classics, Vol. 8 written by Jim Lawson and published by IDW Publishing. This book was released on with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 8 begins collecting the Mirage Studios series Teenage Mutant Ninja Turtles Volume 2 that ran from 1993_1995. Includes the stories "Memories of the Future," "Winds of Change," "Evolution," "Intruders," and "Death Race", all written and drawn by Turtles veteran Jim Lawson.

Bibliography of Agriculture

Author :
Publisher :
ISBN 13 :
Total Pages : 1732 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Bibliography of Agriculture by :

Download or read book Bibliography of Agriculture written by and published by . This book was released on 1976 with total page 1732 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Teenage Mutant Ninja Turtles, Vol. 22: City At War, Pt. 1

Author : Tom Waltz
Publisher : IDW Publishing
ISBN 13 : 1684067987
Total Pages : 156 pages
Book Rating : 4.6/5 (84 download)

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Book Synopsis Teenage Mutant Ninja Turtles, Vol. 22: City At War, Pt. 1 by : Tom Waltz

Download or read book Teenage Mutant Ninja Turtles, Vol. 22: City At War, Pt. 1 written by Tom Waltz and published by IDW Publishing. This book was released on 2019-09-25 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: It's all been leading up to this! A massive showdown on the streets of NYC! Everything comes together in this explosive story that sees New York City torn apart by different factions, mutant and human alike! Karai returns to New York and the future of the TMNT, and all of NYC, comes down to a final negotiation between Splinter and Karai. Can they reach an agreement before Bishop's new plan begins? Leonardo, Raphael, Donatello, and Michelangelo face a gauntlet of danger unlike anything they have experienced before! Collects issues #90-95 of the ongoing series.

The Corpus Callosum

Author : Mehmet Turgut
Publisher : Springer Nature
ISBN 13 : 3031381149
Total Pages : 371 pages
Book Rating : 4.0/5 (313 download)

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Book Synopsis The Corpus Callosum by : Mehmet Turgut

Download or read book The Corpus Callosum written by Mehmet Turgut and published by Springer Nature. This book was released on 2023-12-29 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an in-depth review of knowledge of the corpus callosum, called white matter or terra incognita, with emphasis on anatomical, embryological, diagnostics, and surgical features. It includes very informative chapters from leaders in the field, organized into six main groups: first, the embryology, neuroanatomy, and morphometry of the corpus callosum, and animal studies related to it; secondly, neurophysiological aspects, callosal disconnection and the split brain; thirdly, neuropathology, including clinical disorders such as dementia, Tourette syndrome, and schizophrenia; fourthly, surgical procedures including partial and complete callosotomy and commissurotomy; fifthly, cognitive neuroscience; and sixthly, other features of the corpus callosum, including its medicolegal aspects and statistical shape analysis. This comprehensive reference book will be an ideal source for neuroscientists at all levels, from graduate students to researchers in specific disciplines studying this region including neuroanatomists, embryologists, neurosurgeons, neurologists, neuroradiologists and pediatricians, who seek both basic and more advanced information regarding the distinctive anatomical, physiological and pathological features of the human corpus callosum.

Teenage Mutant Ninja Turtles, Vol. 11: Attack on Technodrome

Author : Tom Waltz
Publisher : IDW Publishing
ISBN 13 : 1623027802
Total Pages : 107 pages
Book Rating : 4.6/5 (23 download)

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Book Synopsis Teenage Mutant Ninja Turtles, Vol. 11: Attack on Technodrome by : Tom Waltz

Download or read book Teenage Mutant Ninja Turtles, Vol. 11: Attack on Technodrome written by Tom Waltz and published by IDW Publishing. This book was released on 2015-07-01 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Time is short as Krang accelerates his plan to terraform the Earth, which will kill all who live on it! A surprise alliance results in a daring plan-- and the stakes have never been higher! Collects issues #41_44.

Mutant p53 and MDM2 in Cancer

Author : Swati Palit Deb
Publisher : Springer
ISBN 13 : 9401792119
Total Pages : 376 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Mutant p53 and MDM2 in Cancer by : Swati Palit Deb

Download or read book Mutant p53 and MDM2 in Cancer written by Swati Palit Deb and published by Springer. This book was released on 2014-09-08 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.